LOCUS       NP_001383002             500 aa            linear   ROD 22-SEP-2024
DEFINITION  tRNA (guanine(37)-N1)-methyltransferase isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001383002 XP_006240275
VERSION     NP_001383002.1
DBSOURCE    REFSEQ: accession NM_001396073.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 500)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (residues 1 to 500)
  AUTHORS   Powell,C.A., Kopajtich,R., D'Souza,A.R., Rorbach,J., Kremer,L.S.,
            Husain,R.A., Dallabona,C., Donnini,C., Alston,C.L., Griffin,H.,
            Pyle,A., Chinnery,P.F., Strom,T.M., Meitinger,T., Rodenburg,R.J.,
            Schottmann,G., Schuelke,M., Romain,N., Haller,R.G., Ferrero,I.,
            Haack,T.B., Taylor,R.W., Prokisch,H. and Minczuk,M.
  TITLE     TRMT5 Mutations Cause a Defect in Post-transcriptional Modification
            of Mitochondrial tRNA Associated with Multiple Respiratory-Chain
            Deficiencies
  JOURNAL   Am J Hum Genet 97 (2), 319-328 (2015)
   PUBMED   26189817
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Sep 28, 2021 this sequence version replaced XP_006240275.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360190.1272312.1,
                                           SRR26360181.464299.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..500
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q24"
     Protein         1..500
                     /product="tRNA (guanine(37)-N1)-methyltransferase isoform
                     1"
                     /EC_number="2.1.1.31"
                     /note="tRNA (guanine-N(1)-)-methyltransferase; TRM5 tRNA
                     methyltransferase 5 homolog; tRNA
                     (guanine(37)-N1)-methyltransferase"
                     /calculated_mol_wt=56608
     Region          191..411
                     /region_name="Met_10"
                     /note="Met-10+ like-protein; pfam02475"
                     /db_xref="CDD:396850"
     CDS             1..500
                     /gene="Trmt5"
                     /gene_synonym="RGD1306567"
                     /coded_by="NM_001396073.1:49..1551"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:362754"
                     /db_xref="RGD:1306567"
ORIGIN      
        1 mrillkpfgf srllqaewcy lsesillftl vprlrkastn fllgqrqgfs tmpeaeasvr
       61 drelfsppsd vrgmtkldrt afkktvpipv lkarkevvsr lmralrrval qrpgikrvie
      121 dpkdedsrli mldpyrmlts dsfekpelsa lkeldvnpql sqynleltye nfkseeilra
      181 vlpegqdvts gfsrvghiah lnlrdhqlpf khligqvmvd knpgitsavn ktsnidntyr
      241 nfqmevlcge enmltkvren nytyefdfsk vywnprlste hgritellnp gdvlfdvfag
      301 vgpfaipaar knctvfandl npeshrwllh ncklnkvdqk vkvfnmdgkd flqgpvreel
      361 mlrlglsteg kpslhivmnl pakaieflsv frslldgqpc sterlpivhc ycfskdsdpa
      421 kdarqraeav lgvcleasss vhlvrnvapn kemlcitfqi ptatlyrdqa lglqndqepp
      481 lkrqktgepf sgepqsasds
//
