LOCUS       NM_001108676            2113 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tRNA isopentenyltransferase 1 (Trit1), mRNA.
ACCESSION   NM_001108676 XM_001054252 XM_342905
VERSION     NM_001108676.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2113)
  AUTHORS   Yarham,J.W., Lamichhane,T.N., Pyle,A., Mattijssen,S., Baruffini,E.,
            Bruni,F., Donnini,C., Vassilev,A., He,L., Blakely,E.L., Griffin,H.,
            Santibanez-Koref,M., Bindoff,L.A., Ferrero,I., Chinnery,P.F.,
            McFarland,R., Maraia,R.J. and Taylor,R.W.
  TITLE     Defective i6A37 modification of mitochondrial and cytosolic tRNAs
            results from pathogenic mutations in TRIT1 and its substrate tRNA
  JOURNAL   PLoS Genet 10 (6), e1004424 (2014)
   PUBMED   24901367
  REMARK    Publication Status: Online-Only
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473968.1.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001054252.1, XM_342905.3.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMD00132261, SAMD00132262
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2113
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..2113
                     /gene="Trit1"
                     /note="tRNA isopentenyltransferase 1"
                     /db_xref="GeneID:362586"
                     /db_xref="RGD:1304781"
     exon            1..187
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..1453
                     /gene="Trit1"
                     /EC_number="2.5.1.75"
                     /note="tRNA dimethylallyltransferase, mitochondrial"
                     /codon_start=1
                     /product="tRNA dimethylallyltransferase"
                     /protein_id="NP_001102146.1"
                     /db_xref="GeneID:362586"
                     /db_xref="RGD:1304781"
                     /translation="MAAAAAARAVPVSSGFRGLPRTLPLVVILGATGTGKSTLALQLG
                     QRLGGEIVSADSMQVYEGLDIITNKVSAQEQKMCRHHMISFVDPLVTSYTVVDFRNRA
                     TALISLRKLSTHPWRVPSGDIFARDKIPIVVGGTNYYIESLLWKVLVTTKPQGMGTGK
                     AVDRKVELEKEDGHELHKRLSQVDPEMAAKLHPHDKRKVARSLQVFEETGVSHSEFLH
                     RQHAEEGGGPLGGPLKFPNPCILWLHADQADERLDKRVDDMLAAGLLEELRDFHRRYN
                     LKNVSEDSQDYQHGIFQSIGFKEFHEYLTTEGKCTPETSNQLLKKGVEALKQVTKRYA
                     RKQNRWVRNRFLSRPGPSVPPVYGLEVSDVSKWEEFVLEPALSIVQSFIQGSKPTATP
                     VKIPYSETENKRSYHMCDLCDRIIIGDREWAAHTKSKSHLHQLKKRRKLDLDAVSALG
                     SQSNSPDSELERKEGESSGQRDQELKASV"
     exon            188..377
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            378..469
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..615
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            616..758
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            759..864
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..977
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1055
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1056..1165
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1283
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..2113
                     /gene="Trit1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agatgccttc aagatggcgg ctgcggctgc agcacgagcg gttcctgtga gctctggatt
       61 ccgaggcctg ccacgaacac tgccacttgt agtgattctc ggggctactg gcactggcaa
      121 gtccactctg gctcttcaat taggccagcg gctcggcggc gagatcgtca gcgccgactc
      181 catgcaggtc tatgaagggc tagacatcat caccaataag gtctctgccc aggagcagaa
      241 gatgtgccgg caccacatga tcagctttgt ggatccactc gtgaccagct acaccgtggt
      301 agactttagg aacagagcca ctgccctgat atccttaagg aaacttagca cccacccctg
      361 gagggttcct agtggtgata tttttgctcg agacaaaatt cctattgtgg tgggaggaac
      421 caattattac attgagtctc tgctctggaa agttcttgtg actaccaagc cccaggggat
      481 gggcactggg aaagcggttg atcggaaagt agaacttgaa aaggaagatg gtcatgaact
      541 ccataaacgg ctaagccagg tggatccaga aatggctgcc aagctacacc cacatgacaa
      601 acgcaaagtg gccaggagct tgcaagtgtt tgaagaaaca ggagtctctc acagtgaatt
      661 ccttcatcgt caacacgcag aggaaggcgg tggtcctctt ggaggccctc tcaagttccc
      721 taacccatgc atcctctggc ttcatgctga ccaggcagat gagcgcctgg ataagagagt
      781 ggacgacatg cttgctgccg gactcttgga agagctgaga gattttcaca gacgctataa
      841 tcttaagaac gtttcagaag atagccagga ctatcaacat ggtatcttcc agtcaattgg
      901 cttcaaggaa tttcacgagt acctgaccac tgaggggaaa tgcacaccag agactagtaa
      961 ccagcttcta aagaaagggg ttgaggctct gaaacaagta actaagagat atgcccggaa
     1021 acagaaccga tgggttagaa accgcttttt gagcagacct ggtcccagtg tccccccggt
     1081 atatggctta gaagtatctg atgtttccaa gtgggaggag tttgttctgg agcctgctct
     1141 cagtatagtc cagagtttca tccagggtag caaacctaca gccactccag tgaagatacc
     1201 atacagtgaa actgagaaca agagaagtta ccacatgtgt gacctttgtg accggatcat
     1261 cattggggac cgggaatggg cagcacatac aaaatccaaa tctcacttgc accaattgaa
     1321 gaaaagaaga aagttggact tggacgctgt cagtgcctta ggaagccaaa gtaattcacc
     1381 agacagtgag ctggaacgca aagaggggga atcctcagga cagcgtgatc aagagctaaa
     1441 ggccagtgtt tgagagacat gcccagtgac ctttgcagag atgtggggat cgagcccagg
     1501 agggagggga gtgtctctct tccacgcctg gactgaggaa cgctgggcag aaagccccac
     1561 catcttcttt cattctctgg catgatctgc acaggaaaca gcaggccttt cagctcctcg
     1621 tgtgcctgtt gtgtctggta atgatgtggc tcagggtagg attttttttt tttctttgaa
     1681 ccttaaaggt tttattttag aaagaggcac agattgcaca ttttctactt gaggatcttt
     1741 tttagtggtg aataccaaga ttcagtacat cctttaaaga gagttcttgt ccctggcact
     1801 ggctaaaaat agtctcattt ccagatgctt ttgtagatga ctgaagtatt gtaaggcaca
     1861 gtcaggagtt ctggacagga gaacggcagg aaggagtggc ccagagagat gagtaagcga
     1921 gctgccccag ctctgaatct gcagcagagg gggtcaggcc gaggtggctg tgacctggat
     1981 cgtgaaggct aatgaaagaa tctgtgtccc ttgagctgct cctgtgcatg gtggccgtcg
     2041 ttgctggcca tctagggcag acacaatcag attcctttga aatgtaaata aagatttgta
     2101 aaagccctgt agt
//
