LOCUS       NM_001134974            2140 bp    mRNA    linear   ROD 23-APR-2023
DEFINITION  Rattus norvegicus tripartite motif-containing 27 (Trim27), mRNA.
ACCESSION   NM_001134974
VERSION     NM_001134974.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 2140)
  AUTHORS   Wang C, Zhang P, Li Y, Wang X, Guo L, Li J and Jiao H.
  TITLE     Downregulation of TRIM27 alleviates hypoxic-ischemic encephalopathy
            through inhibiting inflammation and microglia cell activation by
            regulating STAT3/HMGB1 axis
  JOURNAL   J Chem Neuroanat 129, 102251 (2023)
   PUBMED   36796734
  REMARK    GeneRIF: Downregulation of TRIM27 alleviates hypoxic-ischemic
            encephalopathy through inhibiting inflammation and microglia cell
            activation by regulating STAT3/HMGB1 axis.
REFERENCE   2  (bases 1 to 2140)
  AUTHORS   Chen Y, Liu Z, Hu Z, Feng X and Zuo L.
  TITLE     Tripartite motif 27 promotes cardiac hypertrophy via PTEN/Akt/mTOR
            signal pathways
  JOURNAL   Bioengineered 13 (4), 8323-8333 (2022)
   PUBMED   35311628
  REMARK    GeneRIF: Tripartite motif 27 promotes cardiac hypertrophy via
            PTEN/Akt/mTOR signal pathways.
REFERENCE   3  (bases 1 to 2140)
  AUTHORS   Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk
            SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni
            N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider
            J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA,
            Pelletier L, Aloy P, Hill DE, Vidal M and Roth FP.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2140)
  AUTHORS   Liu Y, Zhu M, Lin L, Fan X, Piao Z and Jiang X.
  TITLE     Deficiency of Trim27 protects dopaminergic neurons from apoptosis
            in the neurotoxin model of Parkinson's disease
  JOURNAL   Brain Res 1588, 17-24 (2014)
   PUBMED   25223908
  REMARK    GeneRIF: Data showed that Trim27 deficiency decreases apoptosis and
            protects dopaminergic neurons in MPTP poisoning, suggesting that
            Trim27 may be an effective potential target during the treatment of
            Parkinson's disease
REFERENCE   5  (bases 1 to 2140)
  AUTHORS   Hao YH, Doyle JM, Ramanathan S, Gomez TS, Jia D, Xu M, Chen ZJ,
            Billadeau DD, Rosen MK and Potts PR.
  TITLE     Regulation of WASH-dependent actin polymerization and protein
            trafficking by ubiquitination
  JOURNAL   Cell 152 (5), 1051-1064 (2013)
   PUBMED   23452853
REFERENCE   6  (bases 1 to 2140)
  AUTHORS   Bloor AJ, Kotsopoulou E, Hayward P, Champion BR and Green AR.
  TITLE     RFP represses transcriptional activation by bHLH transcription
            factors
  JOURNAL   Oncogene 24 (45), 6729-6736 (2005)
   PUBMED   16007160
REFERENCE   7  (bases 1 to 2140)
  AUTHORS   Dho SH and Kwon KS.
  TITLE     The Ret finger protein induces apoptosis via its RING finger-B
            box-coiled-coil motif
  JOURNAL   J Biol Chem 278 (34), 31902-31908 (2003)
   PUBMED   12807881
REFERENCE   8  (bases 1 to 2140)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   9  (bases 1 to 2140)
  AUTHORS   Shimono Y, Murakami H, Hasegawa Y and Takahashi M.
  TITLE     RET finger protein is a transcriptional repressor and interacts
            with enhancer of polycomb that has dual transcriptional functions
  JOURNAL   J Biol Chem 275 (50), 39411-39419 (2000)
   PUBMED   10976108
REFERENCE   10 (bases 1 to 2140)
  AUTHORS   Szpirer C, Szpirer J, Riviere M, Tazi R and Pontarotti P.
  TITLE     Mapping of the Olf89 and Rfp genes to the rat genome: comparison
            with the mouse and human and new insights into the evolution of the
            rodent genome
  JOURNAL   Cytogenet Cell Genet 78 (2), 137-139 (1997)
   PUBMED   9371408
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC169072.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC169072.1, SRR8487227.59946.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760389
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..2140
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="17"
                     /map="17q11"
     gene            1..2140
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /note="tripartite motif-containing 27"
                     /db_xref="GeneID:291171"
                     /db_xref="RGD:1310105"
     exon            1..711
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..1833
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 27; ret finger protein 1"
                     /codon_start=1
                     /product="zinc finger protein RFP"
                     /protein_id="NP_001128446.1"
                     /db_xref="GeneID:291171"
                     /db_xref="RGD:1310105"
                     /translation="MASGSVAESLQQETTCPVCLQYFVEPMMLDCGHNICCACLARCW
                     GAAETNVSCPQCRETFPQRHMRPNRHLANVTQLVKQLRTERPSGPDGEMGVCEKHREP
                     LKLYCEQDQMPICVVCDRSREHRGHSVLPLEEAVEGFKEQIQNRLDHLRRVKDLKKRR
                     RAQGEQARAELLSLTQMEREKIVWEFEQLYHSLKEHEYRLLARLEELDLAIYNSINGA
                     ITQFSCNISHLSGLIAQLEEKQQQPTRELLQDIGDTLSRAERIRIPEPWITPPDLQEK
                     IHIFAQKCLFLTESLKQFTEKMQSDMEKIQELREAQLYSVDVTLDPDTAYPSLILSDN
                     LRQVRYSYLQQDLPDNPERFNLFPCVLGSPCFIAGRHYWEVEVGDKAKWTIGVCEDSV
                     CRKGGVTSAPQNGFWAVSLWYGKEYWALTSPMTALPLRTPLQRVGIFLDYDAGEVSFY
                     NVTERCHTFTFSHATFCGPVRPYFSLSYSGGKSAAPLIICPMSGIDGFSGHVGNHGHS
                     METSP"
     exon            712..807
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            808..1038
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1039..1061
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1177
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1210
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1237
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..2078
                     /gene="Trim27"
                     /gene_synonym="Rfp1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gggatccctt ccgacgcggc cacgttgccc ggtgagccat cctgcagcgc cgggttcccg
       61 acacccctct gctcggctct cagccgggcc ctggggccca ggccttcccg cgctgtccgt
      121 gaggtgcagc tgtgcgggga cgggtctggc cgccccagag ctccgcacgc gtctaggatc
      181 cccgcgccgg aggccccacc ccgctccgga tctgagaagc cgagagagag cgccgggctc
      241 tgccagagct cggctccggg ctcatgccct gcggcccagc cggctcgcgc catggcctca
      301 gggagcgtgg ccgagtccct gcagcaggag accacctgcc ccgtgtgtct tcaatacttt
      361 gtggaaccca tgatgctcga ctgcggccac aacatctgtt gcgcgtgcct ggcccgctgc
      421 tggggtgccg cggagactaa cgtgtcgtgc ccgcagtgcc gggagacctt cccgcagcgc
      481 cacatgcggc ccaaccggca cctggccaac gtgacccagc tggtgaagca actgcgcacc
      541 gagcggccgt cggggccgga cggcgagatg ggcgtgtgcg agaagcaccg cgagcctctg
      601 aagctgtact gcgagcagga ccagatgccc atctgcgtgg tgtgcgaccg ctcgcgcgag
      661 caccgtggcc acagcgtgct gccgctggag gaggctgtgg aaggcttcaa ggagcaaatc
      721 cagaatcggc tggaccacct aagaagagtg aaagacttga agaagagacg gagggcacag
      781 ggggagcagg cacgagctga gctcctgagc ctgacccaga tggagaggga aaaaattgtt
      841 tgggagtttg agcagctgta tcactctttg aaggaacatg agtatcgcct gttggctcgc
      901 cttgaggagc tagacttggc catctataat agcatcaacg gtgccatcac tcagttctcc
      961 tgcaacatct cccacctcag tggcctgatt gcccaactgg aagagaagca gcagcagccc
     1021 acgagggagc tcttgcagga cattggagac actctgagca gggctgaaag aatcaggatc
     1081 cctgagccct ggatcacacc tccagatcta caagagaaaa tccatatttt tgcccaaaaa
     1141 tgtctgtttt tgacagaaag tctaaaacag ttcacagaaa aaatgcagtc agatatggag
     1201 aagatccaag agttgagaga ggctcaatta tactcagttg acgtgaccct ggacccagac
     1261 acagcctatc ccagcctgat tctttcagat aatcttcggc aagtacggta cagttacctc
     1321 cagcaggatc ttccagacaa ccctgagcgg ttcaatctgt ttccctgtgt cttgggctct
     1381 ccatgtttca tcgctgggag acattactgg gaggtagagg tgggcgataa agccaagtgg
     1441 accataggtg tctgtgaaga ctcagtgtgc agaaaaggtg gggtgacctc agccccccag
     1501 aatggattct gggcagtgtc attgtggtat gggaaagaat attgggctct tacatccccg
     1561 atgactgcac tccccctgcg gacccctctc cagagggtag ggattttctt ggactatgat
     1621 gctggtgagg tttccttcta caatgtgaca gagagatgcc atacctttac tttctctcat
     1681 gctaccttct gtgggccagt ccggccctac ttcagcctaa gttactcggg agggaagagt
     1741 gcggctcctt tgatcatctg ccctatgagt gggattgatg ggttttctgg ccatgttggg
     1801 aatcatggtc attccatgga gacctctcct tgaggaagtg aacttagacc acaagtgctg
     1861 ttgcctgtag tcctacccca ggcacaaggg atcttgttgt cttgttgatt cctgtctatc
     1921 cagcggggtg tcctcacctt ccatgcccta cagtgagaga caagatgtcc atccacgatc
     1981 tctactcact ttcccttccc ttgcagattg tgagatgtaa caaaaagtat tgctatttcc
     2041 cagaaataaa aaccagattt ctcctcttgt gtttcacaaa aaaaaaaaaa aaaaaaaaaa
     2101 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
//
