LOCUS       NM_001128083            3431 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus tripartite motif-containing 8 (Trim8), mRNA.
ACCESSION   NM_001128083 XM_001067572 XM_001070868
VERSION     NM_001128083.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3431)
  AUTHORS   Lu B, Li J, Gui M, Yao L, Fan M, Zhou X and Fu D.
  TITLE     Salvianolic acid B inhibits myocardial I/R-induced ROS generation
            and cell apoptosis by regulating the TRIM8/GPX1 pathway
  JOURNAL   Pharm Biol 60 (1), 1458-1468 (2022)
   PUBMED   35968584
  REMARK    GeneRIF: Salvianolic acid B inhibits myocardial I/R-induced ROS
            generation and cell apoptosis by regulating the TRIM8/GPX1 pathway.
REFERENCE   2  (bases 1 to 3431)
  AUTHORS   Dang X, Qin Y, Gu C, Sun J, Zhang R and Peng Z.
  TITLE     Knockdown of Tripartite Motif 8 Protects H9C2 Cells Against
            Hypoxia/Reoxygenation-Induced Injury Through the Activation of
            PI3K/Akt Signaling Pathway
  JOURNAL   Cell Transplant 29, 963689720949247 (2020)
   PUBMED   32841049
  REMARK    GeneRIF: Knockdown of Tripartite Motif 8 Protects H9C2 Cells
            Against Hypoxia/Reoxygenation-Induced Injury Through the Activation
            of PI3K/Akt Signaling Pathway.
REFERENCE   3  (bases 1 to 3431)
  AUTHORS   Chen L, Huang J, Ji YX, Mei F, Wang PX, Deng KQ, Jiang X, Ma G and
            Li H.
  TITLE     Tripartite Motif 8 Contributes to Pathological Cardiac Hypertrophy
            Through Enhancing Transforming Growth Factor beta-Activated Kinase
            1-Dependent Signaling Pathways
  JOURNAL   Hypertension 69 (2), 249-258 (2017)
   PUBMED   27956576
REFERENCE   4  (bases 1 to 3431)
  AUTHORS   Kimura,T., Jain,A., Choi,S.W., Mandell,M.A., Schroder,K.,
            Johansen,T. and Deretic,V.
  TITLE     TRIM-mediated precision autophagy targets cytoplasmic regulators of
            innate immunity
  JOURNAL   J Cell Biol 210 (6), 973-989 (2015)
   PUBMED   26347139
REFERENCE   5  (bases 1 to 3431)
  AUTHORS   Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J and
            Mothes W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   6  (bases 1 to 3431)
  AUTHORS   Woodsmith J, Jenn RC and Sanderson CM.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   7  (bases 1 to 3431)
  AUTHORS   Zurek B, Schoultz I, Neerincx A, Napolitano LM, Birkner K, Bennek
            E, Sellge G, Lerm M, Meroni G, Soderholm JD and Kufer TA.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   8  (bases 1 to 3431)
  AUTHORS   Okumura F, Okumura AJ, Matsumoto M, Nakayama KI and Hatakeyama S.
  TITLE     TRIM8 regulates Nanog via Hsp90beta-mediated nuclear translocation
            of STAT3 in embryonic stem cells
  JOURNAL   Biochim Biophys Acta 1813 (10), 1784-1792 (2011)
   PUBMED   21689689
REFERENCE   9  (bases 1 to 3431)
  AUTHORS   Uchil PD, Quinlan BD, Chan WT, Luna JM and Mothes W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   10 (bases 1 to 3431)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000054.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001128083.3.
            
            On Feb 10, 2021 this sequence version replaced NM_001128083.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: CO393559.1, SRR8487226.221112.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1586              JACYVU010000054.1  6463673-6465258
            1587-1682           JACYVU010000054.1  6475130-6475225
            1683-1916           JACYVU010000054.1  6475517-6475750
            1917-1948           JACYVU010000054.1  6476598-6476629
            1949-2064           JACYVU010000054.1  6476763-6476878
            2065-3431           JACYVU010000054.1  6477188-6478554
FEATURES             Location/Qualifiers
     source          1..3431
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q54"
     gene            1..3431
                     /gene="Trim8"
                     /note="tripartite motif-containing 8"
                     /db_xref="GeneID:688785"
                     /db_xref="RGD:1585223"
     exon            1..1586
                     /gene="Trim8"
                     /inference="alignment:Splign:2.1.0"
     CDS             1017..2672
                     /gene="Trim8"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 8; probable E3
                     ubiquitin-protein ligase TRIM8"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM8"
                     /protein_id="NP_001121555.1"
                     /db_xref="GeneID:688785"
                     /db_xref="RGD:1585223"
                     /translation="MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWA
                     KDSGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPTALHCVFCRRGPPLP
                     AQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQ
                     VAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQERLEEREQDIEDQLYKLESDK
                     RLVEEKVSQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERM
                     QEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTGSSLSPPKIGHLNSKLFL
                     NEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVNSSGAEKRKHSTAFPEASFLETS
                     SGPVGSQYGAAGPASSEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGS
                     ATQQPMLPQYGGRKILVCSVDNCYCSSVANHGGHQPYPRSGHFPWTVPSQEYSHPLPP
                     TPSVPQSLSGLAVRDWLDASQQPGHQDFYRVYGQPSTKHYVTS"
     exon            1587..1682
                     /gene="Trim8"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1916
                     /gene="Trim8"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..1948
                     /gene="Trim8"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2064
                     /gene="Trim8"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..3431
                     /gene="Trim8"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccgagcctc ctgttcatta gcagttgaga aaaattcctt tctagtttga tcaatccttg
       61 ttttcctcag cgcaggcgag gcgcccgccc agcgcgggga cagggagtgg ggtctctccg
      121 cggagggggc gccctgcgcg gggcctccag ggagcgcaga agtagcgacg agggggtcag
      181 gccggagcac ctcccgggct tctccctccc tccctctctg gttgcctttt tttttttttt
      241 ttccacttct ctccctcccc cttccgtttc tatttgtgaa gggaggagga aggcagaggc
      301 gggctggtgt ctctggccgg ggactggaat ttcatctgaa tgactgcccc agcgcgcacg
      361 cagcgccccg gagtcggccc gcccgcgccc tgcaacccgc agccggccgg ccagctgggg
      421 gacgcccgcg ccacagcccg gggaccgccg gcgcgccttg ctcgccggct ccggctccag
      481 ccagcctcgg cgcggccgaa ctagatttcc tggtccctcg gacctccgcc gggatccagg
      541 cgaggaaggc gcggctcgca gcagccaaga gggagccacc gtcaccgcca aaggaagagt
      601 gcggctcccc agctcggtgc gccgcggggc gcgccccgat gccagctgcg gggccgagcg
      661 caggcctcga gccgccgctg ccctagccgc gctgacggga aggcggcctg ttatatggaa
      721 tttggaccac ggcgctcctc tccagggctg gtgcccgggc cgcggccctg gcgcagcccg
      781 ccgcctcccg ctaggctctc gccaggagga ggagacgcag ccggcggcgc gcgcggcgca
      841 aggacccagg ctccctcctc tggggggcgg gcacgcggaa ggcgctggtg actgagcgac
      901 tggcgcggcc ggcggggacc ggagctccgg gcttggtggg tcctcagctg caccagactg
      961 atccccaggg ttggggagtt agagaggtct acccgggccc cctgcccgca gccgccatgg
     1021 cggagaattg gaagaactgc tttgaggagg agctcatctg ccccatctgc ctgcacgttt
     1081 tcgtggaacc ggtgcagctg ccgtgcaaac acaacttctg ccggggctgc atcggcgagg
     1141 cttgggccaa ggacagtggc cttgtgcgtt gcccggagtg caaccaggcc tacaatcaga
     1201 agccgggcct ggagaagaac ctgaagctca ccaacatcgt ggagaagttc aacgccctgc
     1261 acgtggagaa gcccccgacg gcactgcact gcgtgttctg tcgccgcggc cccccgctgc
     1321 cggcacagaa ggtctgcctg cgctgcgagg ctccctgctg ccagtctcac gtgcagacgc
     1381 acctgcagca gccctccacc gcccgcgggc acctcctggt ggaggcggac gacgtgcggg
     1441 cctggagctg cccgcagcac aacgcctacc gcctgtacca ctgcgaggcc gagcaggtgg
     1501 cggtgtgcca gtactgctgc tactacagcg gcgcgcatca gggacactcg gtgtgtgacg
     1561 tggagatacg gaggaatgag atacggaaga tgctaatgaa gcagcaggag cgactggagg
     1621 agagagagca ggacattgag gaccagttgt acaagcttga gtcagacaag cgcctggtgg
     1681 aggagaaagt gagccaactg aaggaggaag tgaggctgca gtatgaaaag ctgcaccagc
     1741 tgctggacga ggacctgcgg cagacagtgg aggtcctaga caaggcgcag gccaagttct
     1801 gcagcgagaa cgcggcgcag gcgctgcacc tcggggagcg catgcaagag gctaagaagc
     1861 tgctgggctc cctgcagctc ctctttgaca agacagagga cgtcagcttc atgaagaata
     1921 ccaagtctgt gaaaatccta atggacagga cccagacctg cacaggcagc agcctttctc
     1981 cccctaagat cggccacctg aactccaagc tcttcctgaa cgaggtggcc aagaaggaga
     2041 agcagttgcg gaagatgcta gaaggtccct tcagcacgcc ggtgcccttc ctacagagcg
     2101 tccccctgta cccttgtggt gtgaacagct ctggggcaga gaagcgtaag cactccacgg
     2161 ccttcccaga ggctagcttc ctggagactt catcaggccc ggtgggcagc cagtacgggg
     2221 cagcaggccc agccagcagc gaggggcagt ccgggcaacc cctggggccc tgtagctcca
     2281 cgcagcactt ggttgctttg ccaggtggtg cccagccagt acactcgagt cctgtgtttc
     2341 ccccatcaca gtaccccaat ggctctgcca ctcagcagcc catgctaccc cagtatggcg
     2401 gtcgcaagat tctcgtctgt tctgtggaca actgttattg ttcttccgtg gccaaccatg
     2461 gtggccacca gccgtacccc cgatccggcc acttcccctg gacagtgccc tctcaagaat
     2521 actcacaccc acttccaccc acaccctccg tccctcagtc cctctctggc ctggcagtca
     2581 gagactggct cgacgcttcc cagcagcctg gccaccaaga tttctacagg gtgtatgggc
     2641 agccatccac caaacactat gtgacaagct aacgccaagc aggcaatgga cgctggggac
     2701 ccttctcccc agccccggtg gctcgggaat tatgcattca gagaccggcc ctctccaccc
     2761 tcctctctcc tcctttcttc tccattcctc caggtcattt ctttttggat tatgttttat
     2821 ttagggtctt gttttgattt tttttttttt ttaattatgc atctcctgga tgaggaggtg
     2881 atggtgggaa gtggcctggg caggggctgc aggtggccct ggagctggga cagtatccta
     2941 actcaaggca ctgggctctt tatcgttcct tttttaaata aaatcctacc cctttccctt
     3001 caatcccccc atggctggaa gaagccttgg gcgccaactc tccctgctta ccccgggagg
     3061 cagcccagtg cccgctggcc tatttcttcc cccccctcca atgtttcttc tgggcagttt
     3121 gatcactggt ggagtaaaga atgacctata gattgtggag ggttttattt gttttgtttt
     3181 ttaatttttt aaaaaccaag aatgatttct tctactcaac accttcccag ccggatggag
     3241 ttcaagtctc aagcagcctt tggcaccttc aagcctgagt ggaaccctac aaagccagga
     3301 gccccgtgtc caggaaaagc tgagaataaa aaagaacttt gccaatgata gtgaccacag
     3361 caaaagcaaa taataatatt aataataata aagagaaata aaagaaataa tgaataaaaa
     3421 acaagagccc a
//
