LOCUS       NM_001413355            4588 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily C, member 1 (Trpc1), transcript variant 1, mRNA.
ACCESSION   NM_001413355 XM_008766568
VERSION     NM_001413355.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4588)
  AUTHORS   Caminos,E., Murillo-Martinez,M., Garcia-Belando,M.,
            Cabanes-Sanchis,J.J. and Martinez-Galan,J.R.
  TITLE     Robust expression of the TRPC1 channel associated with
            photoreceptor loss in the rat retina
  JOURNAL   Exp Eye Res 236, 109655 (2023)
   PUBMED   37722585
  REMARK    GeneRIF: Robust expression of the TRPC1 channel associated with
            photoreceptor loss in the rat retina.
REFERENCE   2  (bases 1 to 4588)
  AUTHORS   Bektur Aykanat,N.E., Sahin,E., Kacar,S., Bagci,R., Karakaya,S.,
            Burukoglu Donmez,D. and Sahinturk,V.
  TITLE     Cardiac hypertrophy caused by hyperthyroidism in rats: the role of
            ATF-6 and TRPC1 channels
  JOURNAL   Can J Physiol Pharmacol 99 (11), 1226-1233 (2021)
   PUBMED   34283935
  REMARK    GeneRIF: Cardiac hypertrophy caused by hyperthyroidism in rats: the
            role of ATF-6 and TRPC1 channels.
            Erratum:[Can J Physiol Pharmacol. 2024 Jul 1;102(7):429. doi:
            10.1139/cjpp-2024-0182.. PMID: 38842093]
REFERENCE   3  (bases 1 to 4588)
  AUTHORS   Rathor,N., Chung,H.K., Song,J.L., Wang,S.R., Wang,J.Y. and Rao,J.N.
  TITLE     TRPC1-mediated Ca2+ signaling enhances intestinal epithelial
            restitution by increasing alpha4 association with PP2Ac after
            wounding
  JOURNAL   Physiol Rep 9 (9), e14864 (2021)
   PUBMED   33991460
  REMARK    GeneRIF: TRPC1-mediated Ca(2+) signaling enhances intestinal
            epithelial restitution by increasing alpha4 association with PP2Ac
            after wounding.
REFERENCE   4  (bases 1 to 4588)
  AUTHORS   Hu,Q., Ahmad,A.A., Seidel,T., Hunter,C., Streiff,M., Nikolova,L.,
            Spitzer,K.W. and Sachse,F.B.
  TITLE     Location and function of transient receptor potential canonical
            channel 1 in ventricular myocytes
  JOURNAL   J Mol Cell Cardiol 139, 113-123 (2020)
   PUBMED   31982426
  REMARK    GeneRIF: Location and function of transient receptor potential
            canonical channel 1 in ventricular myocytes.
REFERENCE   5  (bases 1 to 4588)
  AUTHORS   Kougioumoutzakis,A., Pelletier,J.G., Laplante,I., Khlaifia,A. and
            Lacaille,J.C.
  TITLE     TRPC1 mediates slow excitatory synaptic transmission in hippocampal
            oriens/alveus interneurons
  JOURNAL   Mol Brain 13 (1), 12 (2020)
   PUBMED   31996247
  REMARK    GeneRIF: TRPC1 mediates slow excitatory synaptic transmission in
            hippocampal oriens/alveus interneurons.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4588)
  AUTHORS   Strubing,C., Krapivinsky,G., Krapivinsky,L. and Clapham,D.E.
  TITLE     TRPC1 and TRPC5 form a novel cation channel in mammalian brain
  JOURNAL   Neuron 29 (3), 645-655 (2001)
   PUBMED   11301024
REFERENCE   7  (bases 1 to 4588)
  AUTHORS   Wang,W., O'Connell,B., Dykeman,R., Sakai,T., Delporte,C., Swaim,W.,
            Zhu,X., Birnbaumer,L. and Ambudkar,I.S.
  TITLE     Cloning of Trp1beta isoform from rat brain: immunodetection and
            localization of the endogenous Trp1 protein
  JOURNAL   Am J Physiol 276 (4), C969-C979 (1999)
   PUBMED   10199829
REFERENCE   8  (bases 1 to 4588)
  AUTHORS   Tsiokas,L., Arnould,T., Zhu,C., Kim,E., Walz,G. and Sukhatme,V.P.
  TITLE     Specific association of the gene product of PKD2 with the TRPC1
            channel
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3934-3939 (1999)
   PUBMED   10097141
REFERENCE   9  (bases 1 to 4588)
  AUTHORS   Zhu,X., Jiang,M., Peyton,M., Boulay,G., Hurst,R., Stefani,E. and
            Birnbaumer,L.
  TITLE     trp, a novel mammalian gene family essential for agonist-activated
            capacitative Ca2+ entry
  JOURNAL   Cell 85 (5), 661-671 (1996)
   PUBMED   8646775
REFERENCE   10 (bases 1 to 4588)
  AUTHORS   Abdel-Malek,Z., Swope,V., Collins,C., Boissy,R., Zhao,H. and
            Nordlund,J.
  TITLE     Contribution of melanogenic proteins to the heterogeneous
            pigmentation of human melanocytes
  JOURNAL   J Cell Sci 106 (Pt 4), 1323-1331 (1993)
   PUBMED   8126111
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 31, 2022 this sequence version replaced XM_008766568.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DQ839447.1, SRR26643298.45980.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-688               JAXUCZ010000008.1  105193139-105193826 c
            689-843             JAXUCZ010000008.1  105186937-105187091 c
            844-945             JAXUCZ010000008.1  105180357-105180458 c
            946-1148            JAXUCZ010000008.1  105175742-105175944 c
            1149-1280           JAXUCZ010000008.1  105168555-105168686 c
            1281-1476           JAXUCZ010000008.1  105164768-105164963 c
            1477-1813           JAXUCZ010000008.1  105161959-105162295 c
            1814-1953           JAXUCZ010000008.1  105159569-105159708 c
            1954-2097           JAXUCZ010000008.1  105158067-105158210 c
            2098-2273           JAXUCZ010000008.1  105148595-105148770 c
            2274-2475           JAXUCZ010000008.1  105146563-105146764 c
            2476-2670           JAXUCZ010000008.1  105146119-105146313 c
            2671-4588           JAXUCZ010000008.1  105142931-105144848 c
FEATURES             Location/Qualifiers
     source          1..4588
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q31"
     gene            1..4588
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /note="transient receptor potential cation channel,
                     subfamily C, member 1"
                     /db_xref="GeneID:89821"
                     /db_xref="RGD:619783"
     exon            1..688
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             517..2898
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /note="isoform 1 is encoded by transcript variant 1; short
                     transient receptor potential channel 1; TRP-1; transient
                     receptor protein 1; short transient receptor potential
                     channel 1-like"
                     /codon_start=1
                     /product="short transient receptor potential channel 1
                     isoform 1"
                     /protein_id="NP_001400284.1"
                     /db_xref="GeneID:89821"
                     /db_xref="RGD:619783"
                     /translation="MMAALYPSTDLSGVSSSSLPSSPSSSSPNEVMALKDVREVKEEN
                     TLNEKLFLLACDKGDYYMVKKILEENSSGDLNINCVDVLGRNAVTITIENESLDILQL
                     LLDYGCQSADALLVAIDSEVVGAVDILLNHRPKRSSRPTIVKLMERIQNPEYSTTMDV
                     APVILAAHRNNYEILTMLLKQDVALPKPHAVGCECTLCSAKNKKDSLRHSRFRLDIYR
                     CLASPALIMLTEEDPILRAFELSADLKELSLVEVEFRNDYEELARQCKMFAKDLLAQA
                     RNSRELEVILNHTSSDEPLDKRGLLEERMNLSRLKLAIKYNQKEFVSQSNCQQFLNTV
                     WFGQMSGYRRKPTCKKIMTVLTVGIFWPVLSLCYLIAPKSQFGRIIHTPFMKFIIHGA
                     SYFTFLLLLNLYSLVYNEDKKNTMGPALERIDYLLILWIIGMIWSDIKRLWYEGLEDF
                     LEESRNQLSFVMNSLYLATFALKVVAHNKFHDFADRKDWDAFHPTLVAEGLFAFANVL
                     SYLRLFFMYTTSSILGPLQISMGQMLQDFGKFLGMFLLVLFSFTIGLTQLYDKGYTSK
                     EQKDCVGIFCEQQSNDTFHSFIGTCFALFWYIFSLAHVAIFVTRFSYGEELQSFVGAV
                     IVGTYNVVVVIVLTKLLVAMLHKSFQLIANHEDKEWKFARAKLWLSYFDDKCTLPPPF
                     NIIPSPKTICYMISSLSKWVCSHTSKGKVRRQNSLKEWRNLKQKRDENYQKVMCCLVH
                     RYLTSMRQKMQSTDQATVENLNELRQDLSKFRNEIRDLLGFRTSKYAMFYPRN"
     exon            689..843
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            844..945
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1148
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1280
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1476
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1477..1813
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1814..1953
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..2097
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2098..2273
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2274..2475
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2476..2670
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..4588
                     /gene="Trpc1"
                     /gene_synonym="Trrp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggggctga ggatgacgtg aggagaaagc cgcgaacctc tgtctcctgc gggtgctgct
       61 gggccagcgg ttcccacagc tccggagcca gacgtactgc aaagcgctcc gccgagctcc
      121 tccgccggcc ggcggcctcc tcactccctc ccaggccggg ccgcctcctg cgcggcccct
      181 gcggctcctg gcacggcccc gcgctcggct gccgccctgg cgcgctccac tctgtcgtcc
      241 ccggacgggc gcggaccagc tcgaccgggg cgccggcggc tgggcagagg gcgctggccc
      301 cggggccgcg ccagtgcggc caccaacctg gggctgtcgg tggagggcga atgctggttc
      361 cggggcgagg cgacgccctt cggggccaac gggccgcaca cagatgtggc cgtgggaacg
      421 actcacccgt tttccagcag ctctgggtcg gggtcggggt cggcgcccat gggggccccg
      481 cctccctctc ctggcctgcc cccgtcctgg gccgcgatga tggcggccct gtacccgagc
      541 acggacctct ctggcgtctc ctcctcctcc ctgccttcct ccccatcctc ctcatcgccc
      601 aacgaagtga tggcgctgaa ggatgtgcga gaggtgaagg aggagaacac cttgaatgag
      661 aagcttttct tgctggcgtg cgacaagggt gactattata tggttaaaaa gattttggag
      721 gaaaacagtt caggtgactt gaacataaat tgcgtagatg tgcttgggag aaatgctgtt
      781 accataacta ttgaaaacga aagcttggat atactgcagc tgcttttgga ctacggttgt
      841 cagtccgcag atgcactttt ggtggcaatc gactctgaag tagtgggagc tgttgatata
      901 ctacttaacc atcggccaaa acgatcatca cgaccaacta ttgtaaaact tatggaacga
      961 attcagaatc cggaatactc aacaacgatg gatgttgcac cagttatttt agctgctcat
     1021 cgtaacaact atgagatcct cacaatgctt ctgaagcagg acgtggcttt gcccaagccc
     1081 catgctgttg gctgtgaatg cacgctgtgt tctgcgaaaa acaaaaagga cagcctcaga
     1141 cattccaggt ttcgtcttga tatctataga tgtctggcca gtccagctct aataatgtta
     1201 acagaggagg atccaattct gagagcgttt gaacttagtg ctgacttaaa ggaactcagc
     1261 cttgtggagg tggaattcag gaatgactat gaagagctag cccgtcagtg caaaatgttt
     1321 gctaaagatt tgcttgcgca agctcggaat tctcgtgaac tggaagttat cctaaaccat
     1381 acatctagtg atgagcctct tgacaaacga ggactactag aagaaagaat gaatttaagt
     1441 cgtctgaaac ttgctatcaa atataaccag aaggagtttg tctcccagtc aaattgccag
     1501 cagttcctga acaccgtttg gttcggacag atgtcaggtt accgccgtaa gcccacctgt
     1561 aagaagataa tgactgtttt gacagttggc attttctggc cagttctgtc actgtgttac
     1621 ttgatagctc ccaaatctca attcggcaga atcattcaca caccgttcat gaagtttatt
     1681 attcatggag cttcatattt cacattcttg ctgttactca atctctactc acttgtctac
     1741 aatgaggaca agaaaaatac aatggggcca gcccttgaga gaatagacta ccttctcata
     1801 ctgtggatta ttgggatgat ttggtcagac attaagaggc tgtggtatga agggttggaa
     1861 gacttcttag aagaatctcg taaccagctc agctttgtta tgaattccct ttacttggca
     1921 acttttgccc tcaaagtggt ggctcacaac aagtttcatg attttgccga ccggaaggac
     1981 tgggatgcgt tccaccccac actggtagca gaagggcttt tcgcctttgc aaacgttctg
     2041 agttaccttc ggctcttctt tatgtacaca accagctcta ttttgggccc actgcagatt
     2101 tcaatgggac agatgttaca agattttggg aaatttctag gaatgttcct tcttgttctg
     2161 ttttccttca cgattggact gacacagctc tatgacaaag ggtacacttc caaagagcag
     2221 aaggactgcg taggcatctt ctgtgaacag caaagcaacg acaccttcca ctcgttcatt
     2281 ggcacctgct ttgctctgtt ctggtacatc ttctccttag cgcatgtggc catctttgtc
     2341 accaggttta gctatgggga agaactgcag tccttcgttg gggctgtgat tgtcggaact
     2401 tacaatgtcg tggttgtgat cgtgcttaca aagctactgg tagcgatgct tcataagagc
     2461 ttccagctga tagcaaatca tgaggataaa gaatggaagt ttgctcgagc gaagctatgg
     2521 ctcagctact ttgatgacaa atgcacactg cccccacctt tcaacatcat tccttctcca
     2581 aagactatct gctatatgat cagcagcctc agcaagtggg tgtgctcgca cacctccaaa
     2641 ggcaaggtca gacggcagaa cagcttgaag gagtggagaa acttaaaaca aaagagagat
     2701 gagaactacc agaaggtgat gtgctgccta gtgcatcgat acctgacctc catgcgacag
     2761 aagatgcaga gcacagacca ggccaccgtg gagaatctca atgaactgcg ccaagatctg
     2821 tcaaaattca gaaatgaaat aagggatttg cttggctttc ggacttctaa atatgctatg
     2881 ttttatccaa gaaattagcc attttctaaa tcttgtagaa ataattttcc ttaataaatc
     2941 tgaaagactg tatttgcata cctttcaatt aaatcaataa gatatatatg ggcataaaca
     3001 attacacaga agccattctt taaatattta tagcataaac atatgttgtg taaatatgta
     3061 tatagagcta gttttttaaa acctgtctgt gactttttgt agaagcaaaa ccattttgtt
     3121 agcatgctac tttgttttct tagttggtca gtgcttacat tcgacgtgtg taagaggggc
     3181 agctctcagt gtacgcatgg cccactccat ttatacgcga agatcagcaa acgcggctac
     3241 cttaagacac acttgaagag ctcatgctgt tgaaatctct tgttttagga gttcacacag
     3301 agttcagtat atattgttta ggagtttagc ttcatctaaa ataccctact ttttcttttg
     3361 ttagaatctt aagcagcaga gaaaagttta taataaatat ttgaatttaa cccagtcatg
     3421 gtgatgaatg cctttaatcc cagcactcgg gaggcagagg caggcagatc tctgagttca
     3481 aggtcagcct ggtctacaga gtgagttcca ggatagcccc ggctacacag agaaaccctg
     3541 tcttggaaaa ataaaaaaca acaaaaaaaa atttaaatta tttatttatg tctatctaaa
     3601 ttcacgttgg tatttgttgt gtagtatatt tacttttaca tggttataat ttatattttt
     3661 aattttgttt tgacataaca ttattttata tatatttctc tatattaagg tagtttatat
     3721 gtttaaatat ttatagacgt ctgtgaattt tgaaaaatag tagccatctt ttacccatag
     3781 aatacttgtt tctatttata ccctcgcaga ggtacctctt aggcatttgg ctagtttagc
     3841 ttttccttct aatttttcaa gttggagtaa aactcatcgt tacaaagtag aagctgctta
     3901 tcttcatgtg cggtcacagt gggcttggcc ggagagcact gggccttgct tgcagaaggc
     3961 tgctttccgt tcactccagg gctcgtgagc tcctcttcca aagtttctcc cacagagcct
     4021 accacagctt ctacaaaact ggcctcgtgc ttgcggcttg agatgtaaag cattgtttat
     4081 tcaatttgaa aataaaaaga atttgactgc ttttcagtgt tcatgtaaag gtggagctga
     4141 aggtttcccc agctatggca cagacattcc tgcagcacgt ttggtgagaa attaccttcg
     4201 gaactgaacg tcagctggca ttgaggccac agagtgcaga cagccctggt ctgtgagcgc
     4261 cgcccacccc ggggcagctg aggagcccag tgtaggtttc atcttgcttt ttgcatttgt
     4321 ttttaatgtc caggtttaag tgttccctct tttgggcaaa ttcttataaa aatgtttatt
     4381 gtaaaattat atattttgtc tacaatggga ttatgcgctt ccaagttgat attttacatc
     4441 aggattttta gtcattctaa aaaaaatacc taattattaa aaaatttata gagtacctat
     4501 gtgtgcatga attactgacg aggtatattt tgaatgacag catattgtaa gaaaagagtg
     4561 aataaaattt ggcattagat tataaatt
//
