LOCUS       NM_001106884            1157 bp    mRNA    linear   ROD 24-JUN-2024
DEFINITION  Rattus norvegicus triggering receptor expressed on myeloid cells 2
            (Trem2), mRNA.
ACCESSION   NM_001106884 XM_001063589 XM_217335
VERSION     NM_001106884.1
KEYWORDS    RefSeq.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1157)
  AUTHORS   Tian,Y., Xiao,X., Liu,W., Cheng,S., Qian,N., Wang,L., Liu,Y., Ai,R.
            and Zhu,X.
  TITLE     TREM2 improves microglia function and synaptic development in
            autism spectrum disorders by regulating P38 MAPK signaling pathway
  JOURNAL   Mol Brain 17 (1), 12 (2024)
   PUBMED   38409127
  REMARK    GeneRIF: TREM2 improves microglia function and synaptic development
            in autism spectrum disorders by regulating P38 MAPK signaling
            pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1157)
  AUTHORS   Jiang,C., Chen,Z., Wang,X., Zhang,Y., Guo,X., Fan,H., Huang,D.,
            He,Y., Tang,X., Ai,Y., Liu,Y., Yang,H. and Hao,D.
  TITLE     Curcumin-activated Olfactory Ensheathing Cells Improve Functional
            Recovery After Spinal Cord Injury by Modulating Microglia
            Polarization Through APOE/TREM2/NF-kappaB Signaling Pathway
  JOURNAL   J Neuroimmune Pharmacol 18 (3), 476-494 (2023)
   PUBMED   37658943
  REMARK    GeneRIF: Curcumin-activated Olfactory Ensheathing Cells Improve
            Functional Recovery After Spinal Cord Injury by Modulating
            Microglia Polarization Through APOE/TREM2/NF-kappaB Signaling
            Pathway.
REFERENCE   3  (bases 1 to 1157)
  AUTHORS   Xu,J., Zhang,L., Li,M., He,X., Luo,J., Wu,R., Hong,Z., Zheng,H. and
            Hu,X.
  TITLE     TREM2 mediates physical exercise-promoted neural functional
            recovery in rats with ischemic stroke via microglia-promoted white
            matter repair
  JOURNAL   J Neuroinflammation 20 (1), 50 (2023)
   PUBMED   36829205
  REMARK    GeneRIF: TREM2 mediates physical exercise-promoted neural
            functional recovery in rats with ischemic stroke via
            microglia-promoted white matter repair.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1157)
  AUTHORS   Greve,H.J., Mumaw,C.L., Messenger,E.J., Kodavanti,P.R.S.,
            Royland,J.L., Kodavanti,U.P. and Block,M.L.
  TITLE     Diesel exhaust impairs TREM2 to dysregulate neuroinflammation
  JOURNAL   J Neuroinflammation 17 (1), 351 (2020)
   PUBMED   33222683
  REMARK    GeneRIF: Diesel exhaust impairs TREM2 to dysregulate
            neuroinflammation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1157)
  AUTHORS   Belayev,L., Hong,S.H., Freitas,R.S., Menghani,H., Marcell,S.J.,
            Khoutorova,L., Mukherjee,P.K., Reid,M.M., Oria,R.B. and Bazan,N.G.
  TITLE     DHA modulates MANF and TREM2 abundance, enhances neurogenesis,
            reduces infarct size, and improves neurological function after
            experimental ischemic stroke
  JOURNAL   CNS Neurosci Ther 26 (11), 1155-1167 (2020)
   PUBMED   32757264
  REMARK    GeneRIF: DHA modulates MANF and TREM2 abundance, enhances
            neurogenesis, reduces infarct size, and improves neurological
            function after experimental ischemic stroke.
REFERENCE   6  (bases 1 to 1157)
  AUTHORS   Humphrey,M.B., Daws,M.R., Spusta,S.C., Niemi,E.C., Torchia,J.A.,
            Lanier,L.L., Seaman,W.E. and Nakamura,M.C.
  TITLE     TREM2, a DAP12-associated receptor, regulates osteoclast
            differentiation and function
  JOURNAL   J Bone Miner Res 21 (2), 237-245 (2006)
   PUBMED   16418779
REFERENCE   7  (bases 1 to 1157)
  AUTHORS   Takahashi,K., Rochford,C.D. and Neumann,H.
  TITLE     Clearance of apoptotic neurons without inflammation by microglial
            triggering receptor expressed on myeloid cells-2
  JOURNAL   J Exp Med 201 (4), 647-657 (2005)
   PUBMED   15728241
REFERENCE   8  (bases 1 to 1157)
  AUTHORS   Paloneva,J., Mandelin,J., Kiialainen,A., Bohling,T., Prudlo,J.,
            Hakola,P., Haltia,M., Konttinen,Y.T. and Peltonen,L.
  TITLE     DAP12/TREM2 deficiency results in impaired osteoclast
            differentiation and osteoporotic features
  JOURNAL   J Exp Med 198 (4), 669-675 (2003)
   PUBMED   12925681
REFERENCE   9  (bases 1 to 1157)
  AUTHORS   Daws,M.R., Sullam,P.M., Niemi,E.C., Chen,T.T., Tchao,N.K. and
            Seaman,W.E.
  TITLE     Pattern recognition by TREM-2: binding of anionic ligands
  JOURNAL   J Immunol 171 (2), 594-599 (2003)
   PUBMED   12847223
REFERENCE   10 (bases 1 to 1157)
  AUTHORS   Bouchon,A., Hernandez-Munain,C., Cella,M. and Colonna,M.
  TITLE     A DAP12-mediated pathway regulates expression of CC chemokine
            receptor 7 and maturation of human dendritic cells
  JOURNAL   J Exp Med 194 (8), 1111-1122 (2001)
   PUBMED   11602640
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from CH473987.2.
            
            [WARNING] On Jul 24, 2024 this sequence was replaced by
            NM_001106884.2.
            
            On or before Oct 4, 2007 this sequence version replaced
            XM_217335.4, XM_001063589.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA5756307, SAMEA5760383
                              [ECO:0000350]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..1157
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10116"
                     /chromosome="9"
                     /map="9q12"
     gene            1..1157
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /note="triggering receptor expressed on myeloid cells 2"
                     /db_xref="GeneID:301227"
                     /db_xref="RGD:1309841"
     exon            1..212
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /inference="alignment:Splign:2.1.0"
     CDS             173..859
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /codon_start=1
                     /product="triggering receptor expressed on myeloid cells 2
                     precursor"
                     /protein_id="NP_001100354.1"
                     /db_xref="GeneID:301227"
                     /db_xref="RGD:1309841"
                     /translation="MEPLHVFVLLLVTELSQALNTTVLQGVAGQSLRVSCTYDALRHW
                     GRRKAWCRQLAEEGPCQRVVSTHGVWLLAFLRKQNGSTVITDDTLAGTVTITLRNLQA
                     GDAGLYQCQSLRGREAEVLQKVVVEVLEDPLDDQDAGDLWVPEESESFEGAQVEHSTS
                     SQVSSCGSPLTYHLPPKEPIRKDLLPTHFHSSPPGLCPPEQASYSQHPLGCGQGQAEA
                     GDTCGQWARL"
     exon            213..563
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            564..654
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            655..894
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /inference="alignment:Splign:2.1.0"
     exon            895..1157
                     /gene="Trem2"
                     /gene_synonym="Trem2-Mia; Trem2-Mib"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcacagcgc ccaccctagt cctggctgtt ggttgctcaa tccaggagca cagttcctgt
       61 gggctgagcc tgactggctt ggtcatctct tttctgcact tcaagggaaa aacaagatct
      121 gacacaaggg acccctgcgt ctgtcccctc cggctggctg aggaagggtg ccatggaacc
      181 tctccacgtg tttgtcctgt tgctggtcac agagctgtcc caagccctca acaccacagt
      241 gctgcagggt gtggctggtc agtccctgag ggtgtcatgt acttatgacg ccttgaggca
      301 ctggggacga cgaaaggcct ggtgtcgcca gctggctgag gaggggccat gccagcgcgt
      361 ggtgagcaca cacggtgtgt ggctgctggc cttcctgagg aagcagaatg ggagcacggt
      421 catcacagat gacacccttg ctggaactgt caccatcact ctgaggaacc tccaagctgg
      481 tgatgcaggc ctctaccagt gtcagagcct ccgaggccga gaggctgagg tcctccagaa
      541 ggtcgtggtg gaggtgctgg aggaccctct agatgaccaa gatgctggag acctctgggt
      601 ccccgaggag tcagagagtt tcgaaggggc ccaagtggag cacagcacct ccagtcaggt
      661 ttcatcctgt gggtcacctc taacctacca tcttcctccc aaggagccaa tcaggaaaga
      721 ccttctcccc acccacttcc attcttctcc tcctggcctg tgtcctcctg agcaagcttc
      781 ttacagccag catcctctgg gctgtggcca ggggcaggca gaagctggag acacctgtgg
      841 ccagtgggct agactgtagc caagatgctg ggcaccaact tcagatcctc actggaccca
      901 gaggtatgtg agagaagtct gagtaggagg agaattacag cttaagtcca gccaggagcc
      961 aatccaattg gcatactctc ccctccacca ccaagacttc tgttctgcta ctttttcttc
     1021 agaggccacg tctgcctaaa gcccacctat cccgggagca ggaatactgg tgtgctgcat
     1081 ctgcgttgag tggggaagac agctggatgg ttgctggtaa acgtctgtac tttggacatt
     1141 aaacactctc acacacc
//
