LOCUS       NM_001191801            2568 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tripartite motif containing 71 (Trim71), mRNA.
ACCESSION   NM_001191801 XM_236676
VERSION     NM_001191801.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2568)
  AUTHORS   Treiber,T., Treiber,N., Plessmann,U., Harlander,S., Daiss,J.L.,
            Eichner,N., Lehmann,G., Schall,K., Urlaub,H. and Meister,G.
  TITLE     A Compendium of RNA-Binding Proteins that Regulate MicroRNA
            Biogenesis
  JOURNAL   Mol Cell 66 (2), 270-284 (2017)
   PUBMED   28431233
REFERENCE   2  (bases 1 to 2568)
  AUTHORS   Loedige,I., Gaidatzis,D., Sack,R., Meister,G. and Filipowicz,W.
  TITLE     The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA
            function
  JOURNAL   Nucleic Acids Res 41 (1), 518-532 (2013)
   PUBMED   23125361
REFERENCE   3  (bases 1 to 2568)
  AUTHORS   Chang,H.M., Martinez,N.J., Thornton,J.E., Hagan,J.P., Nguyen,K.D.
            and Gregory,R.I.
  TITLE     Trim71 cooperates with microRNAs to repress Cdkn1a expression and
            promote embryonic stem cell proliferation
  JOURNAL   Nat Commun 3, 923 (2012)
   PUBMED   22735451
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2568)
  AUTHORS   Chen,J., Lai,F. and Niswander,L.
  TITLE     The ubiquitin ligase mLin41 temporally promotes neural progenitor
            cell maintenance through FGF signaling
  JOURNAL   Genes Dev 26 (8), 803-815 (2012)
   PUBMED   22508726
  REMARK    Erratum:[Genes Dev. 2012 Jun 15;26(12):1392]
REFERENCE   5  (bases 1 to 2568)
  AUTHORS   Rybak,A., Fuchs,H., Hadian,K., Smirnova,L., Wulczyn,E.A.,
            Michel,G., Nitsch,R., Krappmann,D. and Wulczyn,F.G.
  TITLE     The let-7 target gene mouse lin-41 is a stem cell specific E3
            ubiquitin ligase for the miRNA pathway protein Ago2
  JOURNAL   Nat Cell Biol 11 (12), 1411-1420 (2009)
   PUBMED   19898466
REFERENCE   6  (bases 1 to 2568)
  AUTHORS   Maller Schulman,B.R., Liang,X., Stahlhut,C., DelConte,C.,
            Stefani,G. and Slack,F.J.
  TITLE     The let-7 microRNA target gene, Mlin41/Trim71 is required for mouse
            embryonic survival and neural tube closure
  JOURNAL   Cell Cycle 7 (24), 3935-3942 (2008)
   PUBMED   19098426
REFERENCE   7  (bases 1 to 2568)
  AUTHORS   Rybak,A., Fuchs,H., Smirnova,L., Brandt,C., Pohl,E.E., Nitsch,R.
            and Wulczyn,F.G.
  TITLE     A feedback loop comprising lin-28 and let-7 controls pre-let-7
            maturation during neural stem-cell commitment
  JOURNAL   Nat Cell Biol 10 (8), 987-993 (2008)
   PUBMED   18604195
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Jul 17, 2010 this sequence version replaced XM_236676.5.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760389 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-813               JAXUCZ010000008.1  123128204-123129016 c
            814-981             JAXUCZ010000008.1  123091373-123091540 c
            982-1116            JAXUCZ010000008.1  123080530-123080664 c
            1117-2568           JAXUCZ010000008.1  123077400-123078851 c
FEATURES             Location/Qualifiers
     source          1..2568
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..2568
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /note="tripartite motif containing 71"
                     /db_xref="GeneID:301042"
                     /db_xref="RGD:1566388"
     CDS             1..2568
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /EC_number="2.3.2.27"
                     /note="Drosophila dappled/ vertebrate TRipartite Motif
                     protein related; B-box zinc finger, Filamin and NHL repeat
                     containing protein (123.8 kD) (lin-41); tripartite
                     motif-containing protein 71; protein lin-41 homolog;
                     tripartite motif containing 71, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase TRIM71"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM71"
                     /protein_id="NP_001178730.1"
                     /db_xref="GeneID:301042"
                     /db_xref="RGD:1566388"
                     /translation="MASFPETDFQICLLCKEMCGSPAPLSSSSSASSSSSQTSTSSAG
                     GGGPGAAARRLHVLPCLHAFCRPCLEAHRLPAPGGAGPAEALKLRCPVCDQKVVLAEA
                     AGMDALPSSAFLLSNLLDAVVATADEPPPKNGRAGGGPGGAGGHSNHRHHAHHPAQRA
                     AAPAPQPPPGPAASPGSLLLRRPHGCSSCDEGNAASSRCLDCQEHLCDNCVRAHQRVR
                     LTKDHYIERGPPGPAAASAAQQLGLGPPFAGAPFSILSVFPERLGFCQHHDDEVLHLY
                     CDTCSVPICRECTLGRHGGHSFAYLQDALQDSRALTIQLLADAQQGRQAIQLSIEQAQ
                     TVAEQVEMKAKVVQSEVKAVTARHKKALEERECELLWKVEKIRQVKAKSLYLQVEKLR
                     QNLNKLESTISAVQQVLEEGRALDILLARDRMLAQVQELKTIRGLLQPQEDDRVMFTP
                     PDQALYLALKSFGFVSSGAFAPLTKAAGDGIKRALQGKVASFTVMGYDHNGEPRLSGG
                     DLMSVVVLGPDGNLFGAEVSDQQNGTYVVSYRPQLEGEHLVSVTLYNQHIENSPFKVV
                     VKSGRSYVGIGLPVLSFGSEGDGEGKLCRPWGVSVDKEGYIIVADRSNNRIQVFKPCG
                     SFHHKFGTLGSRPGQFDRPAGVACDASRRIVVADKDNHRIQIFTFEGQFLLKFGEKGT
                     KNGQFNYPWDVAVNSEGKILVSDTRNHRIQLFGPDGVFLNKYGFEGSLWKHFDSPRGV
                     AFNHEGHLVVTDFNNHRLLVIHPDCQSARFLGSEGTGNGQFLRPQGVAVDQEGRIIVA
                     DSRNHRVQMFEANGSFLCKFGAQGSGFGQMDRPSGIAVTPEGLIVVVDFGNNRILIF"
     exon            1..813
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
     exon            814..981
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1116
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..2568
                     /gene="Trim71"
                     /gene_synonym="RGD1566388"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atggcttcgt tccctgagac cgacttccag atctgcctgc tgtgcaagga gatgtgcggc
       61 tcgcccgcgc ctctctcctc cagctcgtcc gcctcttcat cgtcctcgca gacgtccacg
      121 tcgtcggcgg gcggcggcgg ccccggggcg gcggcgcggc gcctgcacgt cctgccctgc
      181 ctgcacgcct tctgccggcc gtgcctcgag gcgcaccggc tcccggctcc cggtggcgcc
      241 ggccccgccg aggcgctgaa gctgcgctgt cctgtgtgtg accagaaggt ggtcctggcc
      301 gaggcggcag gcatggacgc gctgccgtcg tccgccttcc tgctcagcaa cctgctggac
      361 gccgtggtgg ccaccgccga cgagccgccg cccaagaacg ggcgcgcggg tggcggcccc
      421 gggggcgcgg gcggccacag caatcaccgg caccacgcgc accacccggc ccagcgcgcc
      481 gccgctccag cgccgcagcc gccgcccggc ccggccgctt ctccagggtc gctgttgttg
      541 cgccggccgc acggctgcag ctcctgcgac gagggcaatg ctgcctcgtc gcgctgcctc
      601 gactgccagg aacacctgtg cgacaactgt gtccgcgcgc accagcgcgt acgcctcacc
      661 aaggaccact acatcgagcg cggcccgccg gggcctgcgg ccgcctccgc ggcgcagcag
      721 ctggggctcg ggccgccctt cgcaggcgcg cccttctcca tcctctcggt gttcccggag
      781 cgcctcggct tctgccaaca ccacgacgac gaggtactac atctgtactg cgacacctgc
      841 tccgtgccca tctgcagaga gtgcacactg ggccgccatg gcggccacag cttcgcctac
      901 ctccaggacg ccctacagga ctcacgggca ctcaccatcc agctgctggc cgacgcccag
      961 cagggccgcc aggccattca gctgagcatt gagcaggcgc agactgtggc agaacaagtg
     1021 gagatgaagg ccaaggtggt ccagtcggag gtcaaggccg tcacggcgag acacaagaaa
     1081 gctctggagg agcgtgagtg cgagctgctg tggaaggtgg agaagatccg gcaggtgaag
     1141 gctaagtctc tctacctgca ggtggagaag ctgcggcaga atctcaacaa gctggagagc
     1201 accatcagcg ccgtccagca ggtcctagaa gagggccgag ccctggacat cctgctggcc
     1261 cgagaccgga tgctggctca ggtgcaggag ctcaagacca tccggggcct cctgcagccc
     1321 caggaagatg accgagttat gttcacaccc cccgaccagg ccctgtacct tgccctcaag
     1381 tcttttggct ttgtcagcag tggggccttt gccccactca cgaaggccgc gggagatggc
     1441 atcaagcgag cccttcaggg aaaggtggcc tccttcactg tcatgggcta tgaccacaat
     1501 ggtgagcccc gcctctcagg aggtgacctg atgtcggtgg tggtccttgg ccctgatgga
     1561 aacctgtttg gtgcagaagt gagcgaccag cagaatggga cctacgtcgt gagctacagg
     1621 ccccagcttg agggtgaaca cttggtatca gtgacgctgt ataaccagca catcgagaac
     1681 agccccttca aggtagtggt caagtcgggc cgcagctatg tgggcatcgg gctcccagtg
     1741 ttgagctttg gcagcgaggg tgatggcgag ggtaagctct gcaggccctg gggcgtgagt
     1801 gtggataagg agggctacat catcgtggct gaccgcagca ataacagaat tcaggtgttt
     1861 aagccctgtg ggtctttcca ccacaagttt ggtaccctag gatctcggcc cgggcagttt
     1921 gaccgaccgg cgggggtggc ctgcgacgcc tcccgcagga tcgtggtggc cgacaaagac
     1981 aatcatcgca tccagatctt caccttcgag ggccagttcc ttctgaagtt tggcgagaaa
     2041 ggaaccaaga atgggcagtt taactacccg tgggatgtag cggtcaactc tgagggcaag
     2101 atcctggttt cagacacccg aaaccaccgc atccagctgt tcggacccga cggcgtcttc
     2161 ctgaataagt atggcttcga gggatctctc tggaagcact tcgactcccc acggggcgtg
     2221 gctttcaacc atgaaggtca cctggtagtc actgatttca acaaccatcg gctcctggtt
     2281 atccaccccg attgccagtc tgcccgcttc ctgggctctg agggcactgg caatgggcag
     2341 ttcctgcgac cacagggtgt ggctgtagac caggaagggc gaatcattgt cgccgattcc
     2401 agaaatcacc gtgtgcagat gtttgaggcc aacggcagct tcctgtgcaa gttcggtgct
     2461 caaggcagcg gcttcgggca gatggaccgc ccctcaggta tcgcggtcac cccggaagga
     2521 ttgatcgtcg tggtggactt tggcaacaat cgaatcctca tcttctaa
//
