LOCUS       NM_001077675            2363 bp    mRNA    linear   ROD 08-DEC-2024
DEFINITION  Rattus norvegicus tripartite motif containing 72 (Trim72), mRNA.
ACCESSION   NM_001077675 XM_001080388 XM_344967
VERSION     NM_001077675.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2363)
  AUTHORS   Zhu,X.Z., Wang,J.Q. and Wu,Y.H.
  TITLE     MG53 ameliorates nerve injury induced neuropathic pain through the
            regulation of Nrf2/HO-1 signaling in rats
  JOURNAL   Behav Brain Res 449, 114489 (2023)
   PUBMED   37169128
  REMARK    GeneRIF: MG53 ameliorates nerve injury induced neuropathic pain
            through the regulation of Nrf2/HO-1 signaling in rats.
REFERENCE   2  (bases 1 to 2363)
  AUTHORS   Huang,L.T., Chou,H.C. and Chen,C.M.
  TITLE     TRIM72 mediates lung epithelial cell death upon hyperoxia exposure
  JOURNAL   J Chin Med Assoc 84 (1), 79-86 (2021)
   PUBMED   32796321
  REMARK    GeneRIF: TRIM72 mediates lung epithelial cell death upon hyperoxia
            exposure.
REFERENCE   3  (bases 1 to 2363)
  AUTHORS   Liu,W., Wang,G., Zhang,C., Ding,W., Cheng,W., Luo,Y., Wei,C. and
            Liu,J.
  TITLE     MG53, A Novel Regulator of KChIP2 and Ito,f, Plays a Critical Role
            in Electrophysiological Remodeling in Cardiac Hypertrophy
  JOURNAL   Circulation 139 (18), 2142-2156 (2019)
   PUBMED   30760025
  REMARK    GeneRIF: These findings establish MG53 as a novel regulator of
            KChIP2 and Ito,f by modulating NF-kappaB activity and reveal its
            critical role in electrophysiological remodeling in cardiac
            hypertrophy.
REFERENCE   4  (bases 1 to 2363)
  AUTHORS   Guo,J., Jia,F., Jiang,Y., Li,Q., Yang,Y., Xiao,M. and Xiao,H.
  TITLE     Potential role of MG53 in the regulation of
            transforming-growth-factor-beta1-induced atrial fibrosis and
            vulnerability to atrial fibrillation
  JOURNAL   Exp Cell Res 362 (2), 436-443 (2018)
   PUBMED   29233682
  REMARK    GeneRIF: This suggests that MG53 is a potential regulator of atrial
            fibrosis induced by the TGF-beta1/Smad pathway in patients with
            atrial fibrillation .
REFERENCE   5  (bases 1 to 2363)
  AUTHORS   Qi,J., Yang,B., Ren,C., Fu,J. and Zhang,J.
  TITLE     Swimming Exercise Alleviated Insulin Resistance by Regulating
            Tripartite Motif Family Protein 72 Expression and AKT Signal
            Pathway in Sprague-Dawley Rats Fed with High-Fat Diet
  JOURNAL   J Diabetes Res 2016, 1564386 (2016)
   PUBMED   27843952
  REMARK    GeneRIF: These results suggest that an 8-week swimming exercise
            improves HFD-induced insulin resistance maybe through a reduction
            of TRIM72 in skeletal muscle and enhancement of AKT signal
            transduction.
REFERENCE   6  (bases 1 to 2363)
  AUTHORS   Yi,J.S., Park,J.S., Ham,Y.M., Nguyen,N., Lee,N.R., Hong,J.,
            Kim,B.W., Lee,H., Lee,C.S., Jeong,B.C., Song,H.K., Cho,H.,
            Kim,Y.K., Lee,J.S., Park,K.S., Shin,H., Choi,I., Lee,S.H.,
            Park,W.J., Park,S.Y., Choi,C.S., Lin,P., Karunasiri,M., Tan,T.,
            Duann,P., Zhu,H., Ma,J. and Ko,Y.G.
  TITLE     MG53-induced IRS-1 ubiquitination negatively regulates skeletal
            myogenesis and insulin signalling
  JOURNAL   Nat Commun 4, 2354 (2013)
   PUBMED   23965929
REFERENCE   7  (bases 1 to 2363)
  AUTHORS   Cao,C.M., Zhang,Y., Weisleder,N., Ferrante,C., Wang,X., Lv,F.,
            Zhang,Y., Song,R., Hwang,M., Jin,L., Guo,J., Peng,W., Li,G.,
            Nishi,M., Takeshima,H., Ma,J. and Xiao,R.P.
  TITLE     MG53 constitutes a primary determinant of cardiac ischemic
            preconditioning
  JOURNAL   Circulation 121 (23), 2565-2574 (2010)
   PUBMED   20516375
  REMARK    GeneRIF: MG53, a member of the muscle-specific transmembrane
            adaptor molecule (TRIM) protein family, is a crucial component of
            the cardiac ischemic preconditioning response.
REFERENCE   8  (bases 1 to 2363)
  AUTHORS   Cai,C., Weisleder,N., Ko,J.K., Komazaki,S., Sunada,Y., Nishi,M.,
            Takeshima,H. and Ma,J.
  TITLE     Membrane repair defects in muscular dystrophy are linked to altered
            interaction between MG53, caveolin-3, and dysferlin
  JOURNAL   J Biol Chem 284 (23), 15894-15902 (2009)
   PUBMED   19380584
REFERENCE   9  (bases 1 to 2363)
  AUTHORS   Cai,C., Masumiya,H., Weisleder,N., Pan,Z., Nishi,M., Komazaki,S.,
            Takeshima,H. and Ma,J.
  TITLE     MG53 regulates membrane budding and exocytosis in muscle cells
  JOURNAL   J Biol Chem 284 (5), 3314-3322 (2009)
   PUBMED   19029292
REFERENCE   10 (bases 1 to 2363)
  AUTHORS   Cai,C., Masumiya,H., Weisleder,N., Matsuda,N., Nishi,M., Hwang,M.,
            Ko,J.K., Lin,P., Thornton,A., Zhao,X., Pan,Z., Komazaki,S.,
            Brotto,M., Takeshima,H. and Ma,J.
  TITLE     MG53 nucleates assembly of cell membrane repair machinery
  JOURNAL   Nat Cell Biol 11 (1), 56-64 (2009)
   PUBMED   19043407
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC127539.1.
            
            On or before Nov 15, 2006 this sequence version replaced
            XM_344967.3, XM_001080388.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC127539.1, FQ224850.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2363
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q37"
     gene            1..2363
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /note="tripartite motif containing 72"
                     /db_xref="GeneID:365377"
                     /db_xref="RGD:1562778"
     exon            1..81
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
     exon            82..478
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1522
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /EC_number="2.3.2.27"
                     /note="mg53; mitsugumin-53; tripartite motif containing
                     72, E3 ubiquitin protein ligase"
                     /codon_start=1
                     /product="tripartite motif-containing protein 72"
                     /protein_id="NP_001071143.1"
                     /db_xref="GeneID:365377"
                     /db_xref="RGD:1562778"
                     /translation="MSTAPGLLRQELSCPLCLQLFDAPVTAECGHSFCRACLIRVAGE
                     PADDGTVACPCCQASTRPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRT
                     LVCGVCASLGSHRGHRLLPAAEAHARLKTQLPQQKAQLQEACMRKEKSVAVLEHQLVE
                     VEETVRQFRGAVGEQLGKMRMFLAALESSLDREAERVRGEAGVALRRELSSLNSYLEQ
                     LRQMEKVLEEVADKPQTEFLMKFCLVTSRLQKILSESPPPARLDIQLPVISDDFKFQV
                     WKKMFRALMPELEELTFDPSSAHPSLVVSASGRRVECSEQKAPPAGEDTCQFDKTVAV
                     VAKQLLSQGEHYWEVEVGDKPRWALGVMAADASRRGRLHAVPSQGLWLLGLRDGKILE
                     AHVEAKEPRALRTPERPPARIGLYLSFADGVLTFYDASNTDALTPLFSFHERLPGPVY
                     PMFDVCWHDKGKNSQPLLLVGPDSEQA"
     exon            479..574
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
     exon            575..805
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
     exon            806..828
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
     exon            829..947
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
     exon            948..2329
                     /gene="Trim72"
                     /gene_synonym="RGD1562778"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ctccggtcac cctgctgtta agcctgttcc tgactggtcc tcctggaaat cttttctggc
       61 ctaagttttc ccaccagacc tgctcaccat gtcgactgca ccaggccttt tgcgccagga
      121 actgtcttgc ccgctgtgct tgcagctgtt cgatgcacca gtgaccgctg agtgtggcca
      181 cagtttctgc cgtgcctgcc tgatccgtgt ggcaggggag cctgccgacg atggcacggt
      241 tgcctgtccc tgttgtcagg catctactcg gccacaggcg ctaagcacta acctccagtt
      301 ggcacgcctt gtggagggtt tggcacaagt gccccaaggc cactgcgagg aacacctgga
      361 tccactgagc atctactgcg agcaggaccg cacacttgtg tgtggtgtgt gtgcctctct
      421 cggttcacac cgtggtcacc gtcttctgcc tgccgcagaa gcccatgcac gtctcaagac
      481 acagcttcca caacagaagg cccagctgca ggaggcatgc atgcgcaagg agaagagtgt
      541 agcagtcctg gagcatcagc tggtggaggt ggaggagacc gtgcgtcagt tccggggagc
      601 tgttggggag cagctgggga agatgcggat gttcctggct gccctagaaa gttctttgga
      661 ccgtgaagca gaaagggttc gaggtgaggc aggggttgcc ttgcggcggg agctgtcaag
      721 cctgaactct tacctggagc aactgaggca gatggagaag gtgctggagg aggtggctga
      781 caagccacag acagaattcc tcatgaaatt ctgcctggtg accagcaggc tgcagaagat
      841 tctgtcagag tcaccacccc cagcaaggct agatatccag ctgcctgtca tctcagatga
      901 cttcaaattc caggtgtgga agaagatgtt ccgggctctg atgccagagt tggaggaact
      961 gacttttgac cccagctctg cgcacccgag cctggtggtg tccgcctctg gtcgccgagt
     1021 ggagtgctcg gagcagaagg cgccgccagc aggagaagac acgtgccagt tcgacaagac
     1081 ggtagcggta gtggcgaagc agctgctgtc acagggggag cactactggg aggtggaggt
     1141 gggcgacaag ccacgctggg ccctgggtgt gatggcggct gacgcttccc gtcgtggccg
     1201 cctgcacgcg gtgccctcac aggggctgtg gttgctcggc ctgcgcgatg gcaagatcct
     1261 ggaggcacac gtggaggcca aggagccacg ggcactgcgc accccagaga ggccaccagc
     1321 gcgcattggc ctctacctaa gctttgcaga tggcgtcctg actttctatg atgcaagcaa
     1381 caccgacgcg cttacaccgc tcttttcttt tcatgagcgt ctgcctgggc cggtgtaccc
     1441 catgtttgac gtgtgctggc acgacaaggg caagaattct cagccgctgt tgctcgtggg
     1501 gccagacagt gagcaggcct gagcttctgc cgactaggag ggaggcctgg tcctgaaggc
     1561 cgtgggatca attaggtcac ctttgttagg cctggattgg tctggttggg gcggacagac
     1621 taggctggcg gtagatgggg aggggatgtt tgtcttctag ggttcaggga agtacacagg
     1681 ttgggaagca taggggagag aggattaagg tctgtgaaga aggaagatta ttcaggtcag
     1741 gggggaaatc tgagtttggg ccaagtgttc caggaggaag ctgaggttta gggaagccgg
     1801 gaagaggata ggatttggaa aggatttagt agaggatctt gggaagtctg tggaacttca
     1861 gccctgcaat ccactcctga aggccccctc tttaaggttg cagattcccc atgcctgcga
     1921 ggttttcagt tagtgtttgc ctctaactgc cttttcaaag cccccagtaa tcctgagggt
     1981 gtgggtgcat gactgtaatc ccagcatcta ggggctgagg cagggggatg gcaaattgaa
     2041 agccagcagg actctgtcac aaacagcagt gactgtgttt ctgatgtcgt aggtagggga
     2101 gggggtcaga gagggcttct tgaagccggg gagggacagg tgtcgggagc acttgctctt
     2161 gcagagctct gagcttcagc agcaacactg tggctcgtaa ctctccaatc acagtgaatc
     2221 gatggcctct tccagcctct gtgggcattt gtagtgcaca gatacacgcg caggcaaaac
     2281 actgatacac gttaagaaaa taaaataaaa agatccctct ctatctcgaa aaaaaaaaaa
     2341 aaaaaaaaaa aaaaaaaaaa aaa
//
