LOCUS       NM_080898               7767 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily C, member 5 (Trpc5), mRNA.
ACCESSION   NM_080898 XM_017601900
VERSION     NM_080898.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 7767)
  AUTHORS   Sakaguchi,R., Takahashi,N., Yoshida,T., Ogawa,N., Ueda,Y.,
            Hamano,S., Yamaguchi,K., Sawamura,S., Yamamoto,S., Hara,Y.,
            Kawamoto,T., Suzuki,R., Nakao,A., Mori,M.X., Furukawa,T.,
            Shimizu,S., Inoue,R. and Mori,Y.
  TITLE     Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS protein
            assembly potentiates the positive feedback interaction between Ca2+
            and NO signals
  JOURNAL   J Biol Chem 300 (9), 107705 (2024)
   PUBMED   39178948
  REMARK    GeneRIF: Dynamic remodeling of TRPC5 channel-caveolin-1-eNOS
            protein assembly potentiates the positive feedback interaction
            between Ca[2+] and NO signals.
REFERENCE   2  (bases 1 to 7767)
  AUTHORS   Wang,M., Wen,W., Chen,Y., Yishajiang,S., Li,Y., Li,Z. and Zhang,X.
  TITLE     TRPC5 channel participates in myocardial injury in chronic
            intermittent hypoxia
  JOURNAL   Clinics (Sao Paulo) 79, 100368 (2024)
   PUBMED   38703717
  REMARK    GeneRIF: TRPC5 channel participates in myocardial injury in chronic
            intermittent hypoxia.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7767)
  AUTHORS   Wen,W., Yao,Q., Chen,Y., Li,Z., Maitikuerban,B., Zhang,Y.,
            Zhang,J., Simayi,Z., Xu,X. and Zhang,X.
  TITLE     Transient receptor potential canonical 5 channel is involved in the
            cardiac damage related to obstructive sleep apnea-hypopnea syndrome
            in rats
  JOURNAL   Ann Palliat Med 9 (3), 895-902 (2020)
   PUBMED   32434348
  REMARK    GeneRIF: Transient receptor potential canonical 5 channel is
            involved in the cardiac damage related to obstructive sleep
            apnea-hypopnea syndrome in rats.
REFERENCE   4  (bases 1 to 7767)
  AUTHORS   Bartoli,F., Moradi Bachiller,S., Antigny,F., Bedouet,K.,
            Gerbaud,P., Sabourin,J. and Benitah,J.P.
  TITLE     Specific Upregulation of TRPC1 and TRPC5 Channels by
            Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes
  JOURNAL   Cells 9 (1), 47 (2019)
   PUBMED   31878108
  REMARK    GeneRIF: Specific Upregulation of TRPC1 and TRPC5 Channels by
            Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7767)
  AUTHORS   Lau,O.C., Shen,B., Wong,C.O., Tjong,Y.W., Lo,C.Y., Wang,H.C.,
            Huang,Y., Yung,W.H., Chen,Y.C., Fung,M.L., Rudd,J.A. and Yao,X.
  TITLE     TRPC5 channels participate in pressure-sensing in aortic
            baroreceptors
  JOURNAL   Nat Commun 7, 11947 (2016)
   PUBMED   27411851
  REMARK    GeneRIF: TRPC5 channels represent a key pressure transducer in the
            baroreceptors and play an important role in maintaining blood
            pressure stability.
            Erratum:[Nat Commun. 2018 Mar 23;9:16184. doi: 10.1038/ncomms16184.
            PMID: 29569578]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 7767)
  AUTHORS   Strubing,C., Krapivinsky,G., Krapivinsky,L. and Clapham,D.E.
  TITLE     Formation of novel TRPC channels by complex subunit interactions in
            embryonic brain
  JOURNAL   J Biol Chem 278 (40), 39014-39019 (2003)
   PUBMED   12857742
REFERENCE   7  (bases 1 to 7767)
  AUTHORS   Yuan,J.P., Kiselyov,K., Shin,D.M., Chen,J., Shcheynikov,N.,
            Kang,S.H., Dehoff,M.H., Schwarz,M.K., Seeburg,P.H., Muallem,S. and
            Worley,P.F.
  TITLE     Homer binds TRPC family channels and is required for gating of
            TRPC1 by IP3 receptors
  JOURNAL   Cell 114 (6), 777-789 (2003)
   PUBMED   14505576
REFERENCE   8  (bases 1 to 7767)
  AUTHORS   Greka,A., Navarro,B., Oancea,E., Duggan,A. and Clapham,D.E.
  TITLE     TRPC5 is a regulator of hippocampal neurite length and growth cone
            morphology
  JOURNAL   Nat Neurosci 6 (8), 837-845 (2003)
   PUBMED   12858178
  REMARK    GeneRIF: TRPC5 channel subunits interact with growth cone-enriched
            protein stathmin 2, are packaged into vesicles and are carried to
            newly forming growth cones and synapses.
REFERENCE   9  (bases 1 to 7767)
  AUTHORS   Lee,Y.M., Kim,B.J., Kim,H.J., Yang,D.K., Zhu,M.H., Lee,K.P., So,I.
            and Kim,K.W.
  TITLE     TRPC5 as a candidate for the nonselective cation channel activated
            by muscarinic stimulation in murine stomach
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 284 (4), G604-G616 (2003)
   PUBMED   12631560
REFERENCE   10 (bases 1 to 7767)
  AUTHORS   Strubing,C., Krapivinsky,G., Krapivinsky,L. and Clapham,D.E.
  TITLE     TRPC1 and TRPC5 form a novel cation channel in mammalian brain
  JOURNAL   Neuron 29 (3), 645-655 (2001)
   PUBMED   11301024
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000021.1.
            
            On or before Aug 31, 2022 this sequence version replaced
            XM_017601900.2, NM_080898.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY064411.1, SRR26360194.1077161.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760389 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-299               JAXUCZ010000021.1  113027340-113027638 c
            300-698             JAXUCZ010000021.1  112882520-112882918 c
            699-1220            JAXUCZ010000021.1  112845712-112846233 c
            1221-1557           JAXUCZ010000021.1  112797751-112798087 c
            1558-1697           JAXUCZ010000021.1  112795643-112795782 c
            1698-2020           JAXUCZ010000021.1  112789433-112789755 c
            2021-2216           JAXUCZ010000021.1  112778926-112779121 c
            2217-2420           JAXUCZ010000021.1  112752787-112752990 c
            2421-2462           JAXUCZ010000021.1  112752477-112752518 c
            2463-2552           JAXUCZ010000021.1  112750478-112750567 c
            2553-7767           JAXUCZ010000021.1  112742828-112748042 c
FEATURES             Location/Qualifiers
     source          1..7767
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="X"
                     /map="Xq34"
     gene            1..7767
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 5"
                     /db_xref="GeneID:140933"
                     /db_xref="RGD:619787"
     exon            1..299
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            300..698
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             321..3245
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /note="transient receptor protein 5"
                     /codon_start=1
                     /product="short transient receptor potential channel 5"
                     /protein_id="NP_543174.1"
                     /db_xref="GeneID:140933"
                     /db_xref="RGD:619787"
                     /translation="MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGD
                     YATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLY
                     AIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKL
                     LVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPIL
                     TAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHS
                     EELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTC
                     MTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTD
                     LHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATI
                     SLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQI
                     SLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFS
                     TLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMM
                     NNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFC
                     PKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTE
                     ENFKELKQDISSFRYEVLDLLGNRKHPRRSFSTSSAEFSQRDDTNDGSGGARAKSKSV
                     SFNLGCKKKACQGAPLIRTMPRASGAQGKPKAESSGKRSFMGPSFKKLGLLFSKFNGQ
                     TSEPTSEPMYTISDGIAQQHSMWQDIRYSQMEKGKAEACSQSEMNLSEVELGEIRGAA
                     RSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTT
                     RL"
     exon            699..1220
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1557
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1558..1697
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1698..2020
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2021..2216
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2217..2420
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2462
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2463..2552
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
     exon            2553..7767
                     /gene="Trpc5"
                     /gene_synonym="Trrp5"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggcactggcg gaggcaaaag gtgaggaggt ctggccagtc agagggaagt ttgataataa
       61 ctgaagagca aagaaggaag cccaggtagg agtcagtccc tgggctcttc tcagcatcct
      121 gatccctttg cctgtactca accacccacc cactcggcag cctccaggcc cgggactgtc
      181 ccaggcggct gccgcttgcg cgccggccgc ggaagaggag tccagtaagg ctgtcgcacc
      241 acgcgccccg gtgcacggac tccagacaac acaaatctga aaaaaacact tggcctgggt
      301 tttctaaatt gctatgaacc atggcccagc tgtactacaa gaaggtcaac tactcaccat
      361 acagagaccg catccccctc caaatcgtga gggctgagac tgagctgtct gctgaggaga
      421 aagctttcct tagtgctgtg gagaaggggg actatgccac cgtgaagcag gcactgcagg
      481 aggccgagat ctactacaat gtcaacatca actgcatgga tcctttgggc aggagcgccc
      541 tactcattgc cattgagaat gagaacttag agatcatgga gctactgctg aaccacagtg
      601 tgtatgtggg cgatgcatta ctctatgcca tccgcaagga ggtggtagga gctgtggaac
      661 ttctgctcag ctacaggaag ccaagtggag agaagcaggt tcccactctg atgatggaca
      721 cccagttctc tgagttcaca ccagacatca cacccatcat gttggcagcc cacaccaaca
      781 actatgaaat catcaaattg cttgtccaaa agcgtgtcac tatcccacgg ccccaccaaa
      841 tccgctgcaa ctgtgtggag tgtgtgtcca gttcagaagt agacagccta cgtcattcaa
      901 ggtcccgact gaacatatac aaggcactgg caagcccttc gctcatcgcc ttatcaagtg
      961 aggaccctat cctcacagca ttccggctgg gctgggaact caaggagctg agcaaggtgg
     1021 aaaatgagtt caaggctgag tatgaggagc tctcccaaca gtgtaagctc tttgccaagg
     1081 acctgctgga tcaagctcgg agctcccgag aactggagat cattctcaac catcgagatg
     1141 accacagcga agaacttgac ccacagaagt accatgacct ggccaagctg aaggtggcaa
     1201 tcaaatatca ccagaaagag tttgtcgctc agccaaactg tcaacaattg ctggccacct
     1261 tgtggtacga tggcttccct ggatggcgaa gaaaacactg ggtagtcaag cttctaacct
     1321 gcatgaccat tggattcctg tttcctatgc tgtccatagc ctatctgatc tcacccagaa
     1381 gcaaccttgg gcttttcatc aagaaaccct ttatcaagtt catctgccac acagcatcct
     1441 atctgacctt cctcttcatg cttctcctgg cttctcagca tattgtcaga acagacctcc
     1501 atgttcaagg acctccccca actgtcgtgg aatggatgat actgccttgg gttctaggtt
     1561 tcatctgggg ggaaataaag gaaatgtggg atggtggatt cactgaatac atccatgatt
     1621 ggtggaattt gatggatttt gcaatgaact ccctctacct ggcaactatt tccttgaaga
     1681 ttgtggccta tgtcaagtat aatggttctc gtccaaggga agaatgggaa atgtggcacc
     1741 cgactctgat tgcggaagca ctcttcgcga tatcgaacat tttaagttcc ttgcgtctca
     1801 tatccttgtt cacagccaac tcccacttag ggcctctgca gatctccttg ggacgcatgc
     1861 tgcttgatat actcaaattt ctctttatct actgcctagt actactggct tttgccaacg
     1921 gactgaacca gctttatttt tactatgaga ccagagctat tgatgaacct aacaactgca
     1981 aaggaatccg gtgtgaaaaa cagaacaacg ccttctccac gctctttgaa acccttcagt
     2041 cactcttctg gtctgtgttt ggccttttaa acctctatgt taccaatgtg aaggcccggc
     2101 atgaattcac ggagtttgtg ggagctacta tgtttgggac atacaacgtc atctccctgg
     2161 tagtgctact gaacatgctc attgccatga tgaacaactc ctaccagctc attgccgacc
     2221 atgctgatat tgagtggaag tttgcgagaa cgaagctctg gatgagttac tttgatgaag
     2281 gtggcacctt accacctcct ttcaacatca tccccagccc caaatcattt ctctatcttg
     2341 gcaactggtt caacaacacc ttctgtccca agagagaccc cgatgggaga cgaaggaggc
     2401 acaacttgag aagcttcaca gaacgtcatg ctgacagcct gatccaaaat caacattatc
     2461 aggaagttat cagaaatcta gtcaagagat atgtggctgc catgataaga aactcgaaaa
     2521 caaatgaggg gctaacagaa gaaaatttta aggaattaaa gcaggacatt tccagctttc
     2581 gatacgaagt acttgacctc ttgggaaata gaaaacatcc aagaagaagc ttttccacta
     2641 gcagcgctga attctctcaa agggatgata ccaatgatgg cagtggtggg gctcgggcca
     2701 aatctaagag tgtctctttc aatttaggct gcaagaaaaa ggcctgccag ggagcacctc
     2761 tcatcagaac catgccaaga gctagtggtg cccaaggaaa gccgaaagct gagtcgtcag
     2821 gcaaacggtc cttcatgggt ccctctttca agaaactggg tctcctgttc tccaagttta
     2881 atggtcagac ctctgaacct acttcggagc caatgtacac aatctctgat ggcatcgcac
     2941 agcagcactc tatgtggcag gacatcagat attctcagat ggagaaaggg aaggcagagg
     3001 cctgttcgca aagtgagatg aacctcagtg aggtagagtt aggtgaaatc cggggtgctg
     3061 ctcggagcag tgaatgcccc ctagcctgtt ccagctctct tcactgtgca tccggcatct
     3121 gctcctcaaa ttcgaaactt ttagactcat cagaggacgt atttgaaact tggggagagg
     3181 cctgtgactt gctcatgcac aaatggggtg atggacagga agaacaagtt acaactcggc
     3241 tctaagtcaa atccccatca tctattctgg aattcaagag aaaaaatttg taatttctca
     3301 aaggtgaccc caaatatgat tccctccctg tcccccctcc aaggagtgaa gctattactt
     3361 tccgtctttt ctagccattc ttgttttgtt tcactgttaa tatcatttgt gttttgtatc
     3421 tataaatact aaatccatct caaaagcaac tgaaggggta cggcccctaa tcagcagagg
     3481 tgcggtcggg tgctttaacc cctttgcttt gctcacccct gcctccttga agctccaggt
     3541 gccactttgc tacaatagct accgcataga ttcctgactt gcctcaggat ctcacaccca
     3601 tctccccaca gagctgaggg atatggtcag caatccctac cagctatcag ataaggcaaa
     3661 tcaacctgcc tgtcttcgtt gctcttcagt gcttacacgc tgcccatgct ggttcgatga
     3721 acagcattaa agggagacta gactccaaag aattgtcagc ttgaggtttc taggtagaac
     3781 aggcctttct gttttgttta taaacactac aacttctaac tgtggggact gttgaggttt
     3841 tgtttcgtaa atgtgtgtta gtttaatgtg tggcaatgag atatttattc tacagtgcgt
     3901 accacatcta gtaagttagc taatttcctc ccctgtgttt gtatatttca gttaacgtac
     3961 catacttcaa aattagtatt taggatgtgt acttttttca aaaaaaatct tttactgtac
     4021 tttaaccaac agttactata tctcatacgc tggcaagaaa aaaacaatta gctggtatat
     4081 ttatagggtc ctatctactg tggatagttt taatcatcat tgatataaaa gcatttctaa
     4141 gattcaagac tggatctgaa atatttttta tcagaaaaat gacattttat tgaggtgtta
     4201 aaacttgggg agaaaatgca cctcaattta attgctttct ggaaagaaaa cccaacagat
     4261 acaaatttag gttcagataa cctaattcag gttgcagcta cagtagcaac tgggggatag
     4321 tgggaactgc atgtgtgaac tgttggaaat ataacataat aatcctagtg gatatgtaca
     4381 actatacttg tggtctaagt tctgccttca aagaaagctg catttataca tccaaattct
     4441 ttcccataca caaggagtac ttaatcaaaa tgtaagttaa aaatgaagct agtgagcatg
     4501 cggtcatcat ctaagatgat gaccaccaga gagccaccaa acaacagctg agcaaacatg
     4561 ggtttaccaa catatgcttg gctcgtagag attaacaatg tatatggcag agaagttaaa
     4621 aggttgttga gcaccacctg gtctttgtaa ggtcccctca tgtgtgatgt ctgctggagg
     4681 agaagtgagg aactgttaaa caatgtaaac gtgtctgtaa agcttgcttt tgacagtgta
     4741 gttttcgtta aaactgattt tccatctcta tccagtaaaa gtatttcata tagagatgag
     4801 ccaaattagg ggcaagccag gcaacaagtg ctgctggata taactcagat actcacaaaa
     4861 aggaattagg agagtaagag ccatcagcat ccatctggct ggcaagggtt tgttgcaaat
     4921 taatcagagt cctattggaa gtgctcattt atttaaatca aactggtgcc ctactttact
     4981 aagagcgacc aacacagaca gcttactttc taaaagttag agttctaaag tcacaattgc
     5041 agctttccca actgtaaatt ttatccttaa taataaatga cacttcaatc cagggatgga
     5101 ggtgcacgcc tttaatccca gtactctgga ggcagaggca ggcaaatctg tttgaggcca
     5161 gcctattcta tagaatgatt tctaggacag caaggattag acacagaaac actgtgtata
     5221 aataaaggaa caataagtaa actgagaaat actgtataaa acaaacaaac ctaaactaca
     5281 atcataattc ataccaccag caacaaagcc aacataaaat atatactcag aacatttttc
     5341 tcatcaatat accaactatt ggtgatctag gcataattgt cctagtggtc agaaaacagg
     5401 gtagcaagcc atgaagtcat gctccaaagc agtctctgtc acttaggacc tgaagagagg
     5461 aaggatacca caatagccaa tctctgctac tgaaagacac cagtgccata tttcctgggg
     5521 aacacattcc agtccagatc tccttcctca tagtcatcat ctttgtgact caggctcagg
     5581 atgtcactag ctaggttgag gcctcattat gatgaaggct gaaactcagt accacgttgg
     5641 tgatagcaac attttttaac tttaagctaa tacccagtag gagaaagaca tcttcctacc
     5701 ctgttaatca gttactgttt aaaaacattt cagggatgga gaactttaac agtcagctct
     5761 aagttctgtt tgcagttcca tttttaaaag gaggctggag agatggctcg atgcttaaag
     5821 gcatgcactg taacaaaaga cccagattct cttcccagca accacgtggc agctcgatct
     5881 gtctgcacct ccagttccag ggcctctgac cgtgctgtta tccttttctg tggacagact
     5941 tcctgggata cggtaaagaa ctgctgaaat tagtagcccc aagagcatcc tctgcatacc
     6001 tgttaaacaa gagctgtcca attcagcttt tctacttttg agggcagaag atactcagac
     6061 cagaaaaagc taacaaaccc aaggaataga atatatacac tttggcaaaa gaaaatctgc
     6121 attgatttat tgtatactta agacattcta attcataacg ctgccatgcc agctaagcag
     6181 ctccttagta tgctgtttgg tggttaggag aaggtcttag taggtggctt tggagtttta
     6241 cttttagaaa atgggatgtt gaagaaacag aaggattaaa tgttactgat ataggcaaca
     6301 agctcatctt caagttcaga attgattttt tgcaacttaa aatcaacttt caatgtgctt
     6361 agagtagtgg cagctttaag gataagttta agacctccta gagaaattta aaaggacaac
     6421 atacttaagt agagaccttc tactgattag ggaacaatca aaatttagcc cctgaaatcc
     6481 ttaagtttaa acagcaaatt ccatcaagag tcccaatggc ccaagttcta aacaaactga
     6541 cagctgtctc tctaaatcct cagtgatcca gaagatacat tttatcatgt acaggtgctg
     6601 ggaagtaggc tgttagcagg attaacagga caaattaatt tttttaaagc cctcaagatt
     6661 ctacagaaaa atggagggga cagttttgga ctggacatgc atagtatcag atgtagtgag
     6721 atggggctca aatagaaaga caaggcagct agctgaattc tcaagccatc cgaaagttct
     6781 atgatcaaag tagaagatcg aatcatttta ttgacaatac agcctcatca tatcactgta
     6841 cacaatgaag gcagttacct gtattcatta agagtgacaa ctataactga catattgtgg
     6901 aagaagcagt cagaatttaa agttttcatg accactagaa ccaatgtcag tgcaggttca
     6961 caaggaaagt tctaaaccca ggctgtcaac tgcattagtt tacttaatgt taaaggaaat
     7021 aatttcataa agtactaact tcagatttac ctatttgaat tcccccttta aacccaatat
     7081 ggccatggtc tcatttcaat ggcacaactg ttacagacct tgtctgagat catttcagtt
     7141 cagataaaac taaatacaac tatccccaga gaaaatacat gaattgtttt tattctttca
     7201 tgtacacact aggggtacta ttcaaggaga aatacttaac ttaaggattc tatttcttca
     7261 cgattttact agaggaggat aagaagtttc tttctagtta gtaattgcta tttggagcta
     7321 cagcttaaca gttgatagga aagaaaaact agaaaacaga ggctatgctt atcaaatttt
     7381 ctcaacgtag accctcacac atcggcatac aatggatgtt tgttaaaact aaggttaaaa
     7441 ttgtatctcc tgagcttaat ttgtgaaaag gaaaacttca gtgtttgtgt aaatggcatt
     7501 ttggctctat ggattatttt aaaagctaaa agcccgagta actactttta tctaaatatt
     7561 ttctgtaaga agtgcaaagt tagtgtcaac ttgaaatgtg tgaaaaacaa tcttgtataa
     7621 taattttgtg tgtttttagc ttcaatatga agaacaaagc atttacttcc cctcccacaa
     7681 aatgtatggc tatttagaaa taagatgttt gtgcctcctt ttccaatgta accatttata
     7741 cctattaata aatgttgatg aacagca
//
