LOCUS       NM_001082572            4079 bp    mRNA    linear   ROD 17-SEP-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 21 (Trim21), mRNA.
ACCESSION   NM_001082572 XM_006229885 XM_219011
VERSION     NM_001082572.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4079)
  AUTHORS   Zhang,Z., Li,Z., Peng,Y., Li,Z., Xv,N., Jin,L., Cao,Y., Jiang,C.
            and Chen,Z.
  TITLE     TRIM21-mediated ubiquitination of PLIN2 regulates neuronal lipid
            droplet accumulation after acute spinal cord injury
  JOURNAL   Exp Neurol 381, 114916 (2024)
   PUBMED   39122166
  REMARK    GeneRIF: TRIM21-mediated ubiquitination of PLIN2 regulates neuronal
            lipid droplet accumulation after acute spinal cord injury.
REFERENCE   2  (bases 1 to 4079)
  AUTHORS   Kimura,T., Jain,A., Choi,S.W., Mandell,M.A., Schroder,K.,
            Johansen,T. and Deretic,V.
  TITLE     TRIM-mediated precision autophagy targets cytoplasmic regulators of
            innate immunity
  JOURNAL   J Cell Biol 210 (6), 973-989 (2015)
   PUBMED   26347139
REFERENCE   3  (bases 1 to 4079)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   4  (bases 1 to 4079)
  AUTHORS   Chen,V.C., Kristensen,A.R., Foster,L.J. and Naus,C.C.
  TITLE     Association of connexin43 with E3 ubiquitin ligase TRIM21 reveals a
            mechanism for gap junction phosphodegron control
  JOURNAL   J Proteome Res 11 (12), 6134-6146 (2012)
   PUBMED   23106098
  REMARK    GeneRIF: Cx43/TRIM21 complex is an active participant of gap
            junction ubiquitylation and turnover.
REFERENCE   5  (bases 1 to 4079)
  AUTHORS   Zurek,B., Schoultz,I., Neerincx,A., Napolitano,L.M., Birkner,K.,
            Bennek,E., Sellge,G., Lerm,M., Meroni,G., Soderholm,J.D. and
            Kufer,T.A.
  TITLE     TRIM27 negatively regulates NOD2 by ubiquitination and proteasomal
            degradation
  JOURNAL   PLoS One 7 (7), e41255 (2012)
   PUBMED   22829933
REFERENCE   6  (bases 1 to 4079)
  AUTHORS   Sabile,A., Meyer,A.M., Wirbelauer,C., Hess,D., Kogel,U.,
            Scheffner,M. and Krek,W.
  TITLE     Regulation of p27 degradation and S-phase progression by Ro52 RING
            finger protein
  JOURNAL   Mol Cell Biol 26 (16), 5994-6004 (2006)
   PUBMED   16880511
REFERENCE   7  (bases 1 to 4079)
  AUTHORS   Wada,K. and Kamitani,T.
  TITLE     UnpEL/Usp4 is ubiquitinated by Ro52 and deubiquitinated by itself
  JOURNAL   Biochem Biophys Res Commun 342 (1), 253-258 (2006)
   PUBMED   16472766
REFERENCE   8  (bases 1 to 4079)
  AUTHORS   Wada,K., Tanji,K. and Kamitani,T.
  TITLE     Oncogenic protein UnpEL/Usp4 deubiquitinates Ro52 by its
            isopeptidase activity
  JOURNAL   Biochem Biophys Res Commun 339 (3), 731-736 (2006)
   PUBMED   16316627
REFERENCE   9  (bases 1 to 4079)
  AUTHORS   Wada,K. and Kamitani,T.
  TITLE     Autoantigen Ro52 is an E3 ubiquitin ligase
  JOURNAL   Biochem Biophys Res Commun 339 (1), 415-421 (2006)
   PUBMED   16297862
REFERENCE   10 (bases 1 to 4079)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000001.1.
            
            On or before Oct 6, 2022 this sequence version replaced
            XM_006229885.3, NM_001082572.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.1222259.1,
                                           SRR26360186.2728566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840106,
                                           SAMN12840108 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                JAXUCZ010000001.1  166399309-166399371 c
            64-495              JAXUCZ010000001.1  166390371-166390802 c
            496-591             JAXUCZ010000001.1  166389902-166389997 c
            592-822             JAXUCZ010000001.1  166388794-166389024 c
            823-845             JAXUCZ010000001.1  166387159-166387181 c
            846-946             JAXUCZ010000001.1  166380246-166380346 c
            947-4079            JAXUCZ010000001.1  166376829-166379961 c
FEATURES             Location/Qualifiers
     source          1..4079
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1q32"
     gene            1..4079
                     /gene="Trim21"
                     /note="tripartite motif-containing 21"
                     /db_xref="GeneID:308901"
                     /db_xref="RGD:1305795"
     exon            1..63
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
     exon            64..495
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1491
                     /gene="Trim21"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 21; 52 kDa Ro protein"
                     /codon_start=1
                     /product="E3 ubiquitin-protein ligase TRIM21"
                     /protein_id="NP_001076041.1"
                     /db_xref="GeneID:308901"
                     /db_xref="RGD:1305795"
                     /translation="MSHSTTSKMSLEKMWEEVTCSICLEPMVEPMSIECGHCFCKECI
                     SEVGGNGGGSCPVCRQHFLLRNLRPNRHIANMVENLKQEAQNTKKGTQEVHCMKHGEI
                     LHLFCEEDGQALCWVCAQSGKHRDHTKVPIEEAAKIYQEKIHKALEKLRKGKELAEKL
                     EMDLAMQRTDWKRNIDTQKSRIHEEFAHQNSLLAQEEQRQLQRLEKDEREHLRLLGEK
                     EAELAEKNQALQELISELERRSRGSELELLKEVRIVLERSVSWKLDTVDVDSPDLTST
                     CHVPGRKKMLRTCWVHITLDRDTANSCLIISKDRRQVRMGDTYQNVSENAERFNNYPM
                     VLGAQRFSSGKMYWEVDVTQKQAWDLGVCRDSVQRKGHFSLSPENGFWTIWLWQKDNY
                     EAGTSPQTTLHIQVPPCQIGIFVDYEAGIVSFYNITDHGSLIYTFSECAFIGPLRPFF
                     SVGFNDDGGNSAPLKLCPLKI"
     exon            496..591
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
     exon            592..822
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
     exon            823..845
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
     exon            846..946
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
     exon            947..4079
                     /gene="Trim21"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agactgcggg cttgcaaaag tgaagctgaa aacagcctag ccaagtctga ggaccctggt
       61 aagattccac ggcagatgtc acactctaca acctcaaaaa tgtccctgga aaagatgtgg
      121 gaggaggtca cctgttctat ctgcctggag cccatggtgg agcctatgag tatcgaatgt
      181 ggccactgct tttgcaagga atgcatttct gaggttgggg gaaatggggg cggttcatgt
      241 cccgtgtgcc ggcaacactt tctgctcaga aacctcaggc ccaatcggca tatagcaaac
      301 atggtggaaa accttaaaca agaggcccag aataccaaaa agggcaccca ggaagtgcac
      361 tgcatgaagc atggagagat acttcacctg ttctgtgagg aagatgggca ggccctttgc
      421 tgggtgtgtg cccagtctgg gaaacaccgg gaccacacca aggtccccat tgaagaggct
      481 gctaagatat accaggagaa gattcacaag gctttagaaa aactgagaaa agggaaagag
      541 ttggccgaga agttggaaat ggatcttgca atgcaaagaa cagactggaa gaggaacatt
      601 gacacccaga agtcgaggat tcacgaagag ttcgcacatc agaatagctt gctggctcag
      661 gaggaacaga ggcagctgca gaggctggag aaggatgaaa gggagcacct gagactcctt
      721 ggggagaagg aggctgagct ggctgagaag aaccaggccc tgcaggaact gatctcagag
      781 ctggagagga ggagccgagg ttcagaactg gagctattga aggaggtgag gatcgtcctg
      841 gaaaggagtg tatcctggaa actggacacg gtagatgttg attccccaga cctgacaagc
      901 acatgccatg tgccagggcg gaagaagatg ctgaggacct gttgggttca tattactctg
      961 gatcgtgaca ctgccaactc gtgcctcatc atctcaaagg atcggagaca agtgaggatg
     1021 ggagacacct atcagaatgt gtctgaaaat gctgagagat ttaataatta ccccatggtg
     1081 ctaggtgccc agagattctc ctctgggaag atgtactggg aggtagatgt gacccaaaag
     1141 caggcctggg atttgggggt ttgcagagat tctgtacaga ggaaagggca tttttcactc
     1201 agtcctgaaa atggcttctg gaccatttgg ctttggcaaa aagacaacta tgaggctggt
     1261 accagtcctc agaccaccct ccatattcag gtacctccgt gccaaattgg gatctttgta
     1321 gactatgaag ctggcattgt ctccttctac aacataactg accacggctc cctcatctac
     1381 accttctcag agtgtgcttt tatcggacct ctgcgaccct tctttagtgt cggtttcaat
     1441 gatgatgggg ggaattcagc ccctctaaag ctctgtccac taaagatatg atggtcagta
     1501 acagtgcctg ctgacagcac ctcccaggca cttacctcct ccttgtcctg atctagatcc
     1561 aatgactgac tactgaggac catttctgga tacccctacc cacttcctgt tggtgttctt
     1621 cagtcatgca ctttgtcatt ttgaccagtc tagttggaac ttccataaag cctcatctct
     1681 ttagagtcag ggtcccagaa tgaaggcatc agctggacat aattagaagt ccatgtcaac
     1741 tgaccttcaa catcaatgta ccagacatag attcctcagt gattcctcaa tgaaacagac
     1801 tcctcacatt gcacccaaac tcatctagct cagacaaaat cccatctctg cctcctttgt
     1861 atgactttct ttgttttctc tttccttggt tgttacctct agccagatac ccatctattc
     1921 ccataccttc tgtggcttgc agaaggactt cctaaaaatt gtgccttggt ctatcctatt
     1981 cagttcttgg taaagctcaa aatattagtc tttaacattg tacatctttt ggtttgcttg
     2041 tttgtttgtt attaggggag gtttggggtt tattgttgtt tgtttgtctg ttttccctcc
     2101 ctggaatgct ctatgcacct catctgtaga ctcaggtcaa gaatatcttc cagggtaaca
     2161 aacaaaaacc aggataaagt agtgaaagtg gttcagacaa gagctgaatg taacactgaa
     2221 agtatactca atatccccag tgagagccaa agtctaggtg ccatgctggt ctgattagtg
     2281 agtcccttct gttgattctc acggggtgga acagctgtgc ttggacactg cctactgtca
     2341 gtttgacaat actctgttcc ctgcttccat tgccttgaag aaagtgaaat tagtagctga
     2401 actcgtacac agatattttt gagaactttg aaaatactgt cagaagagtt aggagaaagt
     2461 atggacaaat gtacaataaa gaaaatgcaa gatggtttct atgaggacat catcattgag
     2521 ctaaagatac gttagcaatg ccaattaatg gctcagtagg ctaaatgagg ttcaagtgta
     2581 tctagttcat gaaaaaaaac atttaaaaaa accttaagca ctaatattta cattgacctt
     2641 tcattcttgt gttctgtctt agagttgaca ctataagtaa tagtttgtat cttttgattt
     2701 tcatactggt ggaaggcagc tattaaaatg atacaacttt catttcctca aaatctgaac
     2761 accatactgt accagatttc ctcactacct ggagatgtat gttacacaga tactaaatcc
     2821 cttgttctcc actgaaagga attatgaggt ttcataccat ctcaactttt cacccccata
     2881 gtcaataaca agtggtctgg gtatgagagt cttgtttgtc acataaaagc taccttaaaa
     2941 aagatctcca agtactggtt ccaattctga ttaatattgt ctttgaaggt caaataaagc
     3001 ctattaattt tcctgggctt ctttcattct acctccacct ttcaaatgaa cagacacaga
     3061 gtattaaaga aatgttatct gtactggccc aggccagaca gaatcacagc aaggagaatg
     3121 atgggcacca agtccctccc ttagctaagg agcgttgggc agtcgctaga aggaccatca
     3181 gttttcttca tactggtgga aggaaactat tataatgtta caactttcag ttcctcaaaa
     3241 tctgaacacc atgctgtacc agattacctt actacctgga gatgtatgtt acatagatgc
     3301 taaatcagtg tgggccctag tgggcccact gaaagcccac tagtgtataa aggcagcata
     3361 aacagtgctt ggtgggtgat ttataaaaag gaagaaaaga aagaggagta atgatacaaa
     3421 gtagggtaga gcatgaactt gggacatgtg aggagggcgg taaatatgat caaaatacat
     3481 tgaaattctt aaataatttt aaaatgagat tagaaaggaa gcagtgtcaa aatttcaaag
     3541 acactaaggg aaaaattttt tcaatatacc tgtagtttat tttgcattat atgtaacaaa
     3601 tttcctgttt ataggtcagt catgctgtgg gtaatgatca acatacaatc agagcacaat
     3661 caagaagtat gaatattatg gcaagcctct atatttgatt caaattaaac tgatgttttg
     3721 acaataaaca tttattaagc tgtaatgttc acaatgattt aattcagctc ttagtcagat
     3781 ctacaaagac ttaaaatatc acaaccaatg actaatcaga aggtatctat cactttgcaa
     3841 caataaacct aatttttttc tgaataagat atttatagtt tgcttcccct aagatgcatg
     3901 gacgcgccct catcccactc tgttctcaca aaattgcttt cttttgcatc aaactgtatt
     3961 atgtaaaatt tctaatgcaa atgtattttt ggttaaatgt atgtgcacca ttacattaat
     4021 tcaaattcat tgtggacatt ttcattgtga tgtactaata aaattcattg tgaatgaaa
//
