LOCUS       NM_001415005            3629 bp    mRNA    linear   ROD 13-DEC-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily C, member 3 (Trpc3), mRNA.
ACCESSION   NM_001415005 XM_006232282
VERSION     NM_001415005.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3629)
  AUTHORS   Zhou,Y., Wang,X.C., Wei,J.H., Xue,H.M., Sun,W.T., He,G.W. and
            Yang,Q.
  TITLE     Soluble epoxide hydrolase and TRPC3 channels jointly contribute to
            homocysteine-induced cardiac hypertrophy: Interrelation and
            regulation by C/EBPbeta
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (4), 166643 (2023)
   PUBMED   36669577
  REMARK    GeneRIF: Soluble epoxide hydrolase and TRPC3 channels jointly
            contribute to homocysteine-induced cardiac hypertrophy:
            Interrelation and regulation by C/EBPbeta.
REFERENCE   2  (bases 1 to 3629)
  AUTHORS   Kato,Y., Nishiyama,K., Man Lee,J., Ibuki,Y., Imai,Y., Noda,T.,
            Kamiya,N., Kusakabe,T., Kanda,Y. and Nishida,M.
  TITLE     TRPC3-Nox2 Protein Complex Formation Increases the Risk of
            SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through
            ACE2 Upregulation
  JOURNAL   Int J Mol Sci 24 (1), 102 (2022)
   PUBMED   36613540
  REMARK    GeneRIF: TRPC3-Nox2 Protein Complex Formation Increases the Risk of
            SARS-CoV-2 Spike Protein-Induced Cardiomyocyte Dysfunction through
            ACE2 Upregulation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3629)
  AUTHORS   Zhu,J., Fan,Y., Lu,Q., Yang,Y., Li,H., Liu,X., Zhang,H., Sun,B.,
            Liu,Q., Zhao,J., Yang,Z., Li,L., Feng,H. and Xu,J.
  TITLE     Increased transient receptor potential canonical 3 activity is
            involved in the pathogenesis of detrusor overactivity by dynamic
            interaction with Na+/Ca2+ exchanger 1
  JOURNAL   Lab Invest 102 (1), 48-56 (2022)
   PUBMED   34497367
  REMARK    GeneRIF: Increased transient receptor potential canonical 3
            activity is involved in the pathogenesis of detrusor overactivity
            by dynamic interaction with Na(+)/Ca(2+) exchanger 1.
REFERENCE   4  (bases 1 to 3629)
  AUTHORS   Saliba,Y., Jebara,V., Hajal,J., Maroun,R., Chacar,S., Smayra,V.,
            Abramowitz,J., Birnbaumer,L. and Fares,N.
  TITLE     Transient Receptor Potential Canonical 3 and Nuclear Factor of
            Activated T Cells C3 Signaling Pathway Critically Regulates
            Myocardial Fibrosis
  JOURNAL   Antioxid Redox Signal 30 (16), 1851-1879 (2019)
   PUBMED   30318928
  REMARK    GeneRIF: We demonstrate that TRPC3-NFATc3 signaling is modulated by
            P.E. and critically regulates ventricular CF phenotype and MF.
            These findings strongly argue for P.E., through TRPC3 targeting, as
            potential and interesting therapeutics for MF management.
REFERENCE   5  (bases 1 to 3629)
  AUTHORS   Sun,D., Ma,H., Ma,J., Wang,J., Deng,X., Hu,C. and Deng,X.
  TITLE     Canonical Transient Receptor Potential Channel 3 Contributes to
            Febrile Seizure Inducing Neuronal Cell Death and Neuroinflammation
  JOURNAL   Cell Mol Neurobiol 38 (6), 1215-1226 (2018)
   PUBMED   29748835
  REMARK    GeneRIF: Inhibition of TRPC3 suppressed intracellular Ca(2+) levels
            in hyperthermia-treated hippocampal neuronal cells
REFERENCE   6  (bases 1 to 3629)
  AUTHORS   Santillan,G., Baldi,C., Katz,S., Vazquez,G. and Boland,R.
  TITLE     Evidence that TRPC3 is a molecular component of the
            1alpha,25(OH)2D3-activated capacitative calcium entry (CCE) in
            muscle and osteoblast cells
  JOURNAL   J Steroid Biochem Mol Biol 89-90 (1-5), 291-295 (2004)
   PUBMED   15225788
REFERENCE   7  (bases 1 to 3629)
  AUTHORS   Yuan,J.P., Kiselyov,K., Shin,D.M., Chen,J., Shcheynikov,N.,
            Kang,S.H., Dehoff,M.H., Schwarz,M.K., Seeburg,P.H., Muallem,S. and
            Worley,P.F.
  TITLE     Homer binds TRPC family channels and is required for gating of
            TRPC1 by IP3 receptors
  JOURNAL   Cell 114 (6), 777-789 (2003)
   PUBMED   14505576
REFERENCE   8  (bases 1 to 3629)
  AUTHORS   Baldi,C., Vazquez,G., Calvo,J.C. and Boland,R.
  TITLE     TRPC3-like protein is involved in the capacitative cation entry
            induced by 1alpha,25-dihydroxy-vitamin D3 in ROS 17/2.8
            osteoblastic cells
  JOURNAL   J Cell Biochem 90 (1), 197-205 (2003)
   PUBMED   12938168
  REMARK    GeneRIF: Results suggest that an endogenous transient receptor
            potential-canonical (TRPC3)-like protein is involved in the route
            activated by 1alpha,25(OH)(2)D3 in a secosteroid target cell.
REFERENCE   9  (bases 1 to 3629)
  AUTHORS   Ohki,G., Miyoshi,T., Murata,M., Ishibashi,K., Imai,M. and Suzuki,M.
  TITLE     A calcium-activated cation current by an alternatively spliced form
            of Trp3 in the heart
  JOURNAL   J Biol Chem 275 (50), 39055-39060 (2000)
   PUBMED   10984475
REFERENCE   10 (bases 1 to 3629)
  AUTHORS   Boulay,G., Zhu,X., Peyton,M., Jiang,M., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     Cloning and expression of a novel mammalian homolog of Drosophila
            transient receptor potential (Trp) involved in calcium entry
            secondary to activation of receptors coupled by the Gq class of G
            protein
  JOURNAL   J Biol Chem 272 (47), 29672-29680 (1997)
   PUBMED   9368034
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Dec 20, 2022 this sequence version replaced XM_006232282.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760386
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-327               JAXUCZ010000002.1  121475497-121475823 c
            328-1099            JAXUCZ010000002.1  121457032-121457803 c
            1100-1288           JAXUCZ010000002.1  121448893-121449081 c
            1289-1453           JAXUCZ010000002.1  121441757-121441921 c
            1454-1670           JAXUCZ010000002.1  121438420-121438636 c
            1671-1904           JAXUCZ010000002.1  121436937-121437170 c
            1905-2169           JAXUCZ010000002.1  121434258-121434522 c
            2170-2365           JAXUCZ010000002.1  121430384-121430579 c
            2366-2575           JAXUCZ010000002.1  121428108-121428317 c
            2576-2659           JAXUCZ010000002.1  121424497-121424580 c
            2660-2735           JAXUCZ010000002.1  121413355-121413430 c
            2736-3629           JAXUCZ010000002.1  121409436-121410329 c
FEATURES             Location/Qualifiers
     source          1..3629
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q25"
     gene            1..3629
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 3"
                     /db_xref="GeneID:60395"
                     /db_xref="RGD:61973"
     exon            1..327
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..2878
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /note="trp-related protein 3; ion channel protein"
                     /codon_start=1
                     /product="short transient receptor potential channel 3"
                     /protein_id="NP_001401934.1"
                     /db_xref="GeneID:60395"
                     /db_xref="RGD:61973"
                     /translation="MSTKVKKCREPARVTLPAPEEEDGEAEGAEPQRRRRGWRGVNGG
                     LEPPCPRAPPSPGPDASSEGSPSRWRTAGMRDKGRRQAVRGPAFMFGARGPSLTAEEE
                     RFLDAAEYGNIPVVRKMLEESRTLNVNCVDYMGQNALQLAVGNEHLEVTELLLKKENL
                     ARIGDALLLAISKGYVRIVEAILGHPGFAASRRLTLSPCEQELRDDDFYAYDEDGTRF
                     SPDITPIILAAHCHKYEVVHLLLLKGARIERPHDYFCRCADCAEKQRLDAFSHSRSRI
                     NAYKGLASPAYLSLSSEDPVLTALELSNELAKLANIEKEFKNDYRKLSMQCKDFVVGV
                     LDLCRDSEEVEAILNGDLESVEPLERHGHKASLSRVKLAIKYEVKKFVAHPNCQQQLL
                     TIWYENLSGLREQTIAIKCLVVLVVALGLPFLAIGYWIAPCSRLGKILRSPFMKFVAH
                     AASFIIFLGLLVFNASDRFEGITTLPNITVIDYPKQIFRVKTTQFTWTEMLIMVWVLG
                     MMWSECKELWLEGPREYIVQLWNVLDFGMLSIFIAAFTARFLAFLQATKAQQYVDSHV
                     QESDLSEVTLPPEVQYFTYARDKWLPSDPQIISEGLYAIAVVLSFSRIAYILPANESF
                     GPLQISLGRTVKDIFKFMVLFIMVFLAFMIGMFILYSYYLGAKVNPAFTTVEESFKTL
                     FWSIFGLSEVTSVVLKYDHKFIENIGYVLYGIYNVTMVVVLLNMLIAMINSSYQEIED
                     DSDVEWKFARSKLWLSYFDDGKTLPPPFSLVPSPKSFVYFIMRITNFSKCRRRRLQKD
                     LELGMGNSKSRLNLFTQSNSRVFESHSFNSILNQPTRYQQIMKRLIKRYVLKAQVDKE
                     NDEVNEGELKEIKQDISSLRYELLEDKSQATEELAILIHKLSEKLNPSALRCE"
     exon            328..1099
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1288
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1453
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1670
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1904
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2169
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2170..2365
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2366..2575
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2659
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2660..2735
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
     exon            2736..3629
                     /gene="Trpc3"
                     /gene_synonym="TrpC3c; Trrp3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaccacgca cagccggcat cgcggccgcg gaccccgagc tccgctgcag gtcgcgcgct
       61 cggcccgggc ggccccggcg ccgcggcccg ggtgcttgac tcagagcggc tgggctgctg
      121 actgcgggcg gcaaggagct cggccgctat gtccaccaag gtcaagaagt gccgggagcc
      181 cgcgagggtg accttgcccg cgccggagga ggaggatggc gaggccgagg gagccgagcc
      241 gcagcgccgc cgccggggct ggaggggcgt caacggcggg ctggagccgc cctgcccgcg
      301 cgcgccgccg tccccggggc ccgacgcgtc gtcggagggc agtccatcca ggtggcgcac
      361 agcagggatg cgtgacaagg gcaggcgcca ggcagtacgt ggcccggcct tcatgttcgg
      421 tgctcgtggg cccagcctca cagctgagga ggagcgcttc ctggacgctg cagagtacgg
      481 caacatccct gtggtgcgca agatgctgga ggagtctcgc acgctcaatg tcaactgcgt
      541 ggactacatg ggccagaatg cgctgcagct ggccgtgggc aatgagcatc tggaggtgac
      601 cgagctgctg ctgaagaagg agaacctggc gcgtatcggt gatgcgctgc tgctcgccat
      661 cagcaaaggc tatgtgcgca tcgtggaggc catcctaggc cacccaggct ttgcggccag
      721 ccggcgcctg accctcagcc cttgcgagca agaactgcgc gatgacgact tctatgctta
      781 cgacgaggat ggcacacgct tctcacctga catcacgccc atcatcctgg ctgcgcattg
      841 ccataaatac gaggtggtgc acctgctgct actcaagggt gcacgcatcg agcggccaca
      901 cgactacttc tgtcgctgcg ccgactgtgc tgagaagcaa aggcttgatg ccttcagcca
      961 ctcaaggtct aggatcaatg cctacaaggg actggccagc ccagcatact tgtcgctgtc
     1021 cagcgaggac cctgtgctca cagcgctgga actcagcaat gagctggcca agctggccaa
     1081 catagagaag gagttcaaga atgactacag gaagctctcc atgcagtgca aagacttcgt
     1141 agtaggtgtg ctggacctgt gccgggactc agaggaggtg gaagccattc tgaatggaga
     1201 tctggaatcg gtggaacccc tggagagaca cgggcacaag gcgtcgctga gtcgggtcaa
     1261 acttgccatt aaatatgaag tcaaaaagtt tgtggctcac cccaactgcc aacagcagct
     1321 tttgaccatc tggtacgaga acctctcggg ccttcgggag cagaccatcg ctatcaagtg
     1381 tctggtcgtg ttggtcgtgg ccttgggcct tccattcctc gccatcggct actggattgc
     1441 accttgtagc aggctgggga aaattcttcg aagccccttc atgaagttcg tggctcacgc
     1501 tgcctccttc atcatcttcc tgggtctgct tgtgttcaac gcctcagacc ggtttgaagg
     1561 catcaccacg ctgcccaaca tcaccgttat tgactacccc aagcaaatct tcagggtgaa
     1621 gaccacccag ttcacatgga cagaaatgct aattatggtc tgggttctcg ggatgatgtg
     1681 gtctgagtgc aaggagctgt ggctggaggg gccccgggag tacatcgtgc agctgtggaa
     1741 cgtgcttgac ttcgggatgc tctccatctt cattgctgcc ttcaccgcca ggttcctagc
     1801 gtttctgcaa gccaccaaag cgcagcagta tgtggacagc cacgtgcagg agagcgacct
     1861 gagcgaagtc acactcccac cagaggttca gtatttcacc tatgctagag ataaatggct
     1921 tccttctgac cctcagatca tatcggaagg cctctatgcc atagctgtgg tgctcagctt
     1981 ctcccggatc gcgtacattc tccctgcaaa cgagagcttt gggcccttgc agatctctct
     2041 ggggaggact gtgaaggaca tattcaagtt catggttctc ttcatcatgg tgttcctggc
     2101 tttcatgatt ggcatgttca tactttactc ctactacctt ggggccaaag taaaccctgc
     2161 ttttaccacg gttgaagaaa gtttcaagac tttgttttgg tccatatttg gactctctga
     2221 agtgacttct gttgtcctca aatatgacca caaattcata gagaacattg gctatgtcct
     2281 ttatggaata tacaatgtaa ctatggtggt cgttctgctc aacatgctga ttgctatgat
     2341 taacagctca taccaagaaa tcgaggatga cagtgatgta gagtggaagt ttgctcgttc
     2401 caaactctgg ctatcctact tcgatgatgg aaaaacatta cctccaccct tcagtctggt
     2461 ccctagtcca aaatcgtttg tttatttcat catgaggatc actaactttt ccaaatgcag
     2521 gaggagaaga cttcagaagg atctggaact gggcatgggt aactcaaagt ccaggttaaa
     2581 cctcttcact cagtctaact cgagagtttt tgaatcacac agttttaaca gcattctcaa
     2641 tcagccaaca cgatatcagc agataatgaa aagactcata aaacggtatg ttttgaaagc
     2701 acaagtagac aaagaaaatg atgaggtgaa cgaaggtgaa ctgaaagaaa tcaagcagga
     2761 tatctccagc cttcgttacg aacttttgga agataagagc caagcgacgg aggaactggc
     2821 catcttgatt cataaactca gtgagaaact gaaccccagt gcgctgaggt gtgaatgagg
     2881 gagccacatg cagtgagact ttgactctgg cacaaatgtg ggcaataata ttcctaagta
     2941 tgaaatactt gaaaaaccgt tgtgtaaaaa ctctagtgtt aataccttca ccatgcggag
     3001 ctttaaaatt aacctagtgg gccacaattc ccattacgtg aaaatgatcc caaggttggc
     3061 ctcagcactc caagcagtga catgctgttg tacttagaag cccagtatta atgtcactga
     3121 tttttttttt ttttttgtca tttttgtctt tatgtcacct gttggcctcc aagagttcct
     3181 tgggggacag ggaccacatc aatctcatct ttatgtctcc aacatttagt gcagtgcctg
     3241 atacacagta ggtgcttggt aaatgttgaa cccagctggc ctggacagcc agtagcatcc
     3301 aagaacacga aagaccattg ctatgtagcc taccttctca tccgaacgct tgaagcgatt
     3361 tttttaaaaa tagaaactga aggtgtttta cgaccagcca tgatgtgtgg agatctttct
     3421 cagaccttta gacatcactg acagttctag ggcttttgaa atgccaggtt taacagtgaa
     3481 atgagctcat tggaaagata catatttaat ttcatagggt tgttcaaaaa caatcattaa
     3541 agatttttct aaaatatatg cttgtgtcct ttctctttgt atctgtggtg tcatgatgta
     3601 aatttggtca ataaagaatg cttttctaa
//
