LOCUS       NM_001395105            3036 bp    mRNA    linear   ROD 27-MAR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 46 (Trim46), mRNA.
ACCESSION   NM_001395105 XM_008761170
VERSION     NM_001395105.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3036)
  AUTHORS   Harterink,M., Vocking,K., Pan,X., Soriano Jerez,E.M., Slenders,L.,
            Freal,A., Tas,R.P., van de Wetering,W.J., Timmer,K., Motshagen,J.,
            van Beuningen,S.F.B., Kapitein,L.C., Geerts,W.J.C., Post,J.A. and
            Hoogenraad,C.C.
  TITLE     TRIM46 Organizes Microtubule Fasciculation in the Axon Initial
            Segment
  JOURNAL   J Neurosci 39 (25), 4864-4873 (2019)
   PUBMED   30967428
  REMARK    GeneRIF: In the present study we developed a novel correlative
            light and electron microscopy approach to study the axon initial
            segment microtubules during neuron development and identified an
            essential role for TRIM46 in microtubule fasciculation
REFERENCE   2  (bases 1 to 3036)
  AUTHORS   Gumy,L.F., Katrukha,E.A., Grigoriev,I., Jaarsma,D., Kapitein,L.C.,
            Akhmanova,A. and Hoogenraad,C.C.
  TITLE     MAP2 Defines a Pre-axonal Filtering Zone to Regulate KIF1- versus
            KIF5-Dependent Cargo Transport in Sensory Neurons
  JOURNAL   Neuron 94 (2), 347-362 (2017)
   PUBMED   28426968
REFERENCE   3  (bases 1 to 3036)
  AUTHORS   van Beuningen,S.F.B., Will,L., Harterink,M., Chazeau,A., van
            Battum,E.Y., Frias,C.P., Franker,M.A.M., Katrukha,E.A., Stucchi,R.,
            Vocking,K., Antunes,A.T., Slenders,L., Doulkeridou,S., Sillevis
            Smitt,P., Altelaar,A.F.M., Post,J.A., Akhmanova,A.,
            Pasterkamp,R.J., Kapitein,L.C., de Graaff,E. and Hoogenraad,C.C.
  TITLE     TRIM46 Controls Neuronal Polarity and Axon Specification by Driving
            the Formation of Parallel Microtubule Arrays
  JOURNAL   Neuron 88 (6), 1208-1226 (2015)
   PUBMED   26671463
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            On Jun 3, 2021 this sequence version replaced XM_008761170.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643298.11990.1,
                                           SRR26360176.783134.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-130               JAXUCZ010000002.1  176951797-176951926 c
            131-392             JAXUCZ010000002.1  176950236-176950497 c
            393-736             JAXUCZ010000002.1  176949676-176950019 c
            737-880             JAXUCZ010000002.1  176948399-176948542 c
            881-976             JAXUCZ010000002.1  176948195-176948290 c
            977-1230            JAXUCZ010000002.1  176944122-176944375 c
            1231-1352           JAXUCZ010000002.1  176943784-176943905 c
            1353-1655           JAXUCZ010000002.1  176942505-176942807 c
            1656-1953           JAXUCZ010000002.1  176941369-176941666 c
            1954-3036           JAXUCZ010000002.1  176939253-176940335 c
FEATURES             Location/Qualifiers
     source          1..3036
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..3036
                     /gene="Trim46"
                     /note="tripartite motif-containing 46"
                     /db_xref="GeneID:310641"
                     /db_xref="RGD:1305993"
     exon            1..130
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     CDS             68..2347
                     /gene="Trim46"
                     /note="tripartite motif protein 46; tripartite
                     motif-containing protein 46-like"
                     /codon_start=1
                     /product="tripartite motif-containing protein 46"
                     /protein_id="NP_001382034.1"
                     /db_xref="GeneID:310641"
                     /db_xref="RGD:1305993"
                     /translation="MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPL
                     VLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRL
                     DRLLKSGFGTYPGRKRGALHPQTILFPCPACQGDVELGERGLSGLFRNLTLERVVERY
                     RQSVSVGGAILCQLCKPPPLEATKGCSECRATFCNECFKLFHPWGTQKAQHEPTLPTL
                     SFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTK
                     SLAYILGNQDTVQTQICELEETIRHTEVSGQQAKEEVSQLVRGLGAVLEEKRSSLLQA
                     IEECQQERLSRLSAQIHEHQSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARA
                     TEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCW
                     RLPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRG
                     CNKAGYGEYSEDVHLHTPPAPVLHFFLDGRWGASRERLAISKDQRAVRSIPGLPLLLA
                     AERLLTGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPD
                     VISPRYDPDSGHDSGAEDAAVEALPPFAFLTIGMGKILLGSGASSNAGLTGRDGPAAS
                     CTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQE
                     PVGTKPERKVTIGGFAKLD"
     exon            131..392
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            393..736
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            737..880
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            881..976
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            977..1230
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1352
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..1655
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1953
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
     exon            1954..3036
                     /gene="Trim46"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 attaagcccc gggttcgcag cagcagccag gatcgtgcac ccgggggcgg gcgggcacag
       61 tagggccatg gctgagggtg aggatatgca gaccttcact tccatcatgg atgcactagt
      121 ccgcatcagt acaagcatga agaacatgga gaaggaactg ctgtgcccag tgtgccaaga
      181 gatgtacaag cagccactag tgctgccttg tacccacaac gtgtgccagg cctgtgcccg
      241 ggaggttttg ggccagcagg ggtacatagg ccatggtggg gatccgagtt cggagcccac
      301 ttctcctgct tccacccctt ctacccgcag cccccgcctc tctcggagaa ctctccccaa
      361 gccagatcgc ttggaccggc tccttaagtc aggctttggg acataccctg ggcggaagcg
      421 tggtgccttg cacccccaga cgatcttatt cccgtgccca gcctgccagg gcgatgtgga
      481 actgggggag aggggccttt ccgggctttt ccgaaacctg accctagagc gagtggtgga
      541 gcggtaccga cagagtgtga gtgtgggcgg cgccatcctg tgccagttgt gcaagccccc
      601 accactagag gccaccaagg gctgctcaga gtgtcgagct accttctgta atgaatgctt
      661 caagctcttc cacccctggg gcactcagaa ggcccaacac gaacccacgc tacccaccct
      721 ctcattccgc cccaagggtc tgatgtgtcc agaccacaag gaagaggtga cccactactg
      781 taagacatgt caacgactgg tgtgccaact ctgcagggta cggcgtaccc acagtgggca
      841 caagatcaca ccagtgctca gtgcctacca ggctctcaag gataagctaa ctaagagcct
      901 ggcatacatc ttgggaaacc aggacacagt gcagacccag atttgtgagc tggaggagac
      961 catcaggcac actgaggtga gtggtcagca ggcgaaagag gaggtgtccc agctggttcg
     1021 gggactaggg gctgtgttgg aagagaagcg atcctcactt cttcaggcca tcgaagagtg
     1081 ccagcaagag cgtttatccc ggctcagtgc ccagatccat gagcaccaga gcctgctgga
     1141 tggctcgggt ttggtgggct acgcccagga agttcttaag gaaacagacc agccttgctt
     1201 tgtacaagca gccaaacagc tgcataacag gattgcccga gccaccgagg ccctccagac
     1261 attccggcca gctgccagct cctccttccg tcattgccag ctggatgtgg gacgggagat
     1321 gaagttgctg acagagctta acttcctgag agtgcccgag gcgcctgtca tcgacaccca
     1381 acgcaccttt gcctatgacc aaatcttcct gtgctggcgg ctgccccctc actcaccacc
     1441 tgcctggcat tacactgtgg agttccggcg cacagatgtc cccgcccagc caggccctac
     1501 acgctggcag cgacgggagg aggtgagggg caccagtgcc ctcctggaga accctgacac
     1561 gggctctgtg tatgtgctgc gtgtccgtgg ctgcaacaaa gctggctacg gagagtacag
     1621 tgaagatgtg cacctgcaca cacccccagc acctgtcctg cacttcttcc tcgatggccg
     1681 ctggggtgca agccgagagc ggctagccat cagcaaggac cagcgggcgg tgcggagtat
     1741 cccagggctt cccttgctgc tggctgctga gcggctgctc acaggctgcc acctgagtgt
     1801 ggacgtggtc ctgggggatg tggctgtgac ccagggccgc agctactggg cctgtgccgt
     1861 agaccctgcc tcctacttgg tcaaggtggg cgtcgggctg gagagcaagc ttcaggaaag
     1921 cttccagggt gccccggatg tgatcagccc cagatatgac ccggacagcg ggcacgacag
     1981 cggtgcagaa gacgccgcag tggaggcctt gccgcccttc gctttcctga ccatcggcat
     2041 gggcaagatc ctgctgggct ccggagcaag ttcaaatgca gggctgacag ggagagacgg
     2101 cccggcagct agctgcacag tgcctctgcc acctcgccta ggcatctgtt tggactacga
     2161 gcgggggcgg gtttccttcc tggatgctgt gtcgttccgc gggctcctgg agtgccccct
     2221 ggactgctca gggcctgtgt gccctgcctt ctgcttcatt gggggtggcg ctgtacagct
     2281 gcaggagccc gtgggcacca agcctgagag gaaagtcacc attgggggct ttgccaagct
     2341 ggactgagcc tttcaggccc ccttttcaga cctaagctct gctccccaag cctctgggca
     2401 tcgggttgtt tacccagcag cttctccccc aagacttccc aaccacgtgg ccctgcccca
     2461 taccttgcca gctgtgtctt cccagggaag ccctgggaac tctcctctgc ttatctctgg
     2521 atgtccttca ttctctgtgt tacctgttgg ccttggccct tggctctgcc tttggcattt
     2581 taaccaaggc atagaaagcc ccattccatc tctgtctggt gctcccgagg cctattggga
     2641 ggggggcacc tggaacagtg ggtatgatca acaactgccc tttgccatgt caagcccctc
     2701 tccccattga tgctgacaca gcctcggcag ccaggctccg agcctcccca ctgaggggga
     2761 ggagaaccta tcctgtttta tttggatccc tataccttcc agctgcatgt cccttctgtc
     2821 ccttttctct tgcatgcttt acctatccag cacccatgcc aacgtgccaa gtctcccatg
     2881 ggaactcagt taaggctggt gtccccatcg ggttgggcca agttaggcct ctggtgcctg
     2941 ctactgtctc cctacagtgg gcatcactgg cctgtgctga gcaacagctg taattttcat
     3001 ggtttataaa caataaactg tgacaccagg cacaca
//
