LOCUS       NM_144755               1433 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Rattus norvegicus tribbles pseudokinase 3 (Trib3), mRNA.
ACCESSION   NM_144755
VERSION     NM_144755.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1433)
  AUTHORS   Zeng,S., Wang,Y., Ai,L., Huang,L., Liu,Z., He,C., Bai,Q. and Li,Y.
  TITLE     Chronic intermittent hypoxia-induced oxidative stress activates
            TRB3 and phosphorylated JNK to mediate insulin resistance and cell
            apoptosis in the pancreas
  JOURNAL   Clin Exp Pharmacol Physiol 51 (3), e13843 (2024)
   PUBMED   38302075
  REMARK    GeneRIF: Chronic intermittent hypoxia-induced oxidative stress
            activates TRB3 and phosphorylated JNK to mediate insulin resistance
            and cell apoptosis in the pancreas.
REFERENCE   2  (bases 1 to 1433)
  AUTHORS   Sui,X., Zhang,L., Zhang,X.F. and Zhang,Y.
  TITLE     TRIB3-Regulated Akt Signal Pathway Affects Trophoblast Invasion in
            the Development of Preeclampsia
  JOURNAL   Am J Perinatol 40 (12), 1359-1366 (2023)
   PUBMED   34553361
  REMARK    GeneRIF: TRIB3-Regulated Akt Signal Pathway Affects Trophoblast
            Invasion in the Development of Preeclampsia.
REFERENCE   3  (bases 1 to 1433)
  AUTHORS   Cao,X., Fang,X., Guo,M., Li,X., He,Y., Xie,M., Xu,Y. and Liu,X.
  TITLE     TRB3 mediates vascular remodeling by activating the MAPK signaling
            pathway in hypoxic pulmonary hypertension
  JOURNAL   Respir Res 22 (1), 312 (2021)
   PUBMED   34906150
  REMARK    GeneRIF: TRB3 mediates vascular remodeling by activating the MAPK
            signaling pathway in hypoxic pulmonary hypertension.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1433)
  AUTHORS   Wei,K., Wan,L., Liu,J., Zhang,B., Li,X., Zhang,Y., Zhang,C. and
            Yao,W.
  TITLE     Downregulation of TRB3 protects neurons against apoptosis induced
            by global cerebral ischemia and reperfusion injury in rats
  JOURNAL   Neuroscience 360, 118-127 (2017)
   PUBMED   28782643
  REMARK    GeneRIF: TRB3 participated in the global cerebral ischemia and
            reperfusion injury-induced neuronal apoptosis
REFERENCE   5  (bases 1 to 1433)
  AUTHORS   Xu,X., Huang,E., Tai,Y., Zhao,X., Chen,X., Chen,C., Chen,R.,
            Liu,C., Lin,Z., Wang,H. and Xie,W.B.
  TITLE     Nupr1 Modulates Methamphetamine-Induced Dopaminergic Neuronal
            Apoptosis and Autophagy through CHOP-Trib3-Mediated Endoplasmic
            Reticulum Stress Signaling Pathway
  JOURNAL   Front Mol Neurosci 10, 203 (2017)
   PUBMED   28694771
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1433)
  AUTHORS   Kiss-Toth,E., Bagstaff,S.M., Sung,H.Y., Jozsa,V., Dempsey,C.,
            Caunt,J.C., Oxley,K.M., Wyllie,D.H., Polgar,T., Harte,M.,
            O'neill,L.A., Qwarnstrom,E.E. and Dower,S.K.
  TITLE     Human tribbles, a protein family controlling mitogen-activated
            protein kinase cascades
  JOURNAL   J Biol Chem 279 (41), 42703-42708 (2004)
   PUBMED   15299019
REFERENCE   7  (bases 1 to 1433)
  AUTHORS   Ord,D. and Ord,T.
  TITLE     Mouse NIPK interacts with ATF4 and affects its transcriptional
            activity
  JOURNAL   Exp Cell Res 286 (2), 308-320 (2003)
   PUBMED   12749859
REFERENCE   8  (bases 1 to 1433)
  AUTHORS   Du,K., Herzig,S., Kulkarni,R.N. and Montminy,M.
  TITLE     TRB3: a tribbles homolog that inhibits Akt/PKB activation by
            insulin in liver
  JOURNAL   Science 300 (5625), 1574-1577 (2003)
   PUBMED   12791994
REFERENCE   9  (bases 1 to 1433)
  AUTHORS   Bowers,A.J., Scully,S. and Boylan,J.F.
  TITLE     SKIP3, a novel Drosophila tribbles ortholog, is overexpressed in
            human tumors and is regulated by hypoxia
  JOURNAL   Oncogene 22 (18), 2823-2835 (2003)
   PUBMED   12743605
REFERENCE   10 (bases 1 to 1433)
  AUTHORS   Mayumi-Matsuda,K., Kojima,S., Suzuki,H. and Sakata,T.
  TITLE     Identification of a novel kinase-like gene induced during neuronal
            cell death
  JOURNAL   Biochem Biophys Res Commun 258 (2), 260-264 (1999)
   PUBMED   10329375
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091120.1.
            
            On Jun 3, 2007 this sequence version replaced NM_144755.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091120.1, SRR8487230.125985.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5756307, SAMN16093042
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1433
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="3"
                     /map="3q41"
     gene            1..1433
                     /gene="Trib3"
                     /gene_synonym="NIPK"
                     /note="tribbles pseudokinase 3"
                     /db_xref="GeneID:246273"
                     /db_xref="RGD:708432"
     exon            1..168
                     /gene="Trib3"
                     /gene_synonym="NIPK"
                     /inference="alignment:Splign:2.1.0"
     CDS             169..1218
                     /gene="Trib3"
                     /gene_synonym="NIPK"
                     /note="TRB-3; neuronal cell death-inducible putative
                     kinase; Neuronal cell death Inducible Putative Kinase"
                     /codon_start=1
                     /product="tribbles homolog 3"
                     /protein_id="NP_653356.1"
                     /db_xref="GeneID:246273"
                     /db_xref="RGD:708432"
                     /translation="MRATSLAASADVPCRKKPLEFDDNIDVECPVLKRVRDEPEPGPT
                     PSLPPASDLSPAVAPATRLGPYILLEREQGNCTYRALHCPTGTEYTCKVYPASEAQAV
                     LAPYARLPTHQHVARPTEVLLGSQLLYTFFTKTHGDLHSLVRSRRGIPEPEAAALFRQ
                     MASAVAHCHKHGLILRDLKLRRFVFSNCERTKLVLENLEDACVMTGPDDSLWDKHACP
                     AYVGPEILSSRPSYSGRAADVWSLGVALFTMLAGRYPFQDSEPALLFGKIRRGTFALP
                     EGLSASARCLIRCLLRREPSERLVALGILLHPWLREDCSQVSPPRSDRREMDQVVPDG
                     PQLEEAEEGEVGLYG"
     exon            169..444
                     /gene="Trib3"
                     /gene_synonym="NIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            445..737
                     /gene="Trib3"
                     /gene_synonym="NIPK"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1431
                     /gene="Trib3"
                     /gene_synonym="NIPK"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cggagccggc gtcccggtgc cgcagcactt tagcagcgga agcggctgct gttgagtacg
       61 tgacggctgg ggtctggcac gggcgtgctg ggactccgag ataggctcag tgaggctggc
      121 agcggtccac gggcgcgggc gcaggcggct ctgagacctc aggacaagat gcgagccaca
      181 tctctggctg cttctgccga tgttccctgc aggaagaaac cgttggagtt tgatgacaac
      241 attgatgtcg agtgtccagt cttaaaacga gtgagagatg agcctgagcc tggaccaacc
      301 cccagcctac ctcccgcctc agacttgtca cctgctgtgg cccctgcaac ccggctgggg
      361 ccctatatcc ttttggaacg agagcaaggc aactgcacct atcgggccct gcactgcccc
      421 acaggcacag agtacacctg caaggtgtat cccgccagcg aggcccaggc ggtgctggca
      481 ccgtatgcaa gactgcctac ccaccagcac gtggcccgtc ccacagaggt cctgctgggc
      541 tctcagctcc tatacacctt tttcacgaag acccatgggg acttgcacag tctggtgcgc
      601 agccgccgcg gtatccccga gcccgaggct gccgcgcttt tccgacagat ggctagtgcg
      661 gtggcacact gccacaagca cgggctcatc ttgcgcgacc tcaagttgcg tcgatttgtc
      721 ttcagcaact gtgagaggac gaagttggtg ctggagaacc tggaggatgc ctgtgtgatg
      781 actggaccag acgactctct gtgggacaag cacgcgtgcc ctgcctatgt gggaccagag
      841 atactcagct cccggccatc ctactccggc agagcggctg atgtctggag cctgggcgtg
      901 gcgctcttca ccatgctggc tggccgatac ccgttccagg actctgaacc agccctgctc
      961 tttggcaaga tccgtagagg gacctttgcc ctgcctgagg gcctatcagc ctctgctcga
     1021 tgcctcatcc gctgtctcct ccgcagggag ccttcagagc gacttgtggc cctgggaatc
     1081 ctgctacatc cctggttgag ggaggattgc agccaagtct ctcctccacg gtctgaccga
     1141 agggagatgg accaggttgt cccagatggg ccacagctgg aggaggcaga ggaaggggag
     1201 gtggggctgt atggctagag ccaccttaac tggcccttca gctccaaggt gtgagttgag
     1261 tactggtgtc tcagctttcg cctgcctttt tgggccaagc taaactgtaa gtgcctttct
     1321 ggaggaagaa acagccattg tgcttcatgc attcctgtgc acagtggggt gatgctgtct
     1381 ggatgacaag ccctgttcta ggtgctgtga acagcaaaga aaaaaaaaaa aaa
//
