LOCUS       NM_001008337            2651 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 10C, mitochondrial RNase P
            subunit (Trmt10c), mRNA.
ACCESSION   NM_001008337 XM_221564
VERSION     NM_001008337.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2651)
  AUTHORS   Oerum,S., Roovers,M., Rambo,R.P., Kopec,J., Bailey,H.J.,
            Fitzpatrick,F., Newman,J.A., Newman,W.G., Amberger,A., Zschocke,J.,
            Droogmans,L., Oppermann,U. and Yue,W.W.
  TITLE     Structural insight into the human mitochondrial tRNA purine
            N1-methyltransferase and ribonuclease P complexes
  JOURNAL   J Biol Chem 293 (33), 12862-12876 (2018)
   PUBMED   29880640
REFERENCE   2  (bases 1 to 2651)
  AUTHORS   Reinhard,L., Sridhara,S. and Hallberg,B.M.
  TITLE     The MRPP1/MRPP2 complex is a tRNA-maturation platform in human
            mitochondria
  JOURNAL   Nucleic Acids Res 45 (21), 12469-12480 (2017)
   PUBMED   29040705
REFERENCE   3  (bases 1 to 2651)
  AUTHORS   Safra,M., Sas-Chen,A., Nir,R., Winkler,R., Nachshon,A.,
            Bar-Yaacov,D., Erlacher,M., Rossmanith,W., Stern-Ginossar,N. and
            Schwartz,S.
  TITLE     The m1A landscape on cytosolic and mitochondrial mRNA at
            single-base resolution
  JOURNAL   Nature 551 (7679), 251-255 (2017)
   PUBMED   29072297
REFERENCE   4  (bases 1 to 2651)
  AUTHORS   Metodiev,M.D., Thompson,K., Alston,C.L., Morris,A.A.M., He,L.,
            Assouline,Z., Rio,M., Bahi-Buisson,N., Pyle,A., Griffin,H.,
            Siira,S., Filipovska,A., Munnich,A., Chinnery,P.F., McFarland,R.,
            Rotig,A. and Taylor,R.W.
  TITLE     Recessive Mutations in TRMT10C Cause Defects in Mitochondrial RNA
            Processing and Multiple Respiratory Chain Deficiencies
  JOURNAL   Am J Hum Genet 98 (5), 993-1000 (2016)
   PUBMED   27132592
  REMARK    Erratum:[Am J Hum Genet. 2016 Jul 7;99(1):246. doi:
            10.1016/j.ajhg.2016.06.013.. PMID: 27392079]
REFERENCE   5  (bases 1 to 2651)
  AUTHORS   Bogenhagen,D.F., Martin,D.W. and Koller,A.
  TITLE     Initial steps in RNA processing and ribosome assembly occur at
            mitochondrial DNA nucleoids
  JOURNAL   Cell Metab 19 (4), 618-629 (2014)
   PUBMED   24703694
REFERENCE   6  (bases 1 to 2651)
  AUTHORS   Vilardo,E., Nachbagauer,C., Buzet,A., Taschner,A., Holzmann,J. and
            Rossmanith,W.
  TITLE     A subcomplex of human mitochondrial RNase P is a bifunctional
            methyltransferase--extensive moonlighting in mitochondrial tRNA
            biogenesis
  JOURNAL   Nucleic Acids Res 40 (22), 11583-11593 (2012)
   PUBMED   23042678
  REMARK    Erratum:[Nucleic Acids Res. 2018 Nov 16;46(20):11126-11127. doi:
            10.1093/nar/gky931.. PMID: 30295808]
REFERENCE   7  (bases 1 to 2651)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   8  (bases 1 to 2651)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   9  (bases 1 to 2651)
  AUTHORS   Brzezniak,L.K., Bijata,M., Szczesny,R.J. and Stepien,P.P.
  TITLE     Involvement of human ELAC2 gene product in 3' end processing of
            mitochondrial tRNAs
  JOURNAL   RNA Biol 8 (4), 616-626 (2011)
   PUBMED   21593607
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC085895.1.
            
            On Dec 16, 2004 this sequence version replaced XM_221564.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC085895.1, CK603493.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2651
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="11"
                     /map="11q12"
     gene            1..2651
                     /gene="Trmt10c"
                     /gene_synonym="Rg9mtd1"
                     /note="tRNA methyltransferase 10C, mitochondrial RNase P
                     subunit"
                     /db_xref="GeneID:304012"
                     /db_xref="RGD:1306333"
     exon            1..47
                     /gene="Trmt10c"
                     /gene_synonym="Rg9mtd1"
                     /inference="alignment:Splign:2.1.0"
     exon            48..2623
                     /gene="Trmt10c"
                     /gene_synonym="Rg9mtd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             69..1313
                     /gene="Trmt10c"
                     /gene_synonym="Rg9mtd1"
                     /EC_number="2.1.1.218"
                     /EC_number="2.1.1.221"
                     /note="mitochondrial ribonuclease P protein 1;
                     mitochondrial RNase P protein 1; RNA
                     (guanine-9-)-methyltransferase domain-containing protein
                     1; RNA (guanine-9-) methyltransferase domain containing 1;
                     tRNA (adenine(9)-N(1))-methyltransferase; tRNA
                     (guanine(9)-N(1))-methyltransferase; mRNA
                     methyladenosine-N(1)-methyltransferase"
                     /codon_start=1
                     /product="tRNA methyltransferase 10 homolog C precursor"
                     /protein_id="NP_001008338.1"
                     /db_xref="GeneID:304012"
                     /db_xref="RGD:1306333"
                     /translation="MNVTVRFLRPFARYLVPYTFHRTRSNSYSRVLQRYVSSKVPSLP
                     CHNKDSTSPPEQLELDGWKTTMKSSIQENGVSVVSDKDEDSLAATRELIEMWRLLGKE
                     VPEHITEEELKTLMECASKSAKKKYLRYLYGKEMMKKAKQMKKEMKAAAREEAKRARS
                     LEPSTGEEQRDFMFLRLWDRQTNIALGWKGVQAMQFGQPLVFDMAYDNYMKPSELQNT
                     VSQLLESEGWNRRNVDPFHIYFCNLEVDGAYHRELVKRYGEKWDKLLLTATEKSPVDL
                     FPKDSIIYLTADSPNVMTTFKHDKIYIIGSFVDKNTQTGTSLAKAKRQNLATECLPLD
                     KYLQWDVGNKNLTLDQMIRILLCLKNTGNWEEALKFVPRRKHTGYLEVPEHSQAAFRK
                     LKKTKTLNSFRKGSLNVHMWKR"
ORIGIN      
        1 ccgaagccgc gataaccaaa accgtctcca gtatcgcgct ttaaagtggt tcctcacatt
       61 tcttcaaaat gaatgtgact gttcgtttct taagaccttt tgccagatat ctggtgccat
      121 ataccttcca taggacaaga agtaattcat attcaagagt tctgcagaga tatgtgtctt
      181 ccaaagtacc ttctttgccc tgtcataata aggacagtac atcccctcct gagcagctag
      241 aattggatgg gtggaaaact acaatgaaat ctagcattca agaaaatggt gtttcagtgg
      301 tctccgacaa agatgaagac tctctggctg caaccagaga gctaattgag atgtggagat
      361 tgcttggcaa agaagtacca gaacacatca ctgaagagga gctcaaaacc cttatggaat
      421 gtgcttctaa gtcagccaaa aagaaatact taaggtattt gtatggtaag gaaatgatga
      481 aaaaagctaa gcaaatgaag aaggaaatga aagcagcagc cagggaagaa gcaaaaaggg
      541 ccaggtcact agagcccagc acgggagagg aacaacggga cttcatgttt ctccgactct
      601 gggaccgaca gaccaacatc gcactgggat ggaagggtgt ccaggccatg cagtttggac
      661 agcctttggt ttttgacatg gcttatgata attacatgaa accaagtgaa ctgcagaata
      721 cagtttctca acttttagaa agtgaaggct ggaacagaag gaatgttgat cctttccaca
      781 tttatttctg caatcttgag gtagatggtg cttaccatag agagctagtt aaacggtatg
      841 gagaaaaatg ggacaagttg ctcttaacag ccacagaaaa gtctcctgtc gatttatttc
      901 caaaggacag tattatatat ttaactgcag attctcccaa tgttatgact accttcaagc
      961 atgataaaat ttatataatt ggatcatttg ttgataaaaa tacacagaca ggaacatcct
     1021 tagccaaggc taaacggcaa aatctagcaa cagaatgcct tccactagat aaatatttac
     1081 aatgggatgt tggtaacaaa aacctcacct tagatcaaat gattcgaatt ctgctctgcc
     1141 tgaaaaacac tggtaactgg gaagaggctc tcaagtttgt tcccaggaga aagcacactg
     1201 gctatttaga ggttcctgag cattcgcagg cagcttttag gaaactgaag aagacaaaga
     1261 ctttaaattc gtttcgaaag ggctccttaa atgtacacat gtggaaaagg tgacctaagt
     1321 gagaaagtaa taagcaggct ggaagtacgg ttaaaagaat gtatttcttt cgagactgac
     1381 agtagaggtt tgcctttttg ttgtttgctt ttttgagaca ggatttctct gtagcctgta
     1441 ctgcaacaag gccagactag gtgtaggtat cagcaaaagt ttggaagttt gttgttttat
     1501 ttgttgtaaa aactatcaga agtttataga ttaatctaga attgaacaca ataaaagtta
     1561 ctagcatttt tttaaatcag tctttgaata tcagactttg ttgtcctgtt tggtttgagg
     1621 gttgatttgg tttttggttt tgttttgtgg gttttccttt gcggggaggg aaggcatgcc
     1681 tctggtagcc tatgccagct tcaaccctta ttctctactt ccccttccca aatgatagga
     1741 tcacaggcat gtgtcaccat ggctggctcc gttacacatt ctctttatca atgttaggat
     1801 ctttttcatg agaaaatttg aagttgtgat tatgaaatta aagcctgtat acaacactgg
     1861 tcatgttaca ggcactaagt taagttatat tgcataacac aatcttggtt gtcaaaaaaa
     1921 ctgactttcc ttggcatgtt aggcagtttt ctaatactgt gaaagttgag tttggaggta
     1981 aaaccaacca attatttagg acagaaatgt atctggactg ggatgatgtc tcagtggtct
     2041 cttgcagaga acttaaattc tgttcccagc accactttgg gtagcttgca accacctgta
     2101 attctagttc cagtggatgt gacacccact ggcctctaag ggtacatgta cgaaatgtaa
     2161 acaactcagg taggcatata cccacatgaa tacaaatctg aaaaaaaaaa atacttggtt
     2221 agtacacagt acttattgta tggatagcat ttctgggaaa tactgtttct ccagccacga
     2281 ggttttaaaa catgtcttag aagttattga ttgaataaaa atgacgccca cagataggtc
     2341 cttggggatt ggcactgtta agtatggcct tgttggagta agtatggcct tgttggagta
     2401 cgtatggttt gttagaggaa gtacatcact aggaggttgg ctttgaagtt tcagatctca
     2461 agccacacaa tgtgactgtc tatttgtgga tccagatata gagctctcag ctccttcccc
     2521 agcactatat ctgcctgcat gccaacatgc ttcctgccat gacaataaca gactaaccct
     2581 ttgaaactgt aagccagccc caataaaatg ttttccttca taaaaaaaaa aaaaaaaaaa
     2641 aaaaaaaaaa a
//
