LOCUS       NM_001024261            2330 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus tRNA nucleotidyl transferase 1 (Trnt1), mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_001024261
VERSION     NM_001024261.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2330)
  AUTHORS   Chakraborty,P.K., Schmitz-Abe,K., Kennedy,E.K., Mamady,H., Naas,T.,
            Durie,D., Campagna,D.R., Lau,A., Sendamarai,A.K., Wiseman,D.H.,
            May,A., Jolles,S., Connor,P., Powell,C., Heeney,M.M.,
            Giardina,P.J., Klaassen,R.J., Kannengiesser,C., Thuret,I.,
            Thompson,A.A., Marques,L., Hughes,S., Bonney,D.K., Bottomley,S.S.,
            Wynn,R.F., Laxer,R.M., Minniti,C.P., Moppett,J., Bordon,V.,
            Geraghty,M., Joyce,P.B., Markianos,K., Rudner,A.D., Holcik,M. and
            Fleming,M.D.
  TITLE     Mutations in TRNT1 cause congenital sideroblastic anemia with
            immunodeficiency, fevers, and developmental delay (SIFD)
  JOURNAL   Blood 124 (18), 2867-2871 (2014)
   PUBMED   25193871
REFERENCE   2  (bases 1 to 2330)
  AUTHORS   Nagaike,T., Suzuki,T., Tomari,Y., Takemoto-Hori,C., Negayama,F.,
            Watanabe,K. and Ueda,T.
  TITLE     Identification and characterization of mammalian mitochondrial tRNA
            nucleotidyltransferases
  JOURNAL   J Biol Chem 276 (43), 40041-40049 (2001)
   PUBMED   11504732
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            On Mar 26, 2021 this sequence version replaced NM_001024261.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC105612.1, SRR26360176.585469.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-170               JAXUCZ010000004.1  141246018-141246187
            171-344             JAXUCZ010000004.1  141246722-141246895
            345-538             JAXUCZ010000004.1  141250461-141250654
            539-677             JAXUCZ010000004.1  141251627-141251765
            678-804             JAXUCZ010000004.1  141253208-141253334
            805-998             JAXUCZ010000004.1  141255068-141255261
            999-1252            JAXUCZ010000004.1  141255899-141256152
            1253-1536           JAXUCZ010000004.1  141256292-141256575
            1537-2330           JAXUCZ010000004.1  141258907-141259700
FEATURES             Location/Qualifiers
     source          1..2330
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q41"
     gene            1..2330
                     /gene="Trnt1"
                     /note="tRNA nucleotidyl transferase 1"
                     /db_xref="GeneID:312616"
                     /db_xref="RGD:1308857"
     exon            1..170
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            171..344
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     CDS             197..1501
                     /gene="Trnt1"
                     /EC_number="2.7.7.72"
                     /note="tRNA-nucleotidyltransferase 1, mitochondrial; tRNA
                     nucleotidyl transferase, CCA-adding, 1"
                     /codon_start=1
                     /product="CCA tRNA nucleotidyltransferase 1,
                     mitochondrial"
                     /protein_id="NP_001019432.1"
                     /db_xref="GeneID:312616"
                     /db_xref="RGD:1308857"
                     /translation="MQSLLYPWHRQVLSCSWSRLCLLKRYLFTMKLQSPEFQSLFTEG
                     LKSLTELFAKENHELRIAGGAVRDLLNGVKPQDVDFATTATPTEMKEMFQAAGIRMIN
                     NKGEKHGTITARLHEENFEVTTLRIDVSTDGRHAEVEFTTDWQKDAERRDLTINSMFL
                     GFDGTLFDYFNGYADLKNKKVRFVGHAKQRIQEDYLRILRYFRFYGRIVDKPGDHDRE
                     TLEAIAENAKGLAGISGERIWVELKKILTGDHVNHLIHLIYDLDVASHIGLPANANLE
                     EFNKVSKNVEGFSPKPMTVLASLFKVQDDVTKLDLRLKISKEEKNLGLFIVKNRKDLI
                     KATDSSEPLKPYQDFVIDSREPDATARVCELLKYQGEHALLKEMQQWSVPPFPVSGHD
                     IRKVGISSGKEIGALLQQLREQWKKSGYQMEKDELLSYIKKT"
     exon            345..538
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            539..677
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            678..804
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..998
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            999..1252
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1253..1536
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..2330
                     /gene="Trnt1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactgtgccg cgacccggaa gtgcgcgtgc ggccgggaca gcggacgggt aagcctgtcc
       61 tcagaatagg aacgccacgt ttctaaggca cctttcgacc ccgctgtgca gcgtgcgtcc
      121 taacgcgccc ttgggagatg gcgggaggtg gaggctgctc cccaatctag atgtgtggtt
      181 ggtgatttgt ctcccgatgc agagcctctt gtacccttgg cacaggcagg tcctgagctg
      241 tagttggagt agattgtgcc ttctaaagcg atacctattt acaatgaagt tgcagtctcc
      301 agaattccag tcacttttca cagaaggatt gaagagcctg acagaattat ttgccaaaga
      361 gaatcatgaa ttaagaatag caggaggggc ggtgagagat ttactaaatg gggtgaagcc
      421 tcaggatgtg gatttcgcca ccactgccac ccctactgag atgaaggaga tgttccaggc
      481 ggctggcatt cgcatgataa acaacaaagg cgagaagcat gggaccatca ctgccaggct
      541 tcatgaagaa aattttgagg ttactacact ccggattgat gttagcactg acggaagaca
      601 tgcggaggta gagttcacaa ctgactggca gaaggatgcc gaacgaagag acctcactat
      661 aaactccatg tttctaggtt ttgatggtac actgtttgat tactttaatg gttatgcaga
      721 tttaaagaat aaaaaggttc gatttgttgg acacgctaag cagagaattc aggaagatta
      781 tcttcgaatt ttaaggtatt tcagatttta tggcagaatt gtcgacaaac ccggtgacca
      841 tgaccgtgag actctagaag caattgcaga aaatgccaaa ggcttggctg gaatatcagg
      901 agagaggatt tgggtagaac tgaagaaaat tcttactggt gaccatgtaa accatttgat
      961 ccacctgatc tatgatcttg atgtggcttc tcacataggt ttacctgcta atgcaaattt
     1021 agaagaattt aacaaagtca gtaaaaatgt tgaaggcttt tcaccgaaac caatgactgt
     1081 tttggcctct ttattcaaag tacaagatga tgtcacaaaa ctggatttga gattgaaaat
     1141 ttcaaaagag gagaaaaatc tgggtttatt tatagttaaa aacaggaaag atttgattaa
     1201 agcaacagat agttcagaac cattgaaacc atatcaagac tttgttatag attctaggga
     1261 accggatgca actgcccgtg tttgtgagct gctgaagtac caaggagagc atgctcttct
     1321 caaggagatg cagcagtggt ctgtgccgcc attccctgtg agtggacacg acatcagaaa
     1381 agtgggcatt tcttcaggga aggaaattgg ggccctgtta cagcagttgc gtgaacagtg
     1441 gaagaaaagt ggttaccaaa tggaaaaaga tgaactacta agttacataa agaagacata
     1501 aaaaacgagc tccgtataaa acagtgggaa gtcttgacgc ttcgtttaac actaaatgaa
     1561 gagtcaacaa aaaaagtaaa cagccgtatt acccgggaaa ccagctgtgc actgtagaag
     1621 gccggcctat cagattcagg ttggaagctt tatacacagt cagtgtctca tgtacatatc
     1681 catggggatt cacatatgct gccattggac cacataagga taagctacaa acaaagaaac
     1741 aatgtggaga ataagacaaa agaaaaatag taattccaga tttttactta tttgggatat
     1801 aagttatact ttttaacctt tgaattttag gtattataca gtactttgtg caaaatgtaa
     1861 gaccagtaca ggaggttggc agatattctg ttggcttgca aatgttcttt gatgattcaa
     1921 agggaaatat tctagtgttt atgaagccta gtgaggtcac gtttttatct ttggacaatt
     1981 agctactttc cccagatgtc agtttcctta actaagtgtt atgtttaaca gcattggcac
     2041 aagttcgaga cccactcaat tttggtcctg tgtgaattgt tatgtgaatt gaagcattca
     2101 cgtttgcttg aagatggcta tctctaaata taaattgagg ggaaatgtta tatagacatt
     2161 agagatgttt ccaggctgga aggtggcctc cctgtgttta tgtgctttac tgaggatatt
     2221 acatcctcac tggaggaaat atggaaagtg gaaccacaga ttctgaaagg gaagatggag
     2281 atatattgag acagattaaa atgcaataaa gatcttacct aaatatttca
//
