LOCUS       NM_022638               3042 bp    mRNA    linear   ROD 19-AUG-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel
            subfamily C member 2 (Trpc2), mRNA.
ACCESSION   NM_022638
VERSION     NM_022638.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3042)
  AUTHORS   Ferrero,D.M., Moeller,L.M., Osakada,T., Horio,N., Li,Q., Roy,D.S.,
            Cichy,A., Spehr,M., Touhara,K. and Liberles,S.D.
  TITLE     A juvenile mouse pheromone inhibits sexual behaviour through the
            vomeronasal system
  JOURNAL   Nature 502 (7471), 368-371 (2013)
   PUBMED   24089208
REFERENCE   2  (bases 1 to 3042)
  AUTHORS   Sukumaran,P., Lof,C., Pulli,I., Kemppainen,K., Viitanen,T. and
            Tornquist,K.
  TITLE     Significance of the transient receptor potential canonical 2
            (TRPC2) channel in the regulation of rat thyroid FRTL-5 cell
            proliferation, migration, adhesion and invasion
  JOURNAL   Mol Cell Endocrinol 374 (1-2), 10-21 (2013)
   PUBMED   23578584
  REMARK    GeneRIF: TRPC2 is an important regulator of rat thyroid cell
            function.
REFERENCE   3  (bases 1 to 3042)
  AUTHORS   Prince,J.E., Brignall,A.C., Cutforth,T., Shen,K. and Cloutier,J.F.
  TITLE     Kirrel3 is required for the coalescence of vomeronasal sensory
            neuron axons into glomeruli and for male-male aggression
  JOURNAL   Development 140 (11), 2398-2408 (2013)
   PUBMED   23637329
REFERENCE   4  (bases 1 to 3042)
  AUTHORS   Viitanen,T.M., Sukumaran,P., Lof,C. and Tornquist,K.
  TITLE     Functional coupling of TRPC2 cation channels and the
            calcium-activated anion channels in rat thyroid cells: implications
            for iodide homeostasis
  JOURNAL   J Cell Physiol 228 (4), 814-823 (2013)
   PUBMED   23018590
  REMARK    GeneRIF: Ca(2+) entry via TRPC2 contributes to CaCC activation.
REFERENCE   5  (bases 1 to 3042)
  AUTHORS   Sukumaran,P., Lof,C., Kemppainen,K., Kankaanpaa,P., Pulli,I.,
            Nasman,J., Viitanen,T. and Tornquist,K.
  TITLE     Canonical transient receptor potential channel 2 (TRPC2) as a major
            regulator of calcium homeostasis in rat thyroid FRTL-5 cells:
            importance of protein kinase C delta (PKCdelta) and stromal
            interaction molecule 2 (STIM2)
  JOURNAL   J Biol Chem 287 (53), 44345-44360 (2012)
   PUBMED   23144458
  REMARK    GeneRIF: TRPC2, by regulating STIM2, PKC expression, and SERCA
            activity, regulates calcium homeostasis in thyroid cells.
REFERENCE   6  (bases 1 to 3042)
  AUTHORS   Stowers,L., Holy,T.E., Meister,M., Dulac,C. and Koentges,G.
  TITLE     Loss of sex discrimination and male-male aggression in mice
            deficient for TRP2
  JOURNAL   Science 295 (5559), 1493-1500 (2002)
   PUBMED   11823606
REFERENCE   7  (bases 1 to 3042)
  AUTHORS   Jungnickel,M.K., Marrero,H., Birnbaumer,L., Lemos,J.R. and
            Florman,H.M.
  TITLE     Trp2 regulates entry of Ca2+ into mouse sperm triggered by egg ZP3
  JOURNAL   Nat Cell Biol 3 (5), 499-502 (2001)
   PUBMED   11331878
REFERENCE   8  (bases 1 to 3042)
  AUTHORS   Hofmann,T., Schaefer,M., Schultz,G. and Gudermann,T.
  TITLE     Cloning, expression and subcellular localization of two novel
            splice variants of mouse transient receptor potential channel 2
  JOURNAL   Biochem J 351 (Pt 1), 115-122 (2000)
   PUBMED   10998353
REFERENCE   9  (bases 1 to 3042)
  AUTHORS   Liman,E.R., Corey,D.P. and Dulac,C.
  TITLE     TRP2: a candidate transduction channel for mammalian pheromone
            sensory signaling
  JOURNAL   Proc Natl Acad Sci U S A 96 (10), 5791-5796 (1999)
   PUBMED   10318963
REFERENCE   10 (bases 1 to 3042)
  AUTHORS   Vannier,B., Peyton,M., Boulay,G., Brown,D., Qin,N., Jiang,M.,
            Zhu,X. and Birnbaumer,L.
  TITLE     Mouse trp2, the homologue of the human trpc2 pseudogene, encodes
            mTrp2, a store depletion-activated capacitative Ca2+ entry channel
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2060-2064 (1999)
   PUBMED   10051594
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Oct 3, 2019 this sequence version replaced NM_022638.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF136401.1, SRR22582424.1318925.1
                                           [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN06680414,
                                           SAMN06680426 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-67                JAXUCZ010000001.1  165871991-165872057
            68-781              JAXUCZ010000001.1  165872702-165873415
            782-994             JAXUCZ010000001.1  165875516-165875728
            995-1159            JAXUCZ010000001.1  165876647-165876811
            1160-1334           JAXUCZ010000001.1  165877287-165877461
            1335-1535           JAXUCZ010000001.1  165878280-165878480
            1536-1698           JAXUCZ010000001.1  165878932-165879094
            1699-1791           JAXUCZ010000001.1  165879506-165879598
            1792-1984           JAXUCZ010000001.1  165881821-165882013
            1985-2112           JAXUCZ010000001.1  165882668-165882795
            2113-2191           JAXUCZ010000001.1  165882888-165882966
            2192-2321           JAXUCZ010000001.1  165883571-165883700
            2322-3042           JAXUCZ010000001.1  165884258-165884978
FEATURES             Location/Qualifiers
     source          1..3042
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..3042
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /note="transient receptor potential cation channel
                     subfamily C member 2"
                     /db_xref="GeneID:64573"
                     /db_xref="RGD:628819"
     exon            1..67
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..2716
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /note="TRP-2; rTrp2; transient receptor protein 2;
                     transient receptor potential cation channel, subfamily C,
                     member 2, pseudogene"
                     /codon_start=1
                     /product="short transient receptor potential channel 2"
                     /protein_id="NP_072160.2"
                     /db_xref="GeneID:64573"
                     /db_xref="RGD:628819"
                     /translation="MDPLSPNWTEIVNKKLKFPPTLLRAIQEGQLGLVQQLLESGSDP
                     SGAGPGGPLRNVEESEDRSWREALNLAIRLGHEVITDVLLANVKFDFRQIHEALLVAV
                     DTNQPAVVRRLLARLEREKGRKVDTKSFSLAFFDSSIDGSRFAPGVTPLTLACQKDLY
                     EIAQLLMDQGHTIARPHPVSCACLECSNARRYDLLKFSLSRINTYRGIASRAHLSLAS
                     EDAMLAAFQLSRELRRLARKEPEFKPQYIALESLCQDYGFELLGMCRNQSEVTAVLND
                     LGEDSETEPEAEGLGQAFEEGIPNLARLRLAVNYNQKQFVAHPICQQVLSSIWCGNLA
                     GWRGSTTIWKLFVAFLIFLTMPFLCIGYWLAPKSRLGRLLKIPVLKFLLHSASYLWFL
                     IFLLGESLVMETQLSTFKGRSQSVWETSLHMIWVTGFLWFECKEVWIEGLRSYLLDWW
                     NFLDVVILSLYLASFALRLLLAGLAYMHCRDASDSSTCRYFTTAERSEWRTEDPQFLA
                     EVLFAVTSMLSFTRLAYILPAHESLGTLQISIGKMIDDMIRFMFILMIILTAFLCGLN
                     NIYVPYQETEKLGNFNETFQFLFWTMFGMEEHSVVDMPQFLVPEFVGRAMYGIFTIVM
                     VIVLLNMLIAMITNSFQKIEDDADVEWKFARSKLYLSYFREGLTLPVPFNILPSPKAA
                     FYLLRRIFRFICCGSSCCKAKKSDYPPIPTFTNPGARAGPGEGEHVSYRLRVIKALVQ
                     RYIETARREFEETRRKDLGNRLTELTKTVSRLQSEVASVQKTVAAGGALRPPDGASIL
                     SRYITRVRNSFQNLGPPAPDTPAELTMPGIVETEVSLEDSLDATGEAGTPASGESSSS
                     SSAHVLVHREQEAEGAGDLPLGEDLETKGES"
     exon            68..781
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            782..994
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1159
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1160..1334
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1535
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1536..1698
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1699..1791
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1792..1984
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2112
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2113..2191
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2321
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..3042
                     /gene="Trpc2"
                     /gene_synonym="Trrp2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagagcagg agttcaagcc ttcagcccct gcccacagaa gtgggtgcag ccatggatcc
       61 cctttcgccc aactggactg agattgtgaa caaaaagctc aaattccccc caacactgct
      121 gcgtgctatc caggagggcc agctgggtct cgtgcagcag ctgctggaat caggctccga
      181 tccctcgggt gctgggccag gtggtcctct gcggaatgtg gaagagtctg aggaccgctc
      241 ctggagggaa gcccttaatc tggccatccg cctgggccac gaggtcatca ctgatgttct
      301 gctggccaat gtcaagtttg acttccggca gatccacgaa gccctgctag tggctgtgga
      361 cacaaaccag ccagcggtag tgcgtcgtct gttagctcgg ctggaacggg agaaaggtcg
      421 aaaagtagac accaagtctt tctctttagc cttctttgac tcatcaatcg atggctcccg
      481 ctttgcccct ggtgttactc cactcacact ggcctgccag aaggacctgt atgagattgc
      541 ccagctgctt atggaccagg gccacactat tgctcggccc cacccagttt cctgtgcctg
      601 cctcgagtgc agcaatgcgc gccgatatga cctgctgaag ttctcactat cccgaatcaa
      661 cacctaccgg ggcattgcta gcagggctca cctctcgctg gccagtgagg atgccatgct
      721 ggcggccttt cagctcagcc gggagctcag gcgccttgca cggaaggagc ctgagtttaa
      781 gcctcagtac attgccctgg agtctctctg ccaggactat ggctttgagt tgctgggcat
      841 gtgccggaat cagagtgagg tcactgcagt gctcaatgac ctgggcgagg atagtgagac
      901 tgagcctgag gctgagggcc tgggccaggc ctttgaggag ggcatcccta acctggcaag
      961 actgcggttg gctgtcaact acaaccagaa acagtttgta gcacacccca tctgccagca
     1021 agtgctgtct tccatttggt gtgggaacct ggctggctgg cgcgggagca ccaccatctg
     1081 gaagctcttt gtggccttcc tcatcttcct caccatgccc ttcctctgca ttggctactg
     1141 gctggcgccc aagtcccggc tgggccgcct gctgaagatc ccagtgttga agttcctgct
     1201 ccattctgcc tcctatctgt ggttcctgat cttcttgctg ggagagtctc tggtcatgga
     1261 gactcagctg agcaccttca aaggccgcag tcagagtgtc tgggagactt ctctgcatat
     1321 gatttgggtc acaggctttc tgtggtttga gtgtaaggag gtgtggatcg agggcttgcg
     1381 aagctacctc ctggactggt ggaacttcct ggacgtggtc atcctgtctc tgtacctggc
     1441 atcctttgca ctgcgcctcc tcctggctgg acttgcctac atgcactgcc gggacgcctc
     1501 agacagcagc acctgccgat acttcaccac agctgagcga agtgagtggc gcacagagga
     1561 cccccagttc ctggccgagg tgctctttgc tgtcacgagc atgctcagtt tcacccgatt
     1621 ggcgtatatt ctgccagctc acgaatcatt gggcactctg cagatctcca ttggcaagat
     1681 gattgacgac atgatccggt tcatgttcat cctcatgatc atcctgactg ccttcctctg
     1741 cggcctcaac aacatctatg tgccctacca ggagacggag aagctgggca atttcaacga
     1801 aacgttccag ttcctcttct ggaccatgtt tggcatggaa gagcactctg tggtggacat
     1861 gccccagttc ctggtgcctg agttcgtggg ccgggccatg tacggcatct ttaccatcgt
     1921 catggtgatt gtgctactca acatgctcat cgccatgatc accaactcct tccagaagat
     1981 cgaggacgat gctgatgtag agtggaagtt tgctcgctcc aagctctacc tgtcctactt
     2041 ccgagagggt ctgacgctgc ctgtgccttt taacatcctg ccatccccaa aggctgcctt
     2101 ctaccttctc aggaggattt tccggttcat ttgctgtggc tcctcctgtt gcaaagccaa
     2161 gaagtcggac tatcccccaa tcccgacctt taccaaccct ggggcaaggg cggggcctgg
     2221 ggaaggagaa catgtgtcct accgccttcg agtcatcaag gctctggtgc agcgctacat
     2281 agagactgcc cggcgcgagt tcgaggagac ccgtcggaaa gatctgggca acagactgac
     2341 agagctgacc aagactgtgt ctcgactgca aagcgaggtg gccagtgtgc agaagactgt
     2401 ggcagcggga ggggcgctgc ggcctccgga tggcgccagc atcctcagtc ggtacatcac
     2461 ccgagtgcgc aacagcttcc agaacctggg cccccctgcc cctgacaccc ccgcagagct
     2521 gacgatgcct gggattgtgg agaccgaagt ctccttagaa gatagccttg atgctacagg
     2581 agaggctggg actccagctt ctggagagtc cagctcttcc tcctcggccc atgtgctggt
     2641 acacagggag caagaagcag agggggcagg ggacttgccc ctgggggaag atctggagac
     2701 caagggcgag tcctaaggca acagaagggt cttttctgtc tctaagtgca gctgcctagt
     2761 tgggtagagc cagggtctca cagtagaaga ccatggtact tttttttttt tttttgcctc
     2821 agtaaagttt ctgctgtgga agtcagatga tcatctccat ctcttaataa cctaagatcc
     2881 cttccttcac tcccctaaaa tggatgctgt gtgaggaggg aagaaagagc ttgctttgag
     2941 ttctggggtt tagaatccta ctttgggatt cctcaggtct ttaaaggaaa aagttctggc
     3001 ctaggagact agaggactgg gagactggag gcctgccagt gg
//
