LOCUS       NM_001396073            1706 bp    mRNA    linear   ROD 22-SEP-2024
DEFINITION  Rattus norvegicus tRNA methyltransferase 5 (Trmt5), transcript
            variant 1, mRNA.
ACCESSION   NM_001396073 XM_006240213
VERSION     NM_001396073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Powell,C.A., Kopajtich,R., D'Souza,A.R., Rorbach,J., Kremer,L.S.,
            Husain,R.A., Dallabona,C., Donnini,C., Alston,C.L., Griffin,H.,
            Pyle,A., Chinnery,P.F., Strom,T.M., Meitinger,T., Rodenburg,R.J.,
            Schottmann,G., Schuelke,M., Romain,N., Haller,R.G., Ferrero,I.,
            Haack,T.B., Taylor,R.W., Prokisch,H. and Minczuk,M.
  TITLE     TRMT5 Mutations Cause a Defect in Post-transcriptional Modification
            of Mitochondrial tRNA Associated with Multiple Respiratory-Chain
            Deficiencies
  JOURNAL   Am J Hum Genet 97 (2), 319-328 (2015)
   PUBMED   26189817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 28, 2021 this sequence version replaced XM_006240213.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1272312.1,
                                           SRR26360181.464299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                JAXUCZ010000006.1  97723347-97723399   c
            54-691              JAXUCZ010000006.1  97721231-97721868   c
            692-816             JAXUCZ010000006.1  97718936-97719060   c
            817-1468            JAXUCZ010000006.1  97717332-97717983   c
            1469-1706           JAXUCZ010000006.1  97716731-97716968   c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     gene            1..1706
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /note="tRNA methyltransferase 5"
                     /db_xref="GeneID:362754"
                     /db_xref="RGD:1306567"
     exon            1..53
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1551
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /EC_number="2.1.1.31"
                     /note="isoform 1 is encoded by transcript variant 1; tRNA
                     (guanine-N(1)-)-methyltransferase; TRM5 tRNA
                     methyltransferase 5 homolog; tRNA
                     (guanine(37)-N1)-methyltransferase"
                     /codon_start=1
                     /product="tRNA (guanine(37)-N1)-methyltransferase isoform
                     1"
                     /protein_id="NP_001383002.1"
                     /db_xref="GeneID:362754"
                     /db_xref="RGD:1306567"
                     /translation="MRILLKPFGFSRLLQAEWCYLSESILLFTLVPRLRKASTNFLLG
                     QRQGFSTMPEAEASVRDRELFSPPSDVRGMTKLDRTAFKKTVPIPVLKARKEVVSRLM
                     RALRRVALQRPGIKRVIEDPKDEDSRLIMLDPYRMLTSDSFEKPELSALKELDVNPQL
                     SQYNLELTYENFKSEEILRAVLPEGQDVTSGFSRVGHIAHLNLRDHQLPFKHLIGQVM
                     VDKNPGITSAVNKTSNIDNTYRNFQMEVLCGEENMLTKVRENNYTYEFDFSKVYWNPR
                     LSTEHGRITELLNPGDVLFDVFAGVGPFAIPAARKNCTVFANDLNPESHRWLLHNCKL
                     NKVDQKVKVFNMDGKDFLQGPVREELMLRLGLSTEGKPSLHIVMNLPAKAIEFLSVFR
                     SLLDGQPCSTERLPIVHCYCFSKDSDPAKDARQRAEAVLGVCLEASSSVHLVRNVAPN
                     KEMLCITFQIPTATLYRDQALGLQNDQEPPLKRQKTGEPFSGEPQSASDS"
     exon            54..691
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /inference="alignment:Splign:2.1.0"
     exon            692..816
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /inference="alignment:Splign:2.1.0"
     exon            817..1468
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1706
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gatgacgtca ccatccgcag aagacccatt tccgagctgc accagagcat gagaatctta
       61 ctgaagccat ttggattctc aagacttctg caagccgaat ggtgttacct cagtgaatca
      121 atattgttgt ttacactggt accgagactt aggaaagcat ctactaattt cttattgggt
      181 caaagacaag ggttctcaac catgccagaa gcggaagcaa gcgtgagaga tagggagttg
      241 ttttcaccac cctctgatgt tcgaggaatg acaaaacttg atagaacagc ttttaaaaag
      301 acagtgccca tccccgtgct taaggcgagg aaagaagtag tcagcagatt gatgcgagcc
      361 ctcaggagag tagcgctgca gcgcccgggc ataaagcgag tgattgagga ccccaaggat
      421 gaagacagta ggctgatcat gttggatccc tacagaatgc ttaccagtga ttcctttgag
      481 aaaccagaac tcagtgcttt aaaagaactt gatgtcaacc cacagttatc acagtacaac
      541 ttggaactca catatgaaaa ttttaagtca gaagaaattt tgagagctgt gcttcctgag
      601 ggtcaagatg tgacctctgg attcagcaga gttggacata ttgcacacct gaatctccga
      661 gatcatcagc tgccgttcaa gcatttaatt ggccaagtta tggttgacaa aaacccagga
      721 atcacctcag cagtaaataa aaccagcaac attgacaata cttatcgaaa tttccaaatg
      781 gaagtgctgt gtggagagga gaatatgctg accaaggttc gagaaaacaa ctacacatat
      841 gagtttgatt tctccaaagt ctactggaat cctcgtctct ctaccgaaca tggccggatc
      901 actgaacttc tcaaccctgg agatgtcttg ttcgatgttt ttgctggggt cgggcccttt
      961 gccattccgg cagcaaggaa aaactgcaca gtgtttgcca acgatctcaa ccccgagtcc
     1021 cacagatggc tgctgcacaa ctgtaagctg aataaagttg accagaaagt aaaagtcttt
     1081 aacatggatg gaaaagactt cctccaaggg ccagtgagag aagagttaat gcttcggcta
     1141 ggactgtcaa ctgaaggaaa gccctctctc cacattgtca tgaacttgcc agctaaggcc
     1201 atcgagtttc tcagtgtttt cagatccctt ttggatgggc agccgtgcag cacagagcgc
     1261 ctacccatag tgcactgtta ctgcttctcc aaagatagcg accctgctaa ggatgctcgc
     1321 cagcgggcag aagctgtgct gggcgtttgt ttggaggcca gtagttcagt tcacctcgta
     1381 aggaacgtgg cccctaacaa ggagatgctg tgcatcacct tccagattcc cactgctaca
     1441 ctctacaggg accaagccct cggtctacag aatgaccaag agccgcctct taaacggcag
     1501 aagacaggtg agcccttctc aggagagccc cagagcgcat cagattctta gtgtgaaatg
     1561 ttttctctgg tctcccggaa gattttatgt aaagaagtac agcgtgtaag ataccgtaaa
     1621 ctttaatgct cagatatttg tttttaagcc cttaagattt gctcctataa atgaaatgtt
     1681 accaaagtaa actgaagtaa gatgaa
//
