LOCUS       NP_001386103             440 aa            linear   ROD 17-JUN-2024
DEFINITION  tripartite motif-containing protein 14 isoform 1 [Rattus
            norvegicus].
ACCESSION   NP_001386103 XP_006238122
VERSION     NP_001386103.1
DBSOURCE    REFSEQ: accession NM_001399174.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (residues 1 to 440)
  AUTHORS   Niu,Z., Qu,S.T., Zhang,L., Dai,J.H., Wang,K., Liu,Y., Chen,L.,
            Song,Y., Sun,R., Xu,Z.H. and Zhang,H.L.
  TITLE     Trim14-IkappaBalpha Signaling Regulates Chronic Inflammatory Pain
            in Rats and Osteoarthritis Patients
  JOURNAL   Neuroscience 548, 39-49 (2024)
   PUBMED   38697463
  REMARK    GeneRIF: Trim14-IkappaBalpha Signaling Regulates Chronic
            Inflammatory Pain in Rats and Osteoarthritis Patients.
REFERENCE   2  (residues 1 to 440)
  AUTHORS   Lv,R., Du,L. and Bai,L.
  TITLE     RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14
  JOURNAL   Int Immunopharmacol 125 (Pt B), 111191 (2023)
   PUBMED   37951197
  REMARK    GeneRIF: RNF125, transcriptionally regulated by NFATC2, alleviates
            osteoarthritis via inhibiting the Wnt/beta-catenin signaling
            pathway through degrading TRIM14.
            Erratum:[Int Immunopharmacol. 2024 Jan 25;127:111425. doi:
            10.1016/j.intimp.2023.111425. PMID: 38142206]
REFERENCE   3  (residues 1 to 440)
  AUTHORS   Hou,H., Chen,Y., Feng,X., Xu,G. and Yan,M.
  TITLE     Tripartite motif-containing 14 may aggravate cardiac hypertrophy
            via the AKT signalling pathway in neonatal rat cardiomyocytes and
            transgenic mice
  JOURNAL   Mol Med Rep 28 (3) (2023)
   PUBMED   37503784
  REMARK    GeneRIF: Tripartite motif-containing 14 may aggravate cardiac
            hypertrophy via the AKT signalling pathway in neonatal rat
            cardiomyocytes and transgenic mice.
REFERENCE   4  (residues 1 to 440)
  AUTHORS   Xie,X., Wang,F. and Li,X.
  TITLE     Inhibition of TRIM14 protects cerebral ischemia/reperfusion injury
            through regulating NF-kappaB/NLRP3 pathway-mediated inflammation
            and apoptosis
  JOURNAL   J Recept Signal Transduct Res 42 (2), 197-205 (2022)
   PUBMED   33691569
  REMARK    GeneRIF: Inhibition of TRIM14 protects cerebral
            ischemia/reperfusion injury through regulating NF-kappaB/NLRP3
            pathway-mediated inflammation and apoptosis.
REFERENCE   5  (residues 1 to 440)
  AUTHORS   Uchil,P.D., Hinz,A., Siegel,S., Coenen-Stass,A., Pertel,T.,
            Luban,J. and Mothes,W.
  TITLE     TRIM protein-mediated regulation of inflammatory and innate immune
            signaling and its association with antiretroviral activity
  JOURNAL   J Virol 87 (1), 257-272 (2013)
   PUBMED   23077300
REFERENCE   6  (residues 1 to 440)
  AUTHORS   Uchil,P.D., Quinlan,B.D., Chan,W.T., Luna,J.M. and Mothes,W.
  TITLE     TRIM E3 ligases interfere with early and late stages of the
            retroviral life cycle
  JOURNAL   PLoS Pathog 4 (2), e16 (2008)
   PUBMED   18248090
REFERENCE   7  (residues 1 to 440)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
REFERENCE   8  (residues 1 to 440)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (residues 1 to 440)
  AUTHORS   Reymond,A., Meroni,G., Fantozzi,A., Merla,G., Cairo,S., Luzi,L.,
            Riganelli,D., Zanaria,E., Messali,S., Cainarca,S., Guffanti,A.,
            Minucci,S., Pelicci,P.G. and Ballabio,A.
  TITLE     The tripartite motif family identifies cell compartments
  JOURNAL   EMBO J 20 (9), 2140-2151 (2001)
   PUBMED   11331580
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000005.1.
            
            On Jan 4, 2022 this sequence version replaced XP_006238122.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC166777.1, SRR26643292.21602.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA5760383,
                                           SAMEA5760386 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..440
                     /organism="Rattus norvegicus"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="5"
                     /map="5q22"
     Protein         1..440
                     /product="tripartite motif-containing protein 14 isoform
                     1"
                     /note="tripartite motif protein 14; tripartite
                     motif-containing protein 14"
                     /calculated_mol_wt=49719
     Region          20..63
                     /region_name="Bbox2_TRIM14"
                     /note="B-box-type 2 zinc finger found in tripartite
                     motif-containing protein 14 (TRIM14) and similar proteins;
                     cd19768"
                     /db_xref="CDD:380826"
     Region          267..439
                     /region_name="SPRY_PRY_TRIM14"
                     /note="PRY/SPRY domain of tripartite motif-binding protein
                     14 (TRIM14); cd13738"
                     /db_xref="CDD:293973"
     CDS             1..440
                     /gene="Trim14"
                     /coded_by="NM_001399174.2:28..1350"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="GeneID:313236"
                     /db_xref="RGD:1311514"
ORIGIN      
        1 masgtaevra pvqsdwtggw rcpehserpa elfcrrcsrc vcalcpvlga hrghpvglae
       61 eeaaraqklm qecleclatk krqhadniaq ledtgerlkv sadsskawlt qkftelrlll
      121 deeealaksf idkntqltlq vyqeqaescr kqievmsdfs irvwdisqvs npvqllqayi
      181 atkaemgqqm spselshpvp lsfepvknff kefveairnt lqtpmdtrlk enincqlsss
      241 sstkpgallk tspsperalf lkyartptld pdtmharlrl stdgltvrcs llgrlgprpa
      301 prfdslrqvl grdgfaagrh ywevdvqeag vgwwvgaayp slrrrgtsta arlgcnresw
      361 cvkrydmeyw afhdcqrsrl rlrrdphrlg vfldyeagil tfydvaggms hlhtfyavfq
      421 eplypalrlw egtisiprlp
//
