LOCUS       NM_001037733            5012 bp    mRNA    linear   ROD 06-OCT-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily M, member 1 (Trpm1), transcript variant 2, mRNA.
ACCESSION   NM_001037733 XM_341868
VERSION     NM_001037733.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 5012)
  AUTHORS   Jirku,M., Lansky,Z., Bednarova,L., Sulc,M., Monincova,L., Majer,P.,
            Vyklicky,L., Vondrasek,J., Teisinger,J. and Bousova,K.
  TITLE     The characterization of a novel S100A1 binding site in the
            N-terminus of TRPM1
  JOURNAL   Int J Biochem Cell Biol 78, 186-193 (2016)
   PUBMED   27435061
  REMARK    GeneRIF: a molecular mechanism for the potential regulation of
            TRPM1 by S100A1
REFERENCE   2  (bases 1 to 5012)
  AUTHORS   Devi,S., Markandeya,Y., Maddodi,N., Dhingra,A., Vardi,N.,
            Balijepalli,R.C. and Setaluri,V.
  TITLE     Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium
            channel function and increases melanin content in human melanocytes
  JOURNAL   Pigment Cell Melanoma Res 26 (3), 348-356 (2013)
   PUBMED   23452348
REFERENCE   3  (bases 1 to 5012)
  AUTHORS   Thameem,F., Puppala,S., Arar,N.H., Blangero,J., Duggirala,R. and
            Abboud,H.E.
  TITLE     Genetic variants in transient receptor potential cation channel,
            subfamily M 1 (TRPM1) and their risk of albuminuria-related traits
            in Mexican Americans
  JOURNAL   Clin Chim Acta 412 (23-24), 2058-2062 (2011)
   PUBMED   21439949
REFERENCE   4  (bases 1 to 5012)
  AUTHORS   Won,J., Shi,L.Y., Hicks,W., Wang,J., Hurd,R., Naggert,J.K.,
            Chang,B. and Nishina,P.M.
  TITLE     Mouse model resources for vision research
  JOURNAL   J Ophthalmol 2011, 391384 (2011)
   PUBMED   21052544
REFERENCE   5  (bases 1 to 5012)
  AUTHORS   Koike,C., Obara,T., Uriu,Y., Numata,T., Sanuki,R., Miyata,K.,
            Koyasu,T., Ueno,S., Funabiki,K., Tani,A., Ueda,H., Kondo,M.,
            Mori,Y., Tachibana,M. and Furukawa,T.
  TITLE     TRPM1 is a component of the retinal ON bipolar cell transduction
            channel in the mGluR6 cascade
  JOURNAL   Proc Natl Acad Sci U S A 107 (1), 332-337 (2010)
   PUBMED   19966281
REFERENCE   6  (bases 1 to 5012)
  AUTHORS   Morgans,C.W., Zhang,J., Jeffrey,B.G., Nelson,S.M., Burke,N.S.,
            Duvoisin,R.M. and Brown,R.L.
  TITLE     TRPM1 is required for the depolarizing light response in retinal
            ON-bipolar cells
  JOURNAL   Proc Natl Acad Sci U S A 106 (45), 19174-19178 (2009)
   PUBMED   19861548
REFERENCE   7  (bases 1 to 5012)
  AUTHORS   Audo,I., Kohl,S., Leroy,B.P., Munier,F.L., Guillonneau,X.,
            Mohand-Said,S., Bujakowska,K., Nandrot,E.F., Lorenz,B.,
            Preising,M., Kellner,U., Renner,A.B., Bernd,A., Antonio,A.,
            Moskova-Doumanova,V., Lancelot,M.E., Poloschek,C.M., Drumare,I.,
            Defoort-Dhellemmes,S., Wissinger,B., Leveillard,T., Hamel,C.P.,
            Schorderet,D.F., De Baere,E., Berger,W., Jacobson,S.G., Zrenner,E.,
            Sahel,J.A., Bhattacharya,S.S. and Zeitz,C.
  TITLE     TRPM1 is mutated in patients with autosomal-recessive complete
            congenital stationary night blindness
  JOURNAL   Am J Hum Genet 85 (5), 720-729 (2009)
   PUBMED   19896113
REFERENCE   8  (bases 1 to 5012)
  AUTHORS   van Genderen,M.M., Bijveld,M.M., Claassen,Y.B., Florijn,R.J.,
            Pearring,J.N., Meire,F.M., McCall,M.A., Riemslag,F.C., Gregg,R.G.,
            Bergen,A.A. and Kamermans,M.
  TITLE     Mutations in TRPM1 are a common cause of complete congenital
            stationary night blindness
  JOURNAL   Am J Hum Genet 85 (5), 730-736 (2009)
   PUBMED   19896109
REFERENCE   9  (bases 1 to 5012)
  AUTHORS   Li,Z., Sergouniotis,P.I., Michaelides,M., Mackay,D.S., Wright,G.A.,
            Devery,S., Moore,A.T., Holder,G.E., Robson,A.G. and Webster,A.R.
  TITLE     Recessive mutations of the gene TRPM1 abrogate ON bipolar cell
            function and cause complete congenital stationary night blindness
            in humans
  JOURNAL   Am J Hum Genet 85 (5), 711-719 (2009)
   PUBMED   19878917
REFERENCE   10 (bases 1 to 5012)
  AUTHORS   Wang,H.P., Pu,X.Y. and Wang,X.H.
  TITLE     Distribution profiles of transient receptor potential
            melastatin-related and vanilloid-related channels in prostatic
            tissue in rat
  JOURNAL   Asian J Androl 9 (5), 634-640 (2007)
   PUBMED   17712480
  REMARK    GeneRIF: Polymerase chain reaction used to check the expression of
            all TRPM and TRPV channel members with specific primers.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AJ867483.1.
            
            On Dec 15, 2005 this sequence version replaced XM_341868.2.
            
            Transcript Variant: This variant (2) uses an alternate splice site
            in the coding region compared to variant 1. The resulting protein
            (isoform 2) is shorter but has the same N- and C-termini compared
            to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AJ867483.1 [ECO:0000332]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..5012
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="DA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q22"
     gene            1..5012
                     /gene="Trpm1"
                     /note="transient receptor potential cation channel,
                     subfamily M, member 1"
                     /db_xref="GeneID:361586"
                     /db_xref="RGD:1597140"
     exon            1..218
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             144..5012
                     /gene="Trpm1"
                     /function="putative ion channel protein"
                     /note="isoform 2 is encoded by transcript variant 2;
                     melastatin; melastatin-1"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily M member 1 isoform 2"
                     /protein_id="NP_001032822.1"
                     /db_xref="GeneID:361586"
                     /db_xref="RGD:1597140"
                     /translation="MGSMRKMSSSFKRGSIKSSTSGSQKGQKAWIEKTFCKRECIFVI
                     PSTKDPNRCCCGQLTNQHIPPLPSVTPSSTAEDTKQGDAQSGKWSVSKHTQSYPTDSY
                     GILEFQGGGYSNKAMYIRVSYDTKPDSLLHLMVKDWQLELPKLLISVHGGLQSFEMQP
                     KLKQVFGKGLIKAAMTTGAWIFTGGVSTGVVSHVGDALKDHSSKSRGRLCAIGIAPWG
                     MVENKEDLVGKDVTRVYQTMSNPLSKLSVLNNSHTHFILADNGTLGKYGAEVKLRRQL
                     EKHISLQKINTRLGQGVPVVGLVVEGGPNVVSIVLEYLREDPPVPVVVCDGSGRASDI
                     LSFAHKYCDEGGVINESLRDQLLVTIQKTFNYSKSQSHQLFAIIMECMKKKELVTVFR
                     MGSEGQQDVEMAILTALLKGTNVSAPDQLSLALAWNRVDIARSQIFVFGPHWPPLGSL
                     APPVDTKVAEKEKKPPTATTKGRGKGKGKKKGKVKEEVEEETDPRKIELLNWVNALEQ
                     AMLDALVLDRVDFVKLLIENGVNMQHFLTIPRLEELYNTRLGPPNTLHLLVRDVKKSN
                     LPPDYHISLIDIGLVLEYLMGGAYRCNYTRKSFRTLYNNLFGPKRPKALKLLGMEDDE
                     PPAKGKKKKKKKKEEEIDIDVDDPAVSRFQYPFHELMVWAVLMKRQKMAVFLWQRGEE
                     CMAKALVACKLYKAMAHESSESELVDDISQDLDNNSKDFGQLAVELLDQSYKHDEQVA
                     MKLLTYELKNWSNSTCLKLAVAAKHRDFIAHTCSQMLLTDMWMGRLRMRKNPGLKVIM
                     GILIPPTILFLEFRSYDDFSYQTSKENEDGKEKEEENVDANADAGSRKGDEENEHKKQ
                     RSIPIGTKICEFYNAPIVKFWFYTISYLGYLLLFNYVILVRMDGWPSPQEWIVISYIV
                     SLALEKIREILMSEPGKLSQKIKVWLQEYWNITDLVAISMFMVGAILRLQNQPYMGYG
                     RVIYCVDIILWYIRVLDIFGVNKYLGPYVMMIGKMMIDMLYFVVIMLVVLMSFGVARQ
                     AILHPEEKPSWKLARNIFYMPYWMIYGEVFADQIDLYAMEINPPCGENLYDEEGKRLP
                     PCIPGAWLTPALMACYLLVANILLVNLLIAVFNNTFFEVKSISNQVWKFQRYQLIMTF
                     HDRPVLPPPMIILSHIYIIVMRLSGRCRKKREGDQEERDRGLKLFLSDEELKKLHEFE
                     EQCVQEHFREKEDEQQSSSDERIRVTSERVENMSMRLEEINERENFMKASLQTVDLRL
                     SQLEELSGRMVGALENLAGIDRSDLIQARSRASSECEATYLLRQSSINSADGYSMYRY
                     HFNGEELLFEEPALSTSPGTVFRKKTCSFRVKEEDVKPHLDQPSSLHHTPGPSPPATP
                     GRSRLALDGPLSTELRPGLDPGISAGELDPRADFKSAEVAPSLNTANVASTQLTVEST
                     VSHPLRESKLARYYPGDLNTYKTMKSRSFVYSEGRKLVRGLSNWGAEYSSIMDQTWNS
                     AEWRCQVQRITRSRSTDIPYIVSEAASQDEFEDEHRESLLAPQISRSALTVSDRPEKE
                     NLLSVKPHQTLGFPCLRSRSLHGHPRSAKPSPSKLDRAGHASSTSNLAVMSDAPEGQN
                     TQQEKGNPETEC"
     exon            219..298
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            299..494
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            495..708
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..833
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            834..1005
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1180
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1304
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1377
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1478
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1649
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1784
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1835
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1976
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1977..2006
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2299
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2300..2528
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2529..2651
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2652..2783
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2784..2912
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..3164
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3165..3339
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3340..3360
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3361..3505
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3506..3708
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3709..3841
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3842..5012
                     /gene="Trpm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tccttctgag ctgactgagc caccaatatc acccccgaac tctgagccct gctgtccagc
       61 ctggtaaaga gaactctctt gcctcagcct attggagact cccatgcagc aggctgggcc
      121 tcacagggaa tgcagaagca ccaatggggt ccatgaggaa aatgagcagc tccttcaagc
      181 gtggttcaat caagagctcc acatcagggt cccagaaggg tcagaaagca tggatagaga
      241 agacgttttg caaaagggaa tgcatcttcg tgattcctag tacaaaagac ccgaacagat
      301 gttgctgtgg tcagctcact aaccagcaca tccccccgct gccgagtgtg actcccagct
      361 caacagcaga ggacaccaag caaggggacg cacagtccgg gaaatggtct gtcagcaaac
      421 acacccagag ctacccaaca gactcctatg ggattcttga attccagggt gggggctact
      481 ccaataaagc catgtatatc cgagtctcct acgacaccaa gccagattct ctgctccatc
      541 tcatggtgaa ggactggcag ctggagctcc ccaagctctt gatatctgtg catggaggcc
      601 tccagagctt tgagatgcag cccaagctga agcaggtctt tgggaaaggt ctgatcaagg
      661 ctgccatgac cacaggggca tggatcttca ccgggggagt gagcactggt gtcgtcagcc
      721 atgtggggga tgccttgaag gaccactcct ccaagtccag aggccggctc tgtgctatcg
      781 gaatcgctcc ctggggcatg gtggagaaca aggaagatct ggttgggaaa gatgtaacga
      841 gagtctacca gaccatgtcc aaccctctga gcaagctctc cgtgctcaac aattctcaca
      901 ctcacttcat cttggctgac aatggcaccc ttggcaagta tggtgccgag gtgaagcttc
      961 gaagacaact ggaaaaacac atctccctgc agaagatcaa cacgaggctg ggccagggtg
     1021 tacctgtcgt gggtctcgtg gtggaaggtg gacctaatgt ggtttctatc gtcctggagt
     1081 atctcagaga agaccctcct gtccctgtgg tggtttgtga cggcagtgga cgcgcctccg
     1141 acattttgtc ttttgcacac aaatactgcg acgaaggagg ggtcataaac gagtccctgc
     1201 gggaccagct tctagttacc attcagaaaa catttaatta cagcaagtcc cagtcgcatc
     1261 agctgtttgc aattatcatg gagtgcatga agaagaaaga actcgtcact gtgtttcgga
     1321 tgggctctga gggtcagcaa gatgttgaga tggcaatttt aactgccttg ctcaaaggaa
     1381 ccaacgtgtc agctccagat cagctgagct tggcactggc ttggaaccgc gtggacatag
     1441 cacgaagcca gatcttcgtc tttggcccac actggccgcc actgggaagc ctggcccctc
     1501 ctgtggacac caaagtcgca gagaaggaga agaagccacc cacagccacc accaagggaa
     1561 gaggaaaagg gaaaggcaag aagaaaggca aagtgaaaga ggaggtggag gaagaaacag
     1621 acccccggaa gatcgagctg ctgaactggg tgaacgccct ggagcaagcc atgctggacg
     1681 ctcttgtctt agaccgggtt gactttgtga agctcctgat tgaaaacgga gtgaacatgc
     1741 agcatttcct cactatcccg aggctggagg agctttacaa cactagactg ggcccaccaa
     1801 acacccttca tctgctggtg cgggatgtga agaagagcaa ccttccacct gactaccaca
     1861 tcagcctcat cgatatagga ctggtgttgg agtacctcat gggaggtgcc taccgctgca
     1921 actacactcg gaaaagcttc cggactctct acaacaactt gtttggccct aagaggccaa
     1981 aagcacttaa actcctggga atggaagatg atgagccccc agccaagggg aagaagaaaa
     2041 agaagaagaa gaaagaggag gagattgata tagatgtgga cgaccccgct gtgagtcggt
     2101 tccagtatcc gttccacgag ctcatggtat gggccgtgct catgaagcgc cagaagatgg
     2161 cagtcttcct gtggcagcgt ggggaggagt gcatggcaaa ggccttggtg gcctgtaagc
     2221 tctacaaggc catggcccac gagtcctcgg agagcgagct ggtggatgac atctcccagg
     2281 atctggacaa caattccaag gattttggcc agctcgctgt ggagctgtta gaccagtctt
     2341 acaagcacga tgagcaagtg gccatgaaac ttctgaccta tgagctcaag aactggagca
     2401 actcgacctg ccttaagctg gccgtggcgg ccaagcacag ggactttatc gctcacacct
     2461 gcagccagat gctgctgaca gacatgtgga tgggaaggct tcgcatgagg aagaaccctg
     2521 gcctgaaggt catcatgggg atccttatcc cgcccaccat cttgtttttg gaattccgtt
     2581 catatgatga cttctcctat caaacatcca aggagaatga agatggcaaa gaaaaggaag
     2641 aagagaatgt ggatgcaaat gcagatgctg gctcaagaaa gggggatgag gagaatgagc
     2701 acaaaaaaca gaggagcatt cccattggaa caaagatctg tgaattctat aatgcgccca
     2761 ttgtcaagtt ctggttttac acaatctcct acttgggcta cttgctgctg ttcaattatg
     2821 tcatcctggt gcggatggac ggctggcctt caccccaaga atggatcgtt atctcctaca
     2881 ttgtgagcct ggcactagag aaaatacgag agatcctcat gtcggaacca ggcaaactca
     2941 gccagaaaat caaagtgtgg ctccaagagt actggaacat cacagacctt gtggccattt
     3001 ccatgttcat ggttggggcc atccttcgcc tccagaacca gccatacatg ggctatggcc
     3061 gggtcatcta ctgtgtggat atcatcctct ggtacatccg agtgttagac atctttggtg
     3121 tcaacaagta tcttggcccc tatgtaatga tgattggaaa gatgatgatt gacatgctgt
     3181 actttgtggt cattatgctg gttgtgctga tgagtttcgg cgtagctcgg caagccatct
     3241 tgcacccaga ggagaagcct tcttggaaac tggcccgaaa catcttctac atgccctact
     3301 ggatgatcta cggagaagtg tttgcagacc agatagacct ctatgccatg gaaatcaacc
     3361 ctccttgtgg tgaaaatctc tatgatgagg aaggcaagag gctccctccc tgcatccctg
     3421 gtgcctggct cacacctgcc ctcatggcct gttatctcct ggtggccaat atcctgctgg
     3481 tcaacctgct gattgctgtt ttcaacaata ccttctttga agtcaagtca atatccaatc
     3541 aagtgtggaa gttccagcgg taccaactga tcatgacatt tcacgacagg ccggtcctgc
     3601 ccccgccaat gatcatctta agccacatct acatcatcgt tatgcgtctc agtggtcgct
     3661 gcagaaaaaa gagagaaggg gaccaggagg agcgggatcg tgggttgaag ctgttcctca
     3721 gcgacgagga actgaaaaaa ctgcatgagt ttgaggagca gtgcgtgcag gagcacttcc
     3781 gagaaaagga ggatgagcag cagtcgtcca gcgatgagcg catccgggtt acaagcgaga
     3841 gagttgaaaa tatgtcaatg aggctggagg aaatcaacga aagagaaaat ttcatgaagg
     3901 cgtctctgca gactgtcgac cttcggctct ctcagctgga ggagctatct ggcaggatgg
     3961 tgggcgctct ggagaatctg gcaggcatcg acaggtctga tctgatccag gctcgatcaa
     4021 gagcatcctc agaatgtgag gccacctacc tgctgcggca gagcagtatc aacagcgccg
     4081 atggctacag catgtaccgc taccatttca atggcgagga gcttctgttt gaggagcccg
     4141 ccctctccac ttcgccaggg acagtgttcc ggaaaaaaac ctgctccttc cgcgtgaagg
     4201 aagaggatgt aaaaccacac ctggaccagc caagtagcct gcaccacacc ccaggcccca
     4261 gcccgcctgc cacgccaggt cgcagccggc ttgcccttga tggtcccttg agcacagagt
     4321 tgagacctgg actggatcct ggtatctctg cgggtgagct tgatccgcgg gcagatttca
     4381 agagcgccga agttgcacca agtctgaaca cggcgaatgt tgcaagcact cagctgaccg
     4441 tcgaaagcac tgtttcccac ccactgcggg agagcaaact cgcgcgctac taccccggag
     4501 acctcaacac ctacaaaaca atgaagtcca gaagcttcgt ctattctgaa ggaagaaaac
     4561 ttgtccgagg tcttagcaac tggggtgccg agtacagttc aatcatggac caaacatgga
     4621 actcggcaga atggagatgt caagttcaaa ggatcacacg ctcccgcagc acagacatcc
     4681 cgtacattgt gtctgaagca gcctcccaag atgagtttga ggatgagcac agagaatctc
     4741 ttctggctcc tcagatctcc cgttcagccc tcacggtctc tgacaggccc gaaaaggaaa
     4801 acttgctgtc tgtgaagcca caccagactt taggattccc ctgcctacgg tcaagaagtt
     4861 tacatggtca tcctaggagt gccaaaccct ctcctagcaa attagacagg gcgggacatg
     4921 ccagcagcac cagcaactta gcagttatgt cagacgctcc agagggacaa aacacccagc
     4981 aggagaaagg aaacccggaa actgaatgct aa
//
