LOCUS       NM_053920               1952 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus thyroid hormone receptor interactor 10 (Trip10),
            mRNA.
ACCESSION   NM_053920 XM_346862
VERSION     NM_053920.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1952)
  AUTHORS   Zhu,Y.C., Wang,Y.K., Bai,S.J., Zha,F.F., Feng,G., Gao,C.P. and
            Liu,J.
  TITLE     Suppression of CIP4/Par6 attenuates TGF-beta1-induced
            epithelial-mesenchymal transition in NRK-52E cells
  JOURNAL   Int J Mol Med 40 (4), 1165-1171 (2017)
   PUBMED   28848997
  REMARK    GeneRIF: The results suggest that the CIP4/Par6 complex plays an
            important role in the occurrence of epithelial-mesenchymal
            transition in TGF-beta1-stimulated epithelial kidney cells.
REFERENCE   2  (bases 1 to 1952)
  AUTHORS   Ba,W., Selten,M.M., van der Raadt,J., van Veen,H., Li,L.L.,
            Benevento,M., Oudakker,A.R., Lasabuda,R.S.E., Letteboer,S.J.,
            Roepman,R., van Wezel,R.J.A., Courtney,M.J., van Bokhoven,H. and
            Nadif Kasri,N.
  TITLE     ARHGAP12 Functions as a Developmental Brake on Excitatory Synapse
            Function
  JOURNAL   Cell Rep 14 (6), 1355-1368 (2016)
   PUBMED   26854232
  REMARK    GeneRIF: ARHGAP12 negatively controls dendritic spine size via its
            RhoGAP activity and promotes, by interacting with CIP4,
            postsynaptic AMPA receptor endocytosis.
REFERENCE   3  (bases 1 to 1952)
  AUTHORS   Xu,C., Zhou,Q., Liu,L., Liu,P., Pei,G., Zeng,R., Han,M. and Xu,G.
  TITLE     Cdc42-Interacting Protein 4 Represses E-Cadherin Expression by
            Promoting beta-Catenin Translocation to the Nucleus in Murine Renal
            Tubular Epithelial Cells
  JOURNAL   Int J Mol Sci 16 (8), 19170-19183 (2015)
   PUBMED   26287173
  REMARK    GeneRIF: CIP4 overexpression represses E-cadherin expression by
            promoting beta-catenin translocation to the nucleus.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1952)
  AUTHORS   Yu,R., Mao,J., Yang,Y., Zhang,Y., Tian,Y. and Zhu,J.
  TITLE     Protective effects of calcitriol on diabetic nephropathy are
            mediated by down regulation of TGF-beta1 and CIP4 in diabetic
            nephropathy rat
  JOURNAL   Int J Clin Exp Pathol 8 (4), 3503-3512 (2015)
   PUBMED   26097534
  REMARK    GeneRIF: Calcitriol may protect diabetic nephropathy from fibrosis
            via inhibition of TGF-beta1 and CIP4.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1952)
  AUTHORS   Rusconi,F., Thakur,H., Li,J. and Kapiloff,M.S.
  TITLE     CIP4 is required for the hypertrophic growth of neonatal cardiac
            myocytes
  JOURNAL   J Biomed Sci 20 (1), 56 (2013)
   PUBMED   23915320
  REMARK    Erratum:[J Biomed Sci. 2014;21:45]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1952)
  AUTHORS   Frost,A., Perera,R., Roux,A., Spasov,K., Destaing,O., Egelman,E.H.,
            De Camilli,P. and Unger,V.M.
  TITLE     Structural basis of membrane invagination by F-BAR domains
  JOURNAL   Cell 132 (5), 807-817 (2008)
   PUBMED   18329367
REFERENCE   7  (bases 1 to 1952)
  AUTHORS   Shimada,A., Niwa,H., Tsujita,K., Suetsugu,S., Nitta,K.,
            Hanawa-Suetsugu,K., Akasaka,R., Nishino,Y., Toyama,M., Chen,L.,
            Liu,Z.J., Wang,B.C., Yamamoto,M., Terada,T., Miyazawa,A.,
            Tanaka,A., Sugano,S., Shirouzu,M., Nagayama,K., Takenawa,T. and
            Yokoyama,S.
  TITLE     Curved EFC/F-BAR-domain dimers are joined end to end into a
            filament for membrane invagination in endocytosis
  JOURNAL   Cell 129 (4), 761-772 (2007)
   PUBMED   17512409
REFERENCE   8  (bases 1 to 1952)
  AUTHORS   Morin,F., Vannier,B., Houdart,F., Regnacq,M., Berges,T. and
            Voisin,P.
  TITLE     A proline-rich domain in the gamma subunit of phosphodiesterase 6
            mediates interaction with SH3-containing proteins
  JOURNAL   Mol Vis 9, 449-459 (2003)
   PUBMED   14502124
  REMARK    Erratum:[Mol Vis. 2003 Sep 18;9:449]
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1952)
  AUTHORS   Holbert,S., Dedeoglu,A., Humbert,S., Saudou,F., Ferrante,R.J. and
            Neri,C.
  TITLE     Cdc42-interacting protein 4 binds to huntingtin: neuropathologic
            and biological evidence for a role in Huntington's disease
  JOURNAL   Proc Natl Acad Sci U S A 100 (5), 2712-2717 (2003)
   PUBMED   12604778
REFERENCE   10 (bases 1 to 1952)
  AUTHORS   Tsuji,E., Tsuji,Y., Misumi,Y., Fujita,A., Sasaguri,M., Ideishi,M.
            and Arakawa,K.
  TITLE     Molecular cloning of a novel rat salt-tolerant protein by
            functional complementation in yeast
  JOURNAL   Biochem Biophys Res Commun 229 (1), 134-138 (1996)
   PUBMED   8954095
  REMARK    Erratum:[Biochem Biophys Res Commun 1997 Nov 7;240(1):244-5]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000009.1.
            
            [WARNING] On Jul 30, 2024 this sequence was replaced by
            NM_053920.3.
            
            On Nov 27, 2020 this sequence version replaced NM_053920.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB006914.1, BC061840.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-71                JAXUCZ010000009.1  2220696-2220766
            72-187              JAXUCZ010000009.1  2221918-2222033
            188-244             JAXUCZ010000009.1  2222125-2222181
            245-392             JAXUCZ010000009.1  2224114-2224261
            393-455             JAXUCZ010000009.1  2224338-2224400
            456-560             JAXUCZ010000009.1  2224931-2225035
            561-689             JAXUCZ010000009.1  2225130-2225258
            690-836             JAXUCZ010000009.1  2225858-2226004
            837-1031            JAXUCZ010000009.1  2226232-2226426
            1032-1141           JAXUCZ010000009.1  2228780-2228889
            1142-1274           JAXUCZ010000009.1  2232526-2232658
            1275-1423           JAXUCZ010000009.1  2233229-2233377
            1424-1542           JAXUCZ010000009.1  2233723-2233841
            1543-1952           JAXUCZ010000009.1  2234358-2234767
FEATURES             Location/Qualifiers
     source          1..1952
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q11"
     gene            1..1952
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /note="thyroid hormone receptor interactor 10"
                     /db_xref="GeneID:116717"
                     /db_xref="RGD:621145"
     exon            1..71
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     CDS             48..1691
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /note="TRIP-10; salt tolerant protein; thyroid
                     receptor-interacting protein 10; TR-interacting protein
                     10"
                     /codon_start=1
                     /product="cdc42-interacting protein 4"
                     /protein_id="NP_446372.2"
                     /db_xref="GeneID:116717"
                     /db_xref="RGD:621145"
                     /translation="MDWGTELWDQFEVLERHTQWGLDLLDKYVKFVKERVEVEQSYAK
                     QLRSLVKKYLPKRPAKDDPEIKFSQQQSFVQLLQEVNDFAGQRELVAESLGIRVCLEL
                     AKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKAAHTAERLDQ
                     DINATKADVEKAKQQAHLRNHMAEESKNEYAAQLQRFNRDQAHFYFSQMPQIFDKLQD
                     MDERRATRLGAGYGLLSEAELQVVPIIGKCLEGMKVAAESVDAKNDSKVLIELHKSGF
                     ARPGDLEFEDFSQVMNRVPSDSSLGTPDGRPELRAASSRSRAKRWPFGKKNKTVVTED
                     FSHLPPEQQRKRLQQQLEERNRELQKEEDQREALKKMKDVYEKTPQMGDPASLEPRIA
                     ETLGNIERLKLEVQKYEAWLAEAESRVLSNRGDSLSRHTRPPDPPTTAPPDSSSSSNN
                     SGSQDNKESSEEPPSEEGQDTPIYTEFDEDFEEPASPIGQCVAIYHFEGSSEGTVSMS
                     EGEDLSLMEEDKGDGWTRVRRKQGGEGYVPTSYLRVTLN"
     exon            72..187
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            188..244
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            245..392
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            393..455
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            456..560
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            561..689
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            690..836
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1031
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            1032..1141
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1274
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            1275..1423
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1542
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1952
                     /gene="Trip10"
                     /gene_synonym="Cip4; STP"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggagacccgg ggcaggaggc ggtggcgtct tcggcggcaa gagcagcatg gattggggta
       61 ccgagttgtg ggatcagttt gaggtgctgg aacgccacac acagtggggg ctggatctgt
      121 tggacaaata cgtgaagttc gtgaaagaac gcgtcgaggt ggagcagtct tatgcgaagc
      181 aactcaggag tctggtgaaa aagtatcttc ccaagagacc tgccaaagat gaccccgaaa
      241 tcaagtttag ccagcaacag tcatttgtcc agcttctcca ggaggtcaat gattttgcag
      301 gccaacgaga gctggtggcc gagagccttg gcatccgagt gtgtctggag ctggctaagt
      361 attcacagga gatgaagcaa gagaggaaga tgcacttcca agaaggccgt cgggcccagc
      421 agcagctgga aaatggcttc aaacagctgg agaatagtaa gcgaaagttt gaacgagact
      481 gtcgcgaggc tgagaaagcg gctcacaccg cagagcggct ggaccaggac attaatgcca
      541 ccaaggcgga tgtggagaag gccaagcagc aagcccacct tcggaaccac atggcagaag
      601 agagcaagaa cgaatacgcg gcccagctgc agcgcttcaa ccgggaccag gctcacttct
      661 acttctcaca gatgccgcag atattcgaca agctgcagga catggatgaa cgccgggcca
      721 cccgccttgg ggccgggtat gggctcttat ctgaagctga actgcaggtg gttcccatta
      781 ttggcaaatg cttggagggc atgaaggtgg ccgcagagtc cgtggatgct aagaacgact
      841 cgaaggtcct catcgaatta cacaagtcag ggtttgcccg cccgggtgac ttggaatttg
      901 aagacttcag ccaagttatg aaccgagtgc cgtcggacag cagcctgggc accccagatg
      961 gcaggcctga gctccgagca gcttccagcc gtagtcgtgc caagcgttgg ccttttggga
     1021 aaaagaacaa gaccgtggtc accgaagatt tcagtcacct gcccccggag cagcagagaa
     1081 agcgactcca gcaacagttg gaagagcgga accgagagtt gcagaaggag gaggaccaga
     1141 gggaggccct gaagaagatg aaagatgtat atgagaaaac accacaaatg ggggaccccg
     1201 ccagcttaga gccccgcatt gcagagaccc tgggcaacat tgaaaggctg aagctggaag
     1261 tgcagaagta tgaggcttgg ttggcagaag ctgaaagccg ggtcctcagt aaccgagggg
     1321 acagcctaag ccgtcacact aggcctcctg atcccccaac tactgcccca cctgatagta
     1381 gcagtagcag caacaacagt ggatcccagg ataataagga gagctcagaa gagccccctt
     1441 cagaagaagg ccaggacacc cccatctaca ctgagttcga tgaggacttt gaagaacctg
     1501 catcccccat cggccagtgt gtggctatct accattttga aggatccagt gaggggaccg
     1561 tctccatgtc cgagggggaa gacctcagtc tgatggagga agacaagggt gatggatgga
     1621 cacgggtgag gaggaaacag ggaggcgagg gctatgtgcc cacctcttac ctccgagtca
     1681 cactcaactg aaccccactg gaggggacga tgggcaggac tgtcagctgc tgcttctggg
     1741 ccacagggga cctttgcact ttattcctgc cctcgtggct tttggctgaa acctgtgtaa
     1801 cctgctgtcc ctcatccgcc tcacctggca ccccacgggg gaccacttgt ggcttcccgt
     1861 gtggctgtac atagttgtca tttcagacct ttctccctgc cgctcggctt gggccaagtt
     1921 ttgttttata ttaaaaagta tatataatta ca
//
