LOCUS       NM_031786               2863 bp    mRNA    linear   ROD 28-MAR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 3 (Trim3), mRNA.
ACCESSION   NM_031786
VERSION     NM_031786.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2863)
  AUTHORS   Raheja,R., Liu,Y., Hukkelhoven,E., Yeh,N. and Koff,A.
  TITLE     The ability of TRIM3 to induce growth arrest depends on
            RING-dependent E3 ligase activity
  JOURNAL   Biochem J 458 (3), 537-545 (2014)
   PUBMED   24393003
REFERENCE   2  (bases 1 to 2863)
  AUTHORS   Hung,A.Y., Sung,C.C., Brito,I.L. and Sheng,M.
  TITLE     Degradation of postsynaptic scaffold GKAP and regulation of
            dendritic spine morphology by the TRIM3 ubiquitin ligase in rat
            hippocampal neurons
  JOURNAL   PLoS One 5 (3), e9842 (2010)
   PUBMED   20352094
  REMARK    GeneRIF: postsynaptic scaffold GKAP is degraded and dendritic spine
            morphology is regulated by the TRIM3 ubiquitin ligase in rat
            hippocampal neurons
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2863)
  AUTHORS   Lise,M.F., Wong,T.P., Trinh,A., Hines,R.M., Liu,L., Kang,R.,
            Hines,D.J., Lu,J., Goldenring,J.R., Wang,Y.T. and El-Husseini,A.
  TITLE     Involvement of myosin Vb in glutamate receptor trafficking
  JOURNAL   J Biol Chem 281 (6), 3669-3678 (2006)
   PUBMED   16338934
REFERENCE   4  (bases 1 to 2863)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   5  (bases 1 to 2863)
  AUTHORS   El-Husseini,A.E., Kwasnicka,D., Yamada,T., Hirohashi,S. and
            Vincent,S.R.
  TITLE     BERP, a novel ring finger protein, binds to alpha-actinin-4
  JOURNAL   Biochem Biophys Res Commun 267 (3), 906-911 (2000)
   PUBMED   10673389
REFERENCE   6  (bases 1 to 2863)
  AUTHORS   El-Husseini,A.E. and Vincent,S.R.
  TITLE     Cloning and characterization of a novel RING finger protein that
            interacts with class V myosins
  JOURNAL   J Biol Chem 274 (28), 19771-19777 (1999)
   PUBMED   10391919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On Dec 1, 2020 this sequence version replaced NM_031786.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF036255.1, SRR26643287.1792.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760433,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               JAXUCZ010000001.1  169385247-169385430 c
            185-350             JAXUCZ010000001.1  169377603-169377768 c
            351-582             JAXUCZ010000001.1  169371838-169372069 c
            583-734             JAXUCZ010000001.1  169371513-169371664 c
            735-915             JAXUCZ010000001.1  169371119-169371299 c
            916-1648            JAXUCZ010000001.1  169370028-169370760 c
            1649-1752           JAXUCZ010000001.1  169369762-169369865 c
            1753-1920           JAXUCZ010000001.1  169365562-169365729 c
            1921-2089           JAXUCZ010000001.1  169365219-169365387 c
            2090-2160           JAXUCZ010000001.1  169364918-169364988 c
            2161-2301           JAXUCZ010000001.1  169363429-169363569 c
            2302-2863           JAXUCZ010000001.1  169362751-169363312 c
FEATURES             Location/Qualifiers
     source          1..2863
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..2863
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /note="tripartite motif-containing 3"
                     /db_xref="GeneID:83616"
                     /db_xref="RGD:70074"
     exon            1..184
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            185..350
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..2454
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 3; brain-expressed RING
                     finger protein; ring finger protein 22"
                     /codon_start=1
                     /product="tripartite motif-containing protein 3"
                     /protein_id="NP_113974.2"
                     /db_xref="GeneID:83616"
                     /db_xref="RGD:70074"
                     /translation="MAKREDSPGPEVQPMDKQFLVCSICLDRYRCPKVLPCLHTFCER
                     CLQNYIPPQSLTLSCPVCRQTSILPEQGVSALQNNFFISSLMEAMQQAPDGAHDPEDP
                     HPLSAVAGRPLSCPNHEGKTMEFYCEACETAMCGECRAGEHREHGTVLLRDVVEQHKA
                     ALQRQLEAVRGRLPQLSAAIALVGGISQQLQERKAEALAQISAAFEDLEQALQQRKQA
                     LVSDLESICGAKQKVLQTQLDTLRQGQEHIGSSCSFAEQALRLGSAPEVLLVRKHMRE
                     RLAALAAQAFPERPHENAQLELVLEVDGLRRSVLNLGALLTTSATAHETVATGEGLRQ
                     ALVGQPASLTVTTKDKDGRLVRTGSAELCAEITGPDGVRLAVPVVDHKNGTYELVYTA
                     RTEGDLLLSVLLYGQPVRGSPFRVRALRPGDLPPSPDDVKRRVKSPGGPGSHVRQKAV
                     RRPSSMYSTGGKRKDNPIEDELVFRVGSRGREKGEFTNLQGVSAASSGRIVVADSNNQ
                     CIQVFSNEGQFKFRFGVRGRSPGQLQRPTGVAVDTNGDIIVADYDNRWVSIFSPEGKF
                     KTKIGAGRLMGPKGVAVDRNGHIIVVDNKSCCVFTFQPNGKLVGRFGGRGATDRHFAG
                     PHFVAVNNKNEIVVTDFHNHSVKVYSADGEFLFKFGSHGEGNGQFNAPTGVAVDSNGN
                     IIVADWGNSRIQVFDSSGSFLSYINTSAEPLYGPQGLALTSDGHVVVADAGNHCFKAY
                     RYLQ"
     exon            351..582
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            583..734
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            735..915
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            916..1648
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            1649..1752
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1920
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2089
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2160
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2301
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2863
                     /gene="Trim3"
                     /gene_synonym="Berp; Rnf22"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcggcgg cgccggcgcg gggacagacg gaggcgcggg acgtggggcg gcgccgcggg
       61 cagggccggg cggacgagcg ctggcagcgg gggcagcgct gcgggccgct ccgagtggct
      121 gcagtccggg ccttgcactc ccatcccgct cccacgccgt gagtgcgcgg cgcgggcccc
      181 aagggctggt gttagtggca ggaaccatct gtggtcacca tggcaaagag ggaggacagc
      241 cctggcccgg aggtgcagcc aatggacaag cagtttctgg tatgcagtat ctgcctggat
      301 cggtaccggt gccccaaagt tctgccttgt ctacacacct tctgcgaaag atgtctccag
      361 aactacatcc ctcctcagag cctgacactc tcgtgtccag tatgccggca gacatccatc
      421 ctcccagaac agggtgtctc agccctacaa aacaacttct tcatcagcag cctcatggag
      481 gccatgcagc aggcacctga tggggcccac gaccctgaag acccccaccc cctcagcgca
      541 gtggctggcc gccctctctc ctgccccaac catgaaggca agacgatgga gttttactgt
      601 gaggcctgtg agactgccat gtgtggtgag tgccgcgcag gggagcaccg tgaacacggc
      661 acagtgctgt tgcgggacgt ggtggagcag cacaaggcag ctctacagcg ccagcttgaa
      721 gctgtgcgtg gccgattgcc acagctgtct gcagctatcg ccttggttgg gggcatcagc
      781 cagcagctgc aagagcgcaa ggcagaggcc ctggcccaga taagtgcagc ctttgaggac
      841 ctggagcaag ctctgcagca gcgcaagcag gctctggtca gcgacttgga gagcatttgt
      901 ggggccaagc agaaggtgtt gcagacacag ttagacacac tgcgccaggg tcaggaacac
      961 attggcagta gctgcagctt tgcagagcag gcactgagac tgggctctgc ccctgaggtt
     1021 ttgctagtaa gaaagcacat gcgagagagg ctggctgctc tggcagctca ggccttccca
     1081 gaaaggcccc atgagaatgc acagctggaa ctggtccttg aagtagatgg gttgcggaga
     1141 tcggtgctca atctgggtgc actgctcacc accagtgcta ctgcacacga gacagtggcc
     1201 accggcgagg gcctgcgcca ggcactggtt ggccagcctg cctcactcac tgtcaccacc
     1261 aaagacaaag atgggcggct ggtgcgcacg ggcagcgcag agctgtgcgc agagatcact
     1321 ggccccgatg gcgtgcgcct tgcggtaccg gtggtggacc acaaaaatgg cacatatgag
     1381 ctggtgtaca cagcacgtac agaaggcgac ctgctcctct cagtgctgct ctatggacag
     1441 ccggtgcgtg gcagcccttt ccgtgtgcgt gccctgagac ccggagactt gccaccttcc
     1501 ccagatgatg tgaagcgccg ggtcaagtct cccggtggtc ctggcagtca tgtgcgccag
     1561 aaggcagtgc gtaggccgag ctccatgtac agcaccggtg gcaaacggaa agacaatcca
     1621 attgaggatg aactcgtctt tcgtgttggc agtcgtggaa gggagaaagg tgaattcacc
     1681 aatttacagg gcgtgtccgc tgctagcagt ggccgaatag tggtagcaga cagcaacaac
     1741 caatgtattc aggttttctc caatgagggc cagttcaagt tccgatttgg agtccgtggg
     1801 cgctcgcctg ggcaactaca gcgtcctacg ggtgtggcag tggacaccaa tggagacatt
     1861 attgtggcag actatgacaa ccgttgggtc agcatcttct ctcctgaggg caagttcaag
     1921 accaaaattg gagctggccg cctcatgggg cccaagggag tggctgtgga ccggaatggg
     1981 catatcattg tagtggataa caagtcttgc tgtgtcttca ccttccagcc caatggcaag
     2041 cttgttgggc gttttggagg ccgtggggcc actgaccgcc acttcgcagg gccccacttt
     2101 gtggctgtga acaacaagaa tgagattgta gtaacggatt tccacaacca ttcagtgaag
     2161 gtgtacagtg ctgatggaga gttcctcttc aaatttggct cacatggcga gggcaatgga
     2221 cagttcaatg cccccacggg agtagctgtg gattccaatg gaaacatcat cgtggctgac
     2281 tggggcaata gtcgcataca ggtattcgac agctctggtt ccttcctgtc ctatatcaac
     2341 acgtctgcag agccactgta tggcccacag ggcttggcat tgacctcgga tggccacgta
     2401 gtagtggctg atgctggcaa ccactgcttt aaggcctatc gatacctcca gtagctgcac
     2461 aagggccctg cttggctcat ggagggacgg acataggggt gattggacaa gagggtctgg
     2521 ctaagaggtg ggccagaccc ggcagcactg aatgtgggcg tgggcatgga tgtgcccaat
     2581 gcccttccct tcctccccaa ccccacggtt gcactttatt tattcggttc ttgctttggt
     2641 gactgggtgg gcctggactg gtcccaagga tgtgtgcaga gcttcaccct aactccttta
     2701 cacaccctcc cttacaccct cagtctgctc tctgaccccc agcctggggc cagaacagcc
     2761 tcttacttca gaagtccctc tggttgtctc cctaacaccc catacacact gacagagaca
     2821 gcaatacccc accccatatt aaataaatgt gttcgccaag gtg
//
