LOCUS       NM_001136229            4203 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 4 (Trpm4), mRNA.
ACCESSION   NM_001136229 XM_574447
VERSION     NM_001136229.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4203)
  AUTHORS   Combe,C.L., Upchurch,C.M., Canavier,C.C. and Gasparini,S.
  TITLE     Cholinergic modulation shifts the response of CA1 pyramidal cells
            to depolarizing ramps via TRPM4 channels with potential
            implications for place field firing
  JOURNAL   Elife 12, e84387 (2023)
   PUBMED   37404129
  REMARK    GeneRIF: Cholinergic modulation shifts the response of CA1
            pyramidal cells to depolarizing ramps via TRPM4 channels with
            potential implications for place field firing.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4203)
  AUTHORS   Alves,Q.L., da Silva Santos,P.V., Santos,W.A., Dantas
            Damasceno,S.C., de Jesus,R.L.C., Froes,T.Q., Castilho,M.S.,
            Barbosa,A.M., de Moraes Gomes,E.R., Dos Santos Cruz,J. and
            Silva,D.F.
  TITLE     Unraveling the Cardiac Effects Induced by Carvacrol in
            Spontaneously Hypertensive Rats: Involvement of Transient Receptor
            Potential Melastatin Subfamily 4 and 7 Channels
  JOURNAL   J Cardiovasc Pharmacol 79 (2), 206-216 (2022)
   PUBMED   35099165
  REMARK    GeneRIF: Unraveling the Cardiac Effects Induced by Carvacrol in
            Spontaneously Hypertensive Rats: Involvement of Transient Receptor
            Potential Melastatin Subfamily 4 and 7 Channels.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4203)
  AUTHORS   Csipo,T., Czikora,A., Fulop,G.A., Gulyas,H., Rutkai,I., Toth,E.P.,
            Porszasz,R., Szalai,A., Bolcskei,K., Helyes,Z., Pinter,E., Papp,Z.,
            Ungvari,Z. and Toth,A.
  TITLE     A Central Role for TRPM4 in Ca2+-Signal Amplification and
            Vasoconstriction
  JOURNAL   Int J Mol Sci 23 (3), 1465 (2022)
   PUBMED   35163382
  REMARK    GeneRIF: A Central Role for TRPM4 in Ca(2+)-Signal Amplification
            and Vasoconstriction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4203)
  AUTHORS   Wang,C., Chen,J., Wang,M., Naruse,K. and Takahashi,K.
  TITLE     Role of the TRPM4 channel in mitochondrial function, calcium
            release, and ROS generation in oxidative stress
  JOURNAL   Biochem Biophys Res Commun 566, 190-196 (2021)
   PUBMED   34144257
  REMARK    GeneRIF: Role of the TRPM4 channel in mitochondrial function,
            calcium release, and ROS generation in oxidative stress.
            Erratum:[Biochem Biophys Res Commun. 2021 Oct 20;575:96-98. doi:
            10.1016/j.bbrc.2021.08.041.. PMID: 34452699]
REFERENCE   5  (bases 1 to 4203)
  AUTHORS   Hazalin,N.A.M.N., Liao,P. and Hassan,Z.
  TITLE     TRPM4 inhibition improves spatial memory impairment and hippocampal
            long-term potentiation deficit in chronic cerebral hypoperfused
            rats
  JOURNAL   Behav Brain Res 393, 112781 (2020)
   PUBMED   32619565
  REMARK    GeneRIF: TRPM4 inhibition improves spatial memory impairment and
            hippocampal long-term potentiation deficit in chronic cerebral
            hypoperfused rats.
REFERENCE   6  (bases 1 to 4203)
  AUTHORS   Cheng,H., Beck,A., Launay,P., Gross,S.A., Stokes,A.J., Kinet,J.P.,
            Fleig,A. and Penner,R.
  TITLE     TRPM4 controls insulin secretion in pancreatic beta-cells
  JOURNAL   Cell Calcium 41 (1), 51-61 (2007)
   PUBMED   16806463
  REMARK    GeneRIF: insulin-secreting cells of the pancreatic beta-cell line
            INS-1 natively express TRPM4 proteins and generate large
            depolarizing membrane currents in response to increased
            intracellular calcium
REFERENCE   7  (bases 1 to 4203)
  AUTHORS   Guinamard,R., Demion,M., Magaud,C., Potreau,D. and Bois,P.
  TITLE     Functional expression of the TRPM4 cationic current in ventricular
            cardiomyocytes from spontaneously hypertensive rats
  JOURNAL   Hypertension 48 (4), 587-594 (2006)
   PUBMED   16966582
  REMARK    GeneRIF: may contribute to the transient inward current implicated
            in delayed-after-depolarizations observed during [Ca(2+)] overload
            of cardiomyocytes.
REFERENCE   8  (bases 1 to 4203)
  AUTHORS   Earley,S., Waldron,B.J. and Brayden,J.E.
  TITLE     Critical role for transient receptor potential channel TRPM4 in
            myogenic constriction of cerebral arteries
  JOURNAL   Circ Res 95 (9), 922-929 (2004)
   PUBMED   15472118
  REMARK    GeneRIF: Activation of TRPM4-dependent currents contributed to
            myogenic vasoconstriction of cerebral arteries.
REFERENCE   9  (bases 1 to 4203)
  AUTHORS   Guinamard,R., Chatelier,A., Lenfant,J. and Bois,P.
  TITLE     Activation of the Ca(2+)-activated nonselective cation channel by
            diacylglycerol analogues in rat cardiomyocytes
  JOURNAL   J Cardiovasc Electrophysiol 15 (3), 342-348 (2004)
   PUBMED   15030426
REFERENCE   10 (bases 1 to 4203)
  AUTHORS   Murakami,M., Xu,F., Miyoshi,I., Sato,E., Ono,K. and Iijima,T.
  TITLE     Identification and characterization of the murine TRPM4 channel
  JOURNAL   Biochem Biophys Res Commun 307 (3), 522-528 (2003)
   PUBMED   12893253
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 28, 2008 this sequence version replaced XM_574447.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643290.1981.1,
                                           SRR26643285.1963.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-70                JAXUCZ010000001.1  104948167-104948236 c
            71-141              JAXUCZ010000001.1  104947863-104947933 c
            142-316             JAXUCZ010000001.1  104942429-104942603 c
            317-497             JAXUCZ010000001.1  104941979-104942159 c
            498-661             JAXUCZ010000001.1  104941686-104941849 c
            662-845             JAXUCZ010000001.1  104941282-104941465 c
            846-907             JAXUCZ010000001.1  104937248-104937309 c
            908-1099            JAXUCZ010000001.1  104936928-104937119 c
            1100-1199           JAXUCZ010000001.1  104936716-104936815 c
            1200-1312           JAXUCZ010000001.1  104934712-104934824 c
            1313-1654           JAXUCZ010000001.1  104933739-104934080 c
            1655-1783           JAXUCZ010000001.1  104933451-104933579 c
            1784-1913           JAXUCZ010000001.1  104932623-104932752 c
            1914-2059           JAXUCZ010000001.1  104932400-104932545 c
            2060-2172           JAXUCZ010000001.1  104930519-104930631 c
            2173-2250           JAXUCZ010000001.1  104930132-104930209 c
            2251-2673           JAXUCZ010000001.1  104925667-104926089 c
            2674-2806           JAXUCZ010000001.1  104924497-104924629 c
            2807-2981           JAXUCZ010000001.1  104924006-104924180 c
            2982-3159           JAXUCZ010000001.1  104923707-104923884 c
            3160-3356           JAXUCZ010000001.1  104920601-104920797 c
            3357-3489           JAXUCZ010000001.1  104920279-104920411 c
            3490-3562           JAXUCZ010000001.1  104920125-104920197 c
            3563-3668           JAXUCZ010000001.1  104919929-104920034 c
            3669-4203           JAXUCZ010000001.1  104918462-104918996 c
FEATURES             Location/Qualifiers
     source          1..4203
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..4203
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 4"
                     /db_xref="GeneID:171143"
                     /db_xref="RGD:620244"
     exon            1..70
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..3673
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /note="LTrpC4; melastatin-like 2; long transient receptor
                     potential channel 4; calcium-activated non-selective
                     cation channel 1; melastatin like 2 protein"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 4"
                     /protein_id="NP_001129701.1"
                     /db_xref="GeneID:171143"
                     /db_xref="RGD:620244"
                     /translation="MVGQEKEQSWIPKIFRKKVCTTFIVDLHDDAGGTLCQCGQPRDA
                     HPSVAVEDAFGAAVVTEWNSDEHTTEKPTDAYGDLDFTYSGRKSSNFLRLSDRTDPAT
                     VYSLVTRSWGFRAPNLVVSVLGGSEGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLH
                     TGIGRHVGVAVRDHQTASTGGSKVVAMGVAPWGVVRNRDMLINPKGSFPARYRWRGDP
                     EDGVEFPLDYNYSAFFLVDDGTYGRMGGENRFRLRFESYVAQQKTGVGGTGIDIPVLL
                     LLIEGDEKMLKRIEDATQAQLPCLLVAGSGGAADCLVETLEDTLAPGSGGLRRGEARD
                     RIRRYFPKGDPEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLRALVKACGSSEAS
                     AYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGL
                     SLGHFLTPVRLAQLYSAVSPNSLIRNLLDQASHASSSKSPPANGAAELRPPNVGQVLR
                     TLLGETCAPRYPARNTRHSLLGQDHRENDSLLMDWANMQQDASFEQAPWSDLLIWALL
                     LNRAQMAIYFWEKGSNSVASALGACLLLRVMARLEWEAEEAARRKDLAAKFESMSVDL
                     FGECYHNSEYRAARLLLRRCPLWGEATCLQLAMQADARAFFAQDGVQSLLTQKWWGEM
                     DSTNPIWALLLTFFCPPLIYTNLILFRKSEEEPTQKDLDFDMDSSMNGAGPLGPAEPS
                     AKVALERRRRRRPGHTLCCGGCSKRWSYFWGAPVTAFLGNVVSYLLFLLLFAHVLLVD
                     FQPTKPGVFELLLYFWAFTLLCEELRQGLGGGWGTLANGGPGPGKAPLRHRLHLYLLD
                     TWNQCDLLALTCFLLGVGCRLTPGLFDLGRTVLCLDFMIFTLRLLHIFTVNKQLGPKI
                     VIVSKMMKDVFFFLFFLCVWLVAYGVATEGILRPQDRSLPSILRRVFYRPYLQIFGQI
                     PQEEMDVALMNPSNCSAERGSWAHPEGPVAGSCVSQYANWLVVLLLIVFLLVANILLL
                     NLLIAMFSYTFNKVHGNSDLYWKAQRYSLIREFHSRPALAPPLIIISHLRLLFKWLRR
                     CHRTNLPASPVFEHFRVCLSKEAERTLLTWESVHKENFLLAQARDKRDSDSERLKRTS
                     QKVDTALKQLGQIREYDRRLRGLEREVQHCSRVLTWMAEALSHSALLPPGGPPPPSPT
                     GSKD"
     exon            71..141
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            142..316
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            317..497
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            498..661
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            662..845
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            846..907
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1099
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1199
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            1200..1312
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1654
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            1655..1783
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1913
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            1914..2059
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2172
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            2173..2250
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            2251..2673
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            2674..2806
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            2807..2981
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            2982..3159
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3356
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            3357..3489
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            3490..3562
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            3563..3668
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
     exon            3669..4203
                     /gene="Trpm4"
                     /gene_synonym="LTrpC-4; Mls2s"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcggctgag agaaatacac ggagccccag gggctgcgac ggcagcatgg tggggcagga
       61 gaaagagcag agttggatcc ctaagatctt caggaagaag gtgtgcacga cgttcatagt
      121 ggacctccac gatgatgcgg gagggacctt gtgccagtgt gggcaacctc gggatgccca
      181 cccttctgtg gctgtggagg atgcctttgg ggcagccgta gttaccgagt ggaacagtga
      241 tgagcacacc acggagaagc ccacagatgc ctacggggac ctggacttca catactctgg
      301 ccgaaagtcc agcaacttcc tccggctgtc tgatcgcacg gatccggcca ctgtgtacag
      361 tctcgtcacc cgctcttggg gctttcgtgc tccaaacttg gtggtgtcag tgctgggggg
      421 gtcggagggc cccgtgctac agacctggct gcaggacctt ctgcgtcgtg ggctggtgcg
      481 agcagcccag agcacagggg cctggatcgt cactggggga ctgcacacag gcattggtcg
      541 gcatgtgggt gtggctgtga gggaccacca gacggccagc accgggggca gcaaggtggt
      601 ggccatgggt gtggccccct ggggagtggt ccggaacaga gacatgctga tcaaccccaa
      661 gggctcattc cctgcaagat accggtggcg tggtgaccct gaggacggag ttgagttccc
      721 cctggactat aactattctg ctttcttctt ggtggatgat ggtacctatg gccgcatggg
      781 tggtgagaac cgcttccgcc ttcggtttga gtcctatgtg gctcagcaga agaccggagt
      841 gggagggact ggaattgaca tccctgtact ccttcttctc atcgaaggcg atgagaagat
      901 gttaaagcgg atagaggatg ccacccaggc tcagctcccc tgcctcttgg tggctggctc
      961 tgggggtgct gcagactgcc tggtggagac cctggaagat actctggccc cagggagtgg
     1021 gggactcagg cgaggtgaag cccgggatcg aattagacgt tacttcccta aaggagaccc
     1081 cgaggtcctg caggcccagg tagagaggat catgacccga aaggagctgc tgacagtcta
     1141 ttcatcagag gacggctccg aggagtttga gactatcgtt ttgagggctc ttgtgaaagc
     1201 ctgtgggagc tccgaggcct cggcttacct ggatgaactg cgtttggctg tggcttggaa
     1261 ccgcgtggac atcgcccaaa gtgaactttt ccgtggggac atccagtggc ggtccttcca
     1321 cctggaggcc tctctcatgg acgctctgct gaatgaccgg cctgagtttg tgcgcttgct
     1381 catctcccat ggccttagtc tgggacactt cctgaccccc gtgcgcctgg cccagctgta
     1441 cagcgcagtg tcccccaact cgctgatccg caatcttctg gaccaggcgt cccacgctag
     1501 tagcagcaaa tctccacctg caaatggagc tgcagagctc cggcctccta atgtggggca
     1561 agttctgagg actctgttgg gagaaacgtg tgcaccgcgg taccccgcca ggaacacccg
     1621 acactccctg ctgggccagg accacagaga gaatgactct ctgctcatgg actgggccaa
     1681 catgcaacag gatgcaagct ttgaacaagc cccctggagt gacctgctta tctgggctct
     1741 gttgttgaac cgagcccaga tggccattta tttctgggag aagggctcca actcagtggc
     1801 ctctgctctc ggggcttgtc tcttactccg agtgatggct cgccttgagt gggaggctga
     1861 ggaagctgca cggcggaagg accttgctgc caagtttgaa agcatgagcg tggacctctt
     1921 tggagagtgt taccacaaca gtgaatatcg agcagcccgc cttcttctgc gtcgctgtcc
     1981 cctctgggga gaggccacct gtctccagct tgccatgcag gctgacgccc gtgcgttctt
     2041 tgcccaggat ggagtacagt ctctgctgac acagaagtgg tggggggaga tggacagcac
     2101 gaaccctatc tgggccctgc ttctcacctt cttctgcccg cctctcatct acaccaacct
     2161 catcctcttc aggaagtcag aggaggagcc cacacagaag gatcttgact tcgatatgga
     2221 cagcagcatg aatggagcag gtcctcttgg gcctgcggag ccctcagcaa aggtggccct
     2281 tgagaggcgg cggcggcggc ggccaggaca taccctctgc tgtggcgggt gctccaagcg
     2341 ctggtcgtac ttttggggcg ccccagtgac cgccttcctg ggtaacgtgg tcagttacct
     2401 gctgttcctg ctgctgtttg cacacgtgtt gctggtggat ttccagccta caaagccggg
     2461 cgtcttcgag ctgctgctgt acttctgggc cttcacgctg ctatgcgagg agctgcgcca
     2521 gggcctgggc ggtggctggg gtaccctggc caacggggga cctggtcctg gcaaagctcc
     2581 cctgcgccat cgtctgcacc tctacctctt ggatacttgg aaccagtgcg acttgctggc
     2641 actcacctgc ttcctgctgg gcgttggctg caggctgact cctggcctgt ttgacttggg
     2701 acgcacagtc ctctgtcttg acttcatgat cttcacactg cgcctgctgc acatcttcac
     2761 ggtgaacaag cagctggggc ccaagattgt catcgtgagc aagatgatga aggatgtatt
     2821 ctttttcctc ttcttcctct gcgtgtggct tgtagcttat ggggtggcca cagaggggat
     2881 cctgaggccc caggaccgca gtctaccgag catcctgcgc agggtcttct accgtccgta
     2941 tctgcagatc ttcggacaaa ttccccagga ggaaatggat gtggccctca tgaatcccag
     3001 taactgctct gccgagcggg gctcctgggc tcacccggag gggccggtcg caggctcctg
     3061 tgtgtcccag tatgccaact ggctggtggt gttgctcctc atcgtcttct tgctggtggc
     3121 caatatcctg ctgctcaatc tgctcatcgc catgttcagc tacaccttca acaaagtgca
     3181 tggcaacagc gacctctact ggaaggcgca gcgctacagc ctcatccggg aattccattc
     3241 gcggcctgcc ctggccccac ccctcatcat catctctcac ctgcgtctcc tcttcaagtg
     3301 gctgcgcagg tgtcatagga ctaacttgcc cgcctcccca gtcttcgagc acttccgtgt
     3361 ctgtctctct aaggaagcag agaggacgct gctgacttgg gagtctgtgc acaaagagaa
     3421 cttcctattg gcacaagctc gtgacaagcg agacagcgac tcggagcgtc tgaaacgcac
     3481 gtcccagaag gtggacactg cactgaagca gctgggacag atcagagagt atgaccggcg
     3541 tctgaggggg ctggagagag aggtccaaca ctgttctcga gtcctgactt ggatggctga
     3601 ggcccttagc cactctgcct tactgcctcc aggggggcca ccccctccaa gccccactgg
     3661 gtccaaagac tgagtgtccc tggtggacat ctaggtgttt gcatcctgag agggttcatt
     3721 ccgagagctg cgcccagtct gcctcaagct acacaactgg tggccttgtc ctcaccgtag
     3781 accccatgtt caggggttgc tgtctcgcca gagggactgc cttccaggag cagcctgacc
     3841 ttgggcagat caagctctga gctggcaatg ttggcccctt tgtgggccca gccacaagca
     3901 gaggaggcca gaaggtcctg gggtgcagga accacagacc ctatgcacag cttccccaca
     3961 atggggaaat aaagccattt gatgagaatt acagcagagg cttgactcat gtggaactgg
     4021 ctggggaaga agctgggagt ctgaccctct accaccactg cagctgtgga cttagaccca
     4081 gagcctcctg tgcagacctc tgtctgggtg gctttccctg caggagacag gggccgtctg
     4141 agcccctgct gctttctgct ttcctgtggg aatctaacag ggtggtaata agagagccgg
     4201 tcc
//
