LOCUS       NM_001170461            2452 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus tripartite motif containing 6 (Trim6), mRNA.
ACCESSION   NM_001170461 XM_001073689 XM_219045
VERSION     NM_001170461.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2452)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2452)
  AUTHORS   Rajsbaum,R., Versteeg,G.A., Schmid,S., Maestre,A.M.,
            Belicha-Villanueva,A., Martinez-Romero,C., Patel,J.R., Morrison,J.,
            Pisanelli,G., Miorin,L., Laurent-Rolle,M., Moulton,H.M.,
            Stein,D.A., Fernandez-Sesma,A., tenOever,B.R. and Garcia-Sastre,A.
  TITLE     Unanchored K48-linked polyubiquitin synthesized by the E3-ubiquitin
            ligase TRIM6 stimulates the interferon-IKKepsilon kinase-mediated
            antiviral response
  JOURNAL   Immunity 40 (6), 880-895 (2014)
   PUBMED   24882218
REFERENCE   3  (bases 1 to 2452)
  AUTHORS   Sato,T., Okumura,F., Ariga,T. and Hatakeyama,S.
  TITLE     TRIM6 interacts with Myc and maintains the pluripotency of mouse
            embryonic stem cells
  JOURNAL   J Cell Sci 125 (Pt 6), 1544-1555 (2012)
   PUBMED   22328504
REFERENCE   4  (bases 1 to 2452)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   5  (bases 1 to 2452)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            FM029933.1, JAXUCZ010000001.1 and CV121315.1.
            
            On or before May 22, 2010 this sequence version replaced
            XM_001073689.3, XM_219045.6.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643299.3693.1,
                                           SRR26643294.3461.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-340               FM029933.1         1-340
            341-498             JAXUCZ010000001.1  168102276-168102433
            499-594             JAXUCZ010000001.1  168102913-168103008
            595-825             JAXUCZ010000001.1  168104073-168104303
            826-848             JAXUCZ010000001.1  168105564-168105586
            849-902             JAXUCZ010000001.1  168106830-168106883
            903-1557            CV121315.1         1-655
            1558-2452           JAXUCZ010000001.1  168107915-168108809
FEATURES             Location/Qualifiers
     source          1..2452
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2452
                     /gene="Trim6"
                     /note="tripartite motif containing 6"
                     /db_xref="GeneID:293294"
                     /db_xref="RGD:1310896"
     exon            1..27
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     exon            28..498
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1542
                     /gene="Trim6"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 6"
                     /codon_start=1
                     /product="tripartite motif-containing protein 6"
                     /protein_id="NP_001163932.1"
                     /db_xref="GeneID:293294"
                     /db_xref="RGD:1310896"
                     /translation="MTSAVLVDIRDEVTCPICLELLTEPLSIDCGHSFCQACIIGNSD
                     NSVLNPEGKSSCPVCRTVYQPGSLRPNRHLAAIVKRLREVVLGPGKQLEVIFCALHGE
                     KLQLFCKEDGKLICWLCERSLEHRGHHTFLMEEVAQEYQDMFQESLKKLRREQQEAEK
                     LKALIQEKRESWKSQVEPERHRIQTEFNQLRSILDREEQRELKKLEVEERKGLSVIEK
                     AEGDLIHQSQALKDLISDLEHRCRGSTVELLQDVGDVTKRSEFWTLKKPQALPTKLKS
                     LFRAPDLKKMLRVFRELTDVQSYWVDVTLNPQTANLNLVLSKNRRQVRFVGAKLSEPS
                     SLEEHYDCSVLGSQHFSSGKYYWEVDVTKKTAWILGVCSTPVEPMFSFSQYSSKQGAY
                     SRYQPQSGYWVIGLQRKHEYRAYEDSSPSLLLSMTVPPRRIGVFLDYEAGTVSFYNVT
                     NHGLPIYTFSKYYFPTALCPYFNPCSCVVPMTLRRPTS"
     exon            499..594
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     exon            595..825
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     exon            826..848
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     exon            849..949
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     exon            950..976
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
     exon            977..2452
                     /gene="Trim6"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cgcactgatc caggccacgg attccaggat tctataagca gacctggaaa gataggagac
       61 aagagagtga ctacaatgac ttcagcagtc ctggtggaca tccgagatga agtcacttgc
      121 cctatctgct tggagctcct gacagaaccc ctgagcatag attgcggtca tagcttctgc
      181 caggcctgca tcataggaaa cagtgataat tcagtgctca acccagaagg gaagagcagc
      241 tgtcctgtgt gccggaccgt ctaccagcct gggagcctcc gtcctaaccg gcacctggcc
      301 gccatagtga aaaggctcag agaagtcgtg ttaggccctg gaaaacagct cgaggtcatt
      361 ttttgtgcgc ttcatggaga gaaacttcaa cttttttgca aggaggatgg gaagttaatt
      421 tgctggcttt gtgagcgatc tctggagcac cgtggtcatc acacattcct catggaggag
      481 gtagcacagg agtaccagga catgttccag gagtctctga agaagctgag gagggagcag
      541 caggaagccg agaagctaaa agctcttatc caagagaaga gggaatcctg gaagagtcag
      601 gtggagcctg agagacaccg gatccagaca gagtttaatc agctccgaag catcctggac
      661 agggaggagc agcgggaact gaagaaactg gaagtggaag agaggaaggg gctgagcgtc
      721 atagaaaagg ccgagggtga cctgatccac cagagccagg cactaaaaga cctcatctca
      781 gacctggagc accggtgccg ggggtccaca gtggaactgt tgcaggatgt gggtgacgtc
      841 acaaaaagga gtgagttctg gaccttgaag aagccccaag ctctccccac caagctgaaa
      901 agtttgtttc gagccccgga tctgaagaag atgctgcgag tctttagaga gctgacagac
      961 gtccaaagct actgggtgga cgtgactctg aatccacaga cggctaattt aaatcttgtc
     1021 ctgtcgaaaa accggagaca ggtgaggttt gtgggtgcca agctgtcgga gccgtctagt
     1081 ctggaagaac attatgactg tagtgtcctg ggttctcagc acttctcctc aggcaaatac
     1141 tactgggaag tggatgtgac caagaagacg gcgtggatct tgggtgtatg cagtacccct
     1201 gtggaaccca tgttctcctt cagccagtac tccagtaagc agggtgccta ctctcggtat
     1261 cagccacaga gtggatactg ggtgataggt ttgcagcgta agcacgagta cagagcctat
     1321 gaggactcct ccccatccct gctcctctcc atgacggtgc cacctcgacg cataggggtt
     1381 ttcttagact atgaggctgg cacggtctcc ttttataatg tcacaaacca tggcttgccc
     1441 atctacacct tctccaagta ttacttccct actgcccttt gtccgtattt taatccctgc
     1501 agctgtgtag tcccgatgac tctgcggcgc ccaacttcct gaggcctgct gcctcttccc
     1561 ataacgaagc agattccttc aaacacatta ctttcctctt cgagcctctg ttctcctagt
     1621 agaacactgc ccattgctga agtgatcact cttgacccat ctcataggaa agtagtgttt
     1681 tgggttggtt tttgtttgtt tgttttgttt tgtttttttg aggtaggatt tctggaactc
     1741 tctctctagg gcaggctgac tttgaactca gagagatcca attacctccc ttctgaatgc
     1801 cagggttgaa gtcatgtgac accgtcccag ttttgtgatt gagaaagtaa ctgaaaattg
     1861 atccagagtc ctaatgcaca tgcccatact tggctgcgat tttgttttaa tgttaagata
     1921 taggccgcaa aaatagtcca agctggccac agactccgtc cttctgcctc acctcccaaa
     1981 tactgagtat aggtttatct gacaacacct ggctaagcat gatatttgat gtgtatggtc
     2041 aaatgtaaaa aattctctat aaattagatg ggaggttttt tggtttggtt ggtttttttg
     2101 tttgtttgtt tgtttgtttt tgttttgttt tttgggttct tttgtaacta ttgaatttaa
     2161 tagatttttt tccctatagt tatttagaga attgtgtacc ctttttattc tgctcctggg
     2221 tcagctacac tgagtagtct aggttgtcaa gttcaccact gattcctgaa gtacatgtgt
     2281 tacattcagt acttcttttt ttttctgact ctaggttcgg ttttcatcga tctttctaaa
     2341 caaaactacc tctaactttg cattctcgtg ctttctggta atatataaaa aagaaattat
     2401 gggcaaggga ttatatgtat atttaggatt ataataaaat aataaaaatc ga
//
