LOCUS       NM_053916               3001 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 28 (Trim28), mRNA.
ACCESSION   NM_053916 XM_001062234 XM_344861
VERSION     NM_053916.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3001)
  AUTHORS   Wang,W., Yan,T., Guo,X., Cai,H., Liang,C., Huang,L., Wang,Y., Ma,P.
            and Qi,S.
  TITLE     KAP1 phosphorylation promotes the survival of neural stem cells
            after ischemia/reperfusion by maintaining the stability of PCNA
  JOURNAL   Stem Cell Res Ther 13 (1), 290 (2022)
   PUBMED   35799276
  REMARK    GeneRIF: KAP1 phosphorylation promotes the survival of neural stem
            cells after ischemia/reperfusion by maintaining the stability of
            PCNA.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3001)
  AUTHORS   Valle-Garcia,D., Qadeer,Z.A., McHugh,D.S., Ghiraldini,F.G.,
            Chowdhury,A.H., Hasson,D., Dyer,M.A., Recillas-Targa,F. and
            Bernstein,E.
  TITLE     ATRX binds to atypical chromatin domains at the 3' exons of zinc
            finger genes to preserve H3K9me3 enrichment
  JOURNAL   Epigenetics 11 (6), 398-414 (2016)
   PUBMED   27029610
REFERENCE   3  (bases 1 to 3001)
  AUTHORS   Serra,R.W., Fang,M., Park,S.M., Hutchinson,L. and Green,M.R.
  TITLE     A KRAS-directed transcriptional silencing pathway that mediates the
            CpG island methylator phenotype
  JOURNAL   Elife 3, e02313 (2014)
   PUBMED   24623306
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3001)
  AUTHORS   Wang,W., Cai,J., Wu,Y., Hu,L., Chen,Z., Hu,J., Chen,Z., Li,W.,
            Guo,M. and Huang,Z.
  TITLE     Novel activity of KRAB domain that functions to reinforce nuclear
            localization of KRAB-containing zinc finger proteins by interacting
            with KAP1
  JOURNAL   Cell Mol Life Sci 70 (20), 3947-3958 (2013)
   PUBMED   23665872
REFERENCE   5  (bases 1 to 3001)
  AUTHORS   Krebs,C.J., Schultz,D.C. and Robins,D.M.
  TITLE     The KRAB zinc finger protein RSL1 regulates sex- and
            tissue-specific promoter methylation and dynamic hormone-responsive
            chromatin configuration
  JOURNAL   Mol Cell Biol 32 (18), 3732-3742 (2012)
   PUBMED   22801370
REFERENCE   6  (bases 1 to 3001)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 3001)
  AUTHORS   Huang,Z., Philippin,B., O'Leary,E., Bonventre,J.V., Kriz,W. and
            Witzgall,R.
  TITLE     Expression of the transcriptional repressor protein Kid-1 leads to
            the disintegration of the nucleolus
  JOURNAL   J Biol Chem 274 (12), 7640-7648 (1999)
   PUBMED   10075651
REFERENCE   8  (bases 1 to 3001)
  AUTHORS   Kim,S.S., Chen,Y.M., O'Leary,E., Witzgall,R., Vidal,M. and
            Bonventre,J.V.
  TITLE     A novel member of the RING finger family, KRIP-1, associates with
            the KRAB-A transcriptional repressor domain of zinc finger proteins
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15299-15304 (1996)
   PUBMED   8986806
REFERENCE   9  (bases 1 to 3001)
  AUTHORS   Moosmann,P., Georgiev,O., Le Douarin,B., Bourquin,J.P. and
            Schaffner,W.
  TITLE     Transcriptional repression by RING finger protein TIF1 beta that
            interacts with the KRAB repressor domain of KOX1
  JOURNAL   Nucleic Acids Res 24 (24), 4859-4867 (1996)
   PUBMED   9016654
REFERENCE   10 (bases 1 to 3001)
  AUTHORS   Friedman,J.R., Fredericks,W.J., Jensen,D.E., Speicher,D.W.,
            Huang,X.P., Neilson,E.G. and Rauscher,F.J. 3rd.
  TITLE     KAP-1, a novel corepressor for the highly conserved KRAB repression
            domain
  JOURNAL   Genes Dev 10 (16), 2067-2078 (1996)
   PUBMED   8769649
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC166843.1.
            
            On or before Oct 23, 2008 this sequence version replaced
            XM_344861.3, XM_001062234.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166843.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3001
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q21"
     gene            1..3001
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /note="tripartite motif-containing 28"
                     /db_xref="GeneID:116698"
                     /db_xref="RGD:620289"
     exon            1..629
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             284..2791
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /EC_number="2.3.2.27"
                     /note="TIF1-beta; KRAB-associated protein 1; nuclear
                     corepressor KAP-1; tripartite motif-containing protein 28;
                     E3 SUMO-protein ligase TRIM28; tripartite motif protein
                     28; RING-type E3 ubiquitin transferase TIF1-beta"
                     /codon_start=1
                     /product="transcription intermediary factor 1-beta"
                     /protein_id="NP_446368.1"
                     /db_xref="GeneID:116698"
                     /db_xref="RGD:620289"
                     /translation="MAASAAAATAAASAATAASAASGSPGSGEGSAGGEKRPAASSAA
                     AASASASSPAGGGGEAQELLEHCGVCRERLRPERDPRLLPCLHSACSACLGPATPAAA
                     NNSGDGGSAGDGAMVDCPVCKQQCYSKDIVENYFMRDSGSKASSDSQDANQCCTSCED
                     NAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPAKTRDGERTVYCNVHKHEP
                     LVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLASLVKRLGDKHATLQKNT
                     KEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTEGQQERLERQH
                     WTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHGEMK
                     FQWDLNAWTKSAEAFGKIVAERPGTNSTGPGPMAPPRAPGPLSKQGSGSSQPMEVQEG
                     YGFGTDDPYSSAEPHVSGMKRSRSGEGEVSGLMRKVPRVSLERLDLDLTSDSQPPVFK
                     VFPGSTTEDYNLIVIERGAAAAAAGQAGTVPPGAPGAPPLPGMAIVKEEETEAAIGAP
                     PAAPEGPETKPVLMALTEGPGAEGPRLASPSGSTSSGLEVVAPEVTSAPVSGPGILDD
                     SATICRVCQKPGDLVMCNQCEFCFHLDCHLPSLQDVPGEEWSCSLCHVLPDLKEEDGS
                     LSLDGADSTGVVAKLSPANQRKCERVLLALFCHEPCRPLHQLATDSTFSMEQPGGTLD
                     LTLIRARLQEKLSPPYSSPQEFAQDVGRMFKQFNKLTEDKADVQSIIGLQRFFETRMN
                     DAFGDTKFSAVLVEPPPLNLPSAGLSSQELSGPGDGP"
     exon            630..742
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            743..875
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1011
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1128
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1243
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1390
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1391..1505
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1612
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1649
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1650..1695
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1696..1948
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..2268
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2392
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2393..2479
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2480..2617
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
     exon            2618..2970
                     /gene="Trim28"
                     /gene_synonym="Kap1; Krip1; Tif1b"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggttgttc gcaattcttg cggcgcgagt ctcagcagca agggaggagg cggcgcgggt
       61 ggcggcgccg tcgtctgtag agaggccggc agccagcggc ttggccgcat ctcggcagcg
      121 cctggggcgc ggcgggcgtc ggcccaggag acgcgtggcg gcgctcggcc tcgcggcatc
      181 ggcggctgcc tggccgttgg cggcgagcgc acttgcgcct gcgcagcggg ctcggtgccc
      241 ctcctcccct gggcggcccc cccaaccccc cggcggcgtg tgaatggcgg cctcggcggc
      301 ggcggcgact gcggcggcct cggccgcgac ggccgcgtca gcggcctctg gtagcccagg
      361 gtcgggcgaa ggctcggcgg gcggtgagaa gcgccccgct gcctcttcag ccgcggcggc
      421 ctcggcctcc gcgtcgtccc ctgcgggggg cggtggcgag gcgcaggagc ttttggagca
      481 ctgcggcgtg tgtcgcgagc gcttgcggcc tgagcgggat cctcggctgc tgccctgtct
      541 gcattcggcc tgtagtgcct gccttggccc cgctacaccc gccgcagcta ataattcggg
      601 ggatggcggc tcggcgggcg acggcgctat ggtggattgt ccagtgtgca aacaacagtg
      661 ctactccaaa gacatcgtgg agaattactt tatgcgtgat agtggcagta aggcctcttc
      721 tgattcccag gatgctaacc agtgctgcac tagctgtgaa gataacgccc cagccactag
      781 ctattgtgtg gagtgctctg aaccactgtg tgagacctgt gtggaggctc accagcgggt
      841 gaaatacacc aaggatcaca ctgtgcgctc cacgggtcct gctaagactc gagatggaga
      901 acgaacagtc tattgtaatg tgcacaagca tgaacccctt gtgctgtttt gtgagagctg
      961 tgacacgctc acttgccggg actgccaact caatgctcac aaggaccacc agtaccaatt
     1021 cttggaagat gcagtaagga accaacgtaa actcttggct tcactggtga aacgtcttgg
     1081 ggacaaacat gccacactgc agaaaaacac caaggaggtt cgaagctcga tccgccaggt
     1141 gtctgatgtg cagaagcgag tgcaggttga tgtgaagatg gccattctgc agatcatgaa
     1201 ggagctgaat aaacggggac gagttctggt caatgatgcc cagaaggtga ctgagggtca
     1261 gcaggaacgt ctggagcgtc agcactggac catgaccaaa atccagaagc accaggaaca
     1321 cattttgcgc tttgcctctt gggctttgga gagtgataac aatacagccc tcttgctctc
     1381 taagaagctg atttatttcc agctgcatcg ggccctcaaa atgattgtgg atcctgtgga
     1441 gcctcatggt gagatgaagt ttcagtggga tctcaatgcc tggaccaaga gtgctgaagc
     1501 ctttggtaag attgtggctg agcgtcctgg tacaaactcc acgggtcctg ggcccatggc
     1561 tcctccaaga gccccaggcc ccctaagcaa gcaaggttct ggtagtagcc agcccatgga
     1621 agtacaagag ggctatggct ttgggacaga tgatccctac tcaagtgcag agccacatgt
     1681 atcaggcatg aagcggtccc gctctggtga gggagaagta agtggcctca tgaggaaggt
     1741 gccacgtgtg agccttgaac gcctggatct ggatctcacc tctgatagcc agccaccagt
     1801 cttcaaggtc tttcctggaa gcaccactga ggactacaat ctaattgtta ttgagcgtgg
     1861 tgctgctgca gcagccgctg gccaggctgg gactgtgcca ccaggagccc ctggtgcccc
     1921 acccctgcct ggcatggcca ttgtcaagga agaagagaca gaagctgcta ttggagcccc
     1981 tcctgctgcc cctgaggggc ctgaaaccaa gcctgtgttg atggctctga ctgaaggccc
     2041 tggggctgag ggacctcgtc tagcttcacc tagtggcagt accagctcag gcttggaggt
     2101 ggtagctcct gaggttacct cagccccagt aagtgggcca ggtatcctgg atgacagtgc
     2161 cactatctgc cgtgtatgcc agaagccagg tgacctggtc atgtgcaacc agtgcgagtt
     2221 ttgcttccac ctggattgtc acctcccttc cctgcaggat gttccagggg aggaatggag
     2281 ttgctcactc tgccacgtgc tccctgatct aaaggaggaa gatggaagcc ttagcttgga
     2341 tggagcagat agcactggtg tggtagctaa actctcacca gccaaccagc ggaaatgtga
     2401 gcgtgttctg ctggcccttt tctgccatga accgtgccgc cccttgcatc agctggctac
     2461 cgactctaca ttctccatgg agcagcctgg tggtacccta gacctgacct tgattcgtgc
     2521 tcgcctccaa gagaagctgt cacctcctta tagctccccc caggagtttg cccaggatgt
     2581 gggccgcatg ttcaaacagt tcaataagct gactgaggac aaggcagatg ttcagtccat
     2641 catcggcctc cagcgcttct ttgagacacg aatgaatgat gcctttggtg acaccaagtt
     2701 ttctgctgtg ctggtagaac caccaccact gaaccttccc agtgctggcc taagttctca
     2761 ggagctgtct ggtcctggtg atggcccctg aagctggggc tcttgtggtc agcccagtcc
     2821 agctctggtc tctgtatttt caacccatac cctgtccttc ctctggtggc ctgactacct
     2881 gttcttgctg gccccatccc tcagtccctc ctcacaaaat ggtttttact tctgtggatt
     2941 taataaaaac ttcactgagt cagtcgctca aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     3001 a
//
