LOCUS       NM_001136141            1985 bp    mRNA    linear   ROD 30-MAR-2024
DEFINITION  Rattus norvegicus trehalase (Treh), mRNA.
ACCESSION   NM_001136141 XM_343380
VERSION     NM_001136141.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 1985)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   2  (bases 1 to 1985)
  AUTHORS   Oesterreicher,T.J., Nanthakumar,N.N., Winston,J.H. and Henning,S.J.
  TITLE     Rat trehalase: cDNA cloning and mRNA expression in adult rat
            tissues and during intestinal ontogeny
  JOURNAL   Am J Physiol 274 (5), R1220-R1227 (1998)
   PUBMED   9644033
REFERENCE   3  (bases 1 to 1985)
  AUTHORS   Ishihara,R., Taketani,S., Sasai-Takedatsu,M., Kino,M., Tokunaga,R.
            and Kobayashi,Y.
  TITLE     Molecular cloning, sequencing and expression of cDNA encoding human
            trehalase
  JOURNAL   Gene 202 (1-2), 69-74 (1997)
   PUBMED   9427547
REFERENCE   4  (bases 1 to 1985)
  AUTHORS   Sasai-Takedatsu,M., Taketani,S., Nagata,N., Furukawa,T.,
            Tokunaga,R., Kojima,T. and Kobayashi,Y.
  TITLE     Human trehalase: characterization, localization, and its increase
            in urine by renal proximal tubular damage
  JOURNAL   Nephron 73 (2), 179-185 (1996)
   PUBMED   8773341
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from
            JAXUCZ010000008.1.
            
            On Oct 23, 2008 this sequence version replaced XM_343380.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR26643288.33398.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN13663621,
                                           SAMN16676809 [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JAXUCZ010000008.1  53886946-53887048
            104-204             JAXUCZ010000008.1  53894941-53895041
            205-349             JAXUCZ010000008.1  53895163-53895307
            350-437             JAXUCZ010000008.1  53895387-53895474
            438-538             JAXUCZ010000008.1  53896482-53896582
            539-631             JAXUCZ010000008.1  53896719-53896811
            632-748             JAXUCZ010000008.1  53897022-53897138
            749-871             JAXUCZ010000008.1  53897229-53897351
            872-921             JAXUCZ010000008.1  53897580-53897629
            922-1116            JAXUCZ010000008.1  53897825-53898019
            1117-1334           JAXUCZ010000008.1  53898585-53898802
            1335-1446           JAXUCZ010000008.1  53898982-53899093
            1447-1559           JAXUCZ010000008.1  53899321-53899433
            1560-1613           JAXUCZ010000008.1  53899687-53899740
            1614-1985           JAXUCZ010000008.1  53899964-53900335
FEATURES             Location/Qualifiers
     source          1..1985
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="8"
                     /map="8q22"
     gene            1..1985
                     /gene="Treh"
                     /note="trehalase"
                     /db_xref="GeneID:60576"
                     /db_xref="RGD:61831"
     exon            1..103
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..1754
                     /gene="Treh"
                     /EC_number="3.2.1.28"
                     /note="trehalase (brush-border membrane glycoprotein)"
                     /codon_start=1
                     /product="trehalase precursor"
                     /protein_id="NP_001129613.1"
                     /db_xref="GeneID:60576"
                     /db_xref="RGD:61831"
                     /translation="MTWELHLLLLLGLGLSSQEALPPPCESQIYCHGELLHQVQMAQL
                     YQDDKQFVDMSLATSPDEVLQKFSELAVAHNHSIPREELQNFVQSYFQPVGQELQPWT
                     PEDWKDSPQFLQKISDSRLRVWAEELHKIWKKLGKKMKAEVLSHPERSSLIYSEHPFI
                     VPGGRFVEFYYWDSYWVMEGLLLSEMASTVKGMLQNFLDLVKTYGHIPNGGRVYYLQR
                     SHPPLLTLMMERYVAHTNDVAFLRENIGTLALELEFWTVNRTVSVGSGGQSYILNRYY
                     VPYGGPRPESYSKDEELAKTVPEGDRETLWAELKAGAESGWDFSSRWLVGGPDPDLLS
                     SIRTSKMVPADLNAFLCQAEELMSNFYSRLGNDTEAKRYRNLRAQRLAAMEAILWDEQ
                     KGAWFDYDLEKGKKNLEFYPSNLTPLWAGCFSDPSVADRALKYLEDNKILTYQYGIPT
                     SLRNTGQQWDFPNAWAPLQDLVIRGLAKSASPRTQEVAFQLAQNWIKTNFKVYSQKSA
                     MYEKYDISNGGHPGGGGEYEVQEGFGWTNGLALMLLDRYGDQLTSGTQLASLGPHCLV
                     TALLLSLLLQ"
     exon            104..204
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            205..349
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            350..437
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            438..538
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            539..631
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            632..748
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            749..871
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            872..921
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            922..1116
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1334
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1446
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1559
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            1560..1613
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
     exon            1614..1985
                     /gene="Treh"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagttccaga caccgtgtcc aggatgacct gggagctgca cctgctgctt ctgctgggcc
       61 tgggacttag ctcccaggag gccctgccac caccctgtga gagccagatc tactgccatg
      121 gggagctcct gcaccaagtt cagatggccc agctctacca agatgacaag cagtttgtgg
      181 atatgtcact ggccacatct ccagacgagg tcctgcagaa gttcagtgag ctggctgtgg
      241 cccacaacca cagcatccct agggaagagc ttcagaactt tgtccagagt tacttccagc
      301 ccgtggggca ggagctgcag ccctggacac ctgaggactg gaaggacagc ccccagttcc
      361 tgcagaagat ctcagattcc aggctgcgtg tctgggccga ggagctacac aagatctgga
      421 aaaagctggg aaagaagatg aaagcagaag tcctcagcca ccccgagagg tcctccctga
      481 tctattcaga gcaccccttc attgtgcccg gagggcgctt tgtcgaattc tactactggg
      541 actcatactg ggtgatggaa ggcctgcttc tctctgagat ggcctcaacg gtgaagggta
      601 tgctgcagaa ctttctggat ctggtgaaga cctacggaca tatccccaac ggcggacgcg
      661 tgtattacct gcaacgcagc caccccccac tcctgactct catgatggag cgatatgtgg
      721 cccacaccaa tgatgtcgcc ttccttcggg agaacattgg gactctagcc ttggaactgg
      781 agttctggac tgtgaacagg actgtctccg tgggctcagg agggcaaagc tatatcttga
      841 atcgttacta tgtcccttat gggggaccca ggccagagtc ctacagcaaa gatgaggaat
      901 tggcaaaaac ggtgccagaa ggggaccgag agactctgtg ggctgagctc aaggctgggg
      961 ctgagtctgg ctgggacttc tcttcacgat ggcttgttgg aggcccagac cctgatttgc
     1021 ttagcagcat tcgaaccagc aaaatggtac ctgctgacct gaacgcgttc ctgtgccaag
     1081 cagaggaact gatgagtaac ttctactcca gactcgggaa tgacactgag gccaaaaggt
     1141 acaggaacct gcgggctcag cgcttggccg ccatggaggc catcctgtgg gacgagcaga
     1201 agggtgcctg gttcgactat gacttggaaa aagggaagaa gaacctggag ttttatccct
     1261 ccaacctcac cccactctgg gctggctgct tctcagaccc tagtgtggct gacagggctc
     1321 tgaagtactt ggaggacaac aagatcttga cctaccagta tgggatccca acctctcttc
     1381 gtaacacagg ccagcagtgg gacttcccca atgcctgggc cccactgcag gacctggtca
     1441 tcagaggttt ggccaagtca gcttcccccc ggactcagga ggtggctttc cagctggccc
     1501 agaattggat caaaaccaac ttcaaagtct actcccaaaa gtcagccatg tatgagaagt
     1561 atgacatcag caatggtgga catccaggtg gaggagggga gtatgaagtt caggaaggat
     1621 ttggctggac aaatggattg gccctgatgc ttctggaccg ctatggtgac cagctgactt
     1681 ccgggaccca gttagcttcc ctgggacccc attgcctagt gactgccctt cttctcagtc
     1741 ttctgctgca gtgacaagga caagaatgga ctcactgcct gtgctttctc ccctagcccc
     1801 agctcatggt tcattaaacc cccgcttccc cctgcgctcc cccctgccct cacaccgtca
     1861 tccccctccc ccctgctcac agtgtactga gccaagaagt gaccaagagg tcaagactgt
     1921 aattttcact agggaagaaa ctgaatccca tcgggtacca catacagccg acttccacac
     1981 tctca
//
