LOCUS       NM_001108288            3528 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 37 (Trim37), mRNA.
ACCESSION   NM_001108288 XM_001081108 XM_001081111 XM_001081112 XM_006247100
            XM_340872
VERSION     NM_001108288.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3528)
  AUTHORS   Bhatnagar,S., Gazin,C., Chamberlain,L., Ou,J., Zhu,X., Tushir,J.S.,
            Virbasius,C.M., Lin,L., Zhu,L.J., Wajapeyee,N. and Green,M.R.
  TITLE     TRIM37 is a new histone H2A ubiquitin ligase and breast cancer
            oncoprotein
  JOURNAL   Nature 516 (7529), 116-120 (2014)
   PUBMED   25470042
REFERENCE   2  (bases 1 to 3528)
  AUTHORS   Wajapeyee,N., Malonia,S.K., Palakurthy,R.K. and Green,M.R.
  TITLE     Oncogenic RAS directs silencing of tumor suppressor genes through
            ordered recruitment of transcriptional repressors
  JOURNAL   Genes Dev 27 (20), 2221-2226 (2013)
   PUBMED   24105743
REFERENCE   3  (bases 1 to 3528)
  AUTHORS   Balestra,F.R., Strnad,P., Fluckiger,I. and Gonczy,P.
  TITLE     Discovering regulators of centriole biogenesis through siRNA-based
            functional genomics in human cells
  JOURNAL   Dev Cell 25 (6), 555-571 (2013)
   PUBMED   23769972
  REMARK    Erratum:[Dev Cell. 2013 Jul 29;26(2):220]
REFERENCE   4  (bases 1 to 3528)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   5  (bases 1 to 3528)
  AUTHORS   Kallijarvi,J., Lahtinen,U., Hamalainen,R., Lipsanen-Nyman,M.,
            Palvimo,J.J. and Lehesjoki,A.E.
  TITLE     TRIM37 defective in mulibrey nanism is a novel RING finger
            ubiquitin E3 ligase
  JOURNAL   Exp Cell Res 308 (1), 146-155 (2005)
   PUBMED   15885686
REFERENCE   6  (bases 1 to 3528)
  AUTHORS   Kallijarvi,J., Avela,K., Lipsanen-Nyman,M., Ulmanen,I. and
            Lehesjoki,A.E.
  TITLE     The TRIM37 gene encodes a peroxisomal RING-B-box-coiled-coil
            protein: classification of mulibrey nanism as a new peroxisomal
            disorder
  JOURNAL   Am J Hum Genet 70 (5), 1215-1228 (2002)
   PUBMED   11938494
REFERENCE   7  (bases 1 to 3528)
  AUTHORS   Zapata,J.M., Pawlowski,K., Haas,E., Ware,C.F., Godzik,A. and
            Reed,J.C.
  TITLE     A diverse family of proteins containing tumor necrosis factor
            receptor-associated factor domains
  JOURNAL   J Biol Chem 276 (26), 24242-24252 (2001)
   PUBMED   11279055
REFERENCE   8  (bases 1 to 3528)
  AUTHORS   Avela,K., Lipsanen-Nyman,M., Idanheimo,N., Seemanova,E.,
            Rosengren,S., Makela,T.P., Perheentupa,J., Chapelle,A.D. and
            Lehesjoki,A.E.
  TITLE     Gene encoding a new RING-B-box-Coiled-coil protein is mutated in
            mulibrey nanism
  JOURNAL   Nat Genet 25 (3), 298-301 (2000)
   PUBMED   10888877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000010.1.
            
            On or before Jun 4, 2021 this sequence version replaced
            XM_006247100.4, NM_001108288.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100655.1, SRR26360176.1363368.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-383               JAXUCZ010000010.1  72440672-72441054
            384-485             JAXUCZ010000010.1  72443731-72443832
            486-526             JAXUCZ010000010.1  72448897-72448937
            527-643             JAXUCZ010000010.1  72451358-72451474
            644-731             JAXUCZ010000010.1  72453509-72453596
            732-854             JAXUCZ010000010.1  72455831-72455953
            855-978             JAXUCZ010000010.1  72459316-72459439
            979-1046            JAXUCZ010000010.1  72461868-72461935
            1047-1171           JAXUCZ010000010.1  72471737-72471861
            1172-1222           JAXUCZ010000010.1  72475746-72475796
            1223-1304           JAXUCZ010000010.1  72478603-72478684
            1305-1381           JAXUCZ010000010.1  72484790-72484866
            1382-1561           JAXUCZ010000010.1  72494402-72494581
            1562-1676           JAXUCZ010000010.1  72498590-72498704
            1677-1895           JAXUCZ010000010.1  72499255-72499473
            1896-2032           JAXUCZ010000010.1  72500943-72501079
            2033-2118           JAXUCZ010000010.1  72503371-72503456
            2119-2313           JAXUCZ010000010.1  72511707-72511901
            2314-2622           JAXUCZ010000010.1  72515920-72516228
            2623-2745           JAXUCZ010000010.1  72520721-72520843
            2746-2935           JAXUCZ010000010.1  72521573-72521762
            2936-3054           JAXUCZ010000010.1  72529728-72529846
            3055-3165           JAXUCZ010000010.1  72539596-72539706
            3166-3244           JAXUCZ010000010.1  72541334-72541412
            3245-3528           JAXUCZ010000010.1  72572548-72572831
FEATURES             Location/Qualifiers
     source          1..3528
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q26"
     gene            1..3528
                     /gene="Trim37"
                     /note="tripartite motif-containing 37"
                     /db_xref="GeneID:360592"
                     /db_xref="RGD:1308349"
     exon            1..383
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     CDS             363..3389
                     /gene="Trim37"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 37"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM37"
                     /protein_id="NP_001101758.1"
                     /db_xref="GeneID:360592"
                     /db_xref="RGD:1308349"
                     /translation="MDEQSVESIAEVFRCFICMEKLRDARLCPHCSKLCCFSCIRRWL
                     TEQRAQCPHCRAPLQLRELVNCRWAEEVTQQLDTLQLCSLTKHEENEKDKCENHHEKL
                     SVFCWTCKKCICHQCALWGGMHGGHTFKPLAEIYEQHVTKVNEEVAKLRRRLMELISL
                     VQEVERNVEAVRNAKDERVREIRNAVEMMIARLDTQLKNKLITLMGQKTSLTQETELL
                     ESLLQEVEHQLRSCSKSELISKSAEILMMFQQVHRKPMASFVTTPVPPDFTSELVPSY
                     DSATFVLENFSTLRQRADPVYSPPLQVSGLCWRLKVYPDGNGVVRGYYLSVFLELSAG
                     LPETSKYEYRVEMVHQSCNDPTKNIIREFASDFEVGECWGYNRFFRLDLLANEGYLNR
                     QNDTVILRFQVRSPTFFQKCRDQHWYITQLEAAQTGYIQQINNLKERLTIELSRTQKS
                     RDLSPPDNHLSPQNDDTPETRAKKAGSCSDMLLEGGPTSASVRETKEDEDEEEKIQNE
                     DYHHELSDGDLDLDLVGEDEVNHLDGSSSSASSTATSNTEENDIDEETMSGENDVEYN
                     SMELEEGELMEDAAAAGPPGSSHSYVGASSRMSRRAHLCSAATSSLLDIDPLILIHLL
                     DLKDRSSMENLWGLQPRPSASLLQPTASYSRKDKDQRKQQAMWRVPSDLKMLKRLKTQ
                     MAEVRCMKTDVKTTLADIKGSSVASADLQTNLFCADQAALATCGPENSGRLQDLGMEL
                     LAKSSVAGCYIRNPTNKKNSPKSARAIAGSLSLRRAVDSGENSRSKGDCQALSEGSPG
                     SSQSGSRHSSPRALTHGIIGDLLPKSEDRQCKALDSDAVVVAVFNGLPTVEKRRKMVT
                     LGTNVKGGRLEGMQLADLESPSDAGEVQPTLPEGASAAPEEGMSSDSDIECDTENEEQ
                     EEHTSMGAFNDPFLAQPPDEDSHSSFPDGEQIDPENLHFNTDEGSGRLLVLGTQQPYC
                     EEVQTSQPGETACTGSHGYELRPLAPANSHHQLPDV"
     exon            384..485
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            486..526
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            527..643
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            644..731
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            732..854
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            855..978
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            979..1046
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1171
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1222
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1304
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1381
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1382..1561
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1562..1676
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1677..1895
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2032
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            2033..2118
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2313
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            2314..2622
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2745
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            2746..2935
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            2936..3054
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            3055..3165
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            3166..3244
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3528
                     /gene="Trim37"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtgtttgcga attctctgct gcgcctgttc cgccctggac tagccccgcg gcggttttca
       61 cacgcgcgcg ccggcgtcac gtgggcctgg gctcccacgc ggacgctggc cggctactga
      121 ggcgggagga aggcgctgcg gctaccgcta gtccttccct ctccgcccca gggctggcgc
      181 gcggataaaa atggcgaaat ggtgggtagc cggtgggaaa cctgacggga tggggcgcgg
      241 aggtggcact gtcgtgggag cctgctgagg tgagcgcagc tgacctggcg acctcgggcc
      301 ggcgcctgac agcagacacg gactccgagg gtcgccgagg gccccgccga gagccggagg
      361 caatggatga gcagagtgtg gagagcattg ctgaggtttt ccgatgcttc atttgtatgg
      421 agaaattgcg ggatgcccga ctgtgtcctc actgctccaa gctctgttgt ttcagctgta
      481 ttaggcgctg gctgacagag cagagagctc agtgtcctca ttgtcgtgct ccactccagc
      541 tacgggaact tgtaaattgt cgctgggcgg aagaggtgac acagcagctg gatactctcc
      601 agctgtgtag tctcaccaaa catgaagaaa atgagaaaga caaatgtgaa aatcaccatg
      661 aaaaacttag tgtgttttgc tggacttgta agaagtgtat ctgccatcag tgtgcacttt
      721 ggggaggaat gcatggtgga cacacgttta aacctttggc agaaatctat gaacagcatg
      781 tcactaaagt gaacgaagag gtagccaaac ttcgtcgacg tctcatggaa ctgatcagct
      841 tagttcaaga agtggaaaga aatgtagaag cggtgagaaa tgcgaaggac gaacgtgttc
      901 gggaaatcag gaacgcggtg gagatgatga ttgcacggct ggacacacag ctgaagaaca
      961 agctcataac cctcatgggt cagaagacgt ctcttactca agaaacagag ctgttggaat
     1021 ctttacttca ggaggtagaa catcagttgc ggtcttgcag taagagtgag ctgatctcca
     1081 agagcgcaga gatcctaatg atgttccagc aagttcaccg aaagcccatg gcttcctttg
     1141 ttaccacacc tgtcccacca gactttacca gtgaattggt accatcttat gattcagcta
     1201 cttttgtttt agagaacttc agcactttgc ggcagagagc agatccggtt tacagcccgc
     1261 ctcttcaagt ttcaggactt tgctggaggt taaaagttta cccagatgga aatggagttg
     1321 tacgtggcta ttatttatct gtatttttgg aactatcggc tggcttacct gaaacttcca
     1381 agtatgaata tcgtgtagaa atggttcatc agtcctgcaa cgatcctact aaaaatatca
     1441 ttcgagaatt tgcatctgac tttgaagttg gagaatgctg gggctacaat agatttttcc
     1501 gtttggactt acttgcaaat gaaggatact tgaaccgaca aaatgataca gtgattttaa
     1561 ggtttcaggt gcgctcacca acattttttc aaaaatgccg ggatcagcac tggtacatta
     1621 ctcaattgga agctgcacag acaggttata ttcaacaaat aaacaatctt aaagagagat
     1681 tgactattga actgtcccga actcagaaat ccagagatct gtcaccacca gataatcatc
     1741 ttagccccca aaatgatgat actcccgaga cacgagctaa gaaagctggg tcatgctctg
     1801 acatgcttct ggaaggtggt cctacttcag cttctgtaag ggagaccaag gaagatgaag
     1861 atgaggagga gaagattcag aatgaagact atcatcatga gctctcagat ggagatctgg
     1921 atctggatct tgtcggtgaa gatgaagtga atcacctgga cggcagcagc tcttctgcta
     1981 gttctacagc aacaagcaac acggaagaaa acgatatcga tgaggagacc atgtctggag
     2041 agaatgatgt agaatataac agcatggagc tggaggaggg agagctcatg gaagacgcag
     2101 ccgcggcggg gcctccaggc agtagccaca gctatgtggg tgccagtagc agaatgtcaa
     2161 gaagagcaca tttatgctct gcagctacca gtagcttatt agacattgat cctttaatcc
     2221 taatacattt actggatctt aaggaccgga gcagtatgga aaatctgtgg ggtttacagc
     2281 ctcgtccatc tgcttcactt ttgcaaccca cagcgtcata ttctcgaaaa gataaagatc
     2341 aaaggaagca gcaggcgatg tggcgagtgc cctctgacct aaagatgctg aaaaggctca
     2401 aaacacaaat ggctgaagtt cggtgtatga agactgatgt gaagactaca ctggcagata
     2461 taaagggcag cagtgttgct tctgcagact tgcagacaaa ccttttctgt gctgaccagg
     2521 cagctctggc tacctgtgga cctgaaaact ctggtagatt gcaggatttg ggcatggagc
     2581 ttctggcaaa gtcgtcagtt gctggctgtt acataagaaa ccccacaaat aagaagaatt
     2641 cacccaagtc agctcgggcc atagcaggca gtctgtcact ccgaagagct gtagactctg
     2701 gagaaaacag ccgttcaaag ggagactgtc aggctttgtc tgaaggctcc ccaggaagct
     2761 ctcagtctgg gagccgacac agctcccccc gggctctgac acatggcatc attggggacc
     2821 ttctgcccaa aagtgaagac cgacagtgca aagctttgga ttctgatgct gtggtggttg
     2881 cagttttcaa tggtttacct actgttgaga aaagaaggaa aatggtcact ctggggacta
     2941 atgtaaaagg aggtcgtctg gaaggaatgc aattggcaga tttggaaagt ccttctgatg
     3001 ctggggaggt acagcccaca ctacctgaag gagcctcagc tgcccctgag gaaggaatga
     3061 gtagtgacag cgacattgaa tgtgacactg agaacgagga gcaggaagag cacaccagca
     3121 tgggtgcctt caacgatccg ttcctggccc agcctccgga tgaagattcg cattccagtt
     3181 ttcctgatgg tgaacaaata gaccctgaaa atctccactt caacaccgat gaaggcagtg
     3241 gaagactgct tgttcttgga acccagcagc catactgtga ggaagtccaa accagccagc
     3301 ctggggagac tgcatgtaca gggtcacacg ggtatgagct gagacctctg gccccagcta
     3361 acagccacca tcagctgcct gacgtgtaag tcacagggct tcagacagca ccagtcttca
     3421 gcctgaggct tccaatccat ggaacagaaa tggggacttg ctgtaccggt ctgaaatcct
     3481 gaccaaaaga aactagagta taataaatga ctttattatg ccactaaa
//
