LOCUS       NM_001108552            6917 bp    mRNA    linear   ROD 07-APR-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 2 (Trim2), mRNA.
ACCESSION   NM_001108552 XM_001065758 XM_001065860 XM_342268
VERSION     NM_001108552.2
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 6917)
  AUTHORS   Xu,K., Li,S., Yang,Q., Zhou,Z., Fu,M., Yang,X., Hao,K., Liu,Y. and
            Ji,H.
  TITLE     MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis of
            retinal ganglion cells via the PI3K/AKT signaling pathway in
            glaucoma
  JOURNAL   J Gene Med 23 (11), e3378 (2021)
   PUBMED   34291866
  REMARK    GeneRIF: MicroRNA-145-5p targeting of TRIM2 mediates the apoptosis
            of retinal ganglion cells via the PI3K/AKT signaling pathway in
            glaucoma.
REFERENCE   2  (bases 1 to 6917)
  AUTHORS   Thompson,S., Pearson,A.N., Ashley,M.D., Jessick,V., Murphy,B.M.,
            Gafken,P., Henshall,D.C., Morris,K.T., Simon,R.P. and Meller,R.
  TITLE     Identification of a novel Bcl-2-interacting mediator of cell death
            (Bim) E3 ligase, tripartite motif-containing protein 2 (TRIM2), and
            its role in rapid ischemic tolerance-induced neuroprotection
  JOURNAL   J Biol Chem 286 (22), 19331-19339 (2011)
   PUBMED   21478148
  REMARK    GeneRIF: a role for TRIM2 in mediating the p42/p44 MAPK-dependent
            ubiquitination of Bim in rapid ischemic tolerance.
REFERENCE   3  (bases 1 to 6917)
  AUTHORS   Tarantino,C., Paolella,G., Cozzuto,L., Minopoli,G., Pastore,L.,
            Parisi,S. and Russo,T.
  TITLE     miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic
            stem cells
  JOURNAL   FASEB J 24 (9), 3255-3263 (2010)
   PUBMED   20439489
REFERENCE   4  (bases 1 to 6917)
  AUTHORS   Balastik,M., Ferraguti,F., Pires-da Silva,A., Lee,T.H.,
            Alvarez-Bolado,G., Lu,K.P. and Gruss,P.
  TITLE     Deficiency in ubiquitin ligase TRIM2 causes accumulation of
            neurofilament light chain and neurodegeneration
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 12016-12021 (2008)
   PUBMED   18687884
REFERENCE   5  (bases 1 to 6917)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000002.1.
            
            [WARNING] On May 14, 2024 this sequence was replaced by
            NM_001108552.3.
            
            On Nov 27, 2020 this sequence version replaced NM_001108552.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26360172.2211236.1,
                                           SRR26360190.1132935.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760393,
                                           SAMN12840105 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               JAXUCZ010000002.1  171862212-171862444 c
            234-415             JAXUCZ010000002.1  171851635-171851816 c
            416-653             JAXUCZ010000002.1  171847937-171848174 c
            654-805             JAXUCZ010000002.1  171833554-171833705 c
            806-986             JAXUCZ010000002.1  171832391-171832571 c
            987-1710            JAXUCZ010000002.1  171830827-171831550 c
            1711-1814           JAXUCZ010000002.1  171818300-171818403 c
            1815-1982           JAXUCZ010000002.1  171817843-171818010 c
            1983-2151           JAXUCZ010000002.1  171812386-171812554 c
            2152-2222           JAXUCZ010000002.1  171811149-171811219 c
            2223-2363           JAXUCZ010000002.1  171805770-171805910 c
            2364-6917           JAXUCZ010000002.1  171798660-171803213 c
FEATURES             Location/Qualifiers
     source          1..6917
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="2"
                     /map="2q34"
     gene            1..6917
                     /gene="Trim2"
                     /note="tripartite motif-containing 2"
                     /db_xref="GeneID:361970"
                     /db_xref="RGD:1310981"
     exon            1..233
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     CDS             231..2516
                     /gene="Trim2"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 2; E3 ubiquitin-protein
                     ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2"
                     /codon_start=1
                     /product="tripartite motif-containing protein 2"
                     /protein_id="NP_001102022.1"
                     /db_xref="GeneID:361970"
                     /db_xref="RGD:1310981"
                     /translation="MQRAGSRTAGPTCQWSRMASEGASIPSPVVRQIDKQFLICSICL
                     ERYKNPKVLPCLHTFCERCLQNYIPAHSLTLSCPVCRQTSILPEKGVAALQNNFFITN
                     LMDVLQRTPGSNGEDPSILQTVTAVAAGKPLSCPNHDGNVMEFYCQSCETAMCRECTE
                     GEHAEHPTVPLKDVVEQHKASLQVQLDAVNKRLPEIDSALQFISEIIHQLTNQKASIV
                     DDIHSTFDELQKTLNVRKSVLLMELEVNYGLKHKVLQSQLDTLLQGQESIKSCSNFTA
                     QALNHGTETEVLLVKKQMSEKLNELADQDFPLHPRENDQLDFIVETEGLKKSIHNLGT
                     ILTTNAVASETVATGEGLRQTIIGQPMSVTITTKDKDGELCKTGNAYLTAELSTPDGS
                     VADGEILDNKNGTYEFLYTVQKEGDFTLSLRLYDQHIRGSPFKLKVIRSADVSPTTEG
                     VKRRVKSPGSGHVKQKAVKRPASMYSTGKRKENPIEDDLIFRVGTKGRNKGEFTNLQG
                     VAASTSGKILIADSNNQCVQIFSNDGQFKSRFGIRGRSPGQLQRPTGVAVHPSGDIII
                     ADYDNKWVSIFSNDGKFKTKIGSGKLMGPKGVSVDRNGHIIVVDNKACCVFIFQPNGK
                     IVTRFGSRGNGDRQFAGPHFAAVNSSNEIIITDFHNHSVKVFNQEGEFMLKFGSNGEG
                     NGQFNAPTGVAVDSNGNIIVADWGNSRIQVFDGSGSFLSYINTSADPLYGPQGLALTS
                     DGHVVVADSGNHCFKVYRYLQ"
     exon            234..415
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            416..653
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            654..805
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..986
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1710
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1711..1814
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..1982
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            1983..2151
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2222
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2223..2363
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..6917
                     /gene="Trim2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcagtctttt caacagacgc tgagaaaaag atgtcctgta agataaagat tgattggtct
       61 gaatacggaa gggggtctcc tacttgttaa tgacccagaa acattcctgc cgactttcct
      121 gagccttctc tcatttcctc catttttctc ttcctctgtc ctggtcatga gccggcacat
      181 cactacttag agcagaagat atgctgggct tctgatgatg gctgcattgc atgcagcgtg
      241 cagggtcgag gacagccggc cccacatgtc agtggtctag gatggccagt gagggcgcca
      301 gcatcccgag tcctgtggta cgccagattg acaagcagtt tctgatctgc agtatatgcc
      361 tggaacggta caagaacccc aaggtcctgc cctgtctgca cactttctgc gagaggtgcc
      421 tgcagaacta cattccagcc cacagtttaa ccctctcctg cccagtgtgt cgtcagacct
      481 ccatcctgcc tgagaaaggg gtggctgcac tccagaacaa cttttttatc acaaacctca
      541 tggatgtgct gcagcgaacg ccaggcagca acggcgagga cccttccatc ctgcagacgg
      601 tcaccgctgt ggctgcagga aagcctctat catgcccgaa ccacgatgga aatgtgatgg
      661 aattttactg ccagtcctgt gagaccgcca tgtgtcggga gtgcacggag ggggagcacg
      721 cagagcaccc cacagtcccg ctgaaggacg tggtggagca gcataaggcc tcactccagg
      781 tccagctgga tgcagtcaac aaaagactcc cagaaataga ttctgctctt cagttcatct
      841 cagaaatcat ccatcagtta accaaccaaa aggccagcat tgtggacgac atccactcca
      901 cctttgatga actgcagaag actttaaatg ttcgcaagag cgtgctgctc atggagcttg
      961 aggtcaacta tggcctcaaa cacaaagtgc tgcagtcgca gctggatacc ctgctccaag
     1021 gccaggaaag cattaagagc tgcagcaact tcacagcgca agccctcaac catggcacgg
     1081 agacggaggt gctgctggtg aagaagcaga tgagcgagaa gctcaacgaa ctggcggacc
     1141 aagacttccc actgcacccg cgcgagaacg atcagctgga ttttatcgtg gaaactgagg
     1201 gattgaaaaa gtctatccac aacctgggga ccatcctcac cactaacgcg gtcgcctctg
     1261 agacggtggc cacgggcgag gggcttcggc agaccatcat cgggcagccc atgtccgtta
     1321 ctataaccac caaggacaaa gacggagagc tgtgcaagac aggcaacgca tacctcaccg
     1381 ctgagctcag cacccccgac ggcagcgtgg cggacggaga gatcctggac aacaagaacg
     1441 gcacctacga gttcctgtat actgtgcaga aggaggggga cttcaccctg tctctcaggc
     1501 tctacgacca acacatccga ggcagtccgt ttaagctcaa ggtcatccgc tcggcggacg
     1561 tgtcccccac caccgagggc gtgaagcgac gagtcaagtc cccagggagc gggcacgtca
     1621 agcagaaggc tgtaaagaga ccggccagca tgtacagcac cggcaagcga aaagagaacc
     1681 ccatcgagga cgacttgatc ttccgagtgg gtaccaaagg aagaaacaaa ggagaattta
     1741 caaacctgca gggtgtggct gcatctacga gtggaaagat attaattgca gatagtaaca
     1801 accagtgtgt gcagatcttt tccaatgacg gacagttcaa aagtcgtttc ggcatccgag
     1861 gtcgatcccc aggacagctc cagcgtccca caggggtagc ggtgcacccc agtggggaca
     1921 tcatcatcgc agattatgac aacaagtggg tcagcatttt ctccaatgat gggaagttta
     1981 agacaaaaat tggatcagga aaactgatgg ggcccaaagg agtttctgtg gaccgcaatg
     2041 ggcacattat tgtggtggac aacaaggcat gctgcgtgtt catctttcag cccaacggga
     2101 aaatagtcac caggtttggt agccgaggaa acggcgacag gcagtttgca ggtccccatt
     2161 ttgcagctgt gaatagcagt aatgagatca tcattacaga tttccataat cattctgtca
     2221 aggtatttaa tcaggaagga gaattcatgt tgaagttcgg ctcaaatgga gaaggaaatg
     2281 ggcagtttaa tgcaccaaca ggtgtagccg tggactcgaa tggaaacatc attgtggctg
     2341 actgggggaa cagcaggatc caggtttttg atgggagtgg atcatttttg tcctatatca
     2401 acacatctgc tgacccgctg tatggccccc aaggcctggc tctaacttcg gatggccacg
     2461 tcgtggttgc agactccgga aaccactgct tcaaggtcta tcggtactta cagtaaccgt
     2521 ggacagctct gtgccgaggt cttgcactag aaactggaat ggagttctca atgtgggacc
     2581 agattccgat aggactttcc gtactaggaa gagtctttgg tgaactttcc aaggttattt
     2641 ctgaatgtaa tcatttcctt aaaaactgct tatccaattt ccgtaattca cttttaggat
     2701 ttaaaaaaga atcttcttct actgaatctg tacaaactgc gaagttttac acccgtgaac
     2761 tatggctcat aggacaggga tttctgtagt taaactaatt ttgcaaatca gacgttaaaa
     2821 agaattagtg tatctgttga ctggtgaatg aatgatagcc tttgcataga acttccaaga
     2881 acaaaacttg tagttgccta ttttatttaa cttcgatcac aagacccaag ggaccgtcta
     2941 acctcacttt tacagtaggt gtcattattc tggtgacatg tttttgctta tcaacaacca
     3001 catataaatt accttagaaa aatccaaggc tgtcttgcaa gatcctccca gctctgactc
     3061 agggccctct tgagttgagc ccatcagaat caatgcaaat ctcccaaatt ttctgggttt
     3121 gatcaaaggt cttttccgtg tgttcttttc accttctcat ttctgctcac cttgcatcag
     3181 aaaatgaaac acgttgtcgg ggaaaacctg aaattcccga tgctttggaa ggcacgtggc
     3241 aaacaaaagc aaggggaccc ctttggttgc tagcttcaga tcaacacact ggaaaggaac
     3301 cgagagaagc cacatccatg tgccatgtgt tcatatgtct ttcctcttcc acatcatgaa
     3361 gcaaaagctt tacctcctgc aaaacgtcag cacatgtagg cggactccag tgtcctggga
     3421 cagagagccc taaacagccc ttaggaggac ggacggtgtc aaccaaaggc gtgtgattga
     3481 gtcagatttc cccttagaga gcaagtgtta ccaaagttct gtttgagcat tacaggtaag
     3541 ggcatgttgc ggttatttat cattgtctaa tgactagtag aggcattaaa ggggcaagta
     3601 tacatggtta gggtaagata gaatgtatta tacatatata taaatatata gccgagtcct
     3661 gggcgtgtgg gaataggcag cactctgaaa gacagaagca ttgtccagcc attcttcagc
     3721 acattccctg gctgctgcgg tctgaagccg tccttgtgga gtgaacccta cagcaggttt
     3781 cggggttgac attttctgac gtgatggtga tgtctggctt ccagtcaaat gaccttcttt
     3841 gtgttcaaga aaaaaagaaa gaaaaagaaa gaaagaaatc tttaaacatt gagcttgagt
     3901 tacccttcat ttaggtgtaa atgcattttg agagctttta cctgtcatac tgtaagcaaa
     3961 gatgtgttct ctttccactg attttctact cagttctacc aaataggaaa gttgcatgtg
     4021 gcgtgtgcga tgatgacttt gggatgtcat tcactgaaag caccttagat atgtaaaaac
     4081 atttccctta gatacaagtg atgtttatgg cttatcttaa aatccaaatg ttcttgatat
     4141 gaaagtttta aaaaatttag aagggaaatc tggctacttc caatggtcta tttaattcat
     4201 tatgcccaaa tctgagtgga aaaactttta ttttcagatt tacattggcg ttttagcttg
     4261 ttatcatttt agttctgtgg ggttttaaaa tatacaagcc tgtctgtact agacataaaa
     4321 ttcaacacca gttttagaat gataaagtga gactacttct gaattccaca aaatgagtct
     4381 ttgactttat attttgggtt ttaatttttc tttcttggtg ctggggatgg tactcatgga
     4441 ctcagacatt cagcaagagc ccggcagttg ggcagtgcct acagcctaag ccttcggtat
     4501 gaacttcagt gttcctatcc actgccttcc taccaggggc caggaatgca tctatgcact
     4561 gggagcagag ggatgcataa aagagagagg catggctgtc ctgtgatagc ttatactctg
     4621 gaaaggagat ttccttgtgc tgtgtattaa tagtctgcct gcagcatttt ttccgcttct
     4681 gggctattta aaagaaagct ttttagaaaa cgagtacatt aattttagtt aattttcaca
     4741 agcagaaaac attttttaag aggctgccat aggctgtttt tgttcgcttg cttgtttgtt
     4801 tctgtggtgc tggtgatgga atccagggcc tcgggcatgc tctgcagctg agctgtacct
     4861 ccaggttgca actcttactt tgaaaatgaa tttaccaaac aggttttttt gtttgtttgt
     4921 ttgttttttg cacaatgttg agatatgtgt gaactgagaa attaacccat acacaagtcg
     4981 gctgcgtatg taaaatcccc catctggctt gatagctcaa taagaaataa tacaaattag
     5041 gtttgttttt tttttcttaa cacacaaata ctggtatgaa ctggaatgag agaataattt
     5101 gatttagacc tgttccacca tcagctacta aagcgcctgc tgtgggcact gcaggaagca
     5161 ctacattcta cacttgggta cgtgtgtgca ttcactgtat ttctttgtgg taagcatatt
     5221 tgggggagag gggagtgctg ctactaagat acacatagac aagatctaaa tgaagtcttg
     5281 tctcatttgg taggaatggt ttctagtaaa ctaagaagga ttattaaaat aagtggcttt
     5341 tttttgttct aggtactgtt actgtctaat tgatctttgt cgagtgtata gaacccgtca
     5401 cacattcatg atgcatagca ctgagaaagt aagcgttcaa atttcccttg ggcacgaagg
     5461 acaaacagtt aggttttata ggttaatggt agtgaatctt ctcccgtcag aaacctcccc
     5521 tgctggacac gggatggtag ggagtcactt gactatccag aaacacacaa ttagaaagtc
     5581 gttatgactg tttgctggtt tttaaatgat gtgtaaggtt ttgatgaaac tttagtctct
     5641 gtaaccaaat aagcccctga gtttcctaaa cttgacaaaa tttgaggcaa taagtagccc
     5701 tggtccacgt ggctgttgtg cgactgctcc cactacatgt acagggtata tatgtcctca
     5761 cagggaatga actggaatag tggtacgtaa ccgggtatgt ggagcctcac tctgaagggt
     5821 tggcataaat gttgtggtaa ttcctacaga ggaaactgga gagaacaggt cgacaccagg
     5881 tcatctgtag atcatgacaa acggggaatg tctctctatg catttggact tagctccccc
     5941 tctcggctca ccagcctctg aacagggagg aggaatttct ttttttggtg aatgctttta
     6001 aaacaagacc tttccgagta ggacagcatt gaagctgccc gatgcaaacc ttagctactt
     6061 tcccttccaa tcaaaagtcc taataccgtt actttatgta aatgttgcag ggttttaaaa
     6121 atttacaatt attttaatat ttttgataac taggagtcta gtattgccat aaaggaaact
     6181 aagtgcccat taaaaatttg tttggtataa ataaatgctt tctgggtttt gtttcaaatg
     6241 acagtaagct acaaatcacg acgctaatct tcagaaacac tttctaatga accgtgtggt
     6301 agttgattgt gtggcctgtt tgtggagagt gtatgggtgc gattcattaa tactctagaa
     6361 gagactaata atcagctatc ttgttccaat gaatgtacgg cacttccatt acttttcaaa
     6421 agcaacacag ccttaacctc aatgcttttg ctttacaaca tggggcgttt ggctatcaac
     6481 gaagcgtccc ctgctaacgt tctttcttat cattcctgac tgcggccttc tgaggctgcc
     6541 tatgagaatg agggttgtct gtttcctttt cgtttctttg aagattttgt acattccacc
     6601 ttgacacatc tgtctcacac attttgtgta cagaccgctg gtcttgcgtt ttctgccatc
     6661 ggtaatgata cagcctcctc atgtgttctt ttatgaattg aaatgctgac tgcctattta
     6721 aatagaacgg acgctgtgca tcaacgtgtt tgtatgttcg tagctacata cgtaccacag
     6781 tattttggat gctttagtct ataataaaac tttaaattaa ttctgtcttg aaacacggga
     6841 gaaacaagat tcatgtgtgt atatcgttac catgcacaaa aatctcaaat cattataata
     6901 ataaagcttg ttctctc
//
