LOCUS       NM_001395753            4047 bp    mRNA    linear   ROD 09-APR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 24 (Trim24), mRNA.
ACCESSION   NM_001395753
VERSION     NM_001395753.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4047)
  AUTHORS   Patel,D.J. and Wang,Z.
  TITLE     Readout of epigenetic modifications
  JOURNAL   Annu Rev Biochem 82, 81-118 (2013)
   PUBMED   23642229
  REMARK    Review article
REFERENCE   2  (bases 1 to 4047)
  AUTHORS   Tsai,W.W., Wang,Z., Yiu,T.T., Akdemir,K.C., Xia,W., Winter,S.,
            Tsai,C.Y., Shi,X., Schwarzer,D., Plunkett,W., Aronow,B., Gozani,O.,
            Fischle,W., Hung,M.C., Patel,D.J. and Barton,M.C.
  TITLE     TRIM24 links a non-canonical histone signature to breast cancer
  JOURNAL   Nature 468 (7326), 927-932 (2010)
   PUBMED   21164480
REFERENCE   3  (bases 1 to 4047)
  AUTHORS   Kikuchi,M., Okumura,F., Tsukiyama,T., Watanabe,M., Miyajima,N.,
            Tanaka,J., Imamura,M. and Hatakeyama,S.
  TITLE     TRIM24 mediates ligand-dependent activation of androgen receptor
            and is repressed by a bromodomain-containing protein, BRD7, in
            prostate cancer cells
  JOURNAL   Biochim Biophys Acta 1793 (12), 1828-1836 (2009)
   PUBMED   19909775
REFERENCE   4  (bases 1 to 4047)
  AUTHORS   Allton,K., Jain,A.K., Herz,H.M., Tsai,W.W., Jung,S.Y., Qin,J.,
            Bergmann,A., Johnson,R.L. and Barton,M.C.
  TITLE     Trim24 targets endogenous p53 for degradation
  JOURNAL   Proc Natl Acad Sci U S A 106 (28), 11612-11616 (2009)
   PUBMED   19556538
REFERENCE   5  (bases 1 to 4047)
  AUTHORS   Ignat,M., Teletin,M., Tisserand,J., Khetchoumian,K., Dennefeld,C.,
            Chambon,P., Losson,R. and Mark,M.
  TITLE     Arterial calcifications and increased expression of vitamin D
            receptor targets in mice lacking TIF1alpha
  JOURNAL   Proc Natl Acad Sci U S A 105 (7), 2598-2603 (2008)
   PUBMED   18287084
REFERENCE   6  (bases 1 to 4047)
  AUTHORS   Nielsen,A.L., Ortiz,J.A., You,J., Oulad-Abdelghani,M.,
            Khechumian,R., Gansmuller,A., Chambon,P. and Losson,R.
  TITLE     Interaction with members of the heterochromatin protein 1 (HP1)
            family and histone deacetylation are differentially involved in
            transcriptional silencing by members of the TIF1 family
  JOURNAL   EMBO J 18 (22), 6385-6395 (1999)
   PUBMED   10562550
REFERENCE   7  (bases 1 to 4047)
  AUTHORS   Niederreither,K., Remboutsika,E., Gansmuller,A., Losson,R. and
            Dolle,P.
  TITLE     Expression of the transcriptional intermediary factor TIF1alpha
            during mouse development and in the reproductive organs
  JOURNAL   Mech Dev 88 (1), 111-117 (1999)
   PUBMED   10525195
REFERENCE   8  (bases 1 to 4047)
  AUTHORS   Klugbauer,S. and Rabes,H.M.
  TITLE     The transcription coactivator HTIF1 and a related protein are fused
            to the RET receptor tyrosine kinase in childhood papillary thyroid
            carcinomas
  JOURNAL   Oncogene 18 (30), 4388-4393 (1999)
   PUBMED   10439047
REFERENCE   9  (bases 1 to 4047)
  AUTHORS   Remboutsika,E., Lutz,Y., Gansmuller,A., Vonesch,J.L., Losson,R. and
            Chambon,P.
  TITLE     The putative nuclear receptor mediator TIF1alpha is tightly
            associated with euchromatin
  JOURNAL   J Cell Sci 112 (Pt 11), 1671-1683 (1999)
   PUBMED   10318760
REFERENCE   10 (bases 1 to 4047)
  AUTHORS   Le Douarin,B., Zechel,C., Garnier,J.M., Lutz,Y., Tora,L.,
            Pierrat,P., Heery,D., Gronemeyer,H., Chambon,P. and Losson,R.
  TITLE     The N-terminal part of TIF1, a putative mediator of the
            ligand-dependent activation function (AF-2) of nuclear receptors,
            is fused to B-raf in the oncogenic protein T18
  JOURNAL   EMBO J 14 (9), 2020-2033 (1995)
   PUBMED   7744009
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000004.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643296.13032.1,
                                           SRR21887620.515196.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-667               JAXUCZ010000004.1  67534335-67535001
            668-786             JAXUCZ010000004.1  67584517-67584635
            787-934             JAXUCZ010000004.1  67589559-67589706
            935-1067            JAXUCZ010000004.1  67597313-67597445
            1068-1184           JAXUCZ010000004.1  67601512-67601628
            1185-1299           JAXUCZ010000004.1  67609847-67609961
            1300-1446           JAXUCZ010000004.1  67612994-67613140
            1447-1564           JAXUCZ010000004.1  67634616-67634733
            1565-1833           JAXUCZ010000004.1  67636811-67637079
            1834-2007           JAXUCZ010000004.1  67640151-67640324
            2008-2181           JAXUCZ010000004.1  67642564-67642737
            2182-2317           JAXUCZ010000004.1  67644547-67644682
            2318-2390           JAXUCZ010000004.1  67647144-67647216
            2391-2559           JAXUCZ010000004.1  67648580-67648748
            2560-2888           JAXUCZ010000004.1  67649045-67649373
            2889-3021           JAXUCZ010000004.1  67651200-67651332
            3022-3096           JAXUCZ010000004.1  67653708-67653782
            3097-3246           JAXUCZ010000004.1  67657417-67657566
            3247-4047           JAXUCZ010000004.1  67658214-67659014
FEATURES             Location/Qualifiers
     source          1..4047
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="4"
                     /map="4q23"
     gene            1..4047
                     /gene="Trim24"
                     /note="tripartite motif-containing 24"
                     /db_xref="GeneID:500084"
                     /db_xref="RGD:1560596"
     exon            1..667
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     CDS             304..3456
                     /gene="Trim24"
                     /EC_number="2.3.2.27"
                     /note="Ab2-427"
                     /codon_start=1
                     /product="transcription intermediary factor 1-alpha"
                     /protein_id="NP_001382682.1"
                     /db_xref="GeneID:500084"
                     /db_xref="RGD:1560596"
                     /translation="MEVAVEKAAAAAALAGAPAAAAPSGENEAESRQGPDSESGGEVS
                     RLNLLDTCAVCHQNIQSRVPKLLPCLHSFCQRCLPAPQRYLMLTAPSLGSAETPPPAP
                     VPAPAPGSPAGGPSPFATQVGVIRCPVCSQECAERHIIDNFFVKDTTEVPSSTVEKSN
                     QVCTSCEDNAEANGFCVECVEWLCKTCIRAHQRVKFTKDHTVRQKEEVSPEAVGVTSQ
                     RPVFCPFHKKEQLKLYCETCDKLTCRDCQLLEHKEHRYQFIEEAFQNQKVIIDTLITK
                     LMEKTKYIKYTGNQIQNRIIEVNQNQKQVEQDIKVAIFTLMVEINKKGKALLHQLESL
                     AKDHRMKLMQQQQEVAGLSKQLEHVMHFSKWAVSSGSSTALLYSKRLITYRLRHLLRA
                     RCDASPVTNNTIQFHCDPSFWAQNIINLGSLVIEEKESQPQMPKQNPVVEQSSQPPGG
                     LPSNQLSKFPTQISLAQLRLQHIQQQVMAQRQQVQRRPAPVGSPNPRMQGPIQQPSIS
                     LQHPPPRLINFQNHSPKPNGPVLPPYPQQLRYPPSQNIPRQAIKPNPLQMAFLAQQAI
                     KQWQISSGQATPTTASSSSSTPSSPTITSAAGYDGKAFSSPMIDLSAPVGGSYNLPSL
                     PDIDCSSTILLDNIARKDTSVDPGQPRPPSNRTVQSPNSSVPSPGLAGPVTMTSVHPP
                     IRSPSASSVGSRGSSGSSSKPAGADSTHKVPVVMLEPIRIKQENSGPPENYDFPVVIV
                     KQESDEESRPQNTNYPRSILTSLLLNSSQSSASEETVLRSDAPDSTGDQPALHHENSP
                     NGKSEWPDASQKSPVHVGETRKEDDPNEDWCAVCQNGGELLCCEKCPKVFHLTCHVPT
                     LTHFPSGEWICTFCRDLSKPEVEYDCDAPSHNSDKRKSEGLTKLTPIDKRKCERLLLF
                     LYCHEMSLAFQDPVPLTVPDYYKIIKNPMDLSTIKKRLQEDYCMYTKPEDFVADFRLI
                     FQNCAEFNEPDSEVANAGIKLESYFEELLKNLYPEKRFPKLEFRHDVEDCKFSDDSDD
                     DFVQPRKKRLKSMEDRQLLK"
     exon            668..786
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            787..934
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1067
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1184
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1299
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1446
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1564
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1833
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..2007
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2181
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2317
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            2318..2390
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2559
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            2560..2888
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3021
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            3022..3096
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            3097..3246
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
     exon            3247..4047
                     /gene="Trim24"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggtggtccaa ggggcccgag agaaaggctg ctaggcgcgg gcgggcgcgc tgggcggaat
       61 cgagcgtctc ggtggcggtt tgcctggcgg cccgcgcggc ggcgtcgcgg tgcgggaacc
      121 ggtccccgtt gacagctccg cgtcttccgg ccgcgccact cgggaagtgg cttcctccct
      181 gcgctccctc cgcgaatacg cgcggcctcg gaagagaagc gggaggcggc ggcagcagcg
      241 gaggtcgtcg ggggcggcgg gcggtgagcg cgctcccgct ttcccggcgg cggccgcagg
      301 acaatggagg tggctgtgga gaaggcagcg gcggcggcgg ctctggccgg ggcccccgca
      361 gcggcggcgc cgagcgggga gaatgaggcc gagagccggc agggcccgga ctcggaaagc
      421 ggcggcgagg tgtcccggct caacctgttg gacacttgcg ccgtgtgcca ccagaacatc
      481 cagagccggg tgcccaagct gctgccctgc ctgcactcgt tctgccagcg ctgcttgccc
      541 gcaccccagc gctatctcat gctgacggcg ccctcgctgg gctcagcaga gacccctcca
      601 ccggctcctg tccccgcccc cgccccgggc tccccggccg gtggtccttc gccattcgcc
      661 acccaagttg gagtcattcg atgcccagtt tgcagtcaag agtgtgctga aagacacatc
      721 atagacaact tttttgtgaa ggacaccact gaggttccca gtagtacagt agaaaagtca
      781 aatcaggtat gtacaagctg tgaagacaat gcagaagcta atgggttttg tgtagagtgt
      841 gttgaatggc tctgcaagac atgtattaga gctcaccaga gggtgaagtt cacaaaagac
      901 cacacagtca ggcagaaaga agaagtatct ccagaggcag ttggtgtgac cagtcagcga
      961 ccagtgtttt gtccgttcca taaaaaggag cagctgaaac tctactgtga aacgtgtgat
     1021 aagctgacat gtcgagactg ccagctgcta gaacacaaag agcacagata tcaatttata
     1081 gaagaagctt ttcagaatca aaaagtaatc atagatactc taatcaccaa actgatggaa
     1141 aaaacaaaat atataaagta cacaggaaat cagatccaaa ataggataat tgaagtaaat
     1201 caaaaccaaa agcaggtgga acaggatatt aaagttgcca tcttcacatt gatggtggag
     1261 ataaacaaga aagggaaagc cctgctgcac cagcttgaga gtcttgcaaa agaccatcga
     1321 atgaaactta tgcaacagca gcaggaagtg gctgggcttt ctaagcagtt agagcatgtc
     1381 atgcattttt ctaaatgggc tgtttccagt ggcagcagca cagccttgct gtacagcaag
     1441 cggctgatta catacaggtt acggcacctt ctccgtgcaa ggtgtgatgc ttctcctgtg
     1501 accaacaaca ccatccagtt tcactgtgat cctagtttct gggctcaaaa tattatcaac
     1561 ttgggttctt tggtaatcga ggagaaagag agccagccac aaatgcctaa gcagaatcct
     1621 gtcgtggaac agagctccca gccaccaggt ggtttaccct ccaaccagtt atccaagttc
     1681 ccaacacaga tcagcctagc tcagttacga ctccagcata ttcagcaaca ggtaatggct
     1741 cagaggcaac aggtgcaacg gaggccggca cctgtgggtt caccaaaccc tagaatgcag
     1801 gggcccatcc agcagccttc catctctctt cagcatccac caccacgctt aataaacttt
     1861 cagaaccaca gccctaagcc caatggacca gtgcttcctc cttatcctca gcagctgagg
     1921 tacccaccca gccagaatat accacggcag gcaataaagc ccaaccccct gcagatggct
     1981 tttttggctc aacaggccat aaaacagtgg cagatcagca gtggacaggc tacgcctaca
     2041 actgccagca gctcctcctc cactccttcc agtcccacga tcacaagtgc agctgggtac
     2101 gatggaaaag ctttcagttc acccatgatt gatctgagtg caccagtggg agggtcttac
     2161 aatcttcctt ctcttccaga tattgattgt tcaagtacta tcttgttgga caatattgca
     2221 aggaaggata caagtgtaga ccctggccag ccaagacctc catcaaacag aaccgtgcag
     2281 tcaccaaatt catcagtgcc gtctccaggc ctggcagggc ctgttactat gactagtgtc
     2341 catcccccaa tacgttcacc tagtgcctcc agtgttggga gccgaggaag ctcgggctct
     2401 tccagcaaac cagcaggagc ggattctact cacaaggtcc cagtagtcat gctggagcca
     2461 attcgaataa aacaggaaaa cagtggacca cctgaaaact atgattttcc tgttgttata
     2521 gtaaaacaag aatcagatga agaatctaga cctcaaaata ctaactatcc aaggagcata
     2581 ctgacctccc tcctcctaaa cagtagccag agctctgctt ctgaggagac ggtgttacgg
     2641 tccgatgccc ctgatagtac aggagatcag cctgcactcc atcatgaaaa ctccccaaat
     2701 ggaaagtctg agtggccgga tgcctcccag aagtcccctg tgcatgttgg agagacaaga
     2761 aaggaggatg accccaatga agactggtgt gctgtttgtc aaaatggtgg agaactccta
     2821 tgctgtgaga aatgtcccaa agtattccat cttacttgtc atgtgcccac actgacacat
     2881 tttccaagtg gagaatggat ttgtactttc tgccgggact tatctaagcc agaagttgaa
     2941 tatgattgtg atgctcccag tcacaactca gataaaagga aaagtgaagg ccttactaaa
     3001 ctaacaccaa tagacaaaag gaaatgtgag cgcctgctcc tgttccttta ctgccatgag
     3061 atgagcctgg ctttccagga ccccgtccct ctgactgtgc ctgattatta taaaataatt
     3121 aaaaacccaa tggacttgtc aaccatcaag aaaagacttc aggaggatta ttgcatgtat
     3181 acaaagcctg aagattttgt agctgatttt agattgatct ttcaaaactg tgctgaattc
     3241 aatgagcctg attctgaagt agccaatgcc ggtataaaac ttgaaagcta ttttgaagaa
     3301 cttctaaaga atctttatcc agagaagagg ttccctaagc tagaattccg gcatgacgtg
     3361 gaagactgta agttcagtga cgactcggat gatgactttg tgcaaccccg gaagaagcgc
     3421 ctcaagagca tggaagaccg gcagctgctc aagtgagcgc actgggcagg gcactgtgtt
     3481 cgagattctc cttcaaaaat aaagcaggca aagaccttgt cagggattta agatcatgac
     3541 agagcagggt ttgtgagctc tctggtctgt tttttctgtt tcccggactt tggtttcttt
     3601 aataacccat ttctttaacc tcttgtcatt gataataaaa aagaaggagg aaggaaatgt
     3661 gttcaagaat aaaagaagga agaaaaggta gaaaaggaag aaacagcaaa gaaagaaaag
     3721 acattcttcc cacttgttgg atttcagaca gcaacctgga gtaagagcta ccatagaaag
     3781 aaatagagtt tgaagtaagt tgagaattta gtgtgacttg gatgtgtgat aatccttctt
     3841 agaatattaa ttttattacc cattaattat ggccaactgt atggagatag gtttactgtg
     3901 cttaaaagaa gtcctccccg aacgtgagtg ggaagcagag ttctttccca ggctgcctgc
     3961 cagaaaaggt gtagacagat gctattaaga caccaaatag tgtccatgta taatggcaaa
     4021 tgcattaaag aaatcaggaa aaacaaa
//
