LOCUS       NM_001106330             591 bp    mRNA    linear   ROD 05-APR-2023
DEFINITION  Rattus norvegicus tRNA methyltransferase activator subunit 11-2
            (Trmt112), mRNA.
ACCESSION   NM_001106330 XM_001072116 XM_215167
VERSION     NM_001106330.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 591)
  AUTHORS   van Tran N, Ernst FGM, Hawley BR, Zorbas C, Ulryck N, Hackert P,
            Bohnsack KE, Bohnsack MT, Jaffrey SR, Graille M and Lafontaine DLJ.
  TITLE     The human 18S rRNA m6A methyltransferase METTL5 is stabilized by
            TRMT112
  JOURNAL   Nucleic Acids Res 47 (15), 7719-7733 (2019)
   PUBMED   31328227
REFERENCE   2  (bases 1 to 591)
  AUTHORS   Metzger E, Wang S, Urban S, Willmann D, Schmidt A, Offermann A,
            Allen A, Sum M, Obier N, Cottard F, Ulferts S, Preca BT, Hermann B,
            Maurer J, Greschik H, Hornung V, Einsle O, Perner S, Imhof A, Jung
            M and Schule R.
  TITLE     KMT9 monomethylates histone H4 lysine 12 and controls proliferation
            of prostate cancer cells
  JOURNAL   Nat Struct Mol Biol 26 (5), 361-371 (2019)
   PUBMED   31061526
REFERENCE   3  (bases 1 to 591)
  AUTHORS   Kusevic D, Kudithipudi S and Jeltsch A.
  TITLE     Substrate Specificity of the HEMK2 Protein Glutamine
            Methyltransferase and Identification of Novel Substrates
  JOURNAL   J Biol Chem 291 (12), 6124-6133 (2016)
   PUBMED   26797129
REFERENCE   4  (bases 1 to 591)
  AUTHORS   Zorbas C, Nicolas E, Wacheul L, Huvelle E, Heurgue-Hamard V and
            Lafontaine DL.
  TITLE     The human 18S rRNA base methyltransferases DIMT1L and
            WBSCR22-TRMT112 but not rRNA modification are required for ribosome
            biogenesis
  JOURNAL   Mol Biol Cell 26 (11), 2080-2095 (2015)
   PUBMED   25851604
REFERENCE   5  (bases 1 to 591)
  AUTHORS   Figaro S, Scrima N, Buckingham RH and Heurgue-Hamard V.
  TITLE     HemK2 protein, encoded on human chromosome 21, methylates
            translation termination factor eRF1
  JOURNAL   FEBS Lett 582 (16), 2352-2356 (2008)
   PUBMED   18539146
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV720088.1 and BP485075.1.
            
            On Oct 12, 2007 this sequence version replaced NM_001106330.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ213514.1, BC166890.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-479               DV720088.1         194-672
            480-591             BP485075.1         483-594
FEATURES             Location/Qualifiers
     source          1..591
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q43"
     gene            1..591
                     /gene="Trmt112"
                     /gene_synonym="RGD1309710"
                     /note="tRNA methyltransferase activator subunit 11-2"
                     /db_xref="GeneID:293700"
                     /db_xref="RGD:1309710"
     exon            1..105
                     /gene="Trmt112"
                     /gene_synonym="RGD1309710"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..405
                     /gene="Trmt112"
                     /gene_synonym="RGD1309710"
                     /note="tRNA methyltransferase 112 homolog; tRNA
                     methyltransferase subunit 11-2"
                     /codon_start=1
                     /product="multifunctional methyltransferase subunit
                     TRM112-like protein"
                     /protein_id="NP_001099800.1"
                     /db_xref="GeneID:293700"
                     /db_xref="RGD:1309710"
                     /translation="MKLLTHNLLSSHVRGVGTRGFPLRLQATEVRINPVEFNPDFVAR
                     MIPKVEWAALVQAADTLNLAEVPKEPTEGYEHDETFLRKMHHVLLEVDVLEGTLQCPE
                     SGRLFPISRGIPNMLLNDEETET"
     exon            106..207
                     /gene="Trmt112"
                     /gene_synonym="RGD1309710"
                     /inference="alignment:Splign:2.1.0"
     exon            208..297
                     /gene="Trmt112"
                     /gene_synonym="RGD1309710"
                     /inference="alignment:Splign:2.1.0"
     exon            298..576
                     /gene="Trmt112"
                     /gene_synonym="RGD1309710"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggcctccgg agctccggtg cgacaacatg aaactgctca cccacaatct cctcagctcg
       61 catgtgcggg gcgtgggcac gcgtggcttc ccgctgcgcc tgcaggccac cgaggtccgc
      121 atcaaccctg tggagttcaa ccccgacttc gtggcgcgga tgatccccaa agtggagtgg
      181 gcggcgcttg tgcaggcagc ggacacctta aacttggccg aggtacccaa agagccgact
      241 gaaggctatg agcacgatga gacgtttttg aggaagatgc accatgtgtt gcttgaggtt
      301 gatgtgctgg agggcaccct gcaatgccca gaatctggtc gtcttttccc catcagccgc
      361 gggatcccca atatgctgtt gaatgatgag gaaaccgaga cgtaaccttg ttagccacat
      421 ctttggtgtt tcgtgactgt gtgtgttatc tgttgtatgg tctgttaact agatgtgtcg
      481 tgcgtgaccc cccaaattcc cccaatgatt caccaaccac cgtgtacttg agctccatag
      541 tatatttttt ttctcattaa aggttcaaaa ccaaaaaaaa aaaaaaaaaa a
//
