LOCUS       NM_001399174            3095 bp    mRNA    linear   ROD 04-DEC-2023
DEFINITION  Rattus norvegicus tripartite motif-containing 14 (Trim14),
            transcript variant 1, mRNA.
ACCESSION   NM_001399174 XM_006238060
VERSION     NM_001399174.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3095)
  AUTHORS   Lv R, Du L and Bai L.
  TITLE     RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111191 (2023)
   PUBMED   37951197
  REMARK    GeneRIF: RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14.
REFERENCE   2  (bases 1 to 3095)
  AUTHORS   Hou H, Chen Y, Feng X, Xu G and Yan M.
  TITLE     Tripartite motif-containing 14 may aggravate cardiac hypertrophy
            via the AKT signalling pathway in neonatal rat cardiomyocytes and
            transgenic mice
  JOURNAL   Mol Med Rep 28 (3) (2023)
   PUBMED   37503784
  REMARK    GeneRIF: Tripartite motif-containing 14 may aggravate cardiac
            hypertrophy via the AKT signalling pathway in neonatal rat
            cardiomyocytes and transgenic mice.
REFERENCE   3  (bases 1 to 3095)
  AUTHORS   Xie X, Wang F and Li X.
  TITLE     Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury
            through regulating NF-kappaB/NLRP3 pathway-mediated inflammation
            and apoptosis
  JOURNAL   J Recept Signal Transduct Res 42 (2), 197-205 (2022)
   PUBMED   33691569
  REMARK    GeneRIF: Inhibition of TRIM14 protects cerebral
            ischemia/reperfusion injury through regulating NF-kappaB/NLRP3
            pathway-mediated inflammation and apoptosis.
REFERENCE   4  (bases 1 to 3095)
  AUTHORS   Uchil PD, Hinz A, Siegel S, Coenen-Stass A, Pertel T, Luban J and
            Mothes W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   5  (bases 1 to 3095)
  AUTHORS   Uchil PD, Quinlan BD, Chan WT, Luna JM and Mothes W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   6  (bases 1 to 3095)
  AUTHORS   Lau NC, Seto AG, Kim J, Kuramochi-Miyagawa S, Nakano T, Bartel DP
            and Kingston RE.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   7  (bases 1 to 3095)
  AUTHORS   Girard A, Sachidanandam R, Hannon GJ and Carmell MA.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   8  (bases 1 to 3095)
  AUTHORS   Reymond A, Meroni G, Fantozzi A, Merla G, Cairo S, Luzi L,
            Riganelli D, Zanaria E, Messali S, Cainarca S, Guffanti A, Minucci
            S, Pelicci PG and Ballabio A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000161.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by
            NM_001399174.2.
            
            On Jan 4, 2022 this sequence version replaced XM_006238060.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166777.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMEA5760400
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-228               JACYVU010000161.1  36248752-36248979   c
            229-324             JACYVU010000161.1  36246362-36246457   c
            325-558             JACYVU010000161.1  36236318-36236551   c
            559-721             JACYVU010000161.1  36234662-36234824   c
            722-814             JACYVU010000161.1  36229717-36229809   c
            815-3095            JACYVU010000161.1  36224697-36226977   c
FEATURES             Location/Qualifiers
     source          1..3095
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     gene            1..3095
                     /gene="Trim14"
                     /note="tripartite motif-containing 14"
                     /db_xref="GeneID:313236"
                     /db_xref="RGD:1311514"
     exon            1..228
                     /gene="Trim14"
                     /inference="alignment:Splign:2.1.0"
     CDS             28..1350
                     /gene="Trim14"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tripartite motif protein 14; tripartite motif-containing
                     protein 14"
                     /codon_start=1
                     /product="tripartite motif-containing protein 14 isoform
                     1"
                     /protein_id="NP_001386103.1"
                     /db_xref="GeneID:313236"
                     /db_xref="RGD:1311514"
                     /translation="MASGTAEVRAPVQSDWTGGWRCPEHSERPAELFCRRCSRCVCAL
                     CPVLGAHRGHPVGLAEEEAARAQKLMQECLECLATKKRQHADNIAQLEDTGERLKVSA
                     DSSKAWLTQKFTELRLLLDEEEALAKSFIDKNTQLTLQVYQEQAESCRKQIEVMSDFS
                     IRVWDISQVSNPVQLLQAYIATKAEMGQQMSPSELSHPVPLSFEPVKNFFKEFVEAIR
                     NTLQTPMDTRLKENINCQLSSSSSTKPGALLKTSPSPERALFLKYARTPTLDPDTMHA
                     RLRLSTDGLTVRCSLLGRLGPRPAPRFDSLRQVLGRDGFAAGRHYWEVDVQEAGVGWW
                     VGAAYPSLRRRGTSTAARLGCNRESWCVKRYDMEYWAFHDCQRSRLRLRRDPHRLGVF
                     LDYEAGILTFYDVAGGMSHLHTFYAVFQEPLYPALRLWEGTISIPRLP"
     exon            229..324
                     /gene="Trim14"
                     /inference="alignment:Splign:2.1.0"
     exon            325..558
                     /gene="Trim14"
                     /inference="alignment:Splign:2.1.0"
     exon            559..721
                     /gene="Trim14"
                     /inference="alignment:Splign:2.1.0"
     exon            722..814
                     /gene="Trim14"
                     /inference="alignment:Splign:2.1.0"
     exon            815..3095
                     /gene="Trim14"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acagaggaca gcggatgcta atgaaaaatg gcgagcggga ctgccgaggt gcgggcgccc
       61 gttcagtctg actggacggg tggctggcgc tgtccggagc acagcgaacg cccggctgag
      121 ctcttctgtc gtcgctgcag ccgttgtgtg tgtgcgctct gcccggttct gggagcgcac
      181 cgcggccacc cggtgggcct ggccgaggag gaggctgcgc gcgcgcagaa actaatgcag
      241 gagtgtttgg agtgtttggc caccaagaag aggcaacatg ctgacaacat agcccaactg
      301 gaagacacgg gggaaaggct caaggtttct gcagactcaa gtaaagcctg gctaacacag
      361 aaattcacag aactcagatt actccttgat gaagaggaag cactggccaa aagcttcatc
      421 gataaaaaca cacagctcac cctccaggtg taccaggagc aagccgagtc ttgcaggaag
      481 caaattgagg tcatgagtga cttctctatc agggtgtggg acatcagcca ggtgtccaac
      541 cctgttcagc tgctgcaggc atatatagcc accaaggcag agatgggaca gcagatgagc
      601 ccctcggagc tgagccaccc tgtgcccctg tctttcgagc ctgtcaagaa cttctttaag
      661 gagtttgtgg aagccatcag gaacacgtta cagacaccaa tggacactcg cctgaaggaa
      721 aacataaact gccaactttc aagctcctcc agcaccaagc caggcgcctt gttgaaaacc
      781 agcccctcgc cagagagagc cctcttcttg aaatacgcgc gcacgccaac gctggacccg
      841 gacacgatgc acgcgcgcct gcgcctgtcg accgacgggc tgactgtacg ctgctcgctg
      901 ctgggccgcc tggggccgcg tcccgctccg cgattcgact cgctgcgtca ggtgctgggc
      961 cgcgacggct tcgcagcggg acgccactac tgggaggtgg acgtgcagga ggcaggcgtg
     1021 ggctggtggg tgggcgcggc ctacccgtcg ctgcggcgcc gcggaacctc cacggctgcc
     1081 cgcctaggct gcaaccgcga gtcgtggtgc gtgaagcgtt acgacatgga gtactgggcc
     1141 ttccacgact gccagcgaag ccgtctgcgg ctccgccgcg accctcaccg gctcggcgtc
     1201 ttcctggact acgaggccgg cattctgacc ttctacgacg tggcgggtgg catgagccac
     1261 ttgcatacct tctatgctgt cttccaggag ccgctctacc cagccctgcg cctctgggag
     1321 gggactatca gcattccccg gttaccctaa gagagaatgt gcttcctttc ctaggctagt
     1381 ctcctgctgt cccctgtgcc ctccccctct tcccccacga tgtttttata atgcaagttc
     1441 ctgaaaggga caccctgctg cctgtatcta ggacactatc gtgcagcgcc tagaacctcc
     1501 tgacacacag taggcacgca gtatcagtga atacttacag tgccttgcag gaggcaagta
     1561 gttcctgaac tgtttccatt tgagccagct gctctccagc cacttgagct tgtccaggtc
     1621 acctccatcc agagcacctg acagggttct ggtctgggtc tgcatcctca cccctcttca
     1681 tcttctacac taaagcatcc tgaaacttag cctggcctct tgggaactaa agggaggctc
     1741 tcaaagagct acaaaaacag cactggcagc actttacctt ggccctttta gtagtctttc
     1801 tggcttttct accctgcctt tgctcatgtc aatcttttca gacatgctcc ggtcggaagc
     1861 tagtttgcag gtgcaccttt gaaccattgt gcttcccacc ataaatagga aaaccggctc
     1921 tctgcctgtc tcagtcttca ggcttatctg ccccaagaag ttccctccac acccgaaaaa
     1981 aaaaaaaaac caatcaggcc tacaaatccc tccaccccac cccctcaaaa acaaacaaac
     2041 aaacaaacag gacctgtcat tccagttgct ttctaaggac atctgtgtgc tttccttcta
     2101 gacgctgagt gatcattagg gcaatttgac gggacatagt aggtccttca ttcacaagac
     2161 cagagctttt cccacacacc actgcaggag gggcccagcc aggcacctct taccaggcat
     2221 tggagtcatg cacttcacac agttgatccc tcaaaggtgg gaagcgatcc cattgtacac
     2281 atggcagact tggtactcgt gagtcagaag actgccccaa gacaatagga tcagtgttgc
     2341 ggtcaggatc tacactgcct agtaggctgt gttgtagatg tgacagctct ctccctctca
     2401 gtgttacttg cctcagtttt ccccgggtca aacctgcttt tagatttacc ttcactggtc
     2461 cctgaaatga ggttgtataa cctttaggat aggggatgga attgtttgag aggatctgat
     2521 ttgggtctaa aacagaaaga ctgattctga gctggggttt gtgctggcta gaaggcttag
     2581 cttccggtca gctgtatggc ctcagacaac attctttcta cttgtggccc ccatctgtaa
     2641 aacatgggtc ggtgatgcca ggctcaaaca agccaaagct aatgaaattg ccttaaaaac
     2701 tataacgtat caggctagga tttgttagca tctccaatag actcttccta ccttgtcaca
     2761 gtgctggacc gcagataccc agcagctggg tggcaaccaa gggagctgcc ttaatattct
     2821 cagggcagtc tccttgtgat ccaaagcatg tgtctgaatg ctcttggttt tgtagaattt
     2881 acctcagagg tacacgaatt attttccctg tgatgcttgt ggtgcgtggt ctagaaccag
     2941 tgaagggctc catccagcta tacatacagc cccagcaggt gtttgcaaga aaaaggctta
     3001 gtcaaggcca gtgaagcaga agacatacat ctctgtgatg acagttttct aatacatgct
     3061 ttgtttaaat aaaatatgaa tgctgtctct tgtaa
//
