LOCUS       NM_023027               1075 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus tRNA selenocysteine 1 associated protein 1
            (Trnau1ap), transcript variant 1, mRNA.
ACCESSION   NM_023027
VERSION     NM_023027.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1075)
  AUTHORS   Li,M.D., Cheng,W.P., Shi,M.X., Ge,T.D., Zheng,X.L., Wu,D.Y.,
            Hu,X.Y., Luo,J.C., Li,F.L. and Li,H.
  TITLE     Role of tRNA selenocysteine 1 associated protein 1 in the
            proliferation and apoptosis of cardiomyocyte-like H9c2 cells
  JOURNAL   Mol Med Rep 15 (2), 988-994 (2017)
   PUBMED   28101579
  REMARK    GeneRIF: Downregulation of Trnau1ap inhibits the proliferation of
            cardiomyocytelike H9c2 cells. Downregulation of Trnau1ap induces
            apoptosis.
REFERENCE   2  (bases 1 to 1075)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   3  (bases 1 to 1075)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   4  (bases 1 to 1075)
  AUTHORS   Xu,X.M., Mix,H., Carlson,B.A., Grabowski,P.J., Gladyshev,V.N.,
            Berry,M.J. and Hatfield,D.L.
  TITLE     Evidence for direct roles of two additional factors, SECp43 and
            soluble liver antigen, in the selenoprotein synthesis machinery
  JOURNAL   J Biol Chem 280 (50), 41568-41575 (2005)
   PUBMED   16230358
REFERENCE   5  (bases 1 to 1075)
  AUTHORS   Ding,F. and Grabowski,P.J.
  TITLE     Identification of a protein component of a mammalian tRNA(Sec)
            complex implicated in the decoding of UGA as selenocysteine
  JOURNAL   RNA 5 (12), 1561-1569 (1999)
   PUBMED   10606267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Aug 31, 2022 this sequence version replaced NM_023027.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF181856.1, SRR22399492.1861447.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-149               JAXUCZ010000005.1  149807972-149808120 c
            150-247             JAXUCZ010000005.1  149807066-149807163 c
            248-347             JAXUCZ010000005.1  149804527-149804626 c
            348-400             JAXUCZ010000005.1  149803804-149803856 c
            401-532             JAXUCZ010000005.1  149800555-149800686 c
            533-652             JAXUCZ010000005.1  149798579-149798698 c
            653-815             JAXUCZ010000005.1  149793899-149794061 c
            816-849             JAXUCZ010000005.1  149793683-149793716 c
            850-1075            JAXUCZ010000005.1  149791631-149791856 c
FEATURES             Location/Qualifiers
     source          1..1075
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1075
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /note="tRNA selenocysteine 1 associated protein 1"
                     /db_xref="GeneID:65241"
                     /db_xref="RGD:619995"
     exon            1..149
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..986
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     selenocysteine-associated protein 1; tRNA selenocysteine
                     associated protein; tRNA selenocysteine 1-associated
                     protein 1-like"
                     /codon_start=1
                     /product="tRNA selenocysteine 1-associated protein 1
                     isoform 1"
                     /protein_id="NP_075416.1"
                     /db_xref="GeneID:65241"
                     /db_xref="RGD:619995"
                     /translation="MAASLWMGDLEPYMDENFISRAFATMGETVMSVKIIRNRLTGIP
                     AGYCFVEFADLATAEKCLHKINGKPLPGATPAKRFKLNYATYGKQPDNSPEYSLFVGD
                     LTPDVDDGMLYEFFVKVYPSCRGGKVVLDQTGVSKGYGFVKFTDELEQKRALTECQGA
                     VGLGCKPVRLSVAIPKASRVKPVEYSQMYSYSYNQYYQQYQNYYAQWGYDQNTGSYSY
                     SYPQYGYTQSTMQTYEEVGDDALEDPAPQLDVTEANKEFMEQSEELYDALMDCHWQPL
                     DTVSSEIPAMM"
     exon            150..247
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            248..347
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            348..400
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..532
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            533..652
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            653..815
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            816..849
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
     exon            850..1075
                     /gene="Trnau1ap"
                     /gene_synonym="Secp43; Trspap1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggatcggcgc gtctggccgc cgaggcagcg tgtacgcagg aggtgcctca ggcgcgggct
       61 cggctgcgca ggctggcgcg gttgcgggcc acaggcccgc acggtccccg accgggtgcg
      121 ggatggcggc cagcctctgg atgggagacc tggaacccta catggatgag aacttcatct
      181 ctagagcctt tgccaccatg ggggagaccg tgatgagtgt caaaattatc cgaaaccgcc
      241 tcactggaat cccagctggc tactgctttg tggaattcgc agacttggcc acagccgaga
      301 agtgtttgca taaaattaat gggaaacccc ttccgggagc cacacctgca aaacgtttta
      361 aactgaatta tgccacttac gggaaacagc cagacaacag ccctgagtac tccctgtttg
      421 tgggggacct gaccccagac gtggacgatg gcatgctgta tgagttcttt gtcaaagtct
      481 acccctcctg ccggggaggc aaggtggttt tggaccagac aggcgtgtct aagggctatg
      541 gctttgtgaa attcacagat gagttggagc agaagcgagc cttgacggag tgccagggag
      601 cagtgggact ggggtgcaag cctgtgcggc tgagtgtggc catccccaaa gcgagccgtg
      661 taaagccagt tgagtacagc cagatgtaca gttacagcta caaccagtat taccagcagt
      721 accagaacta ctatgcccag tggggctatg accagaacac tggcagctac agctacagct
      781 accctcagta tggctatacc cagagcacca tgcagacata tgaagaggtt ggggatgatg
      841 cactggaaga ccctgcgcca cagctggatg tgactgaggc caacaaggag ttcatggaac
      901 agagtgagga actgtacgat gcactgatgg actgtcactg gcagcccctg gataccgtgt
      961 catcagagat ccccgccatg atgtagccag gacagagcac agatgctttt tattgtgaat
     1021 cttttatctt tttgaaagtg atgtataatg ttttaataaa ttaccatttc ctgaa
//
