LOCUS       NM_001044232            1320 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus tRNA methyltransferase 10A (Trmt10a), mRNA.
ACCESSION   NM_001044232 XM_001076299 XM_215716
VERSION     NM_001044232.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1320)
  AUTHORS   Gillis,D., Krishnamohan,A., Yaacov,B., Shaag,A., Jackman,J.E. and
            Elpeleg,O.
  TITLE     TRMT10A dysfunction is associated with abnormalities in glucose
            homeostasis, short stature and microcephaly
  JOURNAL   J Med Genet 51 (9), 581-586 (2014)
   PUBMED   25053765
REFERENCE   2  (bases 1 to 1320)
  AUTHORS   Igoillo-Esteve,M., Genin,A., Lambert,N., Desir,J., Pirson,I.,
            Abdulkarim,B., Simonis,N., Drielsma,A., Marselli,L., Marchetti,P.,
            Vanderhaeghen,P., Eizirik,D.L., Wuyts,W., Julier,C., Chakera,A.J.,
            Ellard,S., Hattersley,A.T., Abramowicz,M. and Cnop,M.
  TITLE     tRNA methyltransferase homolog gene TRMT10A mutation in young onset
            diabetes and primary microcephaly in humans
  JOURNAL   PLoS Genet 9 (10), e1003888 (2013)
   PUBMED   24204302
REFERENCE   3  (bases 1 to 1320)
  AUTHORS   White,J.K., Gerdin,A.K., Karp,N.A., Ryder,E., Buljan,M.,
            Bussell,J.N., Salisbury,J., Clare,S., Ingham,N.J., Podrini,C.,
            Houghton,R., Estabel,J., Bottomley,J.R., Melvin,D.G., Sunter,D.,
            Adams,N.C., Tannahill,D., Logan,D.W., Macarthur,D.G., Flint,J.,
            Mahajan,V.B., Tsang,S.H., Smyth,I., Watt,F.M., Skarnes,W.C.,
            Dougan,G., Adams,D.J., Ramirez-Solis,R., Bradley,A. and Steel,K.P.
  CONSRTM   Sanger Institute Mouse Genetics Project
  TITLE     Genome-wide generation and systematic phenotyping of knockout mice
            reveals new roles for many genes
  JOURNAL   Cell 154 (2), 452-464 (2013)
   PUBMED   23870131
REFERENCE   4  (bases 1 to 1320)
  AUTHORS   Vilardo,E., Nachbagauer,C., Buzet,A., Taschner,A., Holzmann,J. and
            Rossmanith,W.
  TITLE     A subcomplex of human mitochondrial RNase P is a bifunctional
            methyltransferase--extensive moonlighting in mitochondrial tRNA
            biogenesis
  JOURNAL   Nucleic Acids Res 40 (22), 11583-11593 (2012)
   PUBMED   23042678
  REMARK    Erratum:[Nucleic Acids Res. 2018 Nov 16;46(20):11126-11127. doi:
            10.1093/nar/gky931.. PMID: 30295808]
REFERENCE   5  (bases 1 to 1320)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1320)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC099190.1.
            
            On or before Aug 24, 2006 this sequence version replaced
            XM_215716.3, XM_001076299.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC099190.1, FQ232089.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132263, SAMD00132265
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1320
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q43"
     gene            1..1320
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /note="tRNA methyltransferase 10A"
                     /db_xref="GeneID:295496"
                     /db_xref="RGD:1594565"
     exon            1..119
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            120..315
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1138
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /EC_number="2.1.1.221"
                     /note="RNA (guanine-9-)-methyltransferase
                     domain-containing protein 2; RNA (guanine-9-)
                     methyltransferase domain containing 2; tRNA
                     (guanine(9)-N(1))-methyltransferase TRMT10A"
                     /codon_start=1
                     /product="tRNA methyltransferase 10 homolog A"
                     /protein_id="NP_001037697.1"
                     /db_xref="GeneID:295496"
                     /db_xref="RGD:1594565"
                     /translation="MSSEVLPASIEPPNVEGKPGASDSEEERQKQRVDAEAQPISKRQ
                     LKKLMKQRLWEEQREQRKEKRKEKRKRKKLERRCQLESNSDGNDRKRIRRHVAPSNLR
                     LIIDCSFDDLMVLKDIKKLHKQIQRCYAENRRASHPVQFYLTSHGGQLKKNMDENDQG
                     WVNWKDIHIKSEHYSELIKKEDLVYLTSDSPNVLKDLDESKAYVIGGLVDHNHHKGLT
                     FKQASSYGIKHAQLPLAEFVKMNSRKVLAVNHVFEIILEFLETGDWQEAFFTILPPRK
                     GAVPAHKACESSPQDHQALPGGWDSAIEGEHGRDDPGSPHKEQQGQQSSSVSAVSPDP
                     Q"
     exon            316..478
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            479..550
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            551..625
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            626..775
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            776..881
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
     exon            882..1296
                     /gene="Trmt10a"
                     /gene_synonym="Rg9mtd2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ccaccgcctc tgcctctggg agttgaagtt tctgaaggag gactaacgcg tggagccgag
       61 agcatttcag aaaggctttc tgaccgcatc cctgctttcc ccatcgtccc cacggcttga
      121 gacaacaaat atgtcatctg aagtgttgcc agcatccatt gagcctccta atgtagaagg
      181 aaagccgggc gctagtgaca gtgaggagga gagacagaag cagagagtgg atgcagaggc
      241 ccagccaata tctaaacggc aactgaagaa gctgatgaaa cagagactat gggaagagca
      301 gcgggaacag cgcaaggaaa aacgaaaaga aaaacgcaag agaaagaaat tagaacgacg
      361 gtgtcagctg gagtccaact cagatggaaa cgacaggaaa cggatccgaa gacacgttgc
      421 tcctagcaac ctccgcctta tcatagactg cagctttgat gacttgatgg tgttaaagga
      481 tattaagaaa cttcacaaac agattcaacg atgttatgca gagaaccgcc gcgcatcaca
      541 tcccgttcag ttttacttga caagccatgg aggccaactg aagaagaaca tggatgagaa
      601 tgaccaagga tgggtcaact ggaaggatat tcacatcaag tccgagcact atagtgaact
      661 cataaaaaaa gaagacctgg tttatctgac gtcggactca cctaatgtat taaaggactt
      721 agatgagtca aaggcctatg tgattggagg gttagtggac cacaaccacc acaagggact
      781 cacgtttaag caagcatcca gttatggaat caagcatgca cagctccctc ttgcagagtt
      841 cgtgaagatg aacagtcgaa aagtcctggc ggttaaccac gtgtttgaga ttatcctgga
      901 gttcctggag acaggagact ggcaagaggc gttttttaca atcttacccc cacggaaagg
      961 agctgtcccc gcacacaagg cctgcgaaag ctctcctcag gaccaccagg ccctgccagg
     1021 aggatgggac agtgccatcg agggagagca tggcagagat gatcctggct ctccgcacaa
     1081 agagcagcag ggccagcaaa gcagctcggt ttctgcagtg agccctgacc cacagtaacc
     1141 ttcccctgtt ctcttgcttc agagaaacca gacagtgtgg tcggtgcttc ccagaatgct
     1201 cagactgcga gaaaactttc tctcgtctct gttgtggaat tttaaatctt tttaaagagt
     1261 taaatgataa cgaaaaaccc tttaagcact aagaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
