LOCUS       NM_207608               4405 bp    mRNA    linear   ROD 27-JUL-2024
DEFINITION  Rattus norvegicus transient receptor potential cation channel,
            subfamily A, member 1 (Trpa1), mRNA.
ACCESSION   NM_207608 XM_232586
VERSION     NM_207608.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4405)
  AUTHORS   Rumbus,Z., Fekete,K., Kelava,L., Gardos,B., Klonfar,K.,
            Keringer,P., Pinter,E., Pakai,E. and Garami,A.
  TITLE     Ammonium chloride-induced hypothermia is attenuated by transient
            receptor potential channel vanilloid-1, but augmented by ankyrin-1
            in rodents
  JOURNAL   Life Sci 346, 122633 (2024)
   PUBMED   38615746
  REMARK    GeneRIF: Ammonium chloride-induced hypothermia is attenuated by
            transient receptor potential channel vanilloid-1, but augmented by
            ankyrin-1 in rodents.
REFERENCE   2  (bases 1 to 4405)
  AUTHORS   Kozyreva,T.V., Orlov,I.V., Boyarskaya,A.R. and Voronova,I.P.
  TITLE     Hypothalamic TRPM8 and TRPA1 ion channel genes in the regulation of
            temperature homeostasis at water balance changes
  JOURNAL   Neurosci Lett 828, 137763 (2024)
   PUBMED   38574849
  REMARK    GeneRIF: Hypothalamic TRPM8 and TRPA1 ion channel genes in the
            regulation of temperature homeostasis at water balance changes.
REFERENCE   3  (bases 1 to 4405)
  AUTHORS   Imamura,T., Ogawa,T., Minagawa,T., Daimon,H., Nagai,T., Ueno,M.,
            Saito,T. and Ishizuka,O.
  TITLE     Transient receptor potential ankyrin 1 channels in the bladder
            mediate low temperature elicited bladder overactivity in rats
  JOURNAL   Neurourol Urodyn 43 (1), 276-288 (2024)
   PUBMED   38010891
  REMARK    GeneRIF: Transient receptor potential ankyrin 1 channels in the
            bladder mediate low temperature elicited bladder overactivity in
            rats.
REFERENCE   4  (bases 1 to 4405)
  AUTHORS   Nakagawa,M., Takahashi,K., Nishizawa,Y. and Ohta,T.
  TITLE     Involvement of interaction of Cav3.2 and nociceptive TRPA1 in
            pathological pain transmission
  JOURNAL   Biomed Res 45 (1), 45-55 (2024)
   PUBMED   38325845
  REMARK    GeneRIF: Involvement of interaction of Cav3.2 and nociceptive TRPA1
            in pathological pain transmission.
REFERENCE   5  (bases 1 to 4405)
  AUTHORS   Skagen,C., Lovsletten,N.G., Asoawe,L., Al-Karbawi,Z., Rustan,A.C.,
            Thoresen,G.H. and Haugen,F.
  TITLE     Functional expression of the thermally activated transient receptor
            potential channels TRPA1 and TRPM8 in human myotubes
  JOURNAL   J Therm Biol 116, 103623 (2023)
   PUBMED   37542841
  REMARK    GeneRIF: Functional expression of the thermally activated transient
            receptor potential channels TRPA1 and TRPM8 in human myotubes.
REFERENCE   6  (bases 1 to 4405)
  AUTHORS   Obata,K., Katsura,H., Mizushima,T., Yamanaka,H., Kobayashi,K.,
            Dai,Y., Fukuoka,T., Tokunaga,A., Tominaga,M. and Noguchi,K.
  TITLE     TRPA1 induced in sensory neurons contributes to cold hyperalgesia
            after inflammation and nerve injury
  JOURNAL   J Clin Invest 115 (9), 2393-2401 (2005)
   PUBMED   16110328
  REMARK    GeneRIF: Results demonstrate that nerve growth factor-induced TRPA1
            increase in sensory neurons via p38 activation is necessary for
            cold hyperalgesia.
            Erratum:[J Clin Invest. 2010 Jan;120(1):394]
REFERENCE   7  (bases 1 to 4405)
  AUTHORS   Nagata,K., Duggan,A., Kumar,G. and Garcia-Anoveros,J.
  TITLE     Nociceptor and hair cell transducer properties of TRPA1, a channel
            for pain and hearing
  JOURNAL   J Neurosci 25 (16), 4052-4061 (2005)
   PUBMED   15843607
REFERENCE   8  (bases 1 to 4405)
  AUTHORS   Corey,D.P., Garcia-Anoveros,J., Holt,J.R., Kwan,K.Y., Lin,S.Y.,
            Vollrath,M.A., Amalfitano,A., Cheung,E.L., Derfler,B.H., Duggan,A.,
            Geleoc,G.S., Gray,P.A., Hoffman,M.P., Rehm,H.L., Tamasauskas,D. and
            Zhang,D.S.
  TITLE     TRPA1 is a candidate for the mechanosensitive transduction channel
            of vertebrate hair cells
  JOURNAL   Nature 432 (7018), 723-730 (2004)
   PUBMED   15483558
REFERENCE   9  (bases 1 to 4405)
  AUTHORS   Jordt,S.E., Bautista,D.M., Chuang,H.H., McKemy,D.D., Zygmunt,P.M.,
            Hogestatt,E.D., Meng,I.D. and Julius,D.
  TITLE     Mustard oils and cannabinoids excite sensory nerve fibres through
            the TRP channel ANKTM1
  JOURNAL   Nature 427 (6971), 260-265 (2004)
   PUBMED   14712238
  REMARK    GeneRIF: cellular and molecular target for the pungent action of
            mustard oils; support an emerging role for TRP channel ANKTM1 as an
            ionotropic cannabinoid receptor.
REFERENCE   10 (bases 1 to 4405)
  AUTHORS   Story,G.M., Peier,A.M., Reeve,A.J., Eid,S.R., Mosbacher,J.,
            Hricik,T.R., Earley,T.J., Hergarden,A.C., Andersson,D.A.,
            Hwang,S.W., McIntyre,P., Jegla,T., Bevan,S. and Patapoutian,A.
  TITLE     ANKTM1, a TRP-like channel expressed in nociceptive neurons, is
            activated by cold temperatures
  JOURNAL   Cell 112 (6), 819-829 (2003)
   PUBMED   12654248
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 30, 2022 this sequence version replaced NM_207608.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY496961.1, SRR26360176.483863.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               JAXUCZ010000005.1  9163060-9163307
            249-408             JAXUCZ010000005.1  9173842-9174001
            409-584             JAXUCZ010000005.1  9175306-9175481
            585-692             JAXUCZ010000005.1  9180210-9180317
            693-801             JAXUCZ010000005.1  9181537-9181645
            802-947             JAXUCZ010000005.1  9181807-9181952
            948-1084            JAXUCZ010000005.1  9182815-9182951
            1085-1133           JAXUCZ010000005.1  9184304-9184352
            1134-1233           JAXUCZ010000005.1  9185989-9186088
            1234-1334           JAXUCZ010000005.1  9186605-9186705
            1335-1504           JAXUCZ010000005.1  9187623-9187792
            1505-1669           JAXUCZ010000005.1  9187875-9188039
            1670-1784           JAXUCZ010000005.1  9189106-9189220
            1785-1951           JAXUCZ010000005.1  9192884-9193050
            1952-2045           JAXUCZ010000005.1  9194874-9194967
            2046-2105           JAXUCZ010000005.1  9196084-9196143
            2106-2204           JAXUCZ010000005.1  9197090-9197188
            2205-2275           JAXUCZ010000005.1  9197908-9197978
            2276-2441           JAXUCZ010000005.1  9198539-9198704
            2442-2531           JAXUCZ010000005.1  9199698-9199787
            2532-2701           JAXUCZ010000005.1  9201257-9201426
            2702-2831           JAXUCZ010000005.1  9203813-9203942
            2832-3014           JAXUCZ010000005.1  9204315-9204497
            3015-3083           JAXUCZ010000005.1  9205824-9205892
            3084-3194           JAXUCZ010000005.1  9213742-9213852
            3195-3292           JAXUCZ010000005.1  9215501-9215598
            3293-4405           JAXUCZ010000005.1  9216213-9217325
FEATURES             Location/Qualifiers
     source          1..4405
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q11"
     gene            1..4405
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /note="transient receptor potential cation channel,
                     subfamily A, member 1"
                     /db_xref="GeneID:312896"
                     /db_xref="RGD:1303284"
     exon            1..248
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..3515
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /note="ankyrin-like with transmembrane domains protein 1;
                     wasabi receptor"
                     /codon_start=1
                     /product="transient receptor potential cation channel
                     subfamily A member 1"
                     /protein_id="NP_997491.2"
                     /db_xref="GeneID:312896"
                     /db_xref="RGD:1303284"
                     /translation="MKRSLRRVLRPEERKEVQGVVYRGVGEDMDCSKESFKVDIEGDM
                     CRLEAFIKNRRKLSKYEDENLCLLHHAAAEGQVELMQLIINGSSCEALNVMDDYGNTP
                     LHWAAEKNQVESVKFLLSQGANPNLRNRNMMAPLHIAVQGMYNEVIKVLTEHKATNIN
                     LEGENGNTALMSTCAKDNSEALQILLEKGAKLCKSNKWGDYPVHQAAFSGAKRCMELI
                     LAYGEKTGYSREAHINFVNHKKASPLHLAVQSGDLDMIKMCLDSGAHIDMMENAKCMA
                     LHFAATQGATDIVKLMISSYTGSSDIVNAVDGNQETLLHRASLFDHHDLADYLISVGA
                     DINSTDSEGRSPLILATASASWNIVNLLLSKGAKVDIKDHLGRNFLHLTVQQPYGLRN
                     LRPEFLQMQHIKELVMDEDNDGCTPLHYACRQGAPVSVNNLLRFNVSVHSKSKDKKSP
                     LHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGAL
                     FLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEEGNTALHFAAREGHAKAVA
                     MLLSYNADILLNKKQASFLHIALHNKRKEVVLTTIRSKRWDECLQVFTHDSPSNRCPI
                     MEMVEYLPECMKVLLDFCMIPSTEDKSCQDYHIEYNFKYLQCPLSMTKKVTPTQDVIY
                     EPLTILNVMVQHNRIELLNHPVCREYLLMKWCAYGFRAHMMNLGSYCLGLIPMTLLVV
                     KIQPGMAFNSTGIINETISTHEERINTLNSFPLKICMILVFLSSIFGYCKEVVQIFQQ
                     KRNYFLDYNNALEWVIYTTSMIFVLPLFLDIPAYMQWQCGAIAIFFYWMNFLLYLQRF
                     ENCGIFIVMLEVIFKTLLRSTGVFIFLLLAFGLSFYVLLNFQDAFSTPLLSLIQTFSM
                     MLGDINYRDAFLEPLFRNELAYPVLTFGQLIAFTMFVPIVLMNLLIGLAVGDIAEVQK
                     HASLKRIAMQVELHTNLEKKLPFWYLRKVDQRSTIVYPNRPRHGRMLRFFHYFLSMQE
                     TRQEAPNIDTCLEMEILKQKYRLKDLTSLLEKQHELIKLIIQKMEIISETEDEDNHCS
                     FQDRFKKERLEQMHSKWNFVLNAVKTKTHCSISHPDI"
     exon            249..408
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            409..584
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            585..692
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            693..801
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            802..947
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1084
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1133
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1233
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1234..1334
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1504
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1669
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1784
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1785..1951
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            1952..2045
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2105
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..2204
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2205..2275
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2441
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2442..2531
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2701
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2702..2831
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            2832..3014
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3015..3083
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3084..3194
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3195..3292
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
     exon            3293..4405
                     /gene="Trpa1"
                     /gene_synonym="Anktm1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctggtcgcag aaccggcttt agcttcaggg atccctccag cagagcgcag tgaggtccag
       61 ctccagcttc cggtgccctg tccctaggtg ccgctttgtg gagagctgcc gcgccagcag
      121 gagcccaggt ggagtcaatg aagcgcagct tgaggagggt tctgcgcccc gaggaaagaa
      181 aggaggtcca gggcgtcgtc tatcgcggcg tgggggaaga catggactgc tccaaggaat
      241 cctttaaggt ggacattgaa ggagatatgt gcagattaga agccttcatc aagaaccgaa
      301 gaaaactaag caagtacgag gatgaaaatc tctgtcttct gcatcacgcc gcagccgaag
      361 gtcaagttga actgatgcaa ttgatcatca atggctcttc ctgtgaagcg ctgaatgtaa
      421 tggatgatta tggaaatacc ccactacatt gggctgcaga aaaaaatcaa gttgaaagtg
      481 tgaagtttct tctcagccaa ggagcaaatc caaacctccg aaatagaaac atgatggcac
      541 cccttcacat agctgtacag ggcatgtaca acgaagtgat caaggtcttg accgagcaca
      601 aggccactaa catcaattta gaaggagaga atgggaacac agctttgatg tccacgtgtg
      661 ccaaagacaa cagtgaagct ttgcaaattt tgttagaaaa aggagctaag ctgtgtaaat
      721 caaataaatg gggagactac cctgtgcacc aggcagcatt ttcaggtgcc aaaagatgca
      781 tggaattaat cttagcatat ggtgaaaaga ccggctatag ccgggaggct cacattaact
      841 ttgtgaatca taagaaagcc agccctctcc acctcgcagt tcagagcggc gacttggaca
      901 tgattaagat gtgcctggac agcggtgcac acatcgacat gatggagaat gccaaatgca
      961 tggccctcca ttttgctgca acccagggag ccactgacat cgttaaactc atgatctcat
     1021 cctatactgg aagcagcgat atcgtgaatg cagtcgatgg caatcaggag accctgcttc
     1081 acagagcctc attatttgat catcatgacc tggcagacta cctaatttca gtgggagcag
     1141 acatcaacag cactgattct gaaggacgct ctccacttat tttagcaact gcttctgcat
     1201 cctggaatat tgtgaatttg ctcctctcta aaggtgccaa agtagacata aaagatcatc
     1261 ttgggcgtaa ctttttacat ttgactgtgc agcagcctta tgggctaagg aatttgcggc
     1321 ctgagttttt gcagatgcaa cacatcaagg agctggtgat ggatgaggac aatgatggat
     1381 gtacgcctct ccattatgct tgtaggcagg gggcccctgt ctctgtaaat aacctcctca
     1441 ggttcaatgt gtccgttcat tccaaaagca aagataagaa gtctcccctg cactttgccg
     1501 ccagctatgg gcgcatcaat acatgtcaga ggcttctgca agacatcagc gacacaaggc
     1561 ttttgaatga aggggatctc catggaatga cccctctcca tctggcagca aagaatggac
     1621 atgataaagt cgttcaactt cttctcaaga aaggggcctt gtttcttagt gaccacaatg
     1681 gctggactgc tttgcatcat gcgtccatgg gtggctacac tcagaccatg aaggtcattc
     1741 ttgacactaa cttgaagtgc acagaccggc tagatgaaga agggaacaca gcacttcact
     1801 ttgcagcacg ggaaggccat gcaaaggctg ttgcgatgct tttgagctac aatgctgaca
     1861 tcctcctgaa caagaagcaa gcttcctttc tgcatattgc actgcacaat aagcgcaagg
     1921 aagtggttct cacaaccatc aggagtaaaa gatgggatga gtgtcttcaa gtttttactc
     1981 atgattctcc aagcaatcgc tgtccaatca tggaaatggt ggaatacctc cccgagtgca
     2041 tgaaagttct tctagatttc tgcatgatac cttccacaga agacaagtcc tgccaagact
     2101 accatattga gtataatttc aagtatctcc aatgcccatt atccatgacc aaaaaagtaa
     2161 cccccaccca ggatgtgatc tatgagcctc ttacaatcct caatgtcatg gtccaacata
     2221 accgcataga gctcctcaac caccctgtgt gtagggaata cttacttatg aaatggtgtg
     2281 cctatggctt cagagctcat atgatgaacc taggatctta ttgtcttggt ctcataccca
     2341 tgacccttct tgttgtcaaa atacagcctg gaatggcctt caattctact ggaataatca
     2401 atgaaactat tagtactcat gaggaaagaa taaacactct gaattcgttt ccattaaaaa
     2461 tatgtatgat tctagttttt ttatcaagta tatttggata ttgcaaagaa gtggtccaaa
     2521 ttttccaaca gaaaaggaac tactttctgg actacaacaa tgctctggag tgggtcatct
     2581 acaccaccag tatgatcttc gtgttgccct tattcctcga catccccgcg tatatgcagt
     2641 ggcaatgtgg agcgatagca atattcttct actggatgaa cttcctacta tatcttcaaa
     2701 ggtttgagaa ctgtggcatt ttcattgtta tgttggaggt gatttttaaa acattgctga
     2761 gatcgacggg agtgtttatc ttcctgctat tggcttttgg cctcagcttt tacgtcctcc
     2821 tgaatttcca agatgccttc agcaccccgt tgctttcctt aatccagacg ttcagtatga
     2881 tgctgggaga catcaattac cgagatgctt tcctagaacc gttgttcagg aatgagttgg
     2941 catacccggt cctcaccttt gggcagctta ttgccttcac aatgttcgtc ccaattgttc
     3001 tcatgaacct actgattggt ttggcagttg gggacattgc tgaggtccag aagcatgcat
     3061 cattaaagag gattgctatg caggtggaac tgcataccaa cttagaaaaa aagctgccat
     3121 tctggtactt gcgcaaagtg gatcagaggt ccaccatcgt gtatccgaat agacccaggc
     3181 acggcaggat gctgcggttt tttcattact ttcttagtat gcaagaaaca cgacaagaag
     3241 caccaaacat tgacacatgt ttggaaatgg aaatactgaa acagaaatac cggctgaagg
     3301 acctcacttc tcttttggaa aagcagcacg agctcatcaa actcatcatc caaaagatgg
     3361 agatcatctc ggagacagaa gatgaagata accattgctc tttccaagac aggttcaaaa
     3421 aggaacggct agaacaaatg catagcaaat ggaactttgt cttaaacgca gttaagacta
     3481 aaacacattg ttctattagc cacccagaca tctagtgggg tgtcttatgg gagtgggaga
     3541 ctgctttaat tacttcagtg aatttcagtt tggaaaagag caaagaaaca gaagtttgac
     3601 taatattgtt gcatgggaga ttctagtccc ttcaacctct cttatatata tgctcatatt
     3661 ttctgtcaat cactgtattg agaagatctt ttctgacatg tttaaattgg actttaatga
     3721 agggtaatct cttttgagtg aatagaaaac agtgttgttg gaatgcacat tatgaaggac
     3781 aagaattaat gtaactatta aggcgggata caaatgtcaa tactagattt ctacttaata
     3841 actacataat acaaaatgca tataatccca agtactgtat tcgatcccct atcttgtaaa
     3901 gcctaactgg gttagaacct gagagttaca ctgtaatctc tgttcctact atgattaact
     3961 cagtctcacc ctcctcatcc catcacatag ggccacattt tgagccatat aacggaagtc
     4021 ccagttacta gactgtgata agtatgaatg ttacaacaga tatttgttcc ctctgtattt
     4081 atagtcatca gttgggctgg tgtaaatgag aaatgttgcc cacaggctca tgcactgaaa
     4141 cgcttggtcc cagtagatgc tactgcctag ggaagccaca caacctcgct tgctccctcc
     4201 ttttgggtgt ggatagaaat gtgatcggtc agattcctgc tcctgctgct gtgccctttt
     4261 ctctattatg gactctttct gaaactgtaa gcaaaaatta agtgtttctt cctcaaattt
     4321 ctttttttgt gtggtactat atcatagcaa cagaaagtaa tttatatacc aatggtctta
     4381 ataaaggtta aaacatgtat ggtca
//
