LOCUS       NM_001024989            1101 bp    mRNA    linear   ROD 21-MAR-2023
DEFINITION  Rattus norvegicus three prime repair exonuclease 1 (Trex1), mRNA.
ACCESSION   NM_001024989
VERSION     NM_001024989.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1101)
  AUTHORS   Achleitner M, Kleefisch M, Hennig A, Peschke K, Polikarpova A,
            Oertel R, Gabriel B, Schulze L, Lindeman D, Gerbaulet A, Fiebig U,
            Lee-Kirsch MA, Roers A and Behrendt R.
  TITLE     Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of
            Antiretroviral Drugs
  JOURNAL   J Immunol 199 (7), 2261-2269 (2017)
   PUBMED   28835460
REFERENCE   2  (bases 1 to 1101)
  AUTHORS   Scholtissek B, Zahn S, Maier J, Klaeschen S, Braegelmann C, Hoelzel
            M, Bieber T, Barchet W and Wenzel J.
  TITLE     Immunostimulatory Endogenous Nucleic Acids Drive the Lesional
            Inflammation in Cutaneous Lupus Erythematosus
  JOURNAL   J Invest Dermatol 137 (7), 1484-1492 (2017)
   PUBMED   28351661
REFERENCE   3  (bases 1 to 1101)
  AUTHORS   Hasan M, Gonugunta VK, Dobbs N, Ali A, Palchik G, Calvaruso MA,
            DeBerardinis RJ and Yan N.
  TITLE     Chronic innate immune activation of TBK1 suppresses mTORC1 activity
            and dysregulates cellular metabolism
  JOURNAL   Proc Natl Acad Sci U S A 114 (4), 746-751 (2017)
   PUBMED   28069950
REFERENCE   4  (bases 1 to 1101)
  AUTHORS   Gao D, Li T, Li XD, Chen X, Li QZ, Wight-Carter M and Chen ZJ.
  TITLE     Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune
            diseases
  JOURNAL   Proc Natl Acad Sci U S A 112 (42), E5699-E5705 (2015)
   PUBMED   26371324
REFERENCE   5  (bases 1 to 1101)
  AUTHORS   Hasan M, Fermaintt CS, Gao N, Sakai T, Miyazaki T, Jiang S, Li QZ,
            Atkinson JP, Morse HC 3rd, Lehrman MA and Yan N.
  TITLE     Cytosolic Nuclease TREX1 Regulates Oligosaccharyltransferase
            Activity Independent of Nuclease Activity to Suppress Immune
            Activation
  JOURNAL   Immunity 43 (3), 463-474 (2015)
   PUBMED   26320659
REFERENCE   6  (bases 1 to 1101)
  AUTHORS   Yoshioka K, Yoshioka Y and Hsieh P.
  TITLE     ATR kinase activation mediated by MutSalpha and MutLalpha in
            response to cytotoxic O6-methylguanine adducts
  JOURNAL   Mol Cell 22 (4), 501-510 (2006)
   PUBMED   16713580
REFERENCE   7  (bases 1 to 1101)
  AUTHORS   Morita M, Stamp G, Robins P, Dulic A, Rosewell I, Hrivnak G, Daly
            G, Lindahl T and Barnes DE.
  TITLE     Gene-targeted mice lacking the Trex1 (DNase III) 3'-->5' DNA
            exonuclease develop inflammatory myocarditis
  JOURNAL   Mol Cell Biol 24 (15), 6719-6727 (2004)
   PUBMED   15254239
REFERENCE   8  (bases 1 to 1101)
  AUTHORS   Cortez D, Guntuku S, Qin J and Elledge SJ.
  TITLE     ATR and ATRIP: partners in checkpoint signaling
  JOURNAL   Science 294 (5547), 1713-1716 (2001)
   PUBMED   11721054
REFERENCE   9  (bases 1 to 1101)
  AUTHORS   Mazur DJ and Perrino FW.
  TITLE     Excision of 3' termini by the Trex1 and TREX2 3'-->5' exonucleases.
            Characterization of the recombinant proteins
  JOURNAL   J Biol Chem 276 (20), 17022-17029 (2001)
   PUBMED   11279105
REFERENCE   10 (bases 1 to 1101)
  AUTHORS   Mazur DJ and Perrino FW.
  TITLE     Identification and expression of the TREX1 and TREX2 cDNA sequences
            encoding mammalian 3'-->5' exonucleases
  JOURNAL   J Biol Chem 274 (28), 19655-19660 (1999)
   PUBMED   10391904
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC091242.1.
            
            On or before May 30, 2007 this sequence version replaced
            XM_345983.1, XM_217284.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC091242.1, FQ233170.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMD00132261, SAMD00132262
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1101
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q32"
     gene            1..1101
                     /gene="Trex1"
                     /gene_synonym="RGD1309596"
                     /note="three prime repair exonuclease 1"
                     /db_xref="GeneID:100049583"
                     /db_xref="RGD:1311998"
     exon            1..18
                     /gene="Trex1"
                     /gene_synonym="RGD1309596"
                     /inference="alignment:Splign:2.1.0"
     exon            19..1020
                     /gene="Trex1"
                     /gene_synonym="RGD1309596"
                     /inference="alignment:Splign:2.1.0"
     CDS             26..976
                     /gene="Trex1"
                     /gene_synonym="RGD1309596"
                     /EC_number="3.1.11.2"
                     /codon_start=1
                     /product="three-prime repair exonuclease 1"
                     /protein_id="NP_001020160.1"
                     /db_xref="GeneID:100049583"
                     /db_xref="RGD:1311998"
                     /translation="MGSQALPHGHMQTLIFLDLEATGLPYSQPKITELCLLAVHRHAL
                     ENSSMSEGQPPPVPKPPRVVDKLSLCIAPGKPCSSGASEITGLTTAGLEAHGRQRFND
                     NLATLLQVFLQRQPQPCCLVAHNGDRYDFPLLQAELASLSVISPLDGTFCVDSIAALK
                     TLEQASSPSEHGPRKSYSLGSIYTRLYGQAPTDSHTAEGDVLALLSICQWKPQALLQW
                     VDKHARPFSTIKPMYGMAATTGTASPRLCAATTSSPLATANLSPSNGRSRGKRPTSPP
                     PENVPEAPSREGLLAPLGLLTFLTLAIAVLYGIFLASPGQ"
ORIGIN      
        1 cttgttgcct gcttatcggc tcagcatggg ctcacaggcc ctgccccacg gtcacatgca
       61 gaccctcatc ttcttagacc tggaagccac tggcctgcct tactctcagc ccaaaatcac
      121 agagctgtgc ctgctggctg tccacagaca tgccctggag aactcctcca tgtctgaggg
      181 gcagccacct ccggtgccca aaccaccccg tgtggtggac aagctctctc tctgcattgc
      241 tccagggaaa ccctgcagtt ctggggccag tgagatcaca ggtctgacca cagctgggct
      301 ggaagcacac gggcgtcaac gcttcaatga caacctggcc accctgctcc aagtcttcct
      361 gcagcgccag ccacagccct gctgccttgt ggcccacaac ggtgaccgct acgactttcc
      421 tctgctccag gcagagcttg cttcgctgag cgttatcagt cctctggacg gtaccttctg
      481 tgtggatagc atcgctgccc tgaagacctt ggagcaagcc agcagcccct cagagcatgg
      541 tccgaggaaa agctatagcc tgggtagtat ctacacccgc ctgtacgggc aagcaccaac
      601 agactcacac actgctgaag gcgacgttct agccctgctc agcatctgtc agtggaagcc
      661 acaggcccta ctgcagtggg tggacaaaca cgcccggccc tttagcacca tcaagcccat
      721 gtatggcatg gcagctacta ctggaacggc cagcccaagg ctgtgtgctg ccacaacctc
      781 ctcacccctg gccacagcca acttaagtcc cagcaatggc aggagcaggg gcaagcgacc
      841 tacgagtcct cctccagaga acgtcccaga agccccatca cgggaggggc tgctggcccc
      901 actgggcctg ctgaccttcc tgaccttggc aatagccgtt ctgtatggaa tcttcctggc
      961 ctcacctggg cagtaagtca agagggaaga tatgattaat aaagactacc atagcactga
     1021 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1081 aaaaaaaaaa aaaaaaaaaa a
//
