LOCUS       NM_001014023            2470 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 5 (Trim5), mRNA.
ACCESSION   NM_001014023 XM_219046
VERSION     NM_001014023.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2470)
  AUTHORS   Mandell,M.A., Jain,A., Arko-Mensah,J., Chauhan,S., Kimura,T.,
            Dinkins,C., Silvestri,G., Munch,J., Kirchhoff,F., Simonsen,A.,
            Wei,Y., Levine,B., Johansen,T. and Deretic,V.
  TITLE     TRIM proteins regulate autophagy and can target autophagic
            substrates by direct recognition
  JOURNAL   Dev Cell 30 (4), 394-409 (2014)
   PUBMED   25127057
REFERENCE   2  (bases 1 to 2470)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   3  (bases 1 to 2470)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 2470)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   5  (bases 1 to 2470)
  AUTHORS   Pertel,T., Hausmann,S., Morger,D., Zuger,S., Guerra,J., Lascano,J.,
            Reinhard,C., Santoni,F.A., Uchil,P.D., Chatel,L., Bisiaux,A.,
            Albert,M.L., Strambio-De-Castillia,C., Mothes,W., Pizzato,M.,
            Grutter,M.G. and Luban,J.
  TITLE     TRIM5 is an innate immune sensor for the retrovirus capsid lattice
  JOURNAL   Nature 472 (7343), 361-365 (2011)
   PUBMED   21512573
REFERENCE   6  (bases 1 to 2470)
  AUTHORS   O'Connor,C., Pertel,T., Gray,S., Robia,S.L., Bakowska,J.C.,
            Luban,J. and Campbell,E.M.
  TITLE     p62/sequestosome-1 associates with and sustains the expression of
            retroviral restriction factor TRIM5alpha
  JOURNAL   J Virol 84 (12), 5997-6006 (2010)
   PUBMED   20357094
REFERENCE   7  (bases 1 to 2470)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   8  (bases 1 to 2470)
  AUTHORS   Li,X., Gold,B., O'hUigin,C., Diaz-Griffero,F., Song,B., Si,Z.,
            Li,Y., Yuan,W., Stremlau,M., Mische,C., Javanbakht,H., Scally,M.,
            Winkler,C., Dean,M. and Sodroski,J.
  TITLE     Unique features of TRIM5alpha among closely related human TRIM
            family members
  JOURNAL   Virology 360 (2), 419-433 (2007)
   PUBMED   17156811
REFERENCE   9  (bases 1 to 2470)
  AUTHORS   Xu,L., Yang,L., Moitra,P.K., Hashimoto,K., Rallabhandi,P., Kaul,S.,
            Meroni,G., Jensen,J.P., Weissman,A.M. and D'Arpa,P.
  TITLE     BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the
            RBCC/tripartite motif protein, TRIM5delta
  JOURNAL   Exp Cell Res 288 (1), 84-93 (2003)
   PUBMED   12878161
REFERENCE   10 (bases 1 to 2470)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC078926.1.
            
            On Apr 20, 2005 this sequence version replaced XM_219046.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC078926.1, SRR8487227.124338.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN16676786, SAMN16676809
                                           [ECO:0000348]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..2470
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2470
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /note="tripartite motif-containing 5"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
     exon            1..51
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            52..527
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1643
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /EC_number="2.3.2.27"
                     /codon_start=1
                     /product="tripartite motif-containing protein 5"
                     /protein_id="NP_001014045.1"
                     /db_xref="GeneID:308906"
                     /db_xref="RGD:1304579"
                     /translation="MASEFVMNLKEEVTCPICLDLMVEPVSGDCGHSFCQACITLNYE
                     SSKCNQDEFICPVCRVSYLFKNLRPNRHVANIVQRLKEFKSSPEEEPKVLSCARHGEK
                     LQLFCKKDMMPICWLCERSQEHRGHQTVLIEEVVQEYKEKLQAALQKLMADKKEFENW
                     KDDLQKERTYWQNQIQKDVENVQSEFKGMRDIMDSEEKKELQKLMQEKEDIMSSLEES
                     ENEYSQQSKLLGDLILDVEHQLQCSATEMLQGVENTIKRSHTFSMRKPKTIPKEQRRV
                     FRAPDLQGMLQVLQEVTEAQRYWVQVTLVESNNPNIFITADKRQIRYEDHQARHFARP
                     TENCHAGVLGYPAIQSGKHYWEVDVSGKGSWVLGLSDGSYLFNPIFRSNAERPPNPPL
                     FRLNLSNDSHSRLSLSNDSHYQPKYGFWVIGLWGNSVYNAFEECTFTGKPSVLTLSLM
                     VRPCRVGIFLDCAAGTLSFYNISNHGTLIYRFCAGSFPDRVFPYFNPMGSSEPLTICW
                     PDS"
     exon            528..623
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            624..854
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            855..877
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            878..978
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1005
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..2438
                     /gene="Trim5"
                     /gene_synonym="RGD1304579"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 tgctggtgtg gcagctgccc tgaactacat catcctttcg gttctcatcc tgcacctgag
       61 cagacgtgtg aggagtcagt agagtcagac acaggatcac agcaactatg gcttcagaat
      121 tcgtgatgaa tttaaaagag gaggtgacct gtcctatctg cctggacctg atggtagaac
      181 ctgtgagtgg agattgtggt cacagcttct gccaagcctg catcacgctg aactatgaat
      241 ccagcaaatg caatcaggat gagttcattt gccctgtgtg ccgagttagt tacctgttta
      301 agaacctgag gcccaatcga catgtggcca acatagtgca gaggctcaaa gagttcaagt
      361 ccagcccaga agaggagccg aaggtgcttt cttgtgcaag gcatggagag aaactccagc
      421 tcttctgtaa gaaggacatg atgcccatct gctggctttg tgagcgatct caggagcacc
      481 gtggacacca aacagttctc attgaagagg tggtccagga gtataaggag aagctgcagg
      541 cagctctgca aaagctgatg gcagacaaga aagaatttga gaactggaaa gatgaccttc
      601 aaaaggagag aacttactgg cagaatcaaa tacagaaaga tgtggaaaat gtccagtcag
      661 agtttaaagg aatgagagat atcatggact ctgaggagaa gaaggaattg cagaagctga
      721 tgcaagagaa ggaagacatt atgagcagcc tggaagagtc tgaaaatgag tattctcagc
      781 agagtaagtt gctaggagac ctcatcttag atgtggaaca tcagttacaa tgctcagcca
      841 cggaaatgct gcagggtgta gagaacacca taaaacggag tcatactttt tcgatgagga
      901 agcccaaaac catccccaag gaacaaagaa gagtgttccg agcccctgat ctgcaaggca
      961 tgctgcaagt gttacaagag gtcacagagg cccaacgcta ctgggttcaa gtgacgctgg
     1021 ttgaaagcaa caatccaaac attttcatta ccgccgacaa aagacagata cgatatgaag
     1081 accaccaagc aagacatttt gcccgtccga ctgaaaactg tcatgcaggt gtcctgggat
     1141 acccagctat ccaatcagga aaacactact gggaagtaga tgtgtctgga aaaggttctt
     1201 gggttctggg attaagtgat ggaagctacc tctttaatcc aatatttcgt tcaaatgcag
     1261 aaagaccccc aaaccccccc ttatttcgtt tgaatcttag taatgattca cattctcgtt
     1321 tgagtcttag taatgattca cattatcaac ctaaatatgg cttctgggtt atagggctgt
     1381 ggggaaattc tgtgtataat gcttttgagg agtgtacgtt cacaggcaag cccagtgtgt
     1441 tgaccctctc tctgatggtc cgaccctgtc gtgtcggtat tttcctcgac tgtgcagctg
     1501 gcaccctctc gttttacaat atttccaacc atggcactct tatctacaga ttctgtgcag
     1561 gttcctttcc tgatagggtt tttccatatt ttaaccccat gggaagttca gagccattga
     1621 caatatgctg gccagactct taatcttcac tgtctctgtg catggtctct ggtcctgatg
     1681 tgtatgtcat gtgcctgagc tcatcagcac tattttatcg ttttgttcat gtctctaatc
     1741 tttcattgga aaatatattc atttctctag gccatattct cagtttcttg gggtattttt
     1801 tgtctttgtt ttgttttgtt tttaggtgag actaacaaat cacttcccat atagtcaagg
     1861 acaaatgtct agtgctcact gcgtaagata acaccgatgc aaaattcctc ttattcttca
     1921 tgccagagat ggaaggcaag gccttgtgca cggtgaggat gtgctccacc gctgagctgt
     1981 ttgcttcagc tgtcatgtcc ctataacctc attcggccca tcaatgaaag attaaagaag
     2041 gttcttcgac aacttgtcta ttcatgctga aaattatata taggagtctc tgcttaagaa
     2101 atgcaccctg agctgtaggc caaagaatga aggagaagca tcacaagaag ccttatcact
     2161 gtgactaaat taagtgatca ttaagactgt gcatcagtct tgcctgggag ctcatacctg
     2221 ccatcctgca tctgggaagt tgtggcagga agattgctgt gtatttgaag ccacccttgt
     2281 atagagttaa gagcctgctt aaaaaaaata atcaagaata tgtataaaaa ccactactct
     2341 attttgttct aagaaataga ataactagat ttcagaattg cagggtttgg gtcgttttca
     2401 caatttgtaa ataaatgttt actaaaaata aatgttaaaa aaaaaaaaaa aaaaaaaaaa
     2461 aaaaaaaaaa
//
