LOCUS       NM_013047               3390 bp    mRNA    linear   ROD 09-FEB-2025
DEFINITION  Rattus norvegicus thyrotropin releasing hormone receptor (Trhr),
            mRNA.
ACCESSION   NM_013047 XM_346798
VERSION     NM_013047.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 3390)
  AUTHORS   Barnes,M.J., Rogers,R.C., Van Meter,M.J. and Hermann,G.E.
  TITLE     Co-localization of TRHR1 and LepRb receptors on neurons in the
            hindbrain of the rat
  JOURNAL   Brain Res 1355, 70-85 (2010)
   PUBMED   20691166
  REMARK    GeneRIF: Co-localization of LepRb and TRHR1 is not observed on
            individual fibers in the hindbrain, but these two fiber types
            co-mingle in vagal and reticular nuclei.
REFERENCE   2  (bases 1 to 3390)
  AUTHORS   Zhao,Y., Hou,W.G., Zhu,H.P., Zhao,J., Wang,R.A., Xu,R.J. and
            Zhang,Y.Q.
  TITLE     Expression of thyrotropin-releasing hormone receptors in rat testis
            and their role in isolated Leydig cells
  JOURNAL   Cell Tissue Res 334 (2), 283-294 (2008)
   PUBMED   18795335
  REMARK    GeneRIF: The expression and localization of TRH-R1 and TRH-R2 in
            postnatal development and ethane dimethane sulfonate treated rat
            testes were observed.
REFERENCE   3  (bases 1 to 3390)
  AUTHORS   Mulcahy,L.R., Barker,A.J. and Nillni,E.A.
  TITLE     Disruption of disulfide bond formation alters the trafficking of
            prothyrotropin releasing hormone (proTRH)-derived peptides
  JOURNAL   Regul Pept 133 (1-3), 123-133 (2006)
   PUBMED   16257458
  REMARK    GeneRIF: These data suggest that the proposed disulfide bond of
            proTRH is involved in sorting of proTRH-derived peptides and in
            their retention within maturing secretory granules.
REFERENCE   4  (bases 1 to 3390)
  AUTHORS   Miranda,P., Giraldez,T., de la Pena,P., Manso,D.G., Alonso-Ron,C.,
            Gomez-Varela,D., Dominguez,P. and Barros,F.
  TITLE     Specificity of TRH receptor coupling to G-proteins for regulation
            of ERG K+ channels in GH3 rat anterior pituitary cells
  JOURNAL   J Physiol 566 (Pt 3), 717-736 (2005)
   PUBMED   15905217
  REMARK    GeneRIF: Our results demonstrate that whereas the TRH receptor uses
            a G(q/11) protein for transducing the Ca2+ signal during the
            initial response to TRH, this G-protein is not involved in the
            TRH-induced inhibition of endogenous r-ERG currents in pituitary
            cells.
REFERENCE   5  (bases 1 to 3390)
  AUTHORS   De Miguel,M., Fernandez-Santos,J.M., Utrilla,J.C.,
            Carrillo-Vico,A., Borrero,J., Conde,E., Guerrero,J.M. and
            Martin-Lacave,I.
  TITLE     Thyrotropin-releasing hormone receptor expression in thyroid
            follicular cells: a new paracrine role of C-cells?
  JOURNAL   Histol Histopathol 20 (3), 713-718 (2005)
   PUBMED   15944919
  REMARK    GeneRIF: Data provide new evidence for a novel intrathyroidal
            regulatory pathway of thyroid hormone secretion via
            paracrine/autocrine TRH signaling.
REFERENCE   6  (bases 1 to 3390)
  AUTHORS   de la Pena,P., Delgado,L.M., del Camino,D. and Barros,F.
  TITLE     Two isoforms of the thyrotropin-releasing hormone receptor
            generated by alternative splicing have indistinguishable functional
            properties
  JOURNAL   J Biol Chem 267 (36), 25703-25708 (1992)
   PUBMED   1334485
REFERENCE   7  (bases 1 to 3390)
  AUTHORS   Eidne,K.A., Sellar,R.E., Couper,G., Anderson,L. and Taylor,P.L.
  TITLE     Molecular cloning and characterisation of the rat pituitary
            gonadotropin-releasing hormone (GnRH) receptor
  JOURNAL   Mol Cell Endocrinol 90 (1), R5-R9 (1992)
   PUBMED   1338727
REFERENCE   8  (bases 1 to 3390)
  AUTHORS   de la Pena,P., Delgado,L.M., del Camino,D. and Barros,F.
  TITLE     Cloning and expression of the thyrotropin-releasing hormone
            receptor from GH3 rat anterior pituitary cells
  JOURNAL   Biochem J 284 (Pt 3) (Pt 3), 891-899 (1992)
   PUBMED   1377915
REFERENCE   9  (bases 1 to 3390)
  AUTHORS   Zhao,D., Yang,J., Jones,K.E., Gerald,C., Suzuki,Y., Hogan,P.G.,
            Chin,W.W. and Tashjian,A.H. Jr.
  TITLE     Molecular cloning of a complementary deoxyribonucleic acid encoding
            the thyrotropin-releasing hormone receptor and regulation of its
            messenger ribonucleic acid in rat GH cells
  JOURNAL   Endocrinology 130 (6), 3529-3536 (1992)
   PUBMED   1317787
  REMARK    Erratum:[Endocrinology. 1993 Jun;132(6):2658. doi:
            10.1210/endo.132.6.8389286.. PMID: 8389286]
REFERENCE   10 (bases 1 to 3390)
  AUTHORS   Yamada,M., Monden,T., Satoh,T., Iizuka,M., Murakami,M.,
            Iriuchijima,T. and Mori,M.
  TITLE     Differential regulation of thyrotropin-releasing hormone receptor
            mRNA levels by thyroid hormone in vivo and in vitro (GH3 cells)
  JOURNAL   Biochem Biophys Res Commun 184 (1), 367-372 (1992)
   PUBMED   1373613
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            X66726.1, M90308.1 and AW522207.1.
            
            On Apr 28, 2007 this sequence version replaced NM_013047.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X64630.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA5760383, SAMEA5760393
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1515              X66726.1           2-1516
            1516-1706           M90308.1           1266-1456
            1707-3365           X66726.1           1705-3363
            3366-3390           AW522207.1         1-25                c
FEATURES             Location/Qualifiers
     source          1..3390
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="Sprague-Dawley"
                     /db_xref="taxon:10116"
                     /chromosome="7"
                     /map="7q31"
     gene            1..3390
                     /gene="Trhr"
                     /note="thyrotropin releasing hormone receptor"
                     /db_xref="GeneID:25570"
                     /db_xref="RGD:3904"
     exon            1..238
                     /gene="Trhr"
                     /inference="alignment:Splign:2.1.0"
     exon            239..1128
                     /gene="Trhr"
                     /inference="alignment:Splign:2.1.0"
     CDS             340..1578
                     /gene="Trhr"
                     /note="TRH-R; thyroliberin receptor"
                     /codon_start=1
                     /product="thyrotropin-releasing hormone receptor"
                     /protein_id="NP_037179.1"
                     /db_xref="GeneID:25570"
                     /db_xref="RGD:3904"
                     /translation="MENETVSELNQTELPPQVAVALEYQVVTILLVVVICGLGIVGNI
                     MVVLVVMRTKHMRTATNCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCIT
                     YLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLW
                     FFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVMPMILATVLYGFIARIL
                     FLNPIPSDPKENSKTWKNDSTHQNKNMNLNTTNRCFNSTVSSRKQVTKMLAVVVILFA
                     LLWMPYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKL
                     CNCKQKPTEKAANYSVALNYSVIKESDRFSTELDDITVTDTYVSTTKVSFDDTCLASE
                     KNGPSSCTYGYSLTAKQEKI"
     exon            1129..1515
                     /gene="Trhr"
                     /inference="alignment:Splign:2.1.0"
     exon            1516..3374
                     /gene="Trhr"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3009..3014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Trhr"
ORIGIN      
        1 ctatggtttg acagcctctg tgctgctcct gctgcttctg ttactgcggc tgtgtggtct
       61 gtcatgagtt gagacgggat gtgagggttt agagaaactg ccgctctgaa gcctgagcct
      121 ctgctcagtg atcttcctgc cagagggact ggacaagatt tcttctgcat gattggaaac
      181 ttggacctat tagcacgtca tctacccaga gaagcaggca gcgtgacaga gtgaagaggg
      241 gaaggaacta ctgcagaaac aagcaaacag cacaaaaggt ggaggctgga aagatgtttt
      301 agaaagtctc tgtgtcagag aagcttcaag ccactgaaga tggagaatga aaccgtcagt
      361 gaactgaacc aaaccgagct cccgccgcaa gtagccgtgg ccctcgagta ccaggtggtc
      421 accatcttac ttgtggtggt tatctgtgga ctgggcattg tgggcaacat catggtagtc
      481 ctggtggtca tgagaacgaa gcacatgaga accgctacaa actgctacct ggtgagtctg
      541 gctgtggcgg atctcatggt cctggtggct gcaggcctcc ccaacatcac cgacagcatc
      601 tatggttcct gggtctatgg ctatgttggc tgcctctgca tcacgtatct ccagtactta
      661 ggaattaacg catcttcatg ctcaataaca gcctttacca ttgagaggta catagcaatc
      721 tgccacccca tcaaagccca gtttctgtgc acattttcca gagccaaaaa aatcattatc
      781 tttgtctggg cctttacatc catttactgt atgctgtggt tcttccttct ggatctcaat
      841 atcagcacct acaaagatgc tattgtgata tcctgtggct acaagatctc ccgcaactac
      901 tactcaccta tttacctaat ggactttggc gtcttttatg tcatgccaat gatcctggcc
      961 actgtgcttt acgggtttat agctagaatc ctcttcttaa accccattcc ttcagaccct
     1021 aaagaaaact ctaagacgtg gaaaaatgac tcaacccatc agaacaagaa tatgaattta
     1081 aacaccacca acagatgttt caacagcacc gtttcttcca ggaagcaggt caccaagatg
     1141 cttgcagtgg ttgtaattct gtttgccctt ttatggatgc cctacaggac tcttgtggtt
     1201 gtcaactcat ttctctccag ccctttccag gaaaattggt tcttgctctt ttgcagaatt
     1261 tgcatttatc tcaacagtgc catcaacccg gtgatttaca acctcatgtc tcagaagttt
     1321 cgtgcagcct tcaggaagct ctgcaattgc aagcagaagc ccactgagaa agctgctaac
     1381 tacagtgtgg ccctaaatta cagtgtcatc aaggagtcag accgctttag cacagagcta
     1441 gatgacatca ccgtcactga cacgtatgtg tcaaccacaa aagtatcatt tgatgacacc
     1501 tgcttggcct ccgagaagaa tggacccagt tcttgtacat atggatattc tttgactgcc
     1561 aaacaggaga aaatatgaac ttcctcaaga ataccttggg ctggtattaa taaaggaaat
     1621 ctttcaaaaa attcaatgtg actcaaaaag atccaactga tcgaaggtct tcattcagaa
     1681 gtcagtaaga acatcgtgat acttaaatgg tacagggtgg cacaataagg aagcaaacat
     1741 ctaatcccta gccatgagga caagccactc ctgttttgat atatatatat acaaattact
     1801 ggcatgcttt tccttaatgt gtctctcttt ctcaaaataa ctgttatttg ccagatgact
     1861 ctgaacacat cctggaaacc aatttgttct gagcctccac atatgtcctt caataccctt
     1921 gaataccaaa taattctgaa taggcaagtt aaacagaaaa tcccatggag gacaagttca
     1981 tttcatgttt gtctccaaga aattgaacta agatgctgag ctcaacattg actttctctt
     2041 gaatgaatga acgaacgaac gaaagaatga atgaacatga ataagtaaat ttatgaatct
     2101 ccaactaaga aatataacgt aaaatcttca tgatgcctga tttcctcata gatttgttca
     2161 caaatataaa acttgtttgc cttttgtttt tatcatctta aaccattctc ttggcttatt
     2221 aaaatgtact atattttgtc agatcatggt caccaccatc tctgtgtata tattatgaat
     2281 acaaagttca atagtactct caaatctctc acctaattta ataatgatca agattattac
     2341 atgtatgttc agagaataac aacatactat cactgacatg tgaataaaat taaatgtgca
     2401 gagtacatgg taggaagaga agttatatga tttcagatta caaaccttag aattcctcat
     2461 tgggaaaaga atatcagggg ggtgctagag taattagaac aacctcatag gaaagcttga
     2521 atttcttata agaatagact tggcttagat aggaaaagac aagtgatgta aggaaagaga
     2581 ggtgagtaag ggtaggagga aaagaaacaa actctaggtg taatggataa tgtgtccagt
     2641 taagtgtgac tcattgggga ttgatcaagg caagcaacta gaagaaagga aagaagggaa
     2701 ataaagtatt tcctgattat tgtatttgtt gaggaaatag tcagccagac aggtggtaga
     2761 tgtgtatatt agtaagctgt catgtatttt ctaaacattg taaatttcac ttattatcta
     2821 taaaaatgta gtatgctatt tgtctcctaa gtgttataat tctgtaagta tcctaaagtc
     2881 ataatttcca ggtaaaaact aattgtatat gtgtatatct tttctatatt gcactgttat
     2941 catatatggg atatatttat ttatgtatat atgattcaga ggtccttaac agccatgaag
     3001 ttatccagtt atgctcaccg tagagatcca agctagctca taggcccttc atatgcctaa
     3061 gcatccatat taaatgagaa actgataagc agtgacaagc ttctaatgcc ctcaccctgt
     3121 tgacttgcat gctgcttata tcgtgctcct gaatgcttgg tttcttacaa catgcctctg
     3181 aatgttttgg tttcctttta ccatttgtag agagctgtat actcactcat ctcattgctt
     3241 ggagatcaat cattgtgtcc gtgtggaaaa ataatctcct ttaagaaagt gcagtattat
     3301 gtgttctctc tgcaatggga aactattact gtatgtgtat gcatgcacaa taaagtatca
     3361 aactgaaaga tccaaaaaaa aaaaaaaaaa
//
