LOCUS       NM_053559               2793 bp    mRNA    linear   ROD 14-AUG-2023
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily C, member 6 (Trpc6), mRNA.
ACCESSION   NM_053559
VERSION     NM_053559.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2793)
  AUTHORS   Xu LX, Wang RX, Jiang JF, Yi GC, Chang JJ, He RL, Jiao HX, Zheng B,
            Gui LX, Lin JJ, Huang ZH, Lin MJ and Wu ZJ.
  TITLE     TRPC6 promotes daunorubicin-induced mitochondrial fission and cell
            death in rat cardiomyocytes with the involvement of ERK1/2-DRP1
            activation
  JOURNAL   Toxicol Appl Pharmacol 470, 116547 (2023)
   PUBMED   37178933
  REMARK    GeneRIF: TRPC6 promotes daunorubicin-induced mitochondrial fission
            and cell death in rat cardiomyocytes with the involvement of
            ERK1/2-DRP1 activation.
REFERENCE   2  (bases 1 to 2793)
  AUTHORS   Sun ZH, Liu F, Kong LL, Ji PM, Huang L, Zhou HM, Sun R, Luo J and
            Li WZ.
  TITLE     Interruption of TRPC6-NFATC1 signaling inhibits NADPH oxidase 4 and
            VSMCs phenotypic switch in intracranial aneurysm
  JOURNAL   Biomed Pharmacother 161, 114480 (2023)
   PUBMED   37002575
  REMARK    GeneRIF: Interruption of TRPC6-NFATC1 signaling inhibits NADPH
            oxidase 4 and VSMCs phenotypic switch in intracranial aneurysm.
REFERENCE   3  (bases 1 to 2793)
  AUTHORS   Ma M, Zhao S, Li C, Tang M, Sun T and Zheng Z.
  TITLE     Transient receptor potential channel 6 knockdown prevents high
            glucose-induced Muller cell pyroptosis
  JOURNAL   Exp Eye Res 227, 109381 (2023)
   PUBMED   36642172
  REMARK    GeneRIF: Transient receptor potential channel 6 knockdown prevents
            high glucose-induced Muller cell pyroptosis.
REFERENCE   4  (bases 1 to 2793)
  AUTHORS   Llancalahuen FM, Vallejos A, Aravena D, Prado Y, Gatica S, Otero C
            and Simon F.
  TITLE     alpha1-Adrenergic Stimulation Increases Platelet Adhesion to
            Endothelial Cells Mediated by TRPC6
  JOURNAL   Adv Exp Med Biol 1408, 65-82 (2023)
   PUBMED   37093422
  REMARK    GeneRIF: alpha1-Adrenergic Stimulation Increases Platelet Adhesion
            to Endothelial Cells Mediated by TRPC6.
REFERENCE   5  (bases 1 to 2793)
  AUTHORS   Oda S, Nishiyama K, Furumoto Y, Yamaguchi Y, Nishimura A, Tang X,
            Kato Y, Numaga-Tomita T, Kaneko T, Mangmool S, Kuroda T, Okubo R,
            Sanbo M, Hirabayashi M, Sato Y, Nakagawa Y, Kuwahara K, Nagata R,
            Iribe G, Mori Y and Nishida M.
  TITLE     Myocardial TRPC6-mediated Zn2+ influx induces beneficial positive
            inotropy through beta-adrenoceptors
  JOURNAL   Nat Commun 13 (1), 6374 (2022)
   PUBMED   36289215
  REMARK    GeneRIF: Myocardial TRPC6-mediated Zn(2+) influx induces beneficial
            positive inotropy through beta-adrenoceptors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2793)
  AUTHORS   Jung S, Strotmann R, Schultz G and Plant TD.
  TITLE     TRPC6 is a candidate channel involved in receptor-stimulated cation
            currents in A7r5 smooth muscle cells
  JOURNAL   Am J Physiol Cell Physiol 282 (2), C347-C359 (2002)
   PUBMED   11788346
REFERENCE   7  (bases 1 to 2793)
  AUTHORS   Zhang L and Saffen D.
  TITLE     Muscarinic acetylcholine receptor regulation of TRP6 Ca2+ channel
            isoforms. Molecular structures and functional characterization
  JOURNAL   J Biol Chem 276 (16), 13331-13339 (2001)
   PUBMED   11278449
REFERENCE   8  (bases 1 to 2793)
  AUTHORS   Hofmann T, Schaefer M, Schultz G and Gudermann T.
  TITLE     Cloning, expression and subcellular localization of two novel
            splice variants of mouse transient receptor potential channel 2
  JOURNAL   Biochem J 351 (Pt 1), 115-122 (2000)
   PUBMED   10998353
REFERENCE   9  (bases 1 to 2793)
  AUTHORS   Boulay G, Zhu X, Peyton M, Jiang M, Hurst R, Stefani E and
            Birnbaumer L.
  TITLE     Cloning and expression of a novel mammalian homolog of Drosophila
            transient receptor potential (Trp) involved in calcium entry
            secondary to activation of receptors coupled by the Gq class of G
            protein
  JOURNAL   J Biol Chem 272 (47), 29672-29680 (1997)
   PUBMED   9368034
REFERENCE   10 (bases 1 to 2793)
  AUTHORS   Zhu X, Jiang M, Peyton M, Boulay G, Hurst R, Stefani E and
            Birnbaumer L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB051212.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_053559.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760393,
                              SAMEA5760396 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2793
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q11"
     gene            1..2793
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 6"
                     /db_xref="GeneID:89823"
                     /db_xref="RGD:619788"
     CDS             1..2793
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /note="transient receptor protein 6"
                     /codon_start=1
                     /product="short transient receptor potential channel 6"
                     /protein_id="NP_446011.1"
                     /db_xref="GeneID:89823"
                     /db_xref="RGD:619788"
                     /translation="MSQSPGFVTRRGGSPKAAPGAGARRNESQDYLLMDELGDDGYPQ
                     LQQPPYGYYPSFRGNENRLTHRRQTVLREKGRRLANRGPAYMFNDHSTSLSIEEERFL
                     DAAEYGNIPVVRKMLEECLSLNVNCVDYMGQNALQLAVANEHLEITELLLKKENLSRV
                     GDALLLAISKGYVRIVEAILNHPAFAEGKRLATSPSQSELQQDDFYAYDEDGTRFSHD
                     VTPIILAAHCQEYEIVHTLLRKGARIERPHDYFCKCTECSQKQKHDSFSHSRSRINAY
                     KGLASPAYLSLSSEDPVMTALELSNELAVLANIEKEFKNDYRKLSMQCKDFVVGLLDL
                     CRNTEEVEAILNGDAETRQPGDLARPNLSRLKLAIKYEVKKFVAHPNCQQQLLSIWYE
                     NLSGLRQQTMAVKFLVVLAVAIGLPFLALIYWCAPCSKMGKILRGPFMKFVAHAASFT
                     IFLGLLVMNAADRFEGTKLLPNETSTDNARQLFRMKTSCFSWMEMLIISWVIGMIWAE
                     CKEIWTQGPKEYLFELWNMLDFGMLAIFAASFIARFMAFWHASKAQSIIDANDTLKDL
                     TKVTLGDNVKYYNLARIKWDPTDPQIISEGLYAIAVVLSFSRIAYILPANESFGPLQI
                     SLGRTVKDIFKFMVIFIMVFVAFMIGMFNLYSYYIGAKQNEAFTTVEESFKTLFWAIF
                     GLSEVKSVVINYNHKFIENIGYVLYGVYNVTMVIVLLNMLIAMINSSFQEIEDDADVE
                     WKFARAKLWFSYFEEGRTLPVPFNLVPSPKSLLYLLLKFKKWMSELIQGHKKGFQEDA
                     EMNKRNEEKKFGILGSHEDLSKFSLDRNQLAHNKQSSTRSSEDFHLNSFSNPPRQYQK
                     IMKRLIKRYVLQAQIDKESDEVNEGELKEIKQDISSLRYELLEEKSQNTEDLAELIRK
                     LGERLSLESKQEESRR"
     exon            1..167
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            168..942
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            943..1125
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1126..1290
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1507
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1508..1741
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            1742..2006
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2202
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2406
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2407..2481
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2482..2565
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2566..2641
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
     exon            2642..2792
                     /gene="Trpc6"
                     /gene_synonym="Trrp6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgagccaga gcccggggtt cgtgacccgg aggggtggct ctccgaaggc tgcccctgga
       61 gccggcgcgc ggcgcaacga gagccaggac tatctgctga tggacgagct gggagacgac
      121 ggctacccac agctccagca gccaccttat ggctactatc ccagcttccg gggtaatgaa
      181 aacagactga ctcaccggcg gcagacagtt cttcgtgaga agggaagaag gttggctaat
      241 cgaggaccag catacatgtt taatgatcac tcaaccagcc tgtctattga ggaggaacgc
      301 tttctggatg cagctgaata tggcaacatc ccagtggtgc ggaagatgct agaagaatgt
      361 ctctccctca atgttaactg tgtggattac atgggccaga atgccctaca gttggcggtg
      421 gccaatgagc acctggaaat tacagagctg ttactcaaga aggaaaactt gtctcgagtt
      481 ggggatgctt tacttttagc tatcagtaaa ggttatgtac ggattgtgga ggctattctc
      541 aaccatccag cttttgctga aggcaagagg ttggcgacaa gccccagcca gtctgaactc
      601 cagcaagatg acttttatgc ctatgatgaa gatgggacaa gattctccca cgatgtgacc
      661 ccaatcattc tggctgctca ttgccaggaa tatgaaattg tgcataccct cctgagaaag
      721 ggtgcccgga tcgaacggcc tcatgattat ttctgcaagt gtacagaatg cagccagaaa
      781 caaaagcatg actccttcag ccactctaga tccaggatca atgcctacaa agggctggca
      841 agtccagcat acctgtcact gtccagtgaa gatccagtca tgacagcttt agaactcagc
      901 aatgagctgg cagtgcttgc caacattgag aaagagttca agaatgacta caggaagctg
      961 tccatgcagt gcaaggattt tgttgtgggt ctcctggacc tctgcagaaa cacggaggaa
     1021 gtggaagcca tcctgaacgg ggatgcagag actcgccagc ccggggacct cgctcgtccg
     1081 aatctcagcc gtttaaaact cgctattaaa tatgaagtaa aaaaattcgt ggcgcatccg
     1141 aactgccagc agcagctcct ctccatatgg tatgagaacc tctctggttt acggcagcag
     1201 accatggcag tgaaattcct cgtggtcctc gctgtcgcca ttggactgcc cttcctggct
     1261 ctcatatact ggtgtgctcc ttgcagcaag atggggaaga tattacgagg tccattcatg
     1321 aagttcgtag cacatgcggc ctccttcacc attttcctgg ggctgctcgt catgaatgca
     1381 gctgacagat ttgaaggcac caagctcctc cctaatgaaa ccagcacaga taatgcaagg
     1441 cagctgttca ggatgaaaac atcctgtttc tcatggatgg agatgctcat tatatcctgg
     1501 gtaataggaa tgatatgggc tgaatgtaaa gaaatctgga ctcaaggccc caaagaatat
     1561 ttatttgagt tgtggaatat gcttgacttt ggaatgttag caatctttgc agcatcattc
     1621 attgcaagat ttatggcatt ctggcatgca tccaaagctc agagcatcat cgatgcaaat
     1681 gacactttaa aggacttgac aaaagtcaca ctgggggaca acgtcaaata ctacaatctg
     1741 gccaggataa agtgggaccc taccgatcct cagatcatct ctgaaggtct ttatgcaatc
     1801 gcggtggttt taagtttctc cagaatagct tacattttac cggcaaatga aagctttgga
     1861 cctctgcaga tttcacttgg aagaacagtg aaagatatct tcaaattcat ggtcatattc
     1921 atcatggtgt ttgtagcctt tatgattgga atgttcaacc tctactccta ctacattggt
     1981 gcaaaacaga atgaagcctt cacaacagtt gaggaaagtt ttaagactct gttctgggct
     2041 atatttggtc tttctgaagt gaagtcggtg gtcatcaact acaatcacaa gttcattgag
     2101 aacataggct atgttctgta tggagtctat aatgtcacaa tggtcattgt tttgctaaat
     2161 atgttaattg cgatgatcaa cagttcattc caggaaattg aggatgatgc ggatgtggag
     2221 tggaagtttg caagggccaa attgtggttt tcctactttg aagagggaag aacactgcct
     2281 gtccccttca atcttgtgcc aagtccaaag tccctgcttt atctcctatt gaaatttaag
     2341 aaatggatgt ctgagcttat ccagggtcat aagaaaggct tccaagaaga tgcagagatg
     2401 aacaagagaa atgaagaaaa gaaatttgga attttgggaa gtcatgaaga cctttcaaaa
     2461 ttttcacttg acagaaatca gctggcacac aacaaacaat caagtacaag gagctcagaa
     2521 gatttccatt taaatagctt cagtaatcct ccaagacagt atcagaaaat catgaaaaga
     2581 ctcattaaaa gatacgtact gcaggcccag attgataagg agagtgatga agtgaacgaa
     2641 ggggagctga aggaaattaa gcaggacatc tcaagtctcc gttatgaact ccttgaggaa
     2701 aaatcacaga acacagagga cctagcagaa ctcattagaa agcttgggga gagactgtct
     2761 ttagagtcga aacaagagga aagccgcaga tag
//
