LOCUS       NM_001031659            9642 bp    mRNA    linear   ROD 17-FEB-2024
DEFINITION  Rattus norvegicus thyroid hormone receptor interactor 12 (Trip12),
            mRNA.
ACCESSION   NM_001031659 XM_006245386 XM_237347
VERSION     NM_001031659.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 9642)
  AUTHORS   Kweon,S.M., Chen,Y., Moon,E., Kvederaviciute,K., Klimasauskas,S.
            and Feldman,D.E.
  TITLE     An Adversarial DNA N6-Methyladenine-Sensor Network Preserves
            Polycomb Silencing
  JOURNAL   Mol Cell 74 (6), 1138-1147 (2019)
   PUBMED   30982744
REFERENCE   2  (bases 1 to 9642)
  AUTHORS   Panier,S. and Durocher,D.
  TITLE     Push back to respond better: regulatory inhibition of the DNA
            double-strand break response
  JOURNAL   Nat Rev Mol Cell Biol 14 (10), 661-672 (2013)
   PUBMED   24002223
  REMARK    Review article
REFERENCE   3  (bases 1 to 9642)
  AUTHORS   Gudjonsson,T., Altmeyer,M., Savic,V., Toledo,L., Dinant,C.,
            Grofte,M., Bartkova,J., Poulsen,M., Oka,Y., Bekker-Jensen,S.,
            Mailand,N., Neumann,B., Heriche,J.K., Shearer,R., Saunders,D.,
            Bartek,J., Lukas,J. and Lukas,C.
  TITLE     TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at
            damaged chromosomes
  JOURNAL   Cell 150 (4), 697-709 (2012)
   PUBMED   22884692
  REMARK    Erratum:[Cell. 2014 Dec 4;159(6):1476-7]
REFERENCE   4  (bases 1 to 9642)
  AUTHORS   de Mateo,S., Castillo,J., Estanyol,J.M., Ballesca,J.L. and Oliva,R.
  TITLE     Proteomic characterization of the human sperm nucleus
  JOURNAL   Proteomics 11 (13), 2714-2726 (2011)
   PUBMED   21630459
REFERENCE   5  (bases 1 to 9642)
  AUTHORS   Kajiro,M., Tsuchiya,M., Kawabe,Y., Furumai,R., Iwasaki,N.,
            Hayashi,Y., Katano,M., Nakajima,Y., Goto,N., Watanabe,T.,
            Murayama,A., Oishi,H., Ema,M., Takahashi,S., Kishimoto,H. and
            Yanagisawa,J.
  TITLE     The E3 ubiquitin ligase activity of Trip12 is essential for mouse
            embryogenesis
  JOURNAL   PLoS One 6 (10), e25871 (2011)
   PUBMED   22028794
REFERENCE   6  (bases 1 to 9642)
  AUTHORS   Chen,D., Shan,J., Zhu,W.G., Qin,J. and Gu,W.
  TITLE     Transcription-independent ARF regulation in oncogenic
            stress-mediated p53 responses
  JOURNAL   Nature 464 (7288), 624-627 (2010)
   PUBMED   20208519
REFERENCE   7  (bases 1 to 9642)
  AUTHORS   Ebstein,F., Lange,N., Urban,S., Seifert,U., Kruger,E. and
            Kloetzel,P.M.
  TITLE     Maturation of human dendritic cells is accompanied by functional
            remodelling of the ubiquitin-proteasome system
  JOURNAL   Int J Biochem Cell Biol 41 (5), 1205-1215 (2009)
   PUBMED   19028597
REFERENCE   8  (bases 1 to 9642)
  AUTHORS   Park,Y., Yoon,S.K. and Yoon,J.B.
  TITLE     The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin
            fusion degradation pathway
  JOURNAL   J Biol Chem 284 (3), 1540-1549 (2009)
   PUBMED   19028681
REFERENCE   9  (bases 1 to 9642)
  AUTHORS   Park,Y., Yoon,S.K. and Yoon,J.B.
  TITLE     TRIP12 functions as an E3 ubiquitin ligase of APP-BP1
  JOURNAL   Biochem Biophys Res Commun 374 (2), 294-298 (2008)
   PUBMED   18627766
REFERENCE   10 (bases 1 to 9642)
  AUTHORS   Lee,J.W., Choi,H.S., Gyuris,J., Brent,R. and Moore,D.D.
  TITLE     Two classes of proteins dependent on either the presence or absence
            of thyroid hormone for interaction with the thyroid hormone
            receptor
  JOURNAL   Mol Endocrinol 9 (2), 243-254 (1995)
   PUBMED   7776974
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000215.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001031659.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001031659.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760389,
                              SAMEA5760434 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-131               JACYVU010000215.1  19111604-19111734   c
            132-278             JACYVU010000215.1  19087071-19087217   c
            279-1081            JACYVU010000215.1  19061573-19062375   c
            1082-1187           JACYVU010000215.1  19054156-19054261   c
            1188-1324           JACYVU010000215.1  19048304-19048440   c
            1325-1408           JACYVU010000215.1  19043182-19043265   c
            1409-1504           JACYVU010000215.1  19042243-19042338   c
            1505-1653           JACYVU010000215.1  19035414-19035562   c
            1654-1689           JACYVU010000215.1  19033281-19033316   c
            1690-1785           JACYVU010000215.1  19033101-19033196   c
            1786-1878           JACYVU010000215.1  19032114-19032206   c
            1879-2040           JACYVU010000215.1  19031799-19031960   c
            2041-2109           JACYVU010000215.1  19030506-19030574   c
            2110-2275           JACYVU010000215.1  19030251-19030416   c
            2276-2393           JACYVU010000215.1  19027904-19028021   c
            2394-2550           JACYVU010000215.1  19027660-19027816   c
            2551-2704           JACYVU010000215.1  19025806-19025959   c
            2705-2933           JACYVU010000215.1  19024430-19024658   c
            2934-3052           JACYVU010000215.1  19024054-19024172   c
            3053-3260           JACYVU010000215.1  19020784-19020991   c
            3261-3361           JACYVU010000215.1  19018128-19018228   c
            3362-3536           JACYVU010000215.1  19017782-19017956   c
            3537-3678           JACYVU010000215.1  19016440-19016581   c
            3679-3870           JACYVU010000215.1  19014762-19014953   c
            3871-4022           JACYVU010000215.1  19013513-19013664   c
            4023-4195           JACYVU010000215.1  19011711-19011883   c
            4196-4269           JACYVU010000215.1  19011344-19011417   c
            4270-4469           JACYVU010000215.1  19010349-19010548   c
            4470-4597           JACYVU010000215.1  19009695-19009822   c
            4598-4749           JACYVU010000215.1  19008819-19008970   c
            4750-4892           JACYVU010000215.1  19006555-19006697   c
            4893-5049           JACYVU010000215.1  19005505-19005661   c
            5050-5148           JACYVU010000215.1  19003696-19003794   c
            5149-5263           JACYVU010000215.1  18997568-18997682   c
            5264-5418           JACYVU010000215.1  18997143-18997297   c
            5419-5583           JACYVU010000215.1  18995945-18996109   c
            5584-5748           JACYVU010000215.1  18993144-18993308   c
            5749-5862           JACYVU010000215.1  18991453-18991566   c
            5863-5957           JACYVU010000215.1  18990875-18990969   c
            5958-6061           JACYVU010000215.1  18990525-18990628   c
            6062-9642           JACYVU010000215.1  18986382-18989962   c
FEATURES             Location/Qualifiers
     source          1..9642
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q35"
     gene            1..9642
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /note="thyroid hormone receptor interactor 12"
                     /db_xref="GeneID:316575"
                     /db_xref="RGD:1306607"
     exon            1..131
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            132..278
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..6258
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /EC_number="2.3.2.26"
                     /note="gene trap locus 6; probable E3 ubiquitin-protein
                     ligase TRIP12; TR-interacting protein 12; thyroid
                     receptor-interacting protein 12; HECT-type E3 ubiquitin
                     transferase TRIP12"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIP12"
                     /protein_id="NP_001026829.2"
                     /db_xref="GeneID:316575"
                     /db_xref="RGD:1306607"
                     /translation="MSNRPNNNPGGSLRRSQRNTAGAQPQDDSIGGRSCSSSSAVIVP
                     QPEDPDRANTSERQKTGQVPKKDNSRGVKRSASPDYNRTNSPSSAKKPRAFQHIESLS
                     ETNKPPSKSKKRHLDQEQQLKSAQLPSTSKAHTRKSVAAGSSRSQKRKRTESSCVKSG
                     SGSESTGAEERSAKPTKLASKSATSAKAGCSTITDSSSAASTSSSSSAVASASSTVPA
                     GARVKQGKDQNKARRSRSASSPSPRRSSREKEQSKTGGSSKFDWAARFSPKVSLPKTK
                     LSLPGSSKSETSKPGPSGLQAKLASLRKSTKKRSESPPAELPSLRRSTRQKTTGSCAS
                     TSRRGSGLGKRGAAEARRQEKMADPEGNQETVNSSAARTDEAPQGAAASSSVAGAVGM
                     TTSGESESDDSEMGRLQALLEARGLPPHLFGPLGPRMSQLFHRTIGSGASSKAQQLLQ
                     GLQASDESQQLQAVIEMCQLLVMGNEETLGGFPVKSVVPALITLLQMEHNFDIMNHAC
                     RALTYMMEALPRSSAVVVDAIPVFLEKLQVIQCIDVAEQALTALEMLSRRHSKAILQA
                     GGLADCLLYLEFFSINAQRNALAIAANCCQSITPDEFHFVADSLPLLTQRLTHQDKKS
                     VESTCLCFARLVDNFQHEENLLQQVASKDLLTNVQQLLVVTPPILSSGMFIMVVRMFS
                     LMCSNCPTLAVQLMKQNIAETLHFLLCGASNGSCQEQIDLVPRSPQELYELTSLICEL
                     MPCLPKEGIFAVDTMLKKGNAQNTDGAIWQWRDDRGLWHPYNRIDSRIIEAAHQVGED
                     EISLSTLGRVYTIDFNSMQQINEDTGTARAIQRKPNPLANTNTSGYSDLKKDDARAQL
                     MKEDPELAKSFIKTLFGVLYEVYSSSAGPAVRHKCLRAILRIIYFADAELLKDVLKNH
                     AVSSHIASMLSSQDLKIVVGALQMAEILMQKLPDIFSVYFRREGVMHQVKHLAESESL
                     LTSPPKACTNGSGSLGSTTPASSGTATAATNASADLGSPSLQHSRDDSLDLSPQGRLS
                     DVLKRKRLPKRGPRRPKYSPPRDDDKVDNQAKSPTTTQSPKSSFLASLNPKTWGRLSA
                     QSNSNNIEPARTAGVSGLARAASKDTISNNREKIKGWIKEQAHKFVERYFSSENMDGS
                     NPALNVLQRLCAATEQLNLQVDGGAECLVEIRSIVSESDVSSFEIQHSGFVKQLLLYL
                     TSKSEKDAVSREIRLKRFLHVFFSSPLPGEEPVGRVEPVGHAPLLALVHKMNNCLSQM
                     EQFPVKVHDFPSGNGSGGSFSLNRGSQALKFFNTHQLKCQLQRHPDCANVKQWKGGPV
                     KIDPLALVQAIERYLVVRGYGRVREDDEDSDDDGSDEEIDESLAAQFLNSGNVRHRLQ
                     FYIGEHLLPYNMTVYQAVRQFSVQAEDERESTDDESNPLGRAGIWTKTHTIWYKPVRE
                     DEESSKDCVGGKRGRAQTAPTKTSPRNAKKHDELWHDGVCPSVANPLEVYLIPTPPEN
                     ITFEDPSLDVILLLRVLHAISRYWYYLYDNAMCKEIIPTSEFINSKLTAKANRQLQDP
                     LVIMTGNIPTWLTELGKTCPFFFPFDTRQMLFYVTAFDRDRAMQRLLDTNPEINQSDS
                     QDSRVAPRLDRKKRTVNREELLKQAESVMQDLGSSRAMLEIQYENEVGTGLGPTLEFY
                     ALVSQELQRADLGLWRGEEVTLSNPKGSQEGTKYIQNLQGLFALPFGRTAKPAHIAKV
                     KMKFRFLGKLMAKAIMDFRLVDLPLGLPFYKWMLRQETSLTSHDLFDIDPVVARSVYH
                     LEDIVRQKKRLEQDKSQTKESLQYALETLTMNGCSVEDLGLDFTLPGFPNIELKKGGK
                     DIPVTIHNLEEYLRLVIFWALNEGVCRQFDSFRDGFESVFPLSHLQYFYPEELDQLLC
                     GSKADTWDAKTLMECCRPDHGYTHDSRAVKFLFEILSSFDNEQQRLFLQFVTGSPRLP
                     VGGFRSLNPPLTIVRKTFESTENPDDFLPSVMTCVNYLKLPDYSSIEIMRDKLLIAAR
                     EGQQSFHLS"
     exon            279..1081
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1187
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1324
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1408
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1504
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1653
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1689
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1690..1785
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1786..1878
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..2040
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2041..2109
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2110..2275
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2276..2393
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2394..2550
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2704
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2705..2933
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            2934..3052
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3053..3260
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3261..3361
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3362..3536
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3537..3678
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3679..3870
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            3871..4022
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4023..4195
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4196..4269
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4270..4469
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4470..4597
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4598..4749
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4750..4892
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            4893..5049
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5050..5148
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5149..5263
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5264..5418
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5419..5583
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5584..5748
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5749..5862
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5863..5957
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            5958..6061
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
     exon            6062..9642
                     /gene="Trip12"
                     /gene_synonym="Gtl6; TRIP-12"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctgcggctca gctgataatt gaagggacga caagccgccg ccgtcgccgc cgctgggggg
       61 gggtgggggg agccagtgga agttgccgtc gcgccacgga gtccggacca gagactttgg
      121 ggcctaacta gtgaatggta gtgtctagaa agggtatgtc ccttcaagag agaggtgcca
      181 atgtccaacc ggcctaataa caatccaggg gggtcactgc gacgttcaca gaggaacact
      241 gccggggccc aaccacaaga cgactcaata ggaggaagaa gctgcagttc atcatctgct
      301 gtcatagttc cgcaaccaga ggatccagac agagccaata cttcagaaag gcagaaaacg
      361 gggcaggtgc ctaaaaaaga caattctcga ggagtgaaac gcagtgctag tccagactac
      421 aacaggacca attctcctag ctctgcgaaa aagcccagag catttcagca tattgagtct
      481 ctctcagaaa ccaataagcc acctagtaag tcaaagaaga gacatttaga ccaggagcaa
      541 caactgaaat ctgcacaatt gccgtcaaca agcaaggctc acaccagaaa gagtgtggct
      601 gctggtagtt cacggagtca gaaaagaaaa aggacagaga gttcttgtgt taagagtggt
      661 tctgggtccg aatcaactgg tgccgaagag agatctgcaa aacccaccaa gctggcttca
      721 aaatcggcca cctcagccaa agctgggtgt agcaccatca ctgattcttc ttctgctgcc
      781 tctacttcct cctcatcttc agctgtagcc tcggcctctt ctactgtacc agcaggtgcc
      841 agggtgaaac aaggaaaaga ccagaacaag gccaggcgct cccgctcagc atccagccct
      901 agtcccagaa gaagtagcag ggaaaaagaa cagagtaaaa ctggtggctc ttcaaaattt
      961 gattgggctg ctcgcttcag ccccaaagtt agcctgccta aaacaaaact gtctcttcca
     1021 gggtcttcta agtcagagac atcaaaacct ggaccttctg gattacaggc caaattagca
     1081 agtttaagaa agtctaccaa gaagcgcagt gagtctccac ctgctgagct ccccagtttg
     1141 aggaggagca cacgccaaaa gaccacgggc tcctgtgcta gcaccagtcg gcgaggctct
     1201 ggcctgggca agagaggagc agctgaggcc cggaggcaag agaaaatggc agaccctgaa
     1261 ggcaaccagg agacagtaaa ttcctcagct gctcgaacag atgaagctcc ccaaggagct
     1321 gcagcctcta gttctgttgc aggggctgtt ggcatgacca cctctgggga gagtgaatcc
     1381 gatgattctg agatgggacg attacaagct ctgttagagg ccaggggtct tcctcctcac
     1441 ctctttggtc ctcttggtcc tcggatgtca caacttttcc atagaacaat tggaagcgga
     1501 gctagttcta aggcccagca gcttcttcaa ggactacaag ccagtgatga aagtcaacag
     1561 cttcaggcag tcattgaaat gtgtcagcta ttggtcatgg ggaatgaaga gacactggga
     1621 gggtttcctg tgaagagtgt tgttccagct ttgataacat tactgcagat ggaacataat
     1681 tttgacatta tgaatcatgc ttgccgagcc ttaacatata tgatggaagc gctccctcgg
     1741 tcatctgctg ttgtagtaga tgctatccct gttttcttag aaaagctgca agttattcag
     1801 tgtattgatg tggcagagca ggccttgact gccttggaga tgttgtcacg gcgacacagt
     1861 aaagccatct tacaggcggg tggtttggca gactgcttgt tgtatctcga attcttcagc
     1921 atcaatgccc aaagaaatgc actagcaatt gcagccaatt gctgccagag catcacacca
     1981 gatgagtttc attttgtggc agattcccta ccattgctta cccaaaggct aactcatcag
     2041 gacaaaaagt cagtggaaag cacttgcctt tgttttgcac gtttagtgga caactttcag
     2101 cacgaggaga acttactgca acaggttgct tccaaagatc tactcacaaa tgtccaacaa
     2161 ctgttggtag tgactccacc aattttaagt tctgggatgt ttattatggt ggttcgcatg
     2221 ttttctctga tgtgttccaa ctgtccaaca ttagctgttc aacttatgaa acaaaacatt
     2281 gcagaaacac ttcacttcct cctatgtggt gcctccaatg gaagttgtca agagcagatt
     2341 gatcttgttc cacgaagtcc tcaagagctg tatgagctga catctctgat ttgtgaactt
     2401 atgccatgtt taccaaaaga aggcattttt gcagtggata ccatgttgaa aaagggaaat
     2461 gcgcagaata cagatggtgc aatatggcag tggcgagatg accgaggcct ctggcacccc
     2521 tataacagaa ttgacagccg gatcattgag gcagcccatc aggtcggtga ggatgagata
     2581 agcttgtcca ctctgggacg agtttatact attgatttta attctatgca gcaaatcaat
     2641 gaggacacgg gaacagcacg tgccattcag agaaaaccta accccttagc caatactaac
     2701 actagtggat attcagactt aaagaaggat gatgctcgag cacagctcat gaaagaagat
     2761 ccggaactgg ctaagtcttt cattaagacc ttatttggtg ttctctatga agtgtacagc
     2821 tcctcagcag ggcctgcggt cagacacaag tgccttagag caattcttag gataatttat
     2881 tttgctgatg ctgaacttct aaaggatgtt ctgaaaaatc atgctgtttc aagtcacatt
     2941 gcttccatgc tctcaagcca agacctgaag atagtagttg gggctcttca gatggcagaa
     3001 atcttaatgc aaaagttacc cgatattttt agcgtttact tcaggaggga aggagtgatg
     3061 catcaagtaa aacatttagc agaatcagag tctttgttga caagtccccc gaaggcatgt
     3121 acaaatgggt ctggatcctt ggggtctaca acaccagcca gcagcgggac tgccacagca
     3181 gcaaccaatg cctctgctga tctggggtcg cctagcttgc agcatagcag agatgattct
     3241 ctggatctga gccctcaagg tcgattaagt gatgttctca agagaaaacg actgccaaaa
     3301 agagggccaa gaaggccaaa gtattcccct ccacgagatg atgacaaagt agacaatcaa
     3361 gctaaaagcc ccactactac tcagtcacct aaatcttcct tcctggcaag cttgaatcca
     3421 aaaacatggg gaaggttaag cgcacagtcc aacagcaaca acattgaacc agcacgaact
     3481 gcaggagtta gtggtcttgc cagggcagcc tcaaaagaca ccatatccaa taatagagaa
     3541 aaaattaaag gctggattaa ggagcaggca cataaatttg ttgagcgtta ttttagttct
     3601 gagaatatgg atggaagcaa ccctgccttg aatgtccttc agagactttg tgctgcaact
     3661 gaacaactca acctccaggt ggatggtgga gctgagtgcc ttgtagaaat ccgtagcata
     3721 gtctcagagt cagatgtttc atcatttgaa atccaacata gtggatttgt gaaacaactg
     3781 ttgctgtatt tgacatctaa aagtgaaaag gatgctgtca gcagagagat ccggttaaag
     3841 cgcttccttc atgtattttt ttcttctcca cttcccggag aagagcctgt tggaagagta
     3901 gaaccagtgg gccatgcgcc tttgttggca ctggttcaca agatgaacaa ctgtctcagc
     3961 caaatggagc aatttccagt caaggtgcat gatttcccta gtggaaatgg atctggaggc
     4021 agcttttctc tcaacagagg atcacaagct ttaaagtttt tcaacacaca tcagttaaag
     4081 tgtcagttac aaagacaccc agactgtgca aacgtgaagc agtggaaagg cgggcctgtc
     4141 aagattgatc ccctggctct ggtgcaagct attgagagat accttgtggt tagaggatat
     4201 ggaagagtaa gagaagatga tgaagacagt gatgatgatg ggtcagatga agaaatagat
     4261 gagtctttgg ctgctcagtt tttaaattcg ggaaatgtaa gacacaggct acagttttat
     4321 atcggagaac atttgctacc atataacatg acggtgtatc aggcagtgcg gcagttcagc
     4381 gtacaggctg aagatgaacg agaatctact gatgatgaga gcaatcctct gggaagagct
     4441 ggaatttgga caaagactca tacaatatgg tacaagcctg tgagagagga tgaagaaagt
     4501 agtaaagatt gtgttggtgg caaacggggg agagcacaaa cagctccaac caaaacttcc
     4561 cccagaaacg caaagaaaca cgatgagtta tggcatgatg gagtttgccc atcagtagca
     4621 aatcctttag aagtttacct cattcccaca ccaccagaaa atatcacctt cgaagaccca
     4681 tccttagatg taatactact tttaagagtt ttacatgcca tcagtcgata ctggtattac
     4741 ttgtatgata atgcgatgtg caaggagatt attccaacta gtgaatttat taacagtaaa
     4801 ttaacagcaa aggcgaatag gcagcttcaa gatcctctag taatcatgac aggaaacatc
     4861 ccaacatggc tcactgagct tggaaaaacc tgcccatttt tctttccttt tgatacccga
     4921 caaatgcttt tttatgtaac tgcatttgat cgggaccggg caatgcaaag attacttgat
     4981 accaacccag aaatcaacca gtctgattca caagacagca gagttgcacc tagattggat
     5041 agaaaaaaac gtactgtaaa cagagaggag ctactgaaac aagccgaatc tgtgatgcag
     5101 gaccttggta gctctcgggc catgttagaa atccagtatg aaaatgaggt tggtacaggt
     5161 ctggggccaa cactggagtt ttatgcactt gtttctcagg aactacagag agctgacttg
     5221 ggtctctgga gaggtgaaga agtaactctt agcaatccaa aaggaagcca agaagggacc
     5281 aagtatattc aaaacctcca gggcctgttt gcgcttccct ttggtaggac agctaagcca
     5341 gctcacatcg caaaggttaa gatgaagttt cgcttcttag gaaaattaat ggctaaggct
     5401 atcatggatt tcagattggt ggaccttccg cttggcctgc ccttttataa gtggatgctg
     5461 cggcaggaaa cttcactgac atctcatgat ctgtttgaca ttgatccggt ggtagccaga
     5521 tcagtgtatc acctagaaga cattgtcaga cagaagaaaa gactggagca ggataaatcc
     5581 cagaccaaag agagtctcca gtatgcattg gaaactctca caatgaatgg ctgttcagtg
     5641 gaagatctgg gattggattt tacgctgcct gggtttccca acattgaatt gaagaaagga
     5701 gggaaggata ttccagttac tatccacaat ttggaagaat acctaagatt ggtgatattc
     5761 tgggcactaa atgaaggtgt ttgtcggcag tttgactcat tcagagatgg atttgaatct
     5821 gtcttcccgc tcagccatct tcagtacttc tacccagaag agctggacca gctcctgtgt
     5881 ggcagtaaag cagacacttg ggatgcaaag acattgatgg aatgctgccg gcctgatcat
     5941 ggctatacac atgacagtcg ggctgtgaag ttcttgtttg agattctcag tagttttgat
     6001 aatgagcagc agaggttgtt tctccagttt gtgactggta gcccacgatt gccagtcgga
     6061 ggatttcgga gtttaaatcc acctctgacg attgtgcgga agacatttga atcaacagaa
     6121 aacccagatg acttcttacc atctgtaatg acttgtgtga actatcttaa gttaccggac
     6181 tactcgagca ttgagataat gcgtgacaaa ctgttgatag cagcaagaga aggccaacag
     6241 tcattccatc tttcctgatc acaacaagaa atcaatgtct gcctgttaca gcaaaagaaa
     6301 aaaatcatga tttcttttct gtgtcacctg agtcaaggaa acatgttcct ccctcttgtt
     6361 gtaggaaaac ggcttgcaga tttaaattca taatggccct gtggacttaa gtgatcaggc
     6421 cctaaagcat tgttgtgatg aggtttcttt agcaagttct tgtttaaatt atcatttatt
     6481 tgatgagtga agtttttaac ttgctttgct gtgtgaaatt tcaaagggat gttttttcag
     6541 gctggaacaa taaatgtcgc tgtgcagttt aattctgggc tgtgtgtatc catctagcta
     6601 agtctgcagt ttgtttcttc caaagacaac tcttgtacat aagtacagtc gttaaactca
     6661 tgtgtatttg acaactctag tttagtaaag gggttctgtg tgccttccac ctgtctctaa
     6721 ttttcttttc ccagttcatt gctgcctctg tagttcatac aggtttggtg tttggttttt
     6781 gtttgtttgt tttgcttttt aaatacagca cgcacagttt cattagccct gggccttatc
     6841 ctgtgttgat tcaaattaag atacaatcta aaattcattg aattgaaata tattctcaat
     6901 ataactcagc ctttgtaact aggtaagtag gcctttctta tagcttagtt ttaaaatagt
     6961 tacagagctc acttggcttt ctgccaagtg atacactagg tctgtttaca tggtgtctcc
     7021 attgtcctct agaaggagga aggaaggctc attcatgttt ttctgcatag gttaaaaggt
     7081 ccacagcttg ggctggtcgg tatttattat atggccaaac cattttgaat tggtgtaaag
     7141 ttttaaatga attagttttt ttttttttcc ccccgtcttg gtgttaaaaa aagatatttt
     7201 ctcctccctt actcctgttt gtttctgttc tcagtcttta tttcactctc gtcttctccc
     7261 agggtcaatt gcagacaaac cgtccagcct ttgtctccac acagatcaaa gcacctgtaa
     7321 gcagtgctgt ccatttgttt gtgttctcat ttctcagatc tgcaataatc atcaggttaa
     7381 tgtttctact taaaaataaa acagatttgc ttcaccattt ttgtttatag ttctgtgctg
     7441 tcacacacgc ccccctgtct aagcgcttac attacagtgc aagtgagtcg tcctgtggcc
     7501 acaagtcacg ccatggcggt cttgctgctg tttacagcta cttgaagagc atagaattcg
     7561 gaaaggaagt ggaagcagat ctgtttcttc ctgaggctca aatgaagact agtaaacttg
     7621 aactctctga cttcattaat gcaccattaa aaaacaaaca aacaaacaaa ccaacctgaa
     7681 ctttgaagaa actaattgta ctgacataga gctgccttct ttattctatc acccaaaagg
     7741 aaggtagtgg gttggtttac ctgttactgt cattctacac tgaccttgtc ttatgtgtaa
     7801 acatcccttg ctgacagaaa tctcttgaca gtttgcccag tcagtgggga ggagttgggc
     7861 caggaggtct ctgctcacag aggcttgtca atgaccaatg ggacttggag ggacttggtt
     7921 ctgcagcttc ccttaatggc tatggggttt gggccccttt gtctcctgtt ctcaatgttt
     7981 tacaaacagc acaaagattt ttgtgtggaa atagcatttc ccccctcact ttttaaggat
     8041 ctgttaaaat gtagacatct gtataaaaca aagtgatgtt tcatattaaa gtaatatgta
     8101 tttccatttt acacctgtgg tgctggcaga ttggcttcat tgattccttg tatctattca
     8161 atggttttta tggttctgac gggaatgttt gagtctacag tcactgaaaa agtttgctca
     8221 atatatgggt cctgtggttg gtttagagtg agaaagatcc cgctttaaag cactctgagc
     8281 cagaggcctc attgcacact acgggtgtgt acacttggtt tgctgtgact ccactggtct
     8341 gattcaggga cttagcaaca ggcgtggttg gtgtgctttt aacactcagt cattccagta
     8401 ttgtcaggat gtaccaaaac ctcttcctgg tcccaggaga gtacactgca ttctaggtct
     8461 aggtggcagg agatgtcgta gcccagttga agcaaaagca ttcgatatag ccaccaacac
     8521 tagggaagca gtgaggagtt ttgtgtctaa ctgttgtgaa actaggtaca cctcaagagg
     8581 tgtggtgtag ccaacgggtg ccttctggtt caagagtgac ttcttgggct tcttaaatgt
     8641 gaagggcaag gacagagcag cttctgcatc tcacaggcag attgtcccca tccctttccc
     8701 tgactaccag ggatcctcct gtctttcccc ccccacccca ccccacccca ccccagcact
     8761 ctgcagccat gcctagattt gatttttatt ttttttttaa tgtggctggt gagcgatgac
     8821 cccatgggtc cttgtggctc aagcatcaac cccactgagc catctcccag ccatcaccag
     8881 tggtgttttc tcaagttcat tttgttttga gattcctttt tcatttctta ccagtaagta
     8941 caagttcagg aaataggaag gctagcatta ttccaagagc aatttgtcaa gagtgatatg
     9001 tttgggagaa aaagtgcatt aatatgccta gtctttgctt tacattctgg gtgttttatt
     9061 aacagaagtg gcttccattt cttttacgct ttcagttttc tgacccgttt tgttttcccc
     9121 attgtaatga gcatattgtc ttgaactgtt ttgttttata tgattctttt gaaaggtgtt
     9181 acataggtgt taggtttgat gctgcagtag tggcatccac agtaaggcga gagagaccta
     9241 gtgacacgtc actggaaagt ctcagttgcc tagacaggta atagccctgg cacaacccac
     9301 agcagttaac agggtcaaaa agttggcata tgctaagaag ttcaaacgaa tagttattaa
     9361 tgcaagaaga actttcttag tgcttacaga acttgttctc tattaaggac attcttcagc
     9421 aatgcaagag ggagttttat ttttactaca agcagactca tgaccaaact gataagcaac
     9481 tgctggtctc tgtaaagtgt tttctttctc ttttgatctg aaacatttat ataaactgct
     9541 ggaataatgg aacttcagac taccaagtgt gtatgtaaaa ttgcatcaat accctgactt
     9601 cctgagtata tttttaataa acagcattat ccttcgtggt ta
//
