LOCUS       NM_001012103            3190 bp    mRNA    linear   ROD 23-MAR-2023
DEFINITION  Rattus norvegicus tripartite motif-containing 32 (Trim32), mRNA.
ACCESSION   NM_001012103 XM_233039
VERSION     NM_001012103.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3190)
  AUTHORS   Liu L, Liu TT, Xie GG, Zhu XQ and Wang Y.
  TITLE     Ubiquitin ligase TRIM32 promotes dendrite arborization by mediating
            degradation of the epigenetic factor CDYL
  JOURNAL   FASEB J 36 (1), e22087 (2022)
   PUBMED   34888944
  REMARK    GeneRIF: Ubiquitin ligase TRIM32 promotes dendrite arborization by
            mediating degradation of the epigenetic factor CDYL.
REFERENCE   2  (bases 1 to 3190)
  AUTHORS   Chen F, Guo Q, Chen Q, Han Z, Zhou X, Wu L, Guo X, Ni B and Yang J.
  TITLE     TRIM32 triggers beta-catenin signaling through ubiquitylation of
            AXIN1 to promote inflammatory factor-induced apoptosis of rat
            nucleus pulposus cells
  JOURNAL   Am J Physiol Cell Physiol 318 (3), C695-C703 (2020)
   PUBMED   31967859
  REMARK    GeneRIF: TRIM32 promotes inflammatory factor-induced apoptosis of
            nucleus pulposus cells, in part by degradation of AXIN1 to trigger
            Beta-catenin signaling.
REFERENCE   3  (bases 1 to 3190)
  AUTHORS   Wei L, Zhang JS, Ji SF, Xu H, Zhao ZH, Zhang L, Pang L, Zhang JF,
            Yang PB and Ma H.
  TITLE     Knockdown of TRIM32 Protects Hippocampal Neurons from
            Oxygen-Glucose Deprivation-Induced Injury
  JOURNAL   Neurochem Res 44 (9), 2182-2189 (2019)
   PUBMED   31410708
  REMARK    GeneRIF: Knockdown of TRIM32 protects hippocampal neurons from
            oxygen-glucose deprivation-induced oxidative injury through
            activation of the Nrf2 signaling pathway.
REFERENCE   4  (bases 1 to 3190)
  AUTHORS   Zhang ZB, Xiong LL, Lu BT, Zhang HX, Zhang P and Wang TH.
  TITLE     Suppression of Trim32 Enhances Motor Function Repair after
            Traumatic Brain Injury Associated with Antiapoptosis
  JOURNAL   Cell Transplant 26 (7), 1276-1285 (2017)
   PUBMED   28933219
  REMARK    GeneRIF: suppression of Trim32 promotes the recovery of
            neurological function after traumatic brain injury.
REFERENCE   5  (bases 1 to 3190)
  AUTHORS   Liu Y, Wu W, Yang H, Zhou Z, Zhu X, Sun C, Liu Y, Yu Z, Chen Y and
            Wang Y.
  TITLE     Upregulated Expression of TRIM32 Is Involved in Schwann Cell
            Differentiation, Migration and Neurite Outgrowth After Sciatic
            Nerve Crush
  JOURNAL   Neurochem Res 42 (4), 1084-1095 (2017)
   PUBMED   28025799
  REMARK    GeneRIF: After sciatic nerve crush, TRIM32 expression is rapidly
            increased along with neurite outgrowth.
REFERENCE   6  (bases 1 to 3190)
  AUTHORS   Albor A, El-Hizawi S, Horn EJ, Laederich M, Frosk P, Wrogemann K
            and Kulesz-Martin M.
  TITLE     The interaction of Piasy with Trim32, an E3-ubiquitin ligase
            mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy
            degradation and regulates UVB-induced keratinocyte apoptosis
            through NFkappaB
  JOURNAL   J Biol Chem 281 (35), 25850-25866 (2006)
   PUBMED   16816390
REFERENCE   7  (bases 1 to 3190)
  AUTHORS   Chiang AP, Beck JS, Yen HJ, Tayeh MK, Scheetz TE, Swiderski RE,
            Nishimura DY, Braun TA, Kim KY, Huang J, Elbedour K, Carmi R,
            Slusarski DC, Casavant TL, Stone EM and Sheffield VC.
  TITLE     Homozygosity mapping with SNP arrays identifies TRIM32, an E3
            ubiquitin ligase, as a Bardet-Biedl syndrome gene (BBS11)
  JOURNAL   Proc Natl Acad Sci U S A 103 (16), 6287-6292 (2006)
   PUBMED   16606853
REFERENCE   8  (bases 1 to 3190)
  AUTHORS   Kudryashova E, Kudryashov D, Kramerova I and Spencer MJ.
  TITLE     Trim32 is a ubiquitin ligase mutated in limb girdle muscular
            dystrophy type 2H that binds to skeletal muscle myosin and
            ubiquitinates actin
  JOURNAL   J Mol Biol 354 (2), 413-424 (2005)
   PUBMED   16243356
REFERENCE   9  (bases 1 to 3190)
  AUTHORS   Frosk P, Weiler T, Nylen E, Sudha T, Greenberg CR, Morgan K,
            Fujiwara TM and Wrogemann K.
  TITLE     Limb-girdle muscular dystrophy type 2H associated with mutation in
            TRIM32, a putative E3-ubiquitin-ligase gene
  JOURNAL   Am J Hum Genet 70 (3), 663-672 (2002)
   PUBMED   11822024
REFERENCE   10 (bases 1 to 3190)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC081980.1.
            
            On Feb 11, 2005 this sequence version replaced XM_233039.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC081980.1, BC091385.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3190
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q24"
     gene            1..3190
                     /gene="Trim32"
                     /note="tripartite motif-containing 32"
                     /db_xref="GeneID:313264"
                     /db_xref="RGD:1305238"
     exon            1..57
                     /gene="Trim32"
                     /inference="alignment:Splign:2.1.0"
     exon            58..3164
                     /gene="Trim32"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..2104
                     /gene="Trim32"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 32"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM32"
                     /protein_id="NP_001012103.1"
                     /db_xref="GeneID:313264"
                     /db_xref="RGD:1305238"
                     /translation="MAAAAAASHLNLDALREVLECPICMESFTEEQLRPKLLHCGHTI
                     CRQCLEKLLASSINGVRCPFCSKITRITSLTQLTDNLTVLKIIDTAGLSEAVGLLMCR
                     ACGRRLPRQFCRSCGLVLCEPCREADHQPPGHCTLPVKEAAEERRRDFGEKLTRLREL
                     TGELQRRKAALEGVSRDLQARYKAVLQEYGHEERRVQEELARSRKFFTGSLAEVEKSN
                     SQVVEEQSYLLNIAEVQAVSRCDYFLAKIKQADVALLEETADEEEPELTASLPRELTL
                     QDVELLKVGHVGPLQIGQAVKKPRTVNMEDSWAVEEGAASSASASVTFREMDMSPEEV
                     VPSPRASPAKQRSSEAASSIQQCLFLKKMGAKGSTPGMFNLPVSLYVTSQSEVLVADR
                     GNYRIQVFNRKGFLKEIRRSPSGIDSFVLSFLGADLPNLTPLSVAMNCHGLIGVTDSY
                     DNSLKVYTLDGHCVACHRSQLSKPWGITALPSGQFVVTDVEGGKLWCFTVDRGAGVVK
                     YSCLCSAVRPKFVTCDAEGTVYFTQGLGLNVENRQNEHHLEGGFSIGSVGPDGQLGRQ
                     ISHFFSENEDFRCIAGMCVDARGDLIVADSSRKEILHFPKGGGYSVLIREGLTCPVGI
                     ALTPKGQLLVLDCWDHCVKIYSYHLRRYSTP"
ORIGIN      
        1 ggcagcgggc gggtgggctg gcagcggtgg actcgcgtcg gagccgcggg cggtcagcag
       61 gaatttgaca ctggggcatg aatattaagc tattcggctc taggctgtgt taacaggaac
      121 cctctctaga agagcaatgg ctgcggctgc agcagcgtct cacctgaacc tggatgccct
      181 ccgggaagtg ctagaatgtc ccatctgcat ggaatccttc actgaagagc agctgcggcc
      241 caagctgctg cactgtggcc ataccatctg ccgccagtgt ctggagaagc tcctggccag
      301 tagcatcaat ggtgtccgct gtcccttttg cagcaagatt actcgcatca ccagcctgac
      361 ccagctgacc gacaacctga cagtgctgaa gatcattgac acagccggcc tcagtgaggc
      421 cgtcgggctg ctcatgtgcc gagcctgtgg caggcggctg cctcggcagt tctgccgaag
      481 ctgtggtttg gtgttgtgtg aaccctgccg agaggcagat caccaacctc ctggccactg
      541 cacactccct gtcaaggagg cagctgagga acgtcggagg gactttgggg agaagttgac
      601 tcgtctaagg gaacttactg gagagctgca aaggaggaag gcagctttag agggtgtctc
      661 tagagatctt caggcaaggt ataaggctgt tcttcaagaa tatggccacg aggaacgcag
      721 ggtccaggaa gagctagccc gctctcggaa gttcttcaca ggctctttgg ctgaggttga
      781 gaagtccaac agccaagtag tagaggaaca gagctaccta ctcaacattg cggaggtgca
      841 ggccgtgtct cgctgtgact actttctagc caagatcaag caagctgatg tagcactcct
      901 ggaggagaca gcagatgagg aggagccaga gctcactgca agcctacccc gggagcttac
      961 cctgcaagat gtggagcttc ttaaagtagg acatgttggt cctctgcaaa ttggccaggc
     1021 tgttaagaag ccccggacag ttaacatgga agattcctgg gcagtggagg agggagcagc
     1081 atcttctgcc tcagcctctg taacctttag agagatggac atgagccctg aagaagtagt
     1141 tcccagccct agggcttcac ctgcgaaaca gcggagttct gaggcagcct ccagtatcca
     1201 acagtgtctc tttctcaaga agatgggagc gaaaggcagc actccaggca tgttcaacct
     1261 tccagtcagt ctctatgtga ccagtcagag tgaggtgctg gttgcagacc ggggcaacta
     1321 tcgcatacaa gtgttcaacc gcaaaggctt tttgaaggag atccgccgca gccccagtgg
     1381 cattgacagc tttgtgctaa gcttccttgg agccgacttg cccaatctca ctcctctttc
     1441 agtggccatg aactgccatg ggctgattgg tgtcactgac agctatgaca actcccttaa
     1501 agtctatacc ttggatggcc actgtgtggc ctgtcacagg agccagctga gcaaaccatg
     1561 gggcatcaca gccctaccgt ctggccagtt tgttgtgact gatgtggaag gcgggaagct
     1621 ctggtgtttc actgtggacc gaggagctgg agtagtcaaa tacagctgcc tctgcagtgc
     1681 tgtgaggccc aagtttgtca cctgtgatgc tgaaggcaca gtctatttca cccaaggctt
     1741 gggtctcaat gtggaaaacc gacagaatga acaccacctg gagggtggct tctccatcgg
     1801 ctctgtgggc cccgatgggc agctgggccg acagatcagc cacttcttct ctgagaatga
     1861 agatttccgc tgcatcgctg gcatgtgtgt ggatgctcgg ggtgacctca ttgtggctga
     1921 tagcagccgc aaggaaatcc tccattttcc caagggcggt ggctacagcg tccttattcg
     1981 agagggcctt acctgtccag tgggcatcgc cctcacaccc aaggggcagc tgctggtctt
     2041 ggactgttgg gatcactgtg tcaagatcta cagctaccat ctgagaagat actctacccc
     2101 ttagaagatg agaaatacca gtttcttctt tccccccaac cgagtttcct tccctttcct
     2161 tccttcgttg ttgatggtgt cgtagagtag atgtggcctg tgtcctgatt ctagtagggt
     2221 tgctctagaa ttgtggaagc tctagttttc ggtgattttg cttgttattc ccctcttccc
     2281 acccccttcc ccttctctcc ttctaaattt agagcttaga gctttaacag gtactttgtc
     2341 ccacgtagaa tagatgatgc tcttagcaga agttgcttag aagtcaggca cttcaaggct
     2401 ttagtagaga gaaccacttt agccctttgc ccttgtgttt gaactttgta ttggtataga
     2461 gtagtcattg atctttccct ttggactctg aggtccctag tctactgtcc tcttcctgtt
     2521 acagtgtgct tcatctgtgg ctttaactct ggctgcattc tgtgtgcatg ctccagtggg
     2581 atctgctcaa cccgtcagtg atattatatc tctgtagcat ggtgtctcct ttgatcacct
     2641 ttaccagtgt gagactgtat cattaagtgt cactaaggtg acacaaagtc cctttgggaa
     2701 gcaggacctc ttgactggga atttctgaca acatagattg tcttctcttg cagatgtgcg
     2761 agaggatggt ttgactgacc ctagttggat agtgttgaac acttgagtct agaaatcact
     2821 tgccttttaa aggagtttct aggttagaat tatgccatag ccaaggcaga tgggaacagg
     2881 taagccttgc taacatatcc agcaaacctg gatatttttt agggctcaga atgtttcata
     2941 ctccttccat tgacctatgc taagagtttt tggaagaatt ggattatgtg ggcttcgacc
     3001 aacaatgcgg gggaaggtcg acgtatccat tttcattacg gaagaacaaa ccattaggta
     3061 gctaactctg tattttcttc aagtgagtgc atattgtttg actttgagat ttctttctgt
     3121 tctatgaagc attaaactaa taaaactagt aactttcttc atcaaaaaaa aaaaaaaaaa
     3181 aaaaaaaaaa
//
