LOCUS       NM_001100637            3308 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 23 (Trim23), mRNA.
ACCESSION   NM_001100637 XM_001064021 XM_001064069 XM_342183
VERSION     NM_001100637.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3308)
  AUTHORS   Chen,J., Zhang,R., Li,F., Lin,S. and Wang,J.
  TITLE     Integrated analysis and validation of TRIM23/p53 signaling pathway
            in hepatic stellate cells ferroptosis and liver fibrosis
  JOURNAL   Dig Liver Dis 56 (2), 281-290 (2024)
   PUBMED   37495427
  REMARK    GeneRIF: Integrated analysis and validation of TRIM23/p53 signaling
            pathway in hepatic stellate cells ferroptosis and liver fibrosis.
REFERENCE   2  (bases 1 to 3308)
  AUTHORS   Xue,W., Zhao,Y., Xiao,Z., Wu,X., Ma,D., Han,J., Li,X., Xue,X.,
            Yang,Y., Fang,Y., Fan,C., Liu,S., Xu,B., Han,S., Chen,B., Zhang,H.,
            Fan,Y., Liu,W., Dong,Q. and Dai,J.
  TITLE     Epidermal growth factor receptor-extracellular-regulated kinase
            blockade upregulates TRIM32 signaling cascade and promotes
            neurogenesis after spinal cord injury
  JOURNAL   Stem Cells 38 (1), 118-133 (2020)
   PUBMED   31621984
  REMARK    GeneRIF: Epidermal growth factor receptor-extracellular-regulated
            kinase blockade upregulates TRIM32 signaling cascade and promotes
            neurogenesis after spinal cord injury.
REFERENCE   3  (bases 1 to 3308)
  AUTHORS   Woodsmith,J., Jenn,R.C. and Sanderson,C.M.
  TITLE     Systematic analysis of dimeric E3-RING interactions reveals
            increased combinatorial complexity in human ubiquitination networks
  JOURNAL   Mol Cell Proteomics 11 (7), M111.016162 (2012)
   PUBMED   22493164
REFERENCE   4  (bases 1 to 3308)
  AUTHORS   Vichi,A., Payne,D.M., Pacheco-Rodriguez,G., Moss,J. and Vaughan,M.
  TITLE     E3 ubiquitin ligase activity of the trifunctional ARD1
            (ADP-ribosylation factor domain protein 1)
  JOURNAL   Proc Natl Acad Sci U S A 102 (6), 1945-1950 (2005)
   PUBMED   15684077
REFERENCE   5  (bases 1 to 3308)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
REFERENCE   6  (bases 1 to 3308)
  AUTHORS   Vitale,N., Horiba,K., Ferrans,V.J., Moss,J. and Vaughan,M.
  TITLE     Localization of ADP-ribosylation factor domain protein 1 (ARD1) in
            lysosomes and Golgi apparatus
  JOURNAL   Proc Natl Acad Sci U S A 95 (15), 8613-8618 (1998)
   PUBMED   9671726
REFERENCE   7  (bases 1 to 3308)
  AUTHORS   Vitale,N., Moss,J. and Vaughan,M.
  TITLE     ARD1, a 64-kDa bifunctional protein containing an 18-kDa
            GTP-binding ADP-ribosylation factor domain and a 46-kDa
            GTPase-activating domain
  JOURNAL   Proc Natl Acad Sci U S A 93 (5), 1941-1944 (1996)
   PUBMED   8700863
REFERENCE   8  (bases 1 to 3308)
  AUTHORS   Mishima,K., Tsuchiya,M., Nightingale,M.S., Moss,J. and Vaughan,M.
  TITLE     ARD 1, a 64-kDa guanine nucleotide-binding protein with a
            carboxyl-terminal ADP-ribosylation factor domain
  JOURNAL   J Biol Chem 268 (12), 8801-8807 (1993)
   PUBMED   8473324
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB696360.1, FM052834.1, L04760.1, CK470479.1, FM085917.1,
            DV726798.1 and AA965268.1.
            
            On or before May 22, 2010 this sequence version replaced
            XM_342183.4, XM_001064069.2, XM_001064021.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: L04760.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132284, SAMD00132290
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                CB696360.1         1-16
            17-149              FM052834.1         1-133
            150-1709            L04760.1           1-1560
            1710-2185           CK470479.1         212-687
            2186-2497           FM085917.1         335-646
            2498-3284           DV726798.1         27-813
            3285-3308           AA965268.1         1-24                c
FEATURES             Location/Qualifiers
     source          1..3308
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q13"
     gene            1..3308
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /note="tripartite motif-containing 23"
                     /db_xref="GeneID:81002"
                     /db_xref="RGD:621587"
     exon            1..170
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1814
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /EC_number="2.3.2.27"
                     /note="GTP-binding protein ARD-1; tripartite
                     motif-containing protein 23; ADP-ribosylation factor
                     domain-containing protein 1; nucleotide binding protein;
                     tripartite motif protein 23; ADP-ribosylation factor
                     domain protein 1, 64kD; RING-type E3 ubiquitin transferase
                     TRIM23"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM23"
                     /protein_id="NP_001094107.1"
                     /db_xref="GeneID:81002"
                     /db_xref="RGD:621587"
                     /translation="MAALAVNKPGAGVDSGRQGSRGTAVVKVLECGVCEDVFSLQGDK
                     VPRLLLCGHTVCHDCLSRLPLHGRAIRCPFDRQVTDLGDSGVWGLKKNFALLELLERL
                     QNGHIGQYGAAEEALGISGESIIRCDEDEAHVASVYCTVCATHLCSECSQVTHSTKTL
                     AKHRRVPLADKPHEKTMCCQHQVHAIEFVCLEEACQTSPLMCCVCKEYGKHQGHKHSV
                     LEPEANQIRASILDMAHCIRTFTEEISDYSRKLVGIVQHIEGGEQIVEDGIGMAHTEH
                     VPGTAENARSCVRAYFSDLHETLCRQEEMALSVVDAHVREKLIWLRQQQEDMTILLSQ
                     VSTACLHCEKTLQQDDCRVVLAKQEITRLLETLQKQQQQFTEVADHIQLDASIPVTFT
                     KDNRVYIGPKMEIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKF
                     TIWDVGEKHKLRPLWKHYYLNTQAVVFVVDSSHRDRISEAHSELAKLLTEKELRDALL
                     LIFANKQDVAGALSVEEITELLSLHKLCCGRSWYIQGCDARSGMGLYEGLDWLSRQLV
                     AAGVLDVA"
     exon            171..333
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            334..455
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            456..734
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..917
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1133
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1268
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1269..1398
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1509
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1634
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
     exon            1635..3294
                     /gene="Trim23"
                     /gene_synonym="Ard1; Arfd1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcggcacgcg ccgaggcttc tgggtaggtc gctcaacccc tcctctcagt taaaggctct
       61 actgcagctg tgccgctgct ccttccagga tggctgccct cgctgtaaac aagcccggag
      121 caggagtaga cagtgggcgg cagggcagcc gggggacggc tgtggtgaag gttctggagt
      181 gtggtgtttg tgaagatgtc ttctctctgc aaggagataa agttcctcgc cttctccttt
      241 gtggccacac agtctgtcat gactgtctct ctcgcttgcc tctgcatgga agagcaatac
      301 gttgcccatt tgatcgacaa gtgacagacc taggagattc aggtgtctgg ggtttgaaaa
      361 aaaattttgc tttactggag cttttagaac gtttgcaaaa tggacatatt ggtcagtatg
      421 gagctgcaga agaagccctt gggatatctg gagagagtat cattcgctgt gatgaagatg
      481 aagctcacgt tgcatctgtg tactgcactg tgtgtgcgac tcacttgtgc tcagagtgtt
      541 ctcaagtcac tcattctaca aagactctgg ccaagcatag gcgagtgcct ctagctgata
      601 aacctcatga gaagaccatg tgctgtcagc accaggtaca tgccattgag tttgtttgct
      661 tggaagaagc ttgtcaaact agtcctctca tgtgctgtgt ctgcaaagaa tatggaaaac
      721 accagggtca caagcactca gtactggagc cagaagctaa ccagatccga gcgtcaattt
      781 tagacatggc tcactgcata cgaaccttca ctgaggagat ctcagattat tccagaaaat
      841 tagttgggat tgttcagcac attgaaggag gagaacaaat agtggaagat ggaattggaa
      901 tggctcacac ggaacacgtc ccaggtactg cagagaatgc acgatcatgt gtcagagctt
      961 atttttctga tttgcatgaa actctttgtc gtcaagaaga aatggctctc agtgttgttg
     1021 atgcccatgt tcgagaaaaa ctgatttggc ttaggcagca acaagaggat atgactattc
     1081 tcttgtccca ggtttcaaca gcctgtctcc attgtgaaaa gactttgcag caggatgatt
     1141 gcagagttgt cttggcaaaa caagaaatca caagattatt agaaacactg cagaaacagc
     1201 agcagcagtt tacagaagtt gcagatcata ttcagttgga tgccagtatt ccagtcactt
     1261 ttacaaagga caacagagtt tatattggac ccaaaatgga aatacgagta gtcacattag
     1321 gattagatgg tgctggaaaa actactattt tgttcaagtt aaaacaagat gaatttatgc
     1381 agcctattcc aacaattggt tttaatgtgg aaactgtgga atacaaaaat ctaaaattca
     1441 ccatttggga tgtgggtgaa aaacacaaat taagaccatt gtggaaacat tattacctca
     1501 atacacaagc tgttgtattt gttgttgaca gcagtcacag agacagaatt agtgaagcac
     1561 acagtgaact tgcgaagttg ttaacagaaa aagaacttcg agatgcctta ctcttgattt
     1621 ttgctaacaa acaggatgtc gctggggcac tttcggttga agaaatcacc gaacttctca
     1681 gtctccataa attatgctgc ggaaggagct ggtatattca gggctgtgat gctcgaagtg
     1741 gtatggggct ctacgaaggg ttggactggc tgtcccggca acttgtggct gccggagtgt
     1801 tggatgttgc ttgattctat tgcagcagtt gtttcgagct tatggttaaa agttactttg
     1861 catgtaatgc attctaagaa attctacatc tcaagtatga taatttagta tgtgtacgta
     1921 tgaatcctgg actgagaaat gtaccattgc ttttaaaaat tattctgtgg caaatttaag
     1981 tgatcctgtt acattggtta aatagttttg cttttgtttt tttttggata taaactttta
     2041 aaaggtacat taggcattgg aaactttgta cactttgtgt atgacctgta cattgggaga
     2101 gaagtggcca cagagaatga gtagaagctc ctttatttta ttgaaaaaat aggcagtgga
     2161 gtgcctaaca gaacttatgg aaacatggct tctttacccc tcctttttac tcattgttgg
     2221 cagtcgtgga ctagaattta agctgtactg gggtaacagg attacctgac tttcacattc
     2281 agcataacat ctattagtgc tggggaccat caaatacaga aaatcagggt ttttttcccc
     2341 tacagtttta ttataacgct ctcctaaagc attctgcata acgcacaatg agaatgaatg
     2401 ttatctaagt ggacctgagc attagacccg aactaaatta cgaacaatag aactgtgaaa
     2461 gttgtttgat cttcactcat aaaaaccatt tctaggactg ggcctaggtt tatttcctag
     2521 gtcaaagccc taaattggtc ctttcgttca cacttactta ggctaagtaa tagtgcatcc
     2581 tctgttggta aagtgccaca agtcacatga agaaccagtc acctttacat aaacacacag
     2641 agacctaaat agaaaacggc ctagacctta ggaaaggttt tcacacagtg gggaatgcta
     2701 atttctttaa catggttccc aagttaagtg catttactag actataaaaa agatcaaggc
     2761 tctttaggac aaggtctcag ttaaaaggaa gaacacatct aaagtaaaag aaacttaaaa
     2821 agtttacatt tattacggga gtgttatgaa taaaagttaa attttgtgtt ctctatagtt
     2881 tcttatttgt aagatactct tattatggaa gcatgatttc ttatatttaa ataggtagat
     2941 ttcttgttat taatgctttc actttaggat gaagttgaga gctaaatctt agtgcaattg
     3001 ttaaaaggac agtgatgtct gacaatagga tgtgattttt aggtggcaat gttctggttc
     3061 agtttttctc aaataaccct tttttttaac ttagaaaaca gcactacaaa aagtccatcg
     3121 aacattatgg gcaacatgta aataaaaata taataatttt ccctttttca agagtgtaac
     3181 aacacgctgt tacacatagc ttgtgtgcat atgtaataca ctgtaattaa attatttaat
     3241 tttgactgat tttagtaact gtgaaaaata aagacgttgc gtttatttgt gagaaaaaaa
     3301 aaaaaaaa
//
