LOCUS       NM_080396               3127 bp    mRNA    linear   ROD 11-DEC-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily C, member 4 (Trpc4), transcript variant alpha, mRNA.
ACCESSION   NM_080396
VERSION     NM_080396.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3127)
  AUTHORS   Yang,L., Peng,Z., Gong,F., Yan,W., Shi,Y., Li,H., Zhou,C., Yao,H.,
            Yuan,M., Yu,F., Feng,L., Wan,N. and Liu,G.
  TITLE     TRPC4 aggravates hypoxic pulmonary hypertension by promoting
            pulmonary endothelial cell apoptosis
  JOURNAL   Free Radic Biol Med 219, 141-152 (2024)
   PUBMED   38636714
  REMARK    GeneRIF: TRPC4 aggravates hypoxic pulmonary hypertension by
            promoting pulmonary endothelial cell apoptosis.
REFERENCE   2  (bases 1 to 3127)
  AUTHORS   Sabourin,J., Boet,A., Rucker-Martin,C., Lambert,M., Gomez,A.M.,
            Benitah,J.P., Perros,F., Humbert,M. and Antigny,F.
  TITLE     Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation
            in monocrotaline-induced right ventricular hypertrophy
  JOURNAL   J Mol Cell Cardiol 118, 208-224 (2018)
   PUBMED   29634917
  REMARK    GeneRIF: STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current
            participates in Ca(2+) remodeling in right ventricular hypertrophy
            secondary to pulmonary hypertension.
REFERENCE   3  (bases 1 to 3127)
  AUTHORS   Fujita,M., Sato,T., Yajima,T., Masaki,E. and Ichikawa,H.
  TITLE     TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures
  JOURNAL   Cells Tissues Organs 204 (5-6), 293-303 (2017)
   PUBMED   28697491
  REMARK    GeneRIF: In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of
            sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and
            TRPC4, respectively.
REFERENCE   4  (bases 1 to 3127)
  AUTHORS   Wang,Z., Wang,Y., Tian,X., Shen,H., Dou,Y., Li,H. and Chen,G.
  TITLE     Transient receptor potential channel 1/4 reduces subarachnoid
            hemorrhage-induced early brain injury in rats via
            calcineurin-mediated NMDAR and NFAT dephosphorylation
  JOURNAL   Sci Rep 6, 33577 (2016)
   PUBMED   27641617
  REMARK    GeneRIF: 1) TRPC1/4 exert protective effects against SAH-induecd
            EBI, including cortical cell death and degenerating; 2) TRPC1/4
            positively regulated the activity of calcineurin. 3) TRPC1/4
            promoted the dephosphorylation of NMDAR via calcineurin.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3127)
  AUTHORS   Zhang,Z., Wang,J., He,J., Zeng,X., Chen,X., Xiong,M., Zhou,Q.,
            Guo,M., Li,D. and Lu,W.
  TITLE     Identification of TRPCs genetic variants that modify risk for lung
            cancer based on the pathway and two-stage study
  JOURNAL   Meta Gene 9, 191-196 (2016)
   PUBMED   27617218
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3127)
  AUTHORS   Schaefer,M., Plant,T.D., Stresow,N., Albrecht,N. and Schultz,G.
  TITLE     Functional differences between TRPC4 splice variants
  JOURNAL   J Biol Chem 277 (5), 3752-3759 (2002)
   PUBMED   11713258
REFERENCE   7  (bases 1 to 3127)
  AUTHORS   Strubing,C., Krapivinsky,G., Krapivinsky,L. and Clapham,D.E.
  TITLE     TRPC1 and TRPC5 form a novel cation channel in mammalian brain
  JOURNAL   Neuron 29 (3), 645-655 (2001)
   PUBMED   11301024
REFERENCE   8  (bases 1 to 3127)
  AUTHORS   Tang,Y., Tang,J., Chen,Z., Trost,C., Flockerzi,V., Li,M., Ramesh,V.
            and Zhu,M.X.
  TITLE     Association of mammalian trp4 and phospholipase C isozymes with a
            PDZ domain-containing protein, NHERF
  JOURNAL   J Biol Chem 275 (48), 37559-37564 (2000)
   PUBMED   10980202
REFERENCE   9  (bases 1 to 3127)
  AUTHORS   Hofmann,T., Schaefer,M., Schultz,G. and Gudermann,T.
  TITLE     Cloning, expression and subcellular localization of two novel
            splice variants of mouse transient receptor potential channel 2
  JOURNAL   Biochem J 351 (Pt 1), 115-122 (2000)
   PUBMED   10998353
REFERENCE   10 (bases 1 to 3127)
  AUTHORS   Funayama,M., Goto,K. and Kondo,H.
  TITLE     Cloning and expression localization of cDNA for rat homolog of TRP
            protein, a possible store-operated calcium (Ca2+) channel
  JOURNAL   Brain Res Mol Brain Res 43 (1-2), 259-266 (1996)
   PUBMED   9037541
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF421363.1.
            
            Transcript Variant: This variant (alpha) encodes the longer isoform
            (alpha).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF421363.1, AF288407.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760393, SAMEA5760396
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..3127
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="W"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q26"
     gene            1..3127
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 4"
                     /db_xref="GeneID:84494"
                     /db_xref="RGD:621276"
     exon            1..381
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..2937
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /note="isoform alpha is encoded by transcript variant
                     alpha; short transient receptor potential channel 4; CCE1;
                     capacitative calcium entry channel 1; transient receptor
                     potential protein 4"
                     /codon_start=1
                     /product="short transient receptor potential channel 4
                     isoform alpha"
                     /protein_id="NP_536321.1"
                     /db_xref="GeneID:84494"
                     /db_xref="RGD:621276"
                     /translation="MAQFYYKRNVNAPYRDRIPLRIVRAESELSPSEKAYLNAVEKGD
                     YASVKKSLEEAEIYFKININCIDPLGRTALLIAIENENLELIELLLSFNVYVGDALLH
                     AIRKEVVGAVELLLNHKKPSGEKQVPPILLDKQFSEFTPDITPIILAAHTNNYEIIKL
                     LVQKGVSVPRPHEVRCNCVECVSSSDVDSLRHSRSRLNIYKALASPSLIALSSEDPFL
                     TAFQLSWELQELSKVENEFKSEYEELSRQCKQFAKDLLDQTRSSRELEIILNYRDDNS
                     LIEEQSGNDLARLKLAIKYRQKEFVAQPNCQQLLASRWYDEFPGWRRRHWAVKMVTCF
                     IIGLLFPVFSVCYLIAPKSPLGLFIRKPFIKFICHTASYLTFLFLLLLASQHIDRSDL
                     NRQGPPPTIVEWMILPWVLGFIWGEIKQMWDGGLQDYIHDWWNLMDFVMNSLYLATIS
                     LKIVAFVKYSALNPRESWDMWHPTLVAEALFAIANIFSSLRLISLFTANSHLGPLQIS
                     LGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYEETKGLSCKGIRCEKQNNAFSTLFE
                     TLQSLFWSIFGLINLYVTNVKAQHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSY
                     QLIADHADIEWKFARTKLWMSYFEEGGTLPTPFNVIPSPKSLWYLVKWIWTHLCKKKM
                     RRKPESFGTIGRRAADNLRRHHQYQEVMRNLVKRYVAAMIREAKTEEGLTEENVKELK
                     QDISSFRFEVLGLLRGSKLSTIQSANAASSASSADSDEKSHSEGNGKDKRKNLSLFDL
                     TTLIHPRSAVIASERHNLSNGSALVVQEPPREKQRKVNFVADIKNFGLFHRRSKQNAA
                     EQNANQIFSVSEEITRQQAAGALERNIQLESQGLASRGDRSIPGLNEQCVLVDHRERN
                     TDTLGLQVGKRVCSSFKSEKVVVEDTVPIIPKEKHAQEEDSSIDYDLSPTDTVAHEDY
                     VTTRL"
     exon            382..900
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            901..1237
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1377
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1691
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1887
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            1888..2082
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..2124
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2214
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
     exon            2215..3127
                     /gene="Trpc4"
                     /gene_synonym="Trp4; Trrp4"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcatggctc agttctatta caaacgaaat gtcaacgccc cctaccgaga ccgcatccca
       61 ctgaggatcg tcagggcaga atctgaactc tcaccatcag agaaagccta cttgaatgcc
      121 gtggaaaagg gggactatgc aagcgtcaag aaatctctgg aggaagccga gatttatttt
      181 aaaatcaaca ttaactgcat tgaccccctt gggaggactg ctcttctcat tgccattgaa
      241 aatgagaacc tggagctgat tgaactgttg ttgagtttca atgtctatgt tggcgatgcg
      301 ctacttcacg ccatcaggaa agaggtggtt ggagccgtgg agctactgct gaaccacaaa
      361 aagcccagcg gagagaagca ggtgcctccc atcctccttg acaaacagtt ctctgaattc
      421 accccagaca tcacgcctat catcttggct gcacatacaa ataattatga gataatcaaa
      481 ctcttggtcc agaagggtgt ctcggtgccc agaccccacg aggtccgctg taactgtgtt
      541 gagtgtgtct ccagctcaga cgtggacagc ctcaggcact cacggtccag gctcaacatc
      601 tacaaggctt tggccagccc ctcgctcatt gcgctgtcaa gtgaagaccc tttcctcacc
      661 gcctttcagt taagctggga gctgcaagaa ctgagtaagg tggagaatga attcaagtcg
      721 gagtatgagg agctgtctag acagtgcaaa cagtttgcta aggacctcct agatcagaca
      781 cggagttcca gagagctgga aatcattctt aattaccgtg atgacaatag cctgatcgaa
      841 gaacagagtg gaaatgatct tgcgaggcta aaattagcca ttaagtaccg tcaaaaagag
      901 tttgttgctc agcccaactg ccagcagctg ctcgcttccc gctggtacga tgagttccca
      961 ggctggagga gaagacactg ggcggtgaag atggtgacat gtttcataat aggactactc
     1021 ttccccgtct tctccgtgtg ctacctgata gctcccaaaa gcccacttgg actgttcatc
     1081 agaaagccat ttatcaagtt tatctgccac acagcctcct atctgacctt tttgtttctg
     1141 ctgctgctag cctctcagca catcgacagg tcagacttga acaggcaagg tccaccacca
     1201 accatcgtgg agtggatgat attaccgtgg gtcctgggtt ttatatgggg agagattaaa
     1261 cagatgtggg atggcggact tcaggattac atccacgact ggtggaatct aatggacttt
     1321 gtgatgaact ccttgtatct ggcgacaatc tccttgaaga ttgtcgcatt tgtaaagtac
     1381 agtgctctga acccacggga atcatgggac atgtggcacc ccaccctggt ggcagaggct
     1441 ttattcgcaa ttgcaaacat cttcagttcc ctccgcctga tctctctgtt cactgccaat
     1501 tctcacctgg ggcctctgca gatatctctg ggaagaatgc tcctggacat cctaaagttc
     1561 ttattcatat actgcctcgt gctgctagct tttgcaaatg gcctaaatca actgtacttc
     1621 tactatgaag aaacgaaggg gttaagctgc aaaggcatac ggtgcgaaaa acagaacaac
     1681 gcgttctcca cgttatttga gactctacag tccctgtttt ggtcaatatt tggactcatc
     1741 aatctctatg ttaccaatgt caaagcccag catgagttca ctgaatttgt tggggccacc
     1801 atgtttggca catataacgt catctctctg gttgtcctcc tgaacatgct gatcgctatg
     1861 atgaataatt cttaccaact aattgccgac cacgcagata tagagtggaa atttgctcga
     1921 acaaagcttt ggatgagcta ctttgaagaa gggggtaccc tgcctacacc tttcaatgtc
     1981 atcccaagcc ccaagtccct gtggtacctg gtcaagtgga tatggacgca cttatgtaag
     2041 aaaaagatga gaagaaagcc agaaagcttt gggacaattg ggcggcgtgc tgctgataac
     2101 ttgagaaggc atcaccaata ccaagaggtg atgaggaatc tggtgaagcg gtacgtggca
     2161 gccatgatca gagaggcaaa aactgaagaa ggcttgacag aggagaatgt taaggaacta
     2221 aagcaagaca tttctagctt ccgcttcgaa gttctgggat tgctccgggg aagcaagctc
     2281 tcaacaatac agtcagccaa cgcagcgagt tcagccagct ccgcggactc cgatgagaag
     2341 agccacagcg aaggtaatgg caaggacaag agaaagaatc tcagcctctt tgatttaacc
     2401 actctgatcc acccgcggtc ggcagtcatt gcctccgaga gacataacct aagcaatggt
     2461 tctgccctgg tggtgcagga gccgcccagg gagaagcaga ggaaagtgaa ttttgtggct
     2521 gatatcaaaa acttcgggtt atttcataga cggtcaaagc aaaatgctgc tgagcaaaac
     2581 gcaaaccaaa tcttctctgt ttcagaagaa attactcgtc aacaggcggc aggagcactt
     2641 gagagaaata tccaactgga atcccaagga ttagcttcac ggggtgaccg cagcattcct
     2701 ggtctcaatg aacagtgtgt gctagtagac catagagaaa ggaatacgga cactttgggt
     2761 ttacaggtag gcaagagagt gtgctcctcc ttcaagtcgg agaaggtggt ggtggaagac
     2821 accgtcccta ttataccaaa ggagaaacac gcccaggagg aggactcaag catagattat
     2881 gatttaagcc ccacggacac agttgcccat gaagattatg tgaccacgag attgtgacaa
     2941 cttggagaag gagtgtttac catacctata catattttcc atagtgctct gggcaggcaa
     3001 aatgtatgaa attacattat caaatgctaa tttacacttt ctaacgttta tctgtcgtgg
     3061 cgtattagcc tgtatttatg tttgaacaaa gcagaggcaa cgtgaaccct cctcttttgt
     3121 agcctgc
//
