LOCUS       NM_001135033            3816 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus tripartite motif-containing 16 (Trim16), mRNA.
ACCESSION   NM_001135033 XM_001078237 XM_220552
VERSION     NM_001135033.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3816)
  AUTHORS   Cui Q and Yan L.
  TITLE     Tripartite motif-containing protein 16 protects against myocardial
            ischemia/reperfusion injury by affecting the Keap1/Nrf2 axis
  JOURNAL   Cell Tissue Res 386 (2), 349-363 (2021)
   PUBMED   34436665
  REMARK    GeneRIF: Tripartite motif-containing protein 16 protects against
            myocardial ischemia/reperfusion injury by affecting the Keap1/Nrf2
            axis.
REFERENCE   2  (bases 1 to 3816)
  AUTHORS   Zheng Q, Shen H, Tong Z, Cheng L, Xu Y, Feng Z, Liao S, Hu X, Pan
            Z, Mao Z and Wang Y.
  TITLE     A thermosensitive, reactive oxygen species-responsive,
            MR409-encapsulated hydrogel ameliorates disc degeneration in rats
            by inhibiting the secretory autophagy pathway
  JOURNAL   Theranostics 11 (1), 147-163 (2021)
   PUBMED   33391467
  REMARK    GeneRIF: A thermosensitive, reactive oxygen species-responsive,
            MR409-encapsulated hydrogel ameliorates disc degeneration in rats
            by inhibiting the secretory autophagy pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3816)
  AUTHORS   Raif A, Marshall GM, Bell JL, Koach J, Tan O, D'andreti C, Thomas
            W, Sekyere E, Norris M, Haber M, Kavallaris M and Cheung BB.
  TITLE     The estrogen-responsive B box protein (EBBP) restores retinoid
            sensitivity in retinoid-resistant cancer cells via effects on
            histone acetylation
  JOURNAL   Cancer Lett 277 (1), 82-90 (2009)
   PUBMED   19147277
REFERENCE   4  (bases 1 to 3816)
  AUTHORS   Munding C, Keller M, Niklaus G, Papin S, Tschopp J, Werner S and
            Beer HD.
  TITLE     The estrogen-responsive B box protein: a novel enhancer of
            interleukin-1beta secretion
  JOURNAL   Cell Death Differ 13 (11), 1938-1949 (2006)
   PUBMED   16575408
REFERENCE   5  (bases 1 to 3816)
  AUTHORS   Cheung BB, Bell J, Raif A, Bohlken A, Yan J, Roediger B, Poljak A,
            Smith S, Lee M, Thomas WD, Kavallaris M, Norris M, Haber M, Liu HL,
            Zajchowski D and Marshall GM.
  TITLE     The estrogen-responsive B box protein is a novel regulator of the
            retinoid signal
  JOURNAL   J Biol Chem 281 (26), 18246-18256 (2006)
   PUBMED   16636064
REFERENCE   6  (bases 1 to 3816)
  AUTHORS   Gwinn MR, Whipkey DL, Tennant LB and Weston A.
  TITLE     Differential gene expression in normal human mammary epithelial
            cells treated with malathion monitored by DNA microarrays
  JOURNAL   Environ Health Perspect 113 (8), 1046-1051 (2005)
   PUBMED   16079077
REFERENCE   7  (bases 1 to 3816)
  AUTHORS   Beer HD, Munding C, Dubois N, Mamie C, Hohl D and Werner S.
  TITLE     The estrogen-responsive B box protein: a novel regulator of
            keratinocyte differentiation
  JOURNAL   J Biol Chem 277 (23), 20740-20749 (2002)
   PUBMED   11919186
REFERENCE   8  (bases 1 to 3816)
  AUTHORS   Liu HL, Golder-Novoselsky E, Seto MH, Webster L, McClary J and
            Zajchowski DA.
  TITLE     The novel estrogen-responsive B-box protein (EBBP) gene is
            tamoxifen-regulated in cells expressing an estrogen receptor
            DNA-binding domain mutant
  JOURNAL   Mol Endocrinol 12 (11), 1733-1748 (1998)
   PUBMED   9817599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000220.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001135033.4.
            
            On Feb 10, 2021 this sequence version replaced NM_001135033.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. There are no full-length rat transcripts
            supporting this RefSeq. The exon combination used for the
            transcript record was based on alignment to full-length mouse mRNA
            AK053139.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA5760383,
                              SAMEA5760384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-536               JACYVU010000220.1  4311179-4311714
            537-632             JACYVU010000220.1  4320143-4320238
            633-866             JACYVU010000220.1  4324802-4325035
            867-1032            JACYVU010000220.1  4327499-4327664
            1033-1128           JACYVU010000220.1  4328045-4328140
            1129-3816           JACYVU010000220.1  4331180-4333867
FEATURES             Location/Qualifiers
     source          1..3816
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="10"
                     /map="10q23"
     gene            1..3816
                     /gene="Trim16"
                     /note="tripartite motif-containing 16"
                     /db_xref="GeneID:303214"
                     /db_xref="RGD:1309749"
     exon            1..536
                     /gene="Trim16"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1712
                     /gene="Trim16"
                     /EC_number="2.3.2.27"
                     /note="tripartite motif protein 16"
                     /codon_start=1
                     /product="tripartite motif-containing protein 16"
                     /protein_id="NP_001128505.1"
                     /db_xref="GeneID:303214"
                     /db_xref="RGD:1309749"
                     /translation="MAELDLIAPGPLTGVTVHPLAPLGPDPGSAIPIGKEDVDLLSKP
                     GEETQGQGDLAKLGAPGDEEEGQILCDFCLGASRVRAVKSCLTCMVNYCEEHLRPHQE
                     NSKLHSHQLTEPTKDQDLRTCPAHHSPLVSFCHTHQQCICQECGTGEHRGDSTVSLDA
                     ARRSKEADLRCMQLDLEQKLKLNENAIARLQANHKSVLVSVSEVKVVAEEKFGELLAA
                     VRKAQTDVMLFLEEKEQAALNQVNGIKTHLEHRSIEMEKNKQELEKLASISNTVLFLE
                     EYCKLKKTEDTAFPSVYIGLKDKLSGIRKVITESTLNLIQLLESYKEKLQEFSREEEY
                     DIRTQVSAIVQRKYRTSKPEPRTRDEFLQYACDITFDPDTAHRYLRLQEDNRKVTNTT
                     PWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEISGGGIYVGLTCKGIDRKGEERN
                     SCISGNSFSWSIHWSGKEFTAWHSDTETPLKASPFRRLGIYVNFPGGTLSFYGVEYDA
                     MTLIQKFDCKFSEPLYAAFWLSKKENTIRIVDLGEEPEKPAVPSVEAAP"
     exon            537..632
                     /gene="Trim16"
                     /inference="alignment:Splign:2.1.0"
     exon            633..866
                     /gene="Trim16"
                     /inference="alignment:Splign:2.1.0"
     exon            867..1032
                     /gene="Trim16"
                     /inference="alignment:Splign:2.1.0"
     exon            1033..1128
                     /gene="Trim16"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..3816
                     /gene="Trim16"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggaccgagga aggacgcctg agtccgcaaa gcttccagat ggctgaattg gatctaattg
       61 ccccagggcc tctgaccggg gtcactgttc accctttggc tcctctcggc ccagaccctg
      121 ggtcagctat tccaatagga aaagaagatg tggaccttct cagcaagcca ggcgaggaaa
      181 cccaggggca gggtgacctc gcaaagctcg gggctcctgg tgatgaagag gagggacaga
      241 tcctgtgtga cttctgtctt ggggccagca gagtaagggc tgtaaagtcc tgtttgacct
      301 gcatggtgaa ttactgtgag gagcacctgc ggccacacca ggagaacagc aaactgcaca
      361 gccaccagct aaccgagccc acaaaagacc aggatctgcg cacctgccct gcccaccaca
      421 gccctttggt ttccttctgc cacacgcacc agcagtgtat ctgccaggaa tgcggcacgg
      481 gtgaacacag aggcgacagc actgtctccc tggatgcagc ccgcaggagc aaagaggctg
      541 accttcggtg catgcagctg gacctggagc agaagctcaa gttgaacgaa aatgccattg
      601 cccggctcca agccaaccac aagtctgttt tggtgtccgt gtcagaggtg aaggtggtgg
      661 ctgaagagaa gtttggggaa ctcctcgcag ccgtgaggaa ggcccagact gatgtgatgc
      721 tcttcttaga ggagaaagaa caggctgcac tgaatcaggt caacggcatc aagacccacc
      781 tggagcacag gagcatcgag atggagaaaa acaagcagga gctggagaag ttggcctcca
      841 tcagcaacac tgtgctcttc ctggaggagt actgcaagct taagaagaca gaggacactg
      901 ccttccccag cgtttacatc gggctgaagg ataaactctc aggcatccgc aaggtcatca
      961 cagagtcaac tctgaacttg atccagttgc tagaaagcta taaggaaaag cttcaggaat
     1021 tttccaggga agaagaatat gacatcagaa ctcaagtgtc tgccattgtc cagcgcaagt
     1081 acaggacctc gaaacccgag cccagaaccc gggatgagtt tcttcaatat gcctgtgaca
     1141 tcacatttga cccagacaca gcacacaggt accttcgcct gcaggaggat aaccgcaagg
     1201 tcaccaacac cacaccctgg gaacaccctt acccagacct ccccagtagg tttctgcact
     1261 ggcggcaggt gctgtcccag cagagtctgt acctgcacag gtattatttt gaggtggaga
     1321 tctctggagg aggcatctat gttggcctga cctgcaaagg catcgaccgt aagggggaag
     1381 aacgaaacag ctgcatttct ggaaacagct tctcctggag cattcactgg agtgggaagg
     1441 agttcacggc ctggcacagt gacacagaga ctccgctcaa ggccagcccc ttcaggaggc
     1501 ttggcatcta tgtaaatttc ccaggaggaa ccctttcctt ctatggtgta gaatatgatg
     1561 ccatgactct gattcagaag tttgactgca agttctcaga gccactctat gctgctttct
     1621 ggctgtctaa gaaagaaaac accatccgga ttgtggatct gggagaggag cctgagaagc
     1681 cagctgtacc ctcagtggag gctgctccct agattctagg atcccagact gctaactgtg
     1741 acaactgggc agcagctggt attttaaagt ggacagagat atctgctgat ggtagttggc
     1801 tttagaagtt gtgtaggggt ccagtgggtg gctggttctt tccttttgtc cggcggccgg
     1861 ctaggagcag catcggagag ctgggagccg cggacaccga ccgcgatcct gggaaaggcc
     1921 atggatagat cagacagtga ggctccctgt agagctgtgg ttatgtcagt ctgccttgtg
     1981 cttgcctcta gggcgtccag ctttgtccag taggcagcag tgtctgctca aggccgggtg
     2041 taaataaaaa ctatcaaaat caaaaaaaaa aaaaaaaaaa aaaaaaaaag aagttgtgta
     2101 gatcctgaat gaactttccc acttgcagaa actctaaggc accaaaagcc tctccccaaa
     2161 tctagtgatg gtctcctgtc tgctcaggca attgtcaccc ttcctccaga ctagggatct
     2221 tcaaaccata accagactgt gagggatcat agtaaatcac aaagacgtcg ctgcacgttt
     2281 cttatgtgct ggccagcgtt ctgaaacctt cctccgtgtt agttcagatc atcttcctga
     2341 gataaatgtt tatattgaac ttgtgatgac gttatgctta cctcattaga tcatgaatgc
     2401 tgtgcgtaag gggtaaacca catgctaaac cacatagcca acagtgtttt cagcatccct
     2461 cttaagagtt tgtgtttttc tgcaggtgcc aggctcaact tggtcatcca gccttgcccc
     2521 atctgagcaa ggcctcaccc ctcacacatc atcagagtca gcggcactga atggttttga
     2581 acagtgagat ttagaataga tgtttttagc aaggtctttt gagaggcata gtcatcctct
     2641 gttctaaggc tatccagtct tcgtggactt gtctattttc ttgtgcaaat ggatagttcc
     2701 ccaggcattt agagacagta ttctcctctc ccaggagctg tactcatgta tttgtgctat
     2761 gttgatactt cctaccctga tcctacttcc cccgacaccc tgttgatgat gtcattctcc
     2821 cttagacagg tgatggacat ccatcaagcc tttatgcaca ccatcttaaa ataggtttcc
     2881 gttgccctaa cttgaagtcc ctagtgggct ttaccagcaa tattacttcc gtgtcctttc
     2941 ccatgctcca tgtcagggca aatcttcctg ttcaaccagt cttgtgatcc taggtttctt
     3001 tacacttctc tgacttgagt ctgagactct gtgcctttgt ctctaaggac gtaaatactt
     3061 ttcactaact tcctcctgcc cctgctgtgc actgagatgt tttcatgatc tagtgcatta
     3121 actctctttc cagcagaaat agattccctg cagagtcaac ggccttctgt catgtctgaa
     3181 ccatcaaggt tcagacttca ttgggttatt caggttatga gagggccaaa ggtttggcac
     3241 actctagcct ctcaggagaa gtgcagtgac aaggctcact gcgtctttct cactgaatat
     3301 catcaaagag cttttcttac ctttttttct cttttctttt tacttgggat agggcctcac
     3361 ctcgtagcct aagctggtct gggatacact atatattctc agactcagtt gtctcttctt
     3421 agcttccaaa tgctcgggtt ataagcatga gttaccagtg cgatgcttgg ctcagcaagg
     3481 gcccttttca gtgacagaaa tcaatgtctg aatttcttgg atctagcaat taaagaatac
     3541 tcttcaaaag acaaaataat ttcttcttgg cctgccctgt ctcctttttt tttctttttc
     3601 tattttaaaa cattttttta tgttgaattt tatttttaat tgacacacag tcactgtgta
     3661 tacttgtgga attcagtgtg gcttttcaat gcatgtatgc agtaataacc aagtaagagc
     3721 atatacttat tcctatacca aaaaatattt atttgttgtg agaccacttc aattcttgtc
     3781 ttccaattgt tttgaaataa acttttttta aaaaaa
//
