LOCUS       NM_001135714            2646 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 65 (Trim65), mRNA.
ACCESSION   NM_001135714 XM_221125
VERSION     NM_001135714.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2646)
  AUTHORS   Kimura,T., Jain,A., Choi,S.W., Mandell,M.A., Schroder,K.,
            Johansen,T. and Deretic,V.
  TITLE     TRIM-mediated precision autophagy targets cytoplasmic regulators of
            innate immunity
  JOURNAL   J Cell Biol 210 (6), 973-989 (2015)
   PUBMED   26347139
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On Jun 23, 2015 this sequence version replaced NM_001135714.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ223610.1, SRR26643299.46558.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-497               JAXUCZ010000010.1  101862429-101862925 c
            498-593             JAXUCZ010000010.1  101859820-101859915 c
            594-827             JAXUCZ010000010.1  101859318-101859551 c
            828-1005            JAXUCZ010000010.1  101859064-101859241 c
            1006-1071           JAXUCZ010000010.1  101858894-101858959 c
            1072-2646           JAXUCZ010000010.1  101856826-101858400 c
FEATURES             Location/Qualifiers
     source          1..2646
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q32.1"
     gene            1..2646
                     /gene="Trim65"
                     /note="tripartite motif-containing 65"
                     /db_xref="GeneID:303684"
                     /db_xref="RGD:1559497"
     exon            1..497
                     /gene="Trim65"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1652
                     /gene="Trim65"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif-containing protein 65"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM65"
                     /protein_id="NP_001129186.1"
                     /db_xref="GeneID:303684"
                     /db_xref="RGD:1559497"
                     /translation="MAVQLLEEDLVTCPICLGRYCDPVTLPCGHTFCGNCIQDSWRCC
                     EKICPECRQPFPEGAKLSRNVKLSTLLQGLPAAIQRLESGTSQSARCPRHGRPLEFFC
                     LTEGLCVCSACTVHDCSHHERALLDVERRVREDRLRARVMVTRQQATQAETQLEELQQ
                     QSSQIESSARTLASVVSRRFSSLLQVLEKQQASTLSDIEGAKKRALDQVLHERQRLTD
                     HLKALSQYDQSVQDLLGQGDDFIFFQGLQQLSEPIGSLGPPTPPQWDEEEQLNSVNQL
                     LSPLCELLLEEKTLPTAADKAASAGPMEALGPLAPVPSAMCPLRKKLWQNYRNLTFDP
                     ETANRYLLLSHKAQQVTHHFQAQSPARSGSFELWQVQCTQSFQTGQHYWEVRASDHSI
                     TLGVTYPELPRRKLGTHTDNIGRGPYSWGLCIQEDSIQAWHNGRAQRLSRAGVSGGLL
                     GVDLNLTSGCLTFYSLEPHTQPLHTFYAVFSRPLFPVFWLLEGRTLSLCHQPEAELPP
                     RPQEEAIAPS"
     exon            498..593
                     /gene="Trim65"
                     /inference="alignment:Splign:2.1.0"
     exon            594..827
                     /gene="Trim65"
                     /inference="alignment:Splign:2.1.0"
     exon            828..1005
                     /gene="Trim65"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1071
                     /gene="Trim65"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..2646
                     /gene="Trim65"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccttgcgc actgccatct tcctggactg tccttcgccc ttccgtagcc tcggtccctt
       61 taagaggtct gcgcacacag gacctcgctt ccgctatggc cgttcagctg ctggaggagg
      121 acctggtgac ttgtcccatc tgcctgggtc gctactgcga ccccgtgacg ctgccctgcg
      181 ggcacacctt ctgcgggaac tgtatccagg attcgtggcg ctgttgcgaa aagatatgcc
      241 ccgaatgtcg ccagcctttc cccgagggcg ccaagctgag ccgcaacgtg aagctgagca
      301 ccttgttgca ggggctgccg gccgccatcc agcgtctgga gtccggcacg agccaaagcg
      361 ctcgctgccc gcgccacggg aggccgctcg agttcttctg tctcacggag ggcctctgcg
      421 tgtgcagcgc gtgcacggtg cacgactgta gccaccacga gagggcgctg ctggacgtgg
      481 agcgccgcgt gcgcgaggac cgactgagag ctagggtaat ggttacccgg caacaggcca
      541 ctcaggcaga gacccagctt gaggagctgc agcagcaaag cagtcagatt gagagttcag
      601 cccgcaccct ggcctcggtg gtctccagga gattcagtag cctgctccag gttctggaga
      661 agcagcaggc ctcaacactg agtgacatag agggagccaa gaagcgggcg ctggaccaag
      721 ttctgcatga gagacagcgg ctgactgacc acctaaaggc cctgtctcag tacgaccaaa
      781 gtgtccagga cctcctgggg cagggggatg atttcatctt cttccagggg ttacagcagc
      841 tctctgagcc catagggtcc ctcgggccac cgactcctcc ccagtgggat gaggaagagc
      901 agttgaacag tgtgaaccag ctgcttagcc cactgtgtga gctcctcctt gaagagaaga
      961 ccctccccac ggcggcagac aaagctgcca gtgctggccc tatggaggcc ttgggtcccc
     1021 tggcaccagt ccccagcgca atgtgtccac tgaggaagaa gctctggcag aattatcgca
     1081 atctgacctt tgacccagag actgccaacc ggtatttgct cttgtctcac aaggcccagc
     1141 aggtgacaca ccatttccag gctcagagcc cagccaggtc aggcagcttt gagctgtggc
     1201 aggtacagtg cacccagagt tttcagactg gacaacatta ctgggaggtg cgtgcctctg
     1261 accactccat cactctgggc gtcacctacc cagagctacc acgccgaaag ctggggaccc
     1321 acacagataa catcggtcgt ggaccctact cgtggggcct ctgcatccag gaggacagta
     1381 ttcaggcctg gcacaatggc agagctcagc gtctgagtcg ggcaggggta tctggaggac
     1441 tcctgggcgt agatttgaac ttgacctctg gctgcctcac cttctacagc ctggagccac
     1501 acacacagcc actgcacact ttctatgcag ttttcagccg gcctctcttc cctgtcttct
     1561 ggctccttga ggggaggacc cttagtcttt gccatcagcc tgaggccgag ctccctccaa
     1621 ggccccagga agaggccata gcacccagct gaggaaggca cagacaggtg ccaccatgct
     1681 tgtgtgccca aaagtggctc cgtccctggc ttagagacca atggccaacc ttctaaaagg
     1741 aacagctggt ggcctctctg tggactcaga ggccagagat gggagaggag ccctaagtcc
     1801 aagtttactt tttactctct tcgaagggcc caggggccag aagaaagccc cggcctcaag
     1861 caagaaccga gttcttggca ttgcttggac atcgatctta gttctattgc tgtgaagaga
     1921 caccatgact aaggcaactc ttacaaagga aagcatttaa ctcagggctt gcttacagtt
     1981 ttagaagttt agtccatggt tatcatggcg ggaagcagac aggcgtggtg ctagaacagt
     2041 agctgagctg gatacatccc aatcaccaga cacacagaga ggggggaggg gagggagaga
     2101 gagagagaaa gagagagaga gggagggaga aaaggaggga aggagagagg gagagggaag
     2161 cttttgtaac cttaaagccc accccaagtg acacacttcc cccaacaagg ccacgcctcc
     2221 tgatccttct caaacagttc caccaagtgg ggtctaagca caggctgtag acagccagtg
     2281 tggcgatggg tatgggtgta gcagatgtga gctgcttgcc tttgctggtc ccaaatatgc
     2341 ttccatgaag gtcctggatg tttttttcct cacatttcta gaagtagaat tttttttttc
     2401 tttttggtcc tgggtatagc acctggggtg ttttgaatgc tagcattcaa agttctgacc
     2461 tctctcaccg atgacatcta cagcccggtg taatttattt acttgaaatg tgctgtgttc
     2521 tggtgttggc ggtagttaca aggaagccca cttttgtaag gtccttttct ttccttttgt
     2581 aattccttaa gcatttgttt tgtatgctca tgggtaaaca tctcccaata aaaagatttc
     2641 agaaat
//
