LOCUS       NM_001012218            2709 bp    mRNA    linear   ROD 12-MAY-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 55 (Trim55), mRNA.
ACCESSION   NM_001012218 XM_345192
VERSION     NM_001012218.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2709)
  AUTHORS   Tan,J., Shen,J., Zhu,H., Gong,Y., Zhu,H., Li,J., Lin,S., Wu,G. and
            Sun,T.
  TITLE     miR-378a-3p inhibits ischemia/reperfusion-induced apoptosis in H9C2
            cardiomyocytes by targeting TRIM55 via the DUSP1-JNK1/2 signaling
            pathway
  JOURNAL   Aging (Albany NY) 12 (10), 8939-8952 (2020)
   PUBMED   32463795
  REMARK    GeneRIF: miR-378a-3p inhibits ischemia/reperfusion-induced
            apoptosis in H9C2 cardiomyocytes by targeting TRIM55 via the
            DUSP1-JNK1/2 signaling pathway.
REFERENCE   2  (bases 1 to 2709)
  AUTHORS   Gralinski,L.E., Ferris,M.T., Aylor,D.L., Whitmore,A.C., Green,R.,
            Frieman,M.B., Deming,D., Menachery,V.D., Miller,D.R., Buus,R.J.,
            Bell,T.A., Churchill,G.A., Threadgill,D.W., Katze,M.G.,
            McMillan,L., Valdar,W., Heise,M.T., Pardo-Manuel de Villena,F. and
            Baric,R.S.
  TITLE     Genome Wide Identification of SARS-CoV Susceptibility Loci Using
            the Collaborative Cross
  JOURNAL   PLoS Genet 11 (10), e1005504 (2015)
   PUBMED   26452100
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2709)
  AUTHORS   Lomonosova,Iu.N., Turtikova,O.V. and Shenkman,B.S.
  TITLE     [Translocation of MuRF isoforms to nuclei in postural muscle during
            gravitational unloading]
  JOURNAL   Ross Fiziol Zh Im I M Sechenova 101 (1), 64-73 (2015)
   PUBMED   25868327
  REMARK    GeneRIF: MuRF1 and MuRF2 translocate to the nuclei in the soleus
            muscle during gravitational unloading.
REFERENCE   4  (bases 1 to 2709)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   5  (bases 1 to 2709)
  AUTHORS   Perera,S., Holt,M.R., Mankoo,B.S. and Gautel,M.
  TITLE     Developmental regulation of MURF ubiquitin ligases and autophagy
            proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly
            and turnover
  JOURNAL   Dev Biol 351 (1), 46-61 (2011)
   PUBMED   21185285
  REMARK    GeneRIF: Neonatal rat cardiomyocytes expressing MURF2+3 specific
            siRNA have reduced expression of both MURF2 and -3
REFERENCE   6  (bases 1 to 2709)
  AUTHORS   Lange,S., Xiang,F., Yakovenko,A., Vihola,A., Hackman,P.,
            Rostkova,E., Kristensen,J., Brandmeier,B., Franzen,G., Hedberg,B.,
            Gunnarsson,L.G., Hughes,S.M., Marchand,S., Sejersen,T., Richard,I.,
            Edstrom,L., Ehler,E., Udd,B. and Gautel,M.
  TITLE     The kinase domain of titin controls muscle gene expression and
            protein turnover
  JOURNAL   Science 308 (5728), 1599-1603 (2005)
   PUBMED   15802564
REFERENCE   7  (bases 1 to 2709)
  AUTHORS   McElhinny,A.S., Perry,C.N., Witt,C.C., Labeit,S. and Gregorio,C.C.
  TITLE     Muscle-specific RING finger-2 (MURF-2) is important for
            microtubule, intermediate filament and sarcomeric M-line
            maintenance in striated muscle development
  JOURNAL   J Cell Sci 117 (Pt 15), 3175-3188 (2004)
   PUBMED   15199100
REFERENCE   8  (bases 1 to 2709)
  AUTHORS   Pizon,V., Iakovenko,A., Van Der Ven,P.F., Kelly,R., Fatu,C.,
            Furst,D.O., Karsenti,E. and Gautel,M.
  TITLE     Transient association of titin and myosin with microtubules in
            nascent myofibrils directed by the MURF2 RING-finger protein
  JOURNAL   J Cell Sci 115 (Pt 23), 4469-4482 (2002)
   PUBMED   12414993
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC087100.1.
            
            On Feb 11, 2005 this sequence version replaced XM_345192.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC087100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760384, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2709
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q24"
     gene            1..2709
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /note="tripartite motif-containing 55"
                     /db_xref="GeneID:365751"
                     /db_xref="RGD:1306943"
     exon            1..296
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     CDS             129..1766
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /EC_number="2.3.2.27"
                     /note="muRF2; MURF-2; muscle-specific RING finger protein
                     2; ring finger protein 29"
                     /codon_start=1
                     /product="tripartite motif-containing protein 55"
                     /protein_id="NP_001012218.1"
                     /db_xref="GeneID:365751"
                     /db_xref="RGD:1306943"
                     /translation="MSTSLNYKSFSKEQQTMDNLEKQLICPICLEMFTKPVVILPCQH
                     NLCRKCASDIFQASNPYLPTRGGTTVASGGRFRCPSCRHEVVLDRHGVYGLQRNLLVE
                     NIIDIYKQESTRPEKKLDQPMCEEHEEERINIYCLNCEVPTCSLCKVFGAHKDCQVAP
                     LTHVFQRQKSELSDGIAVLVGSNDRVQGVISQLEDTCKTIEECCRKQKQDLCEKFDHL
                     YSILEERKTEMTQAITRTQEEKLEHVRTLIRKYSDHLENVSKLVESGIQFMDEPEMAV
                     FLQNAKTLLQKITEASKAFQMEKIEQGYEIMNNFTVNLNREEKIIREIDFSREEEDED
                     DEGEVDEEGEGEDAVEVEEAENVQVASSGEEETLEKAAEPSELAAEIQAASGPLLASS
                     PDSVSSLPPAADVLVTQGEVVPTDSQQTTQSETSGPSAAETADPLFYPSWYKGQSRKM
                     ISNPPHTPGGEGLSQIGPSAAEDSSVQSAEVAEAAANEQAAVSGKESSSTAATSQIGF
                     EASSPQGQAAALGSGGGADSEPARHVFSFSWLNSLNE"
     exon            297..469
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            470..635
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            636..731
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            732..965
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            966..988
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1113
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1355
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1356..1643
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..2658
                     /gene="Trim55"
                     /gene_synonym="Rnf29"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcctccaca gagagggacg taaaggacac ttgatcatta cagtccttgg aattacttcc
       61 aggaaacact tccagaagcc gttcgggagc acccttcccc tggcggcaca cccagggacg
      121 gctaggaaat gagcacttct ctgaattaca agtctttctc caaagagcag cagaccatgg
      181 ataacttaga aaagcaactg atctgtccca tctgcctaga gatgttcacc aagcccgtgg
      241 tcattctccc gtgccagcat aacctgtgca ggaagtgcgc cagtgacatc ttccaggcct
      301 ctaacccgta cttacccaca agaggaggca ccaccgtggc gtcggggggc cgcttccgct
      361 gcccctcttg cagacatgaa gtggtgttag acaggcatgg ggtctatgga ctacagagga
      421 acctgcttgt cgagaacatc attgatatct acaagcagga atccaccagg ccagaaaaaa
      481 agttggacca gcccatgtgt gaggagcatg aagaggaacg catcaacatc tactgtctga
      541 actgtgaagt gcccacctgc tccctgtgca aggtttttgg cgctcataag gactgccagg
      601 tggctcccct gacccatgtg ttccagaggc agaagtcaga gctcagtgat ggtattgctg
      661 tacttgtggg aagcaacgac agagtccagg gtgtgatcag ccagctggag gacacctgta
      721 aaactattga ggagtgctgc agaaagcaga aacaggacct gtgtgagaag tttgatcacc
      781 tgtatagcat cctggaggag aggaagaccg aaatgaccca agccatcacc cgaacacagg
      841 aagagaaact ggagcatgtc cgaactctta tcagaaagta ttctgatcac ctggagaatg
      901 tatcaaagtt ggtggagtca ggaatccagt tcatggatga gccagaaatg gcagtgtttc
      961 tgcagaatgc caagaccctg ttgcaaaaga tcacagaagc atcgaaggcg tttcagatgg
     1021 agaaaataga acaaggttat gagatcatga acaacttcac agtcaacctc aatagagaag
     1081 aaaaaattat ccgtgaaatt gatttttcta gagaagagga agatgaagac gatgaaggag
     1141 aagtagatga agaaggagaa ggagaggatg cagtagaagt agaagaggca gaaaatgttc
     1201 aagtagcatc atcaggagaa gaggagactc tggaaaaagc tgcagagccc tctgagctgg
     1261 ctgcagagat ccaggctgcc tcagggccac tacttgcttc ctctccagat tcagtttcat
     1321 ccctgccacc tgctgcagat gtcctggtga cacaggggga ggtggtgccc actgactctc
     1381 agcagaccac acaatctgaa acttcaggcc cttcagcagc ggaaactgcg gatcccttgt
     1441 tttaccctag ttggtataaa ggccaaagcc ggaaaatgat ctccaaccca cctcacactc
     1501 ctgggggtga aggtctgagt caaatagggc cttcggctgc tgaggattcc agtgtgcagt
     1561 ccgcagaagt agcagaagcc gcagccaatg agcaggcagc agtgagtggt aaggagtcta
     1621 gttcaactgc agctacctct cagattggat ttgaggcctc ttctccccag ggacaggctg
     1681 cagccttggg gagtgggggt ggggctgatt ctgagccagc tcgccacgtc ttctccttct
     1741 cctggttgaa ttccctaaat gaatgatatt tattctcctt gctgccccct gtctgcctgg
     1801 ctgagaagca catagggaaa cctggtggaa attcaccgtg atgcatacga aggggacctc
     1861 tggacaggat ttctaaaacc aaaacaaaac aagaacaaca ccctttaatt ccagatgact
     1921 tatctaactt gttgagaaaa tgattatgct cagaacaaaa attacagaaa atactctgat
     1981 gaagaaactt gatcttatgc ttttattggg tgagaaacat tctgaagggt gtgtaggtgt
     2041 ggtgcgtgta cacatcagct gtgagtggcg agcggttaca aactggcaga acactctcct
     2101 ctctctgggc ttcttgttat tttcggacac tcgtgccttt tgcttttctc cttagcattg
     2161 caggtggtag gtgacattca gtgtcagttc agaactgacc catttatcaa aatatggaga
     2221 ttggtcactg accaaagcta tgtagaatgc tatagaggtt cctcttccct acagatgtca
     2281 caggatgtac agccagaagt tttctttaca tgtggccaca cttccatagt ccagaaggcc
     2341 aaaggtctag ggcaattctt tagacatttt tctaatacta tttacatatc tcataatctt
     2401 atatccatgt aacagccact ttaattgaag actttctggg aggaactgtc tactttctta
     2461 tgtgtctgcc atagcagcaa ttcagcaaac tgtggaacaa ctgcatgtat ttaaatatac
     2521 acacagtctc cccctgtgcg ctttctctct ccctctccct ctcctctctc tcccctctct
     2581 cccttctctc tctccatgct ttcatcacat acgtgtaacg ttactttaaa tgaactccta
     2641 aataaatgtt tttaagaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     2701 aaaaaaaaa
//
