LOCUS       NM_001108015            4268 bp    mRNA    linear   ROD 01-APR-2024
DEFINITION  Rattus norvegicus tribbles pseudokinase 2 (Trib2), mRNA.
ACCESSION   NM_001108015 XM_001068999 XM_233982
VERSION     NM_001108015.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4268)
  AUTHORS   Takaguri,A., Ishizaka,R., Maki,S. and Satoh,K.
  TITLE     The role of tribbles homolog 2 in vascular smooth muscle cell
            proliferation
  JOURNAL   Cell Biol Int 47 (4), 787-795 (2023)
   PUBMED   36626273
  REMARK    GeneRIF: The role of tribbles homolog 2 in vascular smooth muscle
            cell proliferation.
REFERENCE   2  (bases 1 to 4268)
  AUTHORS   Tanaka,S., Honda,Y., Honda,M., Yamada,H., Honda,K. and Kodama,T.
  TITLE     Anti-Tribbles Pseudokinase 2 (TRIB2)-Immunization Modulates
            Hypocretin/Orexin Neuronal Functions
  JOURNAL   Sleep 40 (1) (2017)
   PUBMED   28364459
  REMARK    GeneRIF: The absence of a change in hypocretin cell populations
            suggested that factors other than anti-TRIB2 antibody play a part
            in the loss of hypocretin neurons in narcolepsy. The increased
            anti-TRIB2 antibody after the destruction of hypocretin neurons
            suggest that anti-TRIB2 antibody in narcolepsy patients is the
            consequence rather than the inciting cause of hypocretin cell
            destruction.
REFERENCE   3  (bases 1 to 4268)
  AUTHORS   Xie,S., Xie,N., Li,Y., Wang,P., Zhang,C., Li,Q., Liu,X., Deng,J.,
            Zhang,C. and Lv,C.
  TITLE     Upregulation of TRB2 induced by miR-98 in the early lesions of
            large artery of type-2 diabetic rat
  JOURNAL   Mol Cell Biochem 361 (1-2), 305-314 (2012)
   PUBMED   22012613
  REMARK    GeneRIF: TRB2 plays important roles in the pathogenesis of
            diabetic-2 large artery complications at early stage, and these
            effects may be modulated by miR-98
REFERENCE   4  (bases 1 to 4268)
  AUTHORS   Dedhia,P.H., Keeshan,K., Uljon,S., Xu,L., Vega,M.E., Shestova,O.,
            Zaks-Zilberman,M., Romany,C., Blacklow,S.C. and Pear,W.S.
  TITLE     Differential ability of Tribbles family members to promote
            degradation of C/EBPalpha and induce acute myelogenous leukemia
  JOURNAL   Blood 116 (8), 1321-1328 (2010)
   PUBMED   20410507
REFERENCE   5  (bases 1 to 4268)
  AUTHORS   Deng,J., James,C.H., Patel,L., Smith,A., Burnand,K.G., Rahmoune,H.,
            Lamb,J.R. and Davis,B.
  TITLE     Human tribbles homologue 2 is expressed in unstable regions of
            carotid plaques and regulates macrophage IL-10 in vitro
  JOURNAL   Clin Sci (Lond) 116 (3), 241-248 (2009)
   PUBMED   18643775
REFERENCE   6  (bases 1 to 4268)
  AUTHORS   Naiki,T., Saijou,E., Miyaoka,Y., Sekine,K. and Miyajima,A.
  TITLE     TRB2, a mouse Tribbles ortholog, suppresses adipocyte
            differentiation by inhibiting AKT and C/EBPbeta
  JOURNAL   J Biol Chem 282 (33), 24075-24082 (2007)
   PUBMED   17576771
REFERENCE   7  (bases 1 to 4268)
  AUTHORS   Wilkin,F., Suarez-Huerta,N., Robaye,B., Peetermans,J., Libert,F.,
            Dumont,J.E. and Maenhaut,C.
  TITLE     Characterization of a phosphoprotein whose mRNA is regulated by the
            mitogenic pathways in dog thyroid cells
  JOURNAL   Eur J Biochem 248 (3), 660-668 (1997)
   PUBMED   9342215
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JAXUCZ010000006.1.
            
            On Feb 9, 2022 this sequence version replaced NM_001108015.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FQ231260.1, BC168939.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN12840111,
                                           SAMN12840114 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1625              JAXUCZ010000006.1  44297470-44299094   c
            1626-1918           JAXUCZ010000006.1  44292137-44292429   c
            1919-4268           JAXUCZ010000006.1  44274762-44277111   c
FEATURES             Location/Qualifiers
     source          1..4268
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="6"
                     /map="6q16"
     gene            1..4268
                     /gene="Trib2"
                     /gene_synonym="RGD1564451"
                     /note="tribbles pseudokinase 2"
                     /db_xref="GeneID:313974"
                     /db_xref="RGD:1564451"
     exon            1..1625
                     /gene="Trib2"
                     /gene_synonym="RGD1564451"
                     /inference="alignment:Splign:2.1.0"
     CDS             1356..2387
                     /gene="Trib2"
                     /gene_synonym="RGD1564451"
                     /codon_start=1
                     /product="tribbles homolog 2"
                     /protein_id="NP_001101485.2"
                     /db_xref="GeneID:313974"
                     /db_xref="RGD:1564451"
                     /translation="MNIHRSTPITIARYGRSRNKTQDFEELSSIRSAEPSQSFSPNLG
                     SPSPPETPNLSHCVSCIGKYLLLEPLEGDHVFRAVHLHSGEELVCKVFEISCYQESLA
                     PCFCLSAHSNINQITEILLGETKAYVFFERSYGDMHSFVRTCKKLREEEAARLFYQIA
                     SAVAHCHDGGLVLRDLKLRKFIFKDEERTRVKLESLEDAYILRGDDDSLSDKHGCPAY
                     VSPEILNTNGSYSGKAADVWSLGVMLYTMLVGRYPFHDIEPSSLFSKIRRGQFNIPET
                     LSPKAKCLIRSILRREPSERLTSQEILDHPWFSTDFSVSNSGFGAKEACDQLVPDVNM
                     EENLDPFFN"
     exon            1626..1918
                     /gene="Trib2"
                     /gene_synonym="RGD1564451"
                     /inference="alignment:Splign:2.1.0"
     exon            1919..4268
                     /gene="Trib2"
                     /gene_synonym="RGD1564451"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gagcgcgagc gagcgaggcg cgcgcgcaca catacgcgca cacacagccg ggctcgctcc
       61 gagatccccg gccacgtaag taactattaa taccgcctcg cccggggatg cgggcgtgct
      121 gagcgccggg attggcctag ggcaccgtgg ccatcccctt taatttttaa atacacggtc
      181 ctctcctact tctgggtggc aagaaagaaa agaaaagaag acaagccgtc gatttttatt
      241 tttcctccag aacaagcccg ccgtgcaatt tggtcgcaag gcatcgggag acaagagtgg
      301 tttgcaaatt gttccaagcc tcaagaccca gctgtgcagc ggaaaaagaa cgccgcgggt
      361 taacagagtc cggggagcat ctgcggccag ctcctgcagg acccccggaa atctcctgcc
      421 gctggtcccc ccaggtcacc gcccgcactt cttgcttcat cagaggagga tctgggacgt
      481 gagcggcgac agcaagagct agtgctgacc gcgcgggctc agctttgggc tttgtcgcgg
      541 tacctgtgcc tgccctactc cgcactccct actcagcttt tgcaatcttt tgttgccact
      601 gctgaccgcc ccaagttaaa tgctcctttg ctattttgct tttttttctg tccctttttt
      661 tttttttttt tttgagagcg agagggagag ctctgcgatt ttttggaaaa gcctcagacg
      721 ccatctacag ttaagactta ggtaactgcc ctctctagca cccccttcca cgccccccac
      781 cctttctacc aaaaaggggg ggtgcagcgc ggattctggc tgccgcgcgg cgtgagccgg
      841 tagacccgtg cttatttcct ttttcttttt gtttggtttc taacgcgtgg agggcgagcc
      901 ggcgccgcac gctccctgaa gactgcacaa actccaggca gggctcctcc gcccggtctg
      961 cggatcctca gctggggatc gctcaggatc ccggcgctgc agctccgcac cccagaggca
     1021 cgctcactcg tccagatcca cgcggcgaac agagacccac tgactccaga gtgcggttct
     1081 gcactgcgct ggcggcttct gggtaacaaa aggacccgag ttgtcggccg agcgagcacc
     1141 cccgggagcg gggctcgcag ccggggacca gccctgcggc gcccatctgg gggctagttc
     1201 ttaactctcc tctacggagc cccagacggg tcccctccct tcttgatcct tttaagtctg
     1261 tggcacagag gcgcctgcac ccgcggctca tccatctctc cagtggggtt tttctttttg
     1321 gtttgtttgt tttgtcgtgt gcgatcccca cactcatgaa catacacagg tctaccccta
     1381 tcacaatagc gagatatggg agatcgcgga acaaaaccca ggatttcgaa gagctgtcgt
     1441 ctataaggtc cgctgagccc agccagagtt tcagcccgaa ccttggctct ccgagcccgc
     1501 ccgagactcc gaacttgtcg cattgcgttt cctgcatcgg gaaatactta ctgttggagc
     1561 ctctggaggg agaccacgtt ttccgcgctg tgcatctgca cagcggagag gagctggtgt
     1621 gcaaggtgtt tgagatcagc tgctaccagg agtccctggc cccctgcttc tgcctgtctg
     1681 cccatagcaa catcaaccaa atcacagaaa tcctcctggg agagaccaaa gcctatgtgt
     1741 tcttcgagcg gagctatgga gacatgcatt cctttgtccg cacttgcaag aagctgaggg
     1801 aggaggaggc agcccgactg ttctaccaga ttgcctcggc ggtggcccac tgccatgatg
     1861 gggggctggt gctgcgtgac ctcaagctgc ggaaatttat cttcaaggat gaagagagga
     1921 ctcgtgtcaa gctggagagt ttggaagacg cttacattct ccggggtgat gacgactccc
     1981 tctctgacaa gcatggctgc ccagcatatg tcagcccaga gatcttgaac accaacggca
     2041 gttattcggg caaggcagcg gacgtgtgga gcctgggggt aatgctgtac accatgttgg
     2101 tggggcgtta ccctttccat gacattgagc ctagttccct cttcagtaag atccgcaggg
     2161 gccaattcaa cattccagaa actctgtctc ccaaggccaa gtgcctcatc cgaagcatcc
     2221 tgcgacggga gccctcagag cggctgacct cacaggaaat tctggaccat ccttggtttt
     2281 ctacagattt tagtgtctca aattcgggat ttggtgctaa agaggcatgt gaccagctgg
     2341 tgccagacgt caacatggag gagaacttgg accctttctt taactgagct taaggcccag
     2401 ggacacatag caggtaccag gagcgagaga gagctccaga aaggagttct gggacacagg
     2461 tggcctggct gagaagcaag acggacccat catatttaca catttcttgg ttcagagaag
     2521 gaatatgttc taggaaatga tggaacatgt agcatgggaa caagatgtgt gggatggggg
     2581 ttgggttcag atggacggga gcccttcccc taaacttctc ttcccttggg tagcctgaga
     2641 gtccccctta ccagtagggc tatctggtct accccacttt tcattttgtt cagaaatagt
     2701 tgcagatctc gatagaatcg aaactcttct gcctcaaaca cataccttgg cattgcactg
     2761 ttagcattta acttcttgtt acgattcagg gaagggacaa ttgatcgaag attttttttt
     2821 tcgaacaggc caaccaccta tgtaataatt aataggattc acctaaaaaa taataataat
     2881 tcggtgcaca cagactgacc tgaaacctgg gtgctaaact aaaagaaaac aaaagttcca
     2941 gttgtcgtct ctcatccaca ctttccaatt catttcttct aaataaacaa tttcctattc
     3001 tggttaggaa gtgacatgtt aatgctttgc tccctgaagg gggaagggaa gtctattcct
     3061 tcacagacat ttctgttttg tatcagctgg tttttgtagc aagaaactat atgaagtcaa
     3121 acttccagat acattatcac agtccagggg atgaagaaag gaaaagagaa aaatacaact
     3181 cctttctggt ttttgttctt ttgaaggaag agggttcaca ttgtagacat tgctctctgc
     3241 tccaaatacg gtgagggggt cccagagggc aggcgcctcc tggagtcaga tctttttgat
     3301 gatgctgatc tcaacatttt gtttttgctt tatgggaaac tagtaaaaca agacaggttg
     3361 tcccatgtgt ataaaataca gggcagctat ttccttttct ttgctaagaa tgatcctttg
     3421 ggcttggaaa ggccctctgg tttgaacaga aggagtaaat gggcaataag ccaaaagcca
     3481 ggatgatata catacaaaca gctctctgtc ccaatacgca ccttgtattt attaaggaaa
     3541 atgtcacatt gtgatgtatc aagccagtac ttcaattacg ggtcaatggg atgacatgtt
     3601 acatgctgta gtttaacatt tataatttta ttcccctgtt ttgagtatat ctgtccctgg
     3661 aataaccttt tatttggctc tctctagata gccttatttg atttcgagtg gcaaaatgtt
     3721 ttccttttgt attctggctt ttttattgct gtatgataca gaactctttt ggcataaata
     3781 tttgtgttcc cagtacctca gtcatttggg ttttactgct tgcatatgtt ttgtgaaatg
     3841 gtcctgtttt tgggtaggta acacgtggac tctagtatgt aaatgttact tgaatctgtg
     3901 cttcactctc gtatgtggca tgtgtgtgcg gactcttgga tgcttcacgc ctactccact
     3961 ggagcccctg tccccaggag ggcagcttcc ccattgataa tcaggggaca aagctgccat
     4021 ggatttaccc ttgattctat tttgataatg gaagatacag agaaagggtt tttacattca
     4081 gaagatggtg ctgtggcaag aaggaccttt tatcttccct ctcccctgtt tttaaagtcc
     4141 tgggtgggag gaaagattgg taacatgcat gatggggact aatggcctct ggtgctttgt
     4201 cctgtatttg gtttaatgtt tttgtcctaa tctcttcaat caataaaatt gtgcgtattt
     4261 aactaaaa
//
