LOCUS       NM_080903               1856 bp    mRNA    linear   ROD 29-MAR-2024
DEFINITION  Rattus norvegicus tripartite motif containing 63 (Trim63), mRNA.
ACCESSION   NM_080903 XM_003750058
VERSION     NM_080903.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1856)
  AUTHORS   Wang,H., Wang,H., Li,X. and Xu,W.
  TITLE     MuRF-1 is Involved in Laryngeal Muscle Denervation Atrophy by
            Regulating G-Actin Ubiquitination
  JOURNAL   Laryngoscope 134 (2), 855-864 (2024)
   PUBMED   37658726
  REMARK    GeneRIF: MuRF-1 is Involved in Laryngeal Muscle Denervation Atrophy
            by Regulating G-Actin Ubiquitination.
REFERENCE   2  (bases 1 to 1856)
  AUTHORS   Hu,S.L., Yang,W.C., Zuo,L.Y., Jiang,Q., Zhang,S.L. and Sun,J.Z.
  TITLE     [Effects of different types of exercise on contractile properties
            and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus muscle of
            unloaded rats]
  JOURNAL   Zhongguo Ying Yong Sheng Li Xue Za Zhi 38 (4), 356-360 (2022)
   PUBMED   36414561
  REMARK    GeneRIF: [Effects of different types of exercise on contractile
            properties and expressions of MuRF1, PGC-1alpha /FNDC5 in soleus
            muscle of unloaded rats].
REFERENCE   3  (bases 1 to 1856)
  AUTHORS   Adams,V., Schauer,A., Augstein,A., Kirchhoff,V., Draskowski,R.,
            Jannasch,A., Goto,K., Lyall,G., Mannel,A., Barthel,P., Mangner,N.,
            Winzer,E.B., Linke,A. and Labeit,S.
  TITLE     Targeting MuRF1 by small molecules in a HFpEF rat model improves
            myocardial diastolic function and skeletal muscle contractility
  JOURNAL   J Cachexia Sarcopenia Muscle 13 (3), 1565-1581 (2022)
   PUBMED   35301823
  REMARK    GeneRIF: Targeting MuRF1 by small molecules in a HFpEF rat model
            improves myocardial diastolic function and skeletal muscle
            contractility.
REFERENCE   4  (bases 1 to 1856)
  AUTHORS   Viana,L.R., Chiocchetti,G.M.E., Oroy,L., Vieira,W.F.,
            Busanello,E.N.B., Marques,A.C., Salgado,C.M., de Oliveira,A.L.R.,
            Vieira,A.S., Suarez,P.S., de Sousa,L.M., Castelucci,B.G.,
            Vercesi,A.E., Consonni,S.R. and Gomes-Marcondes,M.C.C.
  TITLE     Leucine-Rich Diet Improved Muscle Function in Cachectic Walker 256
            Tumour-Bearing Wistar Rats
  JOURNAL   Cells 10 (12), 3272 (2021)
   PUBMED   34943780
  REMARK    GeneRIF: Leucine-Rich Diet Improved Muscle Function in Cachectic
            Walker 256 Tumour-Bearing Wistar Rats.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1856)
  AUTHORS   Mochalova,E.P., Belova,S.P., Kostrominova,T.Y., Shenkman,B.S. and
            Nemirovskaya,T.L.
  TITLE     Differences in the Role of HDACs 4 and 5 in the Modulation of
            Processes Regulating MAFbx and MuRF1 Expression during Muscle
            Unloading
  JOURNAL   Int J Mol Sci 21 (13), 4815 (2020)
   PUBMED   32646070
  REMARK    GeneRIF: Differences in the Role of HDACs 4 and 5 in the Modulation
            of Processes Regulating MAFbx and MuRF1 Expression during Muscle
            Unloading.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1856)
  AUTHORS   Lecker,S.H., Jagoe,R.T., Gilbert,A., Gomes,M., Baracos,V.,
            Bailey,J., Price,S.R., Mitch,W.E. and Goldberg,A.L.
  TITLE     Multiple types of skeletal muscle atrophy involve a common program
            of changes in gene expression
  JOURNAL   FASEB J 18 (1), 39-51 (2004)
   PUBMED   14718385
REFERENCE   7  (bases 1 to 1856)
  AUTHORS   Dehoux,M.J., van Beneden,R.P., Fernandez-Celemin,L., Lause,P.L. and
            Thissen,J.P.
  TITLE     Induction of MafBx and Murf ubiquitin ligase mRNAs in rat skeletal
            muscle after LPS injection
  JOURNAL   FEBS Lett 544 (1-3), 214-217 (2003)
   PUBMED   12782319
  REMARK    GeneRIF: MafBx and Murf mRNA are up-regulated in response to LPS
            and might play a role in the muscle proteolysis observed
REFERENCE   8  (bases 1 to 1856)
  AUTHORS   Wray,C.J., Mammen,J.M., Hershko,D.D. and Hasselgren,P.O.
  TITLE     Sepsis upregulates the gene expression of multiple ubiquitin
            ligases in skeletal muscle
  JOURNAL   Int J Biochem Cell Biol 35 (5), 698-705 (2003)
   PUBMED   12672461
REFERENCE   9  (bases 1 to 1856)
  AUTHORS   McElhinny,A.S., Kakinuma,K., Sorimachi,H., Labeit,S. and
            Gregorio,C.C.
  TITLE     Muscle-specific RING finger-1 interacts with titin to regulate
            sarcomeric M-line and thick filament structure and may have nuclear
            functions via its interaction with glucocorticoid modulatory
            element binding protein-1
  JOURNAL   J Cell Biol 157 (1), 125-136 (2002)
   PUBMED   11927605
REFERENCE   10 (bases 1 to 1856)
  AUTHORS   Bodine,S.C., Latres,E., Baumhueter,S., Lai,V.K., Nunez,L.,
            Clarke,B.A., Poueymirou,W.T., Panaro,F.J., Na,E., Dharmarajan,K.,
            Pan,Z.Q., Valenzuela,D.M., DeChiara,T.M., Stitt,T.N.,
            Yancopoulos,G.D. and Glass,D.J.
  TITLE     Identification of ubiquitin ligases required for skeletal muscle
            atrophy
  JOURNAL   Science 294 (5547), 1704-1708 (2001)
   PUBMED   11679633
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Dec 1, 2020 this sequence version replaced NM_080903.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC061824.1, AY059627.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760386, SAMEA5760475
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               JAXUCZ010000005.1  151817236-151817484
            250-422             JAXUCZ010000005.1  151818491-151818663
            423-591             JAXUCZ010000005.1  151822169-151822337
            592-687             JAXUCZ010000005.1  151823227-151823322
            688-921             JAXUCZ010000005.1  151824593-151824826
            922-944             JAXUCZ010000005.1  151826590-151826612
            945-1069            JAXUCZ010000005.1  151826918-151827042
            1070-1135           JAXUCZ010000005.1  151829231-151829296
            1136-1856           JAXUCZ010000005.1  151830306-151831026
FEATURES             Location/Qualifiers
     source          1..1856
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q36"
     gene            1..1856
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /note="tripartite motif containing 63"
                     /db_xref="GeneID:140939"
                     /db_xref="RGD:619964"
     exon            1..249
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1146
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /EC_number="2.3.2.27"
                     /note="monomeric E3 ubiquitin ligase; MURF-1;
                     muscle-specific RING finger protein 1; tripartite
                     motif-containing protein 63; muscle ring finger protein 1;
                     ring finger protein 28; tripartite motif protein 63;
                     tripartite motif containing 63, E3 ubiquitin protein
                     ligase; RING-type E3 ubiquitin transferase TRIM63"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM63"
                     /protein_id="NP_543179.1"
                     /db_xref="GeneID:140939"
                     /db_xref="RGD:619964"
                     /translation="MDYKSGLIPDGNAMENLEKQLICPICLEMFTKPVVILPCQHNLC
                     RKCANDIFQAANPYWTNRGGSVSMSGGRFRCPSCRHEVIMDRHGVYGLQRNLLVENII
                     DIYKQECSSRPLQKGSHPMCKEHEDEKINIYCLTCEVPTCSLCKVFGAHQACEVAPLQ
                     SIFQGQKTELSNCISMLVAGNDRVQTIISQLEDSCRVTKENSHQVKEELSHKFDALYA
                     ILDEKKSELLQRITQEQEEKLDFIEALILQYREQLEKSTKLVETAIQSLDEPGGATFL
                     LSAKPLIKSIVEASKGCQLGKTEQGFENMDYFTLNLEHIAEALRAIDFGTDEEEEFTE
                     EEEEEDQEEGVSTEGHQ"
     exon            250..422
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            423..591
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            592..687
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            688..921
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            922..944
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1069
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1135
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1856
                     /gene="Trim63"
                     /gene_synonym="Murf; Murf1; Rnf28"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gttcggggag gaagacaaag aggatccgag tgggatccct tccactcggt gtgacgcagg
       61 tggaagagac agtcgcagtt tcgaagcaat atggattata aatctggctt gattccggac
      121 ggaaatgcta tggagaacct ggagaagcag ctcatctgcc ccatctgcct tgagatgttt
      181 accaagcctg tggtcatcct gccctgccag cacaacctct gccggaagtg tgccaacgac
      241 atcttccagg ctgccaatcc ctactggacc aaccgcggtg gctcggtgtc catgtctgga
      301 ggtcgtttcc gctgcccctc gtgccgccat gaagtgatca tggaccggca tggggtgtac
      361 ggtctgcaga ggaacctgct ggtggagaac atcatcgaca tctacaagca ggaatgctcc
      421 agtcggcccc tgcagaaagg cagccacccg atgtgcaagg aacacgaaga cgagaaaatc
      481 aacatctact gtctcacgtg cgaggtgcct acttgctcct tgtgcaaggt gttcggggct
      541 caccaggcct gtgaagttgc ccccttacaa agcatcttcc aaggacagaa gactgaactg
      601 agcaattgca tctccatgct ggtggcaggg aacgaccgag ttcagactat catctcgcag
      661 ctggaggact cctgccgagt gaccaaggaa aacagccacc aggtgaagga ggaactgagc
      721 cacaagtttg acgccctcta cgccatcctg gacgagaaga agagtgagct gctgcagcgg
      781 atcactcagg agcaggagga gaagctggac ttcatcgagg ccctgatcct ccagtaccga
      841 gagcagttgg aaaagtcgac caagcttgtg gaaacagcca tccagtccct ggatgagccc
      901 ggaggggcca ccttcctctt gagtgccaag ccgctcatca agagcattgt agaagcttcc
      961 aagggctgcc agctggggaa gacagaacaa ggctttgaga acatggacta ctttactctg
     1021 aatttagaac acatagcaga ggccttgagg gccattgact ttgggacaga tgaggaggag
     1081 gagtttactg aagaggagga ggaggaggat caagaagagg gcgtgtccac agagggacac
     1141 caatgaagaa ctggatgagt gagacgccct ctggatgcag agatggggga ggggcgggac
     1201 aggcccatct cgggatgggg ttagggctcc ttgggggcac catagggaag tgtgtcttct
     1261 ctctgctcag agagcaggga ctagcataga agccccacca ttgtgtccag cagctgctga
     1321 aacacgattg gaaatgtatc caaaaatgtc ccaggacact tttttacgtt ggtgcaaaat
     1381 gaaatatttt gtatgttttt aaaatgtgat ttttgtataa acttgtatat gtatgccaat
     1441 ttggtgcttt ttgtacaaga acttttgtat gatcatgcct ggtcattgtg tgaccagcga
     1501 ttgtcacaaa gggggaagga agccaagttc attgagctgc ccacttcctt tccttggcgg
     1561 gagggttggg tctcactcaa aggcctagaa aggggcaatg tactgtactt cagtacccat
     1621 ccccaaacat ggggagagga ctgaatttgt gttatatgtt gttttaataa atgcagaagg
     1681 ggctgggtat tggggggtgc acaccctttg atcccagcac tctggaggca gaggcagttg
     1741 gatctctatg agttcgaggc tagcctggtc tacatggaga gttccagacc agccagggca
     1801 acatagagag actctctgtc tcaaaaataa aaaaatgaaa aagaataaaa aataaa
//
