LOCUS       NM_001106453            2314 bp    mRNA    linear   ROD 03-MAR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 45 (Trim45), mRNA.
ACCESSION   NM_001106453 XM_001066237 XM_215666
VERSION     NM_001106453.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2314)
  AUTHORS   Bassett,J.H., Gogakos,A., White,J.K., Evans,H., Jacques,R.M., van
            der Spek,A.H., Ramirez-Solis,R., Ryder,E., Sunter,D., Boyde,A.,
            Campbell,M.J., Croucher,P.I. and Williams,G.R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Rapid-throughput skeletal phenotyping of 100 knockout mice
            identifies 9 new genes that determine bone strength
  JOURNAL   PLoS Genet 8 (8), e1002858 (2012)
   PUBMED   22876197
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH474015.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_001066237.1, XM_215666.4.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5756307,
                              SAMEA5760383 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2314
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..2314
                     /gene="Trim45"
                     /note="tripartite motif-containing 45"
                     /db_xref="GeneID:295323"
                     /db_xref="RGD:1309168"
     exon            1..934
                     /gene="Trim45"
                     /inference="alignment:Splign:2.1.0"
     CDS             447..2186
                     /gene="Trim45"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 45; tripartite
                     motif-containing protein 45"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM45"
                     /protein_id="NP_001099923.1"
                     /db_xref="GeneID:295323"
                     /db_xref="RGD:1309168"
                     /translation="MSENRKPLPGFVNKLQDASASGSSGKTHCPSCLRLFKVPRLLPC
                     LHTVCTSCLERLDPFSVVDIRGGDSDTSSEGSIFQEPKSCSLKPQIGILCPVCDAQVD
                     LPLGGVKALTVDHLAMNDVMLESLHGEGQGLVCDLCSDREVEKRCQTCKANLCHFCCQ
                     AHRRQKKTTDHTMVDLKDLKGYSRVGKPILCPSHPAEELRLFCELCDRPVCRDCVVGE
                     HREHPYDFTSNVIHKHGDSVRELLRDTQPHVEALEDALAQIKSSNNALQERVEAVAAD
                     VRTFSEGYIRAIEEHRDKLLRQLDDIRVQKENSLQLQKAQLEQLLADMRTGVEFTEHL
                     LTSGSDLEILVTKGVVVERLRKLNKVEYSARPGVNHKICFSPQEKARCQGYEVYGAIN
                     TQEVDPAQCVLQGEDLHRAREKQTASFTLVCKDATGESMSRGGDNVRVEVVPKNKKDS
                     PIRTVVQDNKDGSYRVSYTPKEPGVYTVWVGIREQQVQGSPFNVTVRRKHRPHPGVFH
                     CCTFCSSGGQKTARCACGGTMPGGYLGCGHGHKGHPGRPHWSCCGKFIEKSECSYSTG
                     QSAPRSLLRTVAL"
     exon            935..1665
                     /gene="Trim45"
                     /inference="alignment:Splign:2.1.0"
     exon            1666..1795
                     /gene="Trim45"
                     /inference="alignment:Splign:2.1.0"
     exon            1796..1910
                     /gene="Trim45"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2037
                     /gene="Trim45"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2314
                     /gene="Trim45"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gctgcactct cacactctgg gagagcctaa ggacacctca tcgcctggag gggagggtgc
       61 gcttgtggcg tggtgggggc gggaccagtg gggcgggagg gagggtggcc ttggaggaaa
      121 agaattgctg gggtcagggt gatggtgaca gaactagctg gggactagat ctagaagcgc
      181 ttgcgaggag gacttgggtg atccaggaag gtgtggacgt gactggtgtg ggatgcagtg
      241 gaaaggaagg gccaaaccac gaatccggag tagatctgtg aatggttcct cagaggcgtt
      301 ctctttctgg ttgtcctttt atttggcaac acgagagtcc tcatggtctg tgttcaagtt
      361 cttggaactc tgtctttggg tgaacttaac ctgcattata gcactgccca gggcctgttc
      421 tgatactggg cacatcggtg gggaagatgt cagaaaacag gaaaccgctt ccaggttttg
      481 taaacaaact ccaagatgcg agcgcatctg ggagctcagg caagactcac tgtccttcat
      541 gtctgaggct tttcaaagtc cccaggctct tgccttgctt gcacacggtg tgcacctcat
      601 gtctggaaag gctggatcca ttctcagtag tggacatccg agggggtgac tcagacacaa
      661 gctctgaggg gtcaatattc caggaaccca agtcatgcag cctgaagcca cagatcggca
      721 tcctctgtcc agtatgtgat gctcaagtgg acctgccctt gggtggagtg aaggctttaa
      781 cggtagacca cctggccatg aatgacgtca tgctggagag tctgcacggg gaaggccagg
      841 gcctggtgtg tgacctgtgt agcgacagag aagtagagaa gaggtgtcag acctgcaagg
      901 ccaatctctg ccacttctgc tgccaggctc acaggcggca gaagaagaca acggatcaca
      961 ccatggtgga cctgaaagac ctaaaaggct acagtcgggt tggaaagcct atcctatgtc
     1021 cttcccaccc tgccgaggag ctgaggctgt tctgtgagct ctgtgaccgg ccggtgtgtc
     1081 gggactgtgt agttggggag caccgagagc acccctacga cttcaccagc aacgtcatcc
     1141 acaagcatgg agattccgtg cgggagctgc ttcgagacac ccagccccac gtggaggccc
     1201 tggaagacgc cctggctcag atcaaaagtt cgaacaacgc cctccaagag cgcgtggagg
     1261 cggtggcagc tgacgtccga acgttttctg agggctacat cagagccatc gaggagcatc
     1321 gggacaagct gctacgacag ctggatgaca tacgggtcca gaaggaaaac tctttacagc
     1381 tgcagaaagc acagctggaa cagctgctgg ctgatatgcg gactggagtg gagttcactg
     1441 agcacctgct gaccagcggc tcagacttgg agatcctggt caccaaggga gtggtcgtag
     1501 agcggctcag gaagctgaat aaggttgaat acagtgcccg cccaggagtg aaccataaga
     1561 tctgcttctc ccctcaggag aaggcaaggt gccaaggcta tgaagtatat ggggccatta
     1621 acacgcagga agttgatcca gctcaatgtg tccttcaggg agaagatctc catagagctc
     1681 gagagaaaca gacagcctct tttaccttgg tctgtaagga tgccacggga gagagcatga
     1741 gcaggggagg agacaacgtc cgtgtggaag ttgtccccaa aaataagaag gacagtccga
     1801 tcagaacagt ggtccaggac aacaaggatg gatcctaccg tgtttcctac acccccaagg
     1861 aacctggcgt ctacactgtg tgggttggca tcagagagca gcaagtgcag ggctcaccgt
     1921 tcaatgtgac cgtgaggagg aagcatcggc cgcatccagg cgtgtttcac tgctgcacct
     1981 tctgttccag tggaggccag aagactgcac gctgtgcctg cggaggcacc atgccaggtg
     2041 ggtaccttgg ctgtggccat ggacacaaag gccacccggg gcgtccacac tggtcttgct
     2101 gtgggaagtt tattgagaag tcagagtgtt cgtactcaac tgggcagagc gcaccgagga
     2161 gtctgcttag gaccgtggca ctctgatggc ttcctgggga caagttgggc caggtaaacc
     2221 tgaagttagc atgacttcgg atgtacagag aacccagagc ttgagtagtt ccaaagagac
     2281 tgacagaatt aaagacaaag tgctttctaa cgtc
//
