LOCUS       NM_001011559            5479 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 2 (Trpm2), mRNA.
ACCESSION   NM_001011559 XM_006256248 XM_228069
VERSION     NM_001011559.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5479)
  AUTHORS   Bai,Y., Sun,Y., Pei,Y., Zhou,C., Yan,J. and Qin,L.
  TITLE     Transient receptor potential M2 channel in the hypothalamic
            preoptic area and its impact on thermoregulation during menopause
  JOURNAL   Ann Anat 250, 152132 (2023)
   PUBMED   37454827
  REMARK    GeneRIF: Transient receptor potential M2 channel in the
            hypothalamic preoptic area and its impact on thermoregulation
            during menopause.
REFERENCE   2  (bases 1 to 5479)
  AUTHORS   Zhang,S., Zhao,J., Wu,M., Zhou,Y., Wu,X., Du,A., Tao,Y., Huang,S.,
            Cai,S., Zhou,M., Wei,T., Zhang,Y., Xie,L., Wu,Y. and Xiao,J.
  TITLE     Over-activation of TRPM2 ion channel accelerates blood-spinal cord
            barrier destruction in diabetes combined with spinal cord injury
            rat
  JOURNAL   Int J Biol Sci 19 (8), 2475-2494 (2023)
   PUBMED   37215981
  REMARK    GeneRIF: Over-activation of TRPM2 ion channel accelerates
            blood-spinal cord barrier destruction in diabetes combined with
            spinal cord injury rat.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5479)
  AUTHORS   Serhatlioglu,I., Ozcan,M., Kacar,E., Kuloglu,T., Kaya Tektemur,N.,
            Gulcu Bulmus,F., Bulmus,O., Tan,F., Ercan,Z., Ulker Ertugrul,N.,
            Yardimci,A., Zorlu,G. and Kelestimur,H.
  TITLE     TRPM2 may be involved in high fructose corn syrup-induced
            anxiety-like behavior in adult male rats
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (3), 13-22 (2023)
   PUBMED   37300693
  REMARK    GeneRIF: TRPM2 may be involved in high fructose corn syrup-induced
            anxiety-like behavior in adult male rats.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5479)
  AUTHORS   Thapak,P., Bishnoi,M. and Sharma,S.S.
  TITLE     Pharmacological Inhibition of Transient Receptor Potential
            Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive
            Deficits in Rats: A Mechanistic Study
  JOURNAL   Curr Neurovasc Res 17 (3), 249-258 (2020)
   PUBMED   32294037
  REMARK    GeneRIF: Pharmacological Inhibition of Transient Receptor Potential
            Melastatin 2 (TRPM2) Channels Attenuates Diabetes-induced Cognitive
            Deficits in Rats: A Mechanistic Study.
REFERENCE   5  (bases 1 to 5479)
  AUTHORS   Wang,H., Song,T., Wang,W. and Zhang,Z.
  TITLE     TRPM2 participates the transformation of acute pain to chronic pain
            during injury-induced neuropathic pain
  JOURNAL   Synapse 73 (10), e22117 (2019)
   PUBMED   31120580
  REMARK    GeneRIF: TRPM2 participates in the transformation of acute pain to
            chronic pain during injury-induced neuropathic pain
REFERENCE   6  (bases 1 to 5479)
  AUTHORS   Togashi,K., Hara,Y., Tominaga,T., Higashi,T., Konishi,Y., Mori,Y.
            and Tominaga,M.
  TITLE     TRPM2 activation by cyclic ADP-ribose at body temperature is
            involved in insulin secretion
  JOURNAL   EMBO J 25 (9), 1804-1815 (2006)
   PUBMED   16601673
REFERENCE   7  (bases 1 to 5479)
  AUTHORS   Hill,K., Tigue,N.J., Kelsell,R.E., Benham,C.D., McNulty,S.,
            Schaefer,M. and Randall,A.D.
  TITLE     Characterisation of recombinant rat TRPM2 and a TRPM2-like
            conductance in cultured rat striatal neurones
  JOURNAL   Neuropharmacology 50 (1), 89-97 (2006)
   PUBMED   16260005
REFERENCE   8  (bases 1 to 5479)
  AUTHORS   Fonfria,E., Marshall,I.C., Boyfield,I., Skaper,S.D., Hughes,J.P.,
            Owen,D.E., Zhang,W., Miller,B.A., Benham,C.D. and McNulty,S.
  TITLE     Amyloid beta-peptide(1-42) and hydrogen peroxide-induced toxicity
            are mediated by TRPM2 in rat primary striatal cultures
  JOURNAL   J Neurochem 95 (3), 715-723 (2005)
   PUBMED   16104849
  REMARK    GeneRIF: activation of TRPM2, functionally expressed in primary
            cultures of rat striatum, contributes to Abeta- and oxidative
            stress-induced striatal cell death
REFERENCE   9  (bases 1 to 5479)
  AUTHORS   Kwitek,A.E., Gullings-Handley,J., Yu,J., Carlos,D.C., Orlebeke,K.,
            Nie,J., Eckert,J., Lemke,A., Andrae,J.W., Bromberg,S., Pasko,D.,
            Chen,D., Scheetz,T.E., Casavant,T.L., Soares,M.B., Sheffield,V.C.,
            Tonellato,P.J. and Jacob,H.J.
  TITLE     High-density rat radiation hybrid maps containing over 24,000
            SSLPs, genes, and ESTs provide a direct link to the rat genome
            sequence
  JOURNAL   Genome Res 14 (4), 750-757 (2004)
   PUBMED   15060019
REFERENCE   10 (bases 1 to 5479)
  AUTHORS   Hara,Y., Wakamori,M., Ishii,M., Maeno,E., Nishida,M., Yoshida,T.,
            Yamada,H., Shimizu,S., Mori,E., Kudoh,J., Shimizu,N., Kurose,H.,
            Okada,Y., Imoto,K. and Mori,Y.
  TITLE     LTRPC2 Ca2+-permeable channel activated by changes in redox status
            confers susceptibility to cell death
  JOURNAL   Mol Cell 9 (1), 163-173 (2002)
   PUBMED   11804595
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000020.1.
            
            On or before Sep 9, 2022 this sequence version replaced
            XM_006256248.4, NM_001011559.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360176.2227557.1,
                                           SRR26643284.20872.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-42                JAXUCZ010000020.1  10704472-10704513
            43-289              JAXUCZ010000020.1  10706579-10706825
            290-378             JAXUCZ010000020.1  10707596-10707684
            379-547             JAXUCZ010000020.1  10712547-10712715
            548-728             JAXUCZ010000020.1  10715511-10715691
            729-895             JAXUCZ010000020.1  10716740-10716906
            896-1076            JAXUCZ010000020.1  10718361-10718541
            1077-1138           JAXUCZ010000020.1  10720196-10720257
            1139-1339           JAXUCZ010000020.1  10721202-10721402
            1340-1442           JAXUCZ010000020.1  10723088-10723190
            1443-1564           JAXUCZ010000020.1  10725443-10725564
            1565-1918           JAXUCZ010000020.1  10725757-10726110
            1919-2056           JAXUCZ010000020.1  10728133-10728270
            2057-2186           JAXUCZ010000020.1  10728790-10728919
            2187-2332           JAXUCZ010000020.1  10729144-10729289
            2333-2445           JAXUCZ010000020.1  10730094-10730206
            2446-2659           JAXUCZ010000020.1  10731173-10731386
            2660-2778           JAXUCZ010000020.1  10733032-10733150
            2779-2911           JAXUCZ010000020.1  10733590-10733722
            2912-3083           JAXUCZ010000020.1  10734154-10734325
            3084-3267           JAXUCZ010000020.1  10737613-10737796
            3268-3449           JAXUCZ010000020.1  10739242-10739423
            3450-3582           JAXUCZ010000020.1  10739592-10739724
            3583-3670           JAXUCZ010000020.1  10741072-10741159
            3671-3758           JAXUCZ010000020.1  10742227-10742314
            3759-3916           JAXUCZ010000020.1  10742795-10742952
            3917-3993           JAXUCZ010000020.1  10743597-10743673
            3994-4095           JAXUCZ010000020.1  10743942-10744043
            4096-4182           JAXUCZ010000020.1  10747149-10747235
            4183-4288           JAXUCZ010000020.1  10747950-10748055
            4289-4390           JAXUCZ010000020.1  10749205-10749306
            4391-4507           JAXUCZ010000020.1  10750679-10750795
            4508-5479           JAXUCZ010000020.1  10751824-10752795
FEATURES             Location/Qualifiers
     source          1..5479
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="20"
                     /map="20p12"
     gene            1..5479
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 2"
                     /db_xref="GeneID:294329"
                     /db_xref="RGD:1311889"
     exon            1..42
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            43..289
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..4654
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /EC_number="3.6.1.13"
                     /note="transient receptor potential melastatin family 2"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 2"
                     /protein_id="NP_001011559.2"
                     /db_xref="GeneID:294329"
                     /db_xref="RGD:1311889"
                     /translation="MEPLDQRRTDSDQEEGFGVQSRRATDLGMVPNLRRSNSSLCKSR
                     RLLCSFSSEKQENLSSWIPENIKKKECVYFVESSKLSDAGKVVCECGYTHEQHIEVAI
                     KPHTFQGKEWDPKKHVHEMPTDAFGDIVFTGLSQKVGKYVRLSQDTSSIVIYQLMTQH
                     WGLDVPSLLISVTGGAKNFNMKLRLKSIFRRGLVKVAQTTGAWIITGGSHTGVMKQVG
                     EAVRDFSLSSSCKEGDVITIGIATWGTIHNREALIHPMGGFPAEYMLDEEGQGNLTCL
                     DSNHSHFILVDDGTHGQYGVEIPLRTKLEKFISEQTKERGGVAIKIPIVCVVLEGGPG
                     TLHTIYNAITNGTPCVIVEGSGRVADVIAQVAALPVSEITISLIQQKLSVFFQEMFET
                     FTENQIVEWTKKIQDIVRRRQLLTVFREGKDGQQDVDVAILQALLKASRSQDHFGHEN
                     WDHQLKLAVAWNRVDIARSEIFTDEWQWKPSDLHPMMTAALISNKPEFVRLFLENGVR
                     LKEFVTWDTLLCLYENLEPSCLFHSKLQKVLAEEHERLAYASETPRLQMHHVAQVLRE
                     LLGDSTQLLYPRPRYTDRPRLSLPMPHIKLNVQGVSLRSLYKRSTGHVTFTIDPVRDL
                     LIWAIIQNHRELAGIIWAQSQDCTAAALACSKILKELSKEEEDTDSSEEMLALADEFE
                     HRAIGVFTECYRKDEERAQKLLVRVSEAWGKTTCLQLALEAKDMKFVSHGGIQAFLTK
                     VWWGQLCVDNGLWRIILCMLAFPLLFTGFISFREKRLQALCRLARVRAFFNAPVVIFY
                     LNILSYFAFLCLFAYVLMVDFQPSPSWCEYLIYLWLFSLVCEETRQLFYDPDGCGLMK
                     MASLYFSDFWNKLDVGAILLFIAGLTCRLIPATLYPGRIILSLDFIMFCLRLMHIFTI
                     SKTLGPKIIIVKRMMKDVFFFLFLLAVWVVSFGVAKQAILIHNESRVDWIFRGVIYHS
                     YLTIFGQIPTYIDGVNFSMDQCSPNGTDPYKPKCPESDWTGQAPAFPEWLTVTLLCLY
                     LLFANILLLNLLIAMFNYTFQEVQEHTDQIWKFQRHDLIEEYHGRPPAPPPLILLSHL
                     QLLIKRIVLKIPAKRHKQLKNKLEKNEEAALLSWELYLKENYLQNQQYQHKQRPEQKI
                     QDISEKVDTMVDLLDMDRVKRSGSTEQRLASLEEQVTQMGRSLHWIVTTLKDSGFGSG
                     AGALTLAAQRAFDEPDAELSIRKKGEEGGDGYHVSARHLLYPDARIMRFPVPNEKVPW
                     EAEFLIYDPPFYTAEKKDATLTDPVGDTAEPLSKINYNVVDGLMDRCSFHGTYVVQYG
                     FPLNPMGRTGLRGRGSLSWFGPNHTLQPVVTRWKRNQGGGICRKSVRKMLEVLVVKLP
                     QSEHWALPGGSREPGKMLPRKLKQVLQQEYWVTFETLLRQGTEVYKGYVDDPRNTDNA
                     WIETVAVSIHFQDQNDVELKRLEENLQTHDPKESARGLEMSTEWQVVDRRIPLYVNHK
                     KILQKVASLFGAHF"
     exon            290..378
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            379..547
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            548..728
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            729..895
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1076
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..1138
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            1139..1339
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1442
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1564
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1918
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..2056
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2057..2186
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2187..2332
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2333..2445
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2446..2659
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2778
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2779..2911
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            2912..3083
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3267
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3449
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3450..3582
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3583..3670
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3671..3758
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3759..3916
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3917..3993
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            3994..4095
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            4096..4182
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            4183..4288
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            4289..4390
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            4391..4507
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
     exon            4508..5479
                     /gene="Trpm2"
                     /gene_synonym="Trpm2-predicted"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagctgcgc gtgtgacgct ggggtgcgcg gcctctgagc agagccccca acctcacaaa
       61 tgagaagaga catccctgaa aggcatctag agatctctct cctctggtgg atctggagcc
      121 gtggaggatg gagcccttgg accagagaag aactgactct gatcaagagg agggctttgg
      181 ggtgcagtcc cggagggcca ctgatctggg catggtcccc aatctccgac gaagcaatag
      241 cagtctttgc aagagcagga ggcttctgtg ctccttcagc agtgagaagc aagaaaacct
      301 tagctcatgg attcccgaga acatcaagaa gaaggaatgt gtgtatttcg tggaaagttc
      361 caagctctcg gatgcaggga aggtagtgtg tgagtgtggt tacacccacg agcagcacat
      421 tgaagtggcc atcaagcctc acaccttcca gggcaaggag tgggacccaa agaaacacgt
      481 ccatgagatg cctacagatg cctttggtga cattgtcttc accggcctga gccagaaagt
      541 ggggaagtat gtccgactct cccaggacac gtcgtccatt gtcatctacc agcttatgac
      601 acagcactgg ggcctggatg tccccagcct cctcatctct gtgaccggtg gggccaagaa
      661 cttcaacatg aagctgaggt tgaagagcat cttccggaga ggcctggtta aggtggccca
      721 aaccacgggg gcctggatca tcactggggg ttcccacacc ggtgtgatga agcaggtggg
      781 cgaggcggta cgggacttca gcctaagcag cagctgcaaa gaaggcgacg tcatcaccat
      841 cggcatagcc acgtggggca ccatccacaa ccgtgaggca ctgatccatc ccatgggagg
      901 cttccccgct gagtacatgc tggatgagga aggccaaggg aacctgacct gcctggacag
      961 caaccactcc cacttcatcc tggtggatga tgggacccac gggcagtatg gtgtggagat
     1021 tccgctgagg actaagctgg agaagttcat atcggagcaa acgaaggaaa gagggggtgt
     1081 ggccattaag atccccattg tctgcgtggt gttggagggt ggccctggca ctctgcatac
     1141 catctacaac gccatcacca atggcacacc ctgcgtgata gtggagggct ccggccgagt
     1201 ggctgacgtc atcgctcagg tggccgctct gcccgtctct gagatcacca tctccctgat
     1261 ccagcagaag ctcagcgtct tcttccagga gatgtttgag actttcaccg aaaaccagat
     1321 tgtggaatgg accaaaaaga tccaagatat tgtcaggagg cggcagctgc tgacggtctt
     1381 ccgggaaggc aaggatggtc agcaggatgt ggatgttgcc attctgcaag ctttactgaa
     1441 agcctctcga agccaagatc acttcggcca cgagaactgg gaccatcagc tgaagctggc
     1501 cgtggcctgg aaccgtgtgg acatcgcccg cagtgagatc ttcaccgatg agtggcagtg
     1561 gaagccttca gacctgcatc ccatgatgac ggctgccctc atctccaata agcctgagtt
     1621 tgtgaggctc tttctggaga acggggtgcg gctgaaggag tttgtcacct gggatactct
     1681 tctctgcctc tacgagaacc tggagccatc ctgccttttc cacagcaagc tgcagaaggt
     1741 gctggcagaa gagcatgaac gcttagccta tgcatctgag acaccccggc tgcaaatgca
     1801 ccatgtggcc caggtgctgc gtgagctcct cggagactcc acacagctgc tgtatccccg
     1861 gccccggtac actgaccggc cacggctctc gctgcccatg ccacacatca aactcaacgt
     1921 gcaaggagtg agcctccggt ctctctataa gcgatcaaca ggccacgtta ccttcaccat
     1981 tgacccagtc cgcgatcttc tcatttgggc catcatccag aaccacaggg agctggcggg
     2041 catcatctgg gctcagagcc aggactgcac agcagccgca ctggcctgca gcaagatcct
     2101 gaaggagctg tccaaggagg aggaagatac agacagctct gaggagatgc tggcactcgc
     2161 ggatgagttt gagcatagag ctatcggtgt cttcaccgag tgctacagaa aggatgagga
     2221 aagagcccag aagctgcttg tccgtgtgtc tgaggcctgg gggaagacca cctgcctgca
     2281 gctggccctc gaggccaagg acatgaaatt cgtgtctcac ggagggatcc aggctttcct
     2341 aacaaaggtg tggtggggtc agctctgcgt ggacaatggc ctgtggagga tcatcctgtg
     2401 catgctggcc ttccctctgc tcttcactgg cttcatctcc ttcagggaaa agaggctgca
     2461 ggcactgtgc cgcctggccc gcgtccgcgc cttcttcaac gcgccggtgg tcatcttcta
     2521 cctcaatatt ctctcctact ttgccttcct ctgcctgttt gcctacgtgc tcatggtgga
     2581 ctttcagccc tcaccatcct ggtgcgagta cctcatctac ctgtggctct tctccctggt
     2641 gtgcgaggag acacggcagc tattctacga tcccgatggc tgcgggctca tgaagatggc
     2701 gtccctgtac ttcagtgact tctggaacaa actggacgtt ggggccattc tgctctttat
     2761 agcaggactg acctgccgac tcatcccagc gacgctgtac cctgggcgca tcatcctgtc
     2821 tttggacttc attatgttct gcctccgcct catgcacatc ttcaccatta gcaagacact
     2881 ggggcccaag ataatcatcg tgaagcggat gatgaaggac gtcttcttct tcctctttct
     2941 cctggcggtg tgggtggtgt ccttcggagt ggccaagcag gccatcctca tccacaatga
     3001 gagccgcgtg gactggatct tccgcggagt tatctatcac tcttacctta ccatcttcgg
     3061 gcagatcccg acctacattg acggcgtgaa tttcagcatg gaccagtgca gccccaatgg
     3121 tacagacccc tacaagccca agtgtcctga gagtgactgg acagggcagg cacccgcctt
     3181 ccccgagtgg ctgacagtca cccttctctg cctctacctg ctcttcgcca acatcctgct
     3241 gcttaatttg ctcatcgcca tgttcaacta caccttccag gaggtgcagg agcacacaga
     3301 ccagatctgg aagttccagc gccacgacct gattgaggag taccacggcc ggcccccggc
     3361 ccctccccca ctcatcctcc tcagccacct gcagctcctg atcaagagga ttgtcctgaa
     3421 gatccccgcc aagaggcaca agcagctcaa gaacaagctg gagaagaatg aggaggcagc
     3481 cctcctgtcc tgggagctct acctgaagga gaattacctg cagaaccaac agtaccagca
     3541 caaacagcgg ccagagcaga agatccagga catcagtgag aaagtggaca ccatggtgga
     3601 tctgttggac atggaccgtg tgaagagatc aggctccaca gagcagaggc tggcctccct
     3661 tgaggaacag gtgactcaga tgggcagatc tttgcactgg atcgtgacga ccctgaagga
     3721 cagtggcttt ggctcagggg ccggtgcact gaccctggca gcccaaaggg ccttcgacga
     3781 gccagatgct gagctgagta tcaggaagaa aggagaggag ggaggagatg gctatcatgt
     3841 gagcgcccgg cacctcctct accctgatgc ccgcatcatg cgcttccccg tgcctaatga
     3901 gaaggtgcct tgggaggcag agtttctgat ctacgaccct ccgttttaca cagctgagaa
     3961 gaaggatgcg actctcacag accctgtggg agacactgca gaacctctgt ctaagatcaa
     4021 ttacaacgtc gtggacggac tgatggaccg ttgcagcttc catgggacct atgtggtcca
     4081 atatgggttc cctttgaacc ccatgggccg caccgggttg cgtggtcgtg ggagcctcag
     4141 ctggtttggt cccaaccaca ctctgcagcc agttgttacc cggtggaaga ggaaccaggg
     4201 tggaggcatc tgccggaaga gtgtcaggaa gatgttggag gtgctggtcg tgaagttgcc
     4261 tcaatccgag cactgggcct tgcctggggg ctctcgggag ccagggaaga tgctaccacg
     4321 gaagctgaaa caggtcctcc agcaggagta ctgggtgacc tttgagacct tgctaaggca
     4381 aggtacagag gtgtacaaag gatacgtgga tgacccaagg aacacggaca atgcctggat
     4441 cgagacggtg gctgtcagca tccatttcca ggaccagaat gatgtggagc tgaagaggtt
     4501 ggaagagaac ctgcaaactc atgatccaaa ggagtcggcc cgtggcttgg agatgtctac
     4561 tgaatggcag gttgtagacc ggcggatccc tctgtatgtg aaccacaaga agatcctcca
     4621 aaaggtggcc tcgctgtttg gcgctcactt ctgaccgtgg gttcttgtgg aagctccagg
     4681 ggaaggggtg atcatccatc aatgaccccc ctccaagact tggactgggt ggcaggttgg
     4741 ggtactgggt tggggtggta ggttgtaggg ctgggttggg tgaccacagg gatcttaata
     4801 agtccccaga ggtactgtcc tgaaagccac gtctgccaca acaggaggat cacagcatga
     4861 ggacagaagt attgtattca gtggctcctg aaatctatgt cctcaagtgc catgccttga
     4921 ctagagttta tggggccctg accagcacga tgctgccact actcatagac ctggttggaa
     4981 gtgctacctc taggacaggt gctttccctc ggagggacct ctgtcctcat cgtgggagcc
     5041 ttctgtccta ggcataaggt agacagaggc tatgcctcct tcaggaagag acactgctct
     5101 cataactcct ggtcagtgct gagtcacagg cactgaggaa ggccgtgagg gctttgagct
     5161 gggatcactg tcatctctag actttagaag ggctcctctg aggacactcg ggcaggagca
     5221 caccctccct cagctccagt gccagctctg ctggtcacag aaaacactgg aagaggacaa
     5281 cagggtccca tgtcactgct tctagagaaa tgtacaactg agaacaatag gctttctctc
     5341 acagggtagg tgacggggta ggtgactcaa ggattggtac tggctaggag atcaactctg
     5401 tagtgggggg gggttgttgg aggaacgggc aatgtccggg tttaatggga tggggacaat
     5461 aaagaatgtg tatgatcaa
//
