LOCUS       NM_001354180            6734 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 3 (Trpm3), transcript variant 2, mRNA.
ACCESSION   NM_001354180
VERSION     NM_001354180.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6734)
  AUTHORS   Langen,K.R., Dantzler,H.A., de Barcellos-Filho,P.G. and Kline,D.D.
  TITLE     Hypoxia augments TRPM3-mediated calcium influx in vagal sensory
            neurons
  JOURNAL   Auton Neurosci 247, 103095 (2023)
   PUBMED   37146443
  REMARK    GeneRIF: Hypoxia augments TRPM3-mediated calcium influx in vagal
            sensory neurons.
REFERENCE   2  (bases 1 to 6734)
  AUTHORS   Zhao,M., Liu,L., Chen,Z., Ding,N., Wen,J., Liu,J., Ge,N. and
            Zhang,X.
  TITLE     Upregulation of transient receptor potential cation channel
            subfamily M member-3 in bladder afferents is involved in chronic
            pain in cyclophosphamide-induced cystitis
  JOURNAL   Pain 163 (11), 2200-2212 (2022)
   PUBMED   35413036
  REMARK    GeneRIF: Upregulation of transient receptor potential cation
            channel subfamily M member-3 in bladder afferents is involved in
            chronic pain in cyclophosphamide-induced cystitis.
REFERENCE   3  (bases 1 to 6734)
  AUTHORS   Becker,A., Gotz,C., Montenarh,M. and Philipp,S.E.
  TITLE     Control of TRPM3 Ion Channels by Protein Kinase CK2-Mediated
            Phosphorylation in Pancreatic beta-Cells of the Line INS-1
  JOURNAL   Int J Mol Sci 22 (23), 13133 (2021)
   PUBMED   34884938
  REMARK    GeneRIF: Control of TRPM3 Ion Channels by Protein Kinase
            CK2-Mediated Phosphorylation in Pancreatic beta-Cells of the Line
            INS-1.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6734)
  AUTHORS   Ragozzino,F.J., Arnold,R.A., Fenwick,A.J., Riley,T.P.,
            Lindberg,J.E.M., Peterson,B. and Peters,J.H.
  TITLE     TRPM3 expression and control of glutamate release from primary
            vagal afferent neurons
  JOURNAL   J Neurophysiol 125 (1), 199-210 (2021)
   PUBMED   33296617
  REMARK    GeneRIF: TRPM3 expression and control of glutamate release from
            primary vagal afferent neurons.
REFERENCE   5  (bases 1 to 6734)
  AUTHORS   Ohashi,K., Shibasaki,K., Nakazawa,H., Kunimasa,R., Nagayasu,K.,
            Shirakawa,H. and Kaneko,S.
  TITLE     Transient Receptor Potential Melastatin 3 Is Functionally Expressed
            in Oligodendrocyte Precursor Cells and Is Upregulated in Ischemic
            Demyelinated Lesions
  JOURNAL   Biol Pharm Bull 44 (2), 181-187 (2021)
   PUBMED   33518671
  REMARK    GeneRIF: Transient Receptor Potential Melastatin 3 Is Functionally
            Expressed in Oligodendrocyte Precursor Cells and Is Upregulated in
            Ischemic Demyelinated Lesions.
REFERENCE   6  (bases 1 to 6734)
  AUTHORS   Mayer,S.I., Muller,I., Mannebach,S., Endo,T. and Thiel,G.
  TITLE     Signal transduction of pregnenolone sulfate in insulinoma cells:
            activation of Egr-1 expression involving TRPM3, voltage-gated
            calcium channels, ERK, and ternary complex factors
  JOURNAL   J Biol Chem 286 (12), 10084-10096 (2011)
   PUBMED   21257751
  REMARK    GeneRIF: Signal transduction of pregnenolone sulfate in insulinoma
            cells: activation of Egr-1 expression involving TRPM3,
            voltage-gated calcium channels, ERK, and ternary complex factors.
REFERENCE   7  (bases 1 to 6734)
  AUTHORS   Hoffmann,A., Grimm,C., Kraft,R., Goldbaum,O., Wrede,A., Nolte,C.,
            Hanisch,U.K., Richter-Landsberg,C., Bruck,W., Kettenmann,H. and
            Harteneck,C.
  TITLE     TRPM3 is expressed in sphingosine-responsive myelinating
            oligodendrocytes
  JOURNAL   J Neurochem 114 (3), 654-665 (2010)
   PUBMED   20163522
  REMARK    GeneRIF: TRPM3 participates as a divalent calcium ion-permeable and
            sphingosine-activated channel in oligodendrocyte differentiation
            and nervous system myelination.
REFERENCE   8  (bases 1 to 6734)
  AUTHORS   Wagner,T.F., Loch,S., Lambert,S., Straub,I., Mannebach,S.,
            Mathar,I., Dufer,M., Lis,A., Flockerzi,V., Philipp,S.E. and
            Oberwinkler,J.
  TITLE     Transient receptor potential M3 channels are ionotropic steroid
            receptors in pancreatic beta cells
  JOURNAL   Nat Cell Biol 10 (12), 1421-1430 (2008)
   PUBMED   18978782
  REMARK    GeneRIF: TRPM3 is an essential component of an ionotropic steroid
            receptor enabling unanticipated crosstalk between steroidal and
            insulin-signalling endocrine systems.
REFERENCE   9  (bases 1 to 6734)
  AUTHORS   Wang,H.P., Pu,X.Y. and Wang,X.H.
  TITLE     Distribution profiles of transient receptor potential
            melastatin-related and vanilloid-related channels in prostatic
            tissue in rat
  JOURNAL   Asian J Androl 9 (5), 634-640 (2007)
   PUBMED   17712480
  REMARK    GeneRIF: Polymerase chain reaction used to check the expression of
            all TRPM and TRPV channel members with specific primers.
REFERENCE   10 (bases 1 to 6734)
  AUTHORS   Oberwinkler,J., Lis,A., Giehl,K.M., Flockerzi,V. and Philipp,S.E.
  TITLE     Alternative splicing switches the divalent cation selectivity of
            TRPM3 channels
  JOURNAL   J Biol Chem 280 (23), 22540-22548 (2005)
   PUBMED   15824111
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding sequence compared to variant 1. The resulting isoform (b)
            has a shorter and distinct N-terminus compared to isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760433 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-177               JAXUCZ010000001.1  229435510-229435686
            178-257             JAXUCZ010000001.1  229695610-229695689
            258-462             JAXUCZ010000001.1  229696904-229697108
            463-676             JAXUCZ010000001.1  229709546-229709759
            677-801             JAXUCZ010000001.1  229713038-229713162
            802-973             JAXUCZ010000001.1  229725206-229725377
            974-1148            JAXUCZ010000001.1  229762068-229762242
            1149-1272           JAXUCZ010000001.1  229789163-229789286
            1273-1345           JAXUCZ010000001.1  229851588-229851660
            1346-1446           JAXUCZ010000001.1  229883901-229884001
            1447-1581           JAXUCZ010000001.1  229885229-229885363
            1582-1632           JAXUCZ010000001.1  229888722-229888772
            1633-1773           JAXUCZ010000001.1  229896927-229897067
            1774-1803           JAXUCZ010000001.1  229899303-229899332
            1804-2093           JAXUCZ010000001.1  229900230-229900519
            2094-2322           JAXUCZ010000001.1  229901132-229901360
            2323-2490           JAXUCZ010000001.1  229903746-229903913
            2491-2631           JAXUCZ010000001.1  229907959-229908099
            2632-2760           JAXUCZ010000001.1  229913252-229913380
            2761-3012           JAXUCZ010000001.1  229917311-229917562
            3013-3223           JAXUCZ010000001.1  229930664-229930874
            3224-3374           JAXUCZ010000001.1  229973291-229973441
            3375-3574           JAXUCZ010000001.1  229973552-229973751
            3575-3707           JAXUCZ010000001.1  229976466-229976598
            3708-6734           JAXUCZ010000001.1  229981146-229984172
FEATURES             Location/Qualifiers
     source          1..6734
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q51"
     gene            1..6734
                     /gene="Trpm3"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 3"
                     /db_xref="GeneID:309407"
                     /db_xref="RGD:1304888"
     CDS             1..5160
                     /gene="Trpm3"
                     /note="isoform b is encoded by transcript variant 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 3 isoform b"
                     /protein_id="NP_001341109.1"
                     /db_xref="GeneID:309407"
                     /db_xref="RGD:1304888"
                     /translation="MPGPWGTVYFLGTAQICSFLSSRWNLEGVMNQTDASRPLNWTIR
                     KLCHAAFLPSVRLLKAQKSWIERAFYKRECVHIIPSTKDPHRCCCGRLIGQHVGLTPS
                     ISVLQNEKNESRLSRNDIQSEKWSISKHTQLSPTDAFGTIEFQGGGHSNKAMYVRVSF
                     DTKPDLLLHLMTKEWQLELPKLLISVHGGLQNFELQPKLKQVFGKGLIKAAMTTGAWI
                     FTGGVNTGVIRHVGDALKDHASKSRGKICTIGIAPWGIVENQEDLIGRDVVRPYQTMS
                     NPMSKLTVLNSMHSHFILADNGTTGKYGAEVKLRRQLEKHISLQKINTRIGQGVPVVA
                     LIVEGGPNVISIVLEYLRDTPPVPVVVCDGSGRASDILAFGHKYSEEGGLINESLRDQ
                     LLVTIQKTFTYTRTQAQHLFIILMECMKKKELITVFRMGSEGHQDIDLAILTALLKGA
                     NASAPDQLSLALAWNRVDIARSQIFIYGQQWPVGSLEQAMLDALVLDRVDFVKLLIEN
                     GVSMHRFLTISRLEELYNTRHGPSNTLYHLVRDVKKGNLPPDYRISLIDIGLVIEYLM
                     GGAYRCNYTRKRFRTLYHNLFGPKRPKALKLLGMEDDIPLRRGRKTTKKREEEVDIDL
                     DDPEINHFPFPFHELMVWAVLMKRQKMALFFWQHGEEAMAKALVACKLCKAMAHEASE
                     NDMVDDISQELNHNSRDFGQLAVELLDQSYKQDEQLAMKLLTYELKNWSNATCLQLAV
                     AAKHRDFIAHTCSQMLLTDMWMGRLRMRKNSGLKVILGILLPPSILSLEFKNKDDMPY
                     MTQAQEIHLQEKEPEEPEKPTKEKDEEDMELTAMLGRNNGESSRKKDEEEVQSRHRLI
                     PVGRKIYEFYNAPIVKFWFYTLAYIGYLMLFNYIVLVKMERWPSTQEWIVISYIFTLG
                     IEKMREILMSEPGKLLQKVKVWLQEYWNVTDLIAILLFSVGMILRLQDQPFRSDGRVI
                     YCVNIIYWYIRLLDIFGVNKYLGPYVMMIGKMMIDMMYFVIIMLVVLMSFGVARQAIL
                     FPNEEPSWKLAKNIFYMPYWMIYGEVFADQIDRKQVYDSHTPKSAPCGQNETREDGKT
                     IQLPPCKTGAWIVPAIMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQL
                     IMTFHERPVLPPPLIIFSHMTMIFQHVCCRWRKHESDPDERDYGLKLFITDDELKKVH
                     DFEEQCIEEYFREKDDRFNSSNDERIRVTSERVENMSMRLEEVNEREHSMKASLQTVD
                     IRLAQLEDLIGRMATALERLTGLERAESNKIRSRTSSDCTDAAYIVRQSSFNSQEGNT
                     FKLQESIDPAGEETMSPTSPTLMPRMRSHSFYSVNVKDKGGIEKLESIFKERSLSLHR
                     ATSSHSVAKEPKAPAAPANTLAIVPDSRRPSSCIDIYVSAMDELHCDIDPLDNSMNIL
                     GLGEPSFSALAPSTAPSSSAYATLAPTDRPPSRSIDFEDLTSMDTRSFSSDYTHLPEC
                     QNPWDTDPPMYHTIERSKSSRYLATTPFLLEEAPIVKSHSFMFSPSRSYYANFGVPVK
                     TAEYTSITDCIDTRCVNAPQAIADRATFPGGLGDKVEDLSCCHPEREAELSHPSSDSE
                     ENEARGRRAANPISSQETENADRTLSNNITVPKIERANSYSAEEPSAPYAHTRKSFSI
                     SDKLDRQRNTASLRNPFQRSKSSKPEGRGDSVSMRRLSRTSAFHSFESKHN"
     exon            1..177
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            178..257
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            258..462
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            463..676
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            677..801
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            802..973
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1148
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1272
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1345
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1446
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1581
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1582..1632
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1633..1773
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1774..1803
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..2093
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..2322
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2490
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            2491..2631
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            2632..2760
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..3012
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            3013..3223
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            3224..3374
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..3574
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            3575..3707
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
     exon            3708..6734
                     /gene="Trpm3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgccagggc cgtgggggac cgtttatttt ctaggcactg cccagatttg cagtttctta
       61 tcttcccggt ggaatttgga aggggtcatg aatcagactg atgcttctcg acccctaaat
      121 tggaccatcc ggaagctatg ccacgcagcc tttctcccat ctgtcagact tctcaaggct
      181 cagaaatcct ggattgaaag agcattttat aaaagagaat gtgttcacat catacccagc
      241 accaaagacc cccataggtg ttgctgtggg cgcctgatag gccagcatgt cggactcact
      301 cccagtatct ctgtgcttca gaatgagaaa aatgagagtc gcctctcccg aaatgacatc
      361 cagtctgaga agtggtctat cagcaaacac actcagctca gcccaacgga tgcttttggg
      421 actattgagt tccaaggagg cggtcattcc aacaaagcca tgtatgtccg agtatctttt
      481 gatacgaaac ctgatctctt gctacacctg atgaccaagg aatggcaact agagcttccc
      541 aaacttctca tctctgtgca cggagggctg cagaactttg aactccagcc caaactcaag
      601 caagtcttcg ggaaagggct catcaaagca gccatgacaa ctggagcctg gatcttcact
      661 ggaggggtca acacaggtgt catccgtcat gtgggagatg ccttgaagga ccacgcatct
      721 aagtctcgag ggaagatatg caccataggt atcgcaccct ggggaattgt ggaaaaccag
      781 gaagacctga tcggaagaga tgtagtccga ccataccaga ccatgtcaaa ccctatgagc
      841 aagctcacgg ttctcaacag catgcactcc cacttcatcc tggctgacaa tgggaccacg
      901 ggaaaatacg gggccgaggt gaaactccgc agacaactgg aaaagcacat ttcactccag
      961 aagataaaca caagaatcgg tcaaggggtt ccagtggtgg ccctcatcgt ggaaggagga
     1021 cccaatgtga tctcaattgt tttggaatac cttcgagaca cccctcctgt accagtcgtg
     1081 gtctgcgatg gcagtggacg ggcatccgac attctggcat ttgggcataa atattcagaa
     1141 gaaggcggtc ttatcaatga atctttgagg gaccagctgt tggtgacaat acagaagacc
     1201 ttcacataca cccgcaccca agcccagcac ctgttcatca tcctcatgga atgcatgaag
     1261 aagaaggaat tgatcacagt gtttcgaatg ggatcagaag gccaccagga cattgattta
     1321 gctatcctga cagcactact caaaggagcc aatgcatccg ccccagacca gctgagctta
     1381 gcattagcct ggaacagagt tgacatcgct cgcagccaga tctttattta cgggcagcag
     1441 tggccggtag ggtccctgga gcaagccatg ctggatgccc tagtcctgga cagagtggac
     1501 tttgtgaaat tactcataga aaacggagta agcatgcacc gttttctcac catctccaga
     1561 ctagaggaac tgtacaatac gagacatggg ccctcaaata cattgtacca cttggtcagg
     1621 gatgtcaaaa agggaaacct gcccccggac tacagaatca gcctgataga cattggcctg
     1681 gtgatcgagt acctgatggg tggggcttac cgctgcaact acacacgcaa gcgctttcgg
     1741 accctctacc acaatctctt tggccccaaa aggcccaaag ccttgaaact gctgggaatg
     1801 gaggatgata ttcccttgag gagaggaaga aagacaacta agaaacgtga ggaagaggtg
     1861 gacatagact tggatgaccc tgagatcaac cacttcccat tccctttcca tgagctgatg
     1921 gtgtgggctg tcctcatgaa gaggcagaag atggccctgt tcttctggca gcatggagag
     1981 gaggccatgg ctaaagccct ggtggcctgc aagctctgca aagccatggc ccatgaggct
     2041 tctgagaatg atatggtgga tgacatttcc caagagctga accacaactc cagggacttt
     2101 ggccagctgg ctgtggagct tttggaccag tcctacaaac aggatgagca gctggccatg
     2161 aaactgctga cgtatgagtt gaagaactgg agcaatgcca catgcctgca gctggctgtg
     2221 gctgccaagc accgtgactt cattgcacac acgtgcagcc agatgttact taccgacatg
     2281 tggatgggac ggctccgcat gcgaaagaac tcaggcctca aggtaattct gggaattcta
     2341 cttcctcctt caattctcag cttggagttc aagaacaaag atgacatgcc ctatatgact
     2401 caggcccaag aaattcatct ccaagagaag gagccggagg aaccggagaa gcctacaaag
     2461 gaaaaagatg aagaggacat ggagctaaca gcaatgttgg gacgaaacaa tggggagtca
     2521 tccagaaaga aagacgaaga agaagttcaa agcaggcatc gactaatccc tgtgggccga
     2581 aaaatctatg agttctacaa cgcacccatt gtgaagttct ggttctacac tctggcgtac
     2641 attggatacc tgatgctctt caattacatc gtgctggtga agatggagcg ctggccttcc
     2701 actcaggaat ggatcgtcat ctcctacatc ttcactctgg gaatagagaa gatgagagag
     2761 atcctgatgt cagagccggg caagctgctg cagaaagtca aagtgtggct gcaggagtac
     2821 tggaacgtca cggacctcat cgccatcctc ctcttctcgg tgggaatgat ccttcgtctt
     2881 caagaccagc ccttcaggag tgacgggagg gtcatctact gtgtgaacat catttattgg
     2941 tatatccgtt tactagacat cttcggcgtg aacaagtatc tgggcccata cgtaatgatg
     3001 attgggaaaa tgatgataga catgatgtac ttcgtcatca ttatgctggt ggtgctgatg
     3061 agctttgggg tcgccaggca agccattctc tttcccaatg aggagccatc ttggaaactg
     3121 gccaagaata tcttctacat gccttattgg atgatttatg gggaagtgtt tgctgaccag
     3181 atagaccgta agcaagttta tgattctcat acaccaaagt cagctccctg tggacagaac
     3241 gagacccgag aggatggcaa gacaatccag ctgcccccat gcaagacagg agcatggatt
     3301 gtgccagcca tcatggcctg ctacctctta gtagcgaaca tccttctggt caacctcctt
     3361 attgctgtct tcaacaatac attttttgag gtcaagtcga tatccaacca agtatggaaa
     3421 tttcagaggt accagctcat catgactttc catgagagac cagttctgcc tccaccgctc
     3481 atcatcttca gtcacatgac catgatattc cagcatgtgt gctgccgatg gaggaagcat
     3541 gagagtgacc cggatgaaag ggactacggc ctgaaactct tcataactga tgatgagctc
     3601 aagaaagtac atgattttga agagcagtgc atagaggaat atttcagaga gaaggatgac
     3661 cgcttcaatt catccaatga tgagaggata cgggttacgt cagaaagggt ggagaacatg
     3721 tccatgaggc tggaggaagt caatgagaga gaacattcca tgaaggcttc actccagact
     3781 gtggacatcc ggctagcaca gctggaggat ctcatcgggc gcatggccac tgccctggag
     3841 cgcctaacag gtctggagcg ggcagagtct aacaaaatcc gctcaaggac ctcctcagac
     3901 tgcacagacg cagcctacat cgtccgccag agcagcttca acagtcagga agggaacacc
     3961 ttcaaacttc aagagagtat agaccctgca ggtgaggaga ccatgtcccc aacttctcca
     4021 accttaatgc cccgtatgcg aagccattct ttctattcgg tcaatgtgaa agacaaaggt
     4081 ggtatagaaa agttggagag cattttcaaa gaaaggtccc tgagcttaca ccgtgctact
     4141 agctcccact cagtagccaa ggagcccaaa gctcctgcag cccctgcaaa caccttggcc
     4201 attgttcctg attccagaag accatcgtca tgcatagaca tctatgtctc tgccatggat
     4261 gagctccact gtgatataga ccctctggat aattccatga acatccttgg gctgggcgag
     4321 ccaagctttt cagctctagc accttccaca gccccttcaa gcagtgccta tgcaaccctt
     4381 gcacctacag accgacctcc aagcaggagc attgattttg aagacctcac ctccatggac
     4441 actagatctt tttcttcaga ctatacccac ctcccagaat gccaaaaccc ctgggacaca
     4501 gaccctccaa tgtaccatac catcgagcgt tccaagagta gccgctacct agccactaca
     4561 cccttccttc tggaagaggc ccccattgta aaatcccata gctttatgtt ttctccttca
     4621 aggagttact acgccaactt tggggtgccc gtgaaaacag cagaatacac aagtattaca
     4681 gactgtatcg acacaagatg tgtcaatgcc ccccaagcaa tagctgacag agccaccttc
     4741 cccggaggtc tcggagacaa agtggaagat ttatcttgtt gccaccctga gcgagaagca
     4801 gagctgagcc accctagctc tgacagtgag gaaaatgagg ccagaggccg gagagctgcc
     4861 aatccgatat cctctcagga gactgaaaat gcagacagaa ccctatccaa caacatcaca
     4921 gttcccaaga tagagcgcgc caacagctac tcggcagagg agccaagcgc gccatatgca
     4981 cataccagaa agagcttctc catcagtgac aagcttgata gacagaggaa cacagcaagc
     5041 ctccgaaatc ccttccagag aagtaagtcc tccaagccgg agggccgagg ggacagcgta
     5101 tccatgagaa gactgtctag aacatcggct tttcatagct ttgagagcaa gcacaactaa
     5161 accatcttcc cgtgtgttgc aggaggctca agaatccagc actaaaattc tccccaatgc
     5221 ccaccacgtt ccccattcct tgagttagac ctgctttttt cttagctgag caaaacaaag
     5281 ggagacatta actcaaaggt aacctctggg ccacgggtca agcaattatt ccgtctggcc
     5341 cagtgcaaaa cacaggggtt aaggcatgtt cctatctgtt gggcagggag gggtaaagat
     5401 gacagaaaag gggctagaga cgaatgggtg tcaccaggca ccgcagaaag ccatgagctc
     5461 tggggagcca gtgggctcca gcactctcca tgccgacagg catcttggga tgtcggccct
     5521 gttatcaaga gtcgagggct aaattgcaaa atgaaataaa agtagctagc gtacaagatg
     5581 agatattcta aacttccctt ctgttttctt ttcgcattgg ttccatcacc ggtgactaat
     5641 gaagaacatc ctttttattc agtataagcc ggcagcaagc agttctacct aacgtcccac
     5701 atccttctca tgccaacacc tctgtaattg gtcattataa agaaaaccaa ggtaacagtc
     5761 atatatacag ttcacctgtc tcttatctat tcacttccgg tgccacaact gtttatctct
     5821 ttagaagaaa ataagggaac agaaaaatgc cttttttttt tttgtcttgc gatcaaaatg
     5881 aaggaagaat tgatgttgaa agcaaaagtc ctatgattta taatatacca cgggcaatca
     5941 agtctagtca agtaagctca ggatgaatgt acttagataa ttttatattt ctcagttatt
     6001 ttgtatctca cctgtcatca gagaattcac tcatcaaata tgtaatagcg aactttaagg
     6061 aaaaggtggg aagctctaac attaagttgc cagtgggatg ttgttatagt ctcaccgttc
     6121 atagtgcgtg acgctgctgt gtggccttca tcacctgcat gtctccacta tgtcctccag
     6181 acgcctccaa gatgtaactg ccaaatttcc acaccgctca tcacgtgacc attttgtatt
     6241 tcaacacatg gttatatgtg gatattttca tacctagagt ttagccatcc aatctgggtt
     6301 cagcataaac ttaatcagag tttttcaagg gctggtatct tttttatgga aatgttccaa
     6361 agtacttttt aaggaagttt aaaaaaccat aaataacctt agatttgact agggtcttga
     6421 tatccaccca aacccatcag ttgcagacag gccgtgaata ggtttcttat ttacaaagct
     6481 ataaaaaaga tacagtaggg ctaaatagag aacaaatata ccatatacag agttctatag
     6541 tttatgctgc ttacatgtac atccacatac agacacatgt ttatatacag tatatataca
     6601 gacacataga gatttcttaa aaggctttga cttcctgtca tctgatggta taatcaagat
     6661 tattttttcg tgtccaagaa gtttcactgg aaaaagttgt tgtgctattg gatccactgt
     6721 tgaaattata attt
//
