LOCUS       NM_021666               4325 bp    mRNA    linear   ROD 26-FEB-2024
DEFINITION  Rattus norvegicus triadin (Trdn), mRNA.
ACCESSION   NM_021666
VERSION     NM_021666.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Rattus norvegicus (Norway rat)
  ORGANISM  Rattus norvegicus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Rattus.
REFERENCE   1  (bases 1 to 4325)
  AUTHORS   Ma,J., Pang,X., Wang,T., Ning,M., Liang,Y., Li,X., Tian,X., Mo,Y.,
            Laher,I. and Li,S.
  TITLE     Acute aerobic exercise regulation of myocardial calcium homeostasis
            involves CASQ1, CASQ2, and TRDN
  JOURNAL   J Appl Physiol (1985) 135 (4), 707-716 (2023)
   PUBMED   37589058
  REMARK    GeneRIF: Acute aerobic exercise regulation of myocardial calcium
            homeostasis involves CASQ1, CASQ2, and TRDN.
REFERENCE   2  (bases 1 to 4325)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   3  (bases 1 to 4325)
  AUTHORS   Fourest-Lieuvin,A., Rendu,J., Osseni,A., Pernet-Gallay,K.,
            Rossi,D., Oddoux,S., Brocard,J., Sorrentino,V., Marty,I. and
            Faure,J.
  TITLE     Role of triadin in the organization of reticulum membrane at the
            muscle triad
  JOURNAL   J Cell Sci 125 (Pt 14), 3443-3453 (2012)
   PUBMED   22505613
REFERENCE   4  (bases 1 to 4325)
  AUTHORS   Roux-Buisson,N., Cacheux,M., Fourest-Lieuvin,A., Fauconnier,J.,
            Brocard,J., Denjoy,I., Durand,P., Guicheney,P., Kyndt,F.,
            Leenhardt,A., Le Marec,H., Lucet,V., Mabo,P., Probst,V.,
            Monnier,N., Ray,P.F., Santoni,E., Tremeaux,P., Lacampagne,A.,
            Faure,J., Lunardi,J. and Marty,I.
  TITLE     Absence of triadin, a protein of the calcium release complex, is
            responsible for cardiac arrhythmia with sudden death in human
  JOURNAL   Hum Mol Genet 21 (12), 2759-2767 (2012)
   PUBMED   22422768
REFERENCE   5  (bases 1 to 4325)
  AUTHORS   Olah,T., Fodor,J., Oddoux,S., Ruzsnavszky,O., Marty,I. and
            Csernoch,L.
  TITLE     Trisk 32 regulates IP(3) receptors in rat skeletal myoblasts
  JOURNAL   Pflugers Arch 462 (4), 599-610 (2011)
   PUBMED   21811790
  REMARK    GeneRIF: findings show that Trisk 32 not only co-localizes with,
            but directly contributes to, the regulation of Ca(2+) release via
            IP(3) receptors
REFERENCE   6  (bases 1 to 4325)
  AUTHORS   Gyorke,I., Hester,N., Jones,L.R. and Gyorke,S.
  TITLE     The role of calsequestrin, triadin, and junctin in conferring
            cardiac ryanodine receptor responsiveness to luminal calcium
  JOURNAL   Biophys J 86 (4), 2121-2128 (2004)
   PUBMED   15041652
REFERENCE   7  (bases 1 to 4325)
  AUTHORS   Bach,A.D., Beier,J.P. and Stark,G.B.
  TITLE     Expression of Trisk 51, agrin and nicotinic-acetycholine receptor
            epsilon-subunit during muscle development in a novel
            three-dimensional muscle-neuronal co-culture system
  JOURNAL   Cell Tissue Res 314 (2), 263-274 (2003)
   PUBMED   12955494
  REMARK    GeneRIF: The expression of Trdn was studied during muscle
            development in a novel three-dimensional muscle-neuronal coculture
            system.
REFERENCE   8  (bases 1 to 4325)
  AUTHORS   Marty,I., Thevenon,D., Scotto,C., Groh,S., Sainnier,S., Robert,M.,
            Grunwald,D. and Villaz,M.
  TITLE     Cloning and characterization of a new isoform of skeletal muscle
            triadin
  JOURNAL   J Biol Chem 275 (11), 8206-8212 (2000)
   PUBMED   10713145
REFERENCE   9  (bases 1 to 4325)
  AUTHORS   Zhang,L., Kelley,J., Schmeisser,G., Kobayashi,Y.M. and Jones,L.R.
  TITLE     Complex formation between junctin, triadin, calsequestrin, and the
            ryanodine receptor. Proteins of the cardiac junctional sarcoplasmic
            reticulum membrane
  JOURNAL   J Biol Chem 272 (37), 23389-23397 (1997)
   PUBMED   9287354
REFERENCE   10 (bases 1 to 4325)
  AUTHORS   Carl,S.L., Felix,K., Caswell,A.H., Brandt,N.R., Brunschwig,J.P.,
            Meissner,G. and Ferguson,D.G.
  TITLE     Immunolocalization of triadin, DHP receptors, and ryanodine
            receptors in adult and developing skeletal muscle of rats
  JOURNAL   Muscle Nerve 18 (11), 1232-1243 (1995)
   PUBMED   7565919
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            JACYVU010000008.1.
            
            [WARNING] On Apr 3, 2024 this sequence was replaced by NM_021666.5.
            
            On Feb 10, 2021 this sequence version replaced NM_021666.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA5760383, SAMEA5760384
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-103               JACYVU010000008.1  22479539-22479641   c
            104-313             JACYVU010000008.1  22427803-22428012   c
            314-475             JACYVU010000008.1  22409580-22409741   c
            476-508             JACYVU010000008.1  22408461-22408493   c
            509-568             JACYVU010000008.1  22375724-22375783   c
            569-631             JACYVU010000008.1  22364385-22364447   c
            632-691             JACYVU010000008.1  22361317-22361376   c
            692-874             JACYVU010000008.1  22357789-22357971   c
            875-934             JACYVU010000008.1  22351747-22351806   c
            935-1006            JACYVU010000008.1  22282162-22282233   c
            1007-1069           JACYVU010000008.1  22259183-22259245   c
            1070-1129           JACYVU010000008.1  22258158-22258217   c
            1130-1183           JACYVU010000008.1  22184409-22184462   c
            1184-1213           JACYVU010000008.1  22181897-22181926   c
            1214-1243           JACYVU010000008.1  22173494-22173523   c
            1244-1261           JACYVU010000008.1  22172651-22172668   c
            1262-1294           JACYVU010000008.1  22168931-22168963   c
            1295-1321           JACYVU010000008.1  22168780-22168806   c
            1322-1348           JACYVU010000008.1  22158919-22158945   c
            1349-1396           JACYVU010000008.1  22140545-22140592   c
            1397-1441           JACYVU010000008.1  22120297-22120341   c
            1442-1468           JACYVU010000008.1  22073645-22073671   c
            1469-1498           JACYVU010000008.1  22073208-22073237   c
            1499-1528           JACYVU010000008.1  22072763-22072792   c
            1529-1558           JACYVU010000008.1  22072307-22072336   c
            1559-1588           JACYVU010000008.1  22069572-22069601   c
            1589-1615           JACYVU010000008.1  22067357-22067383   c
            1616-1663           JACYVU010000008.1  22066951-22066998   c
            1664-1711           JACYVU010000008.1  22064553-22064600   c
            1712-1756           JACYVU010000008.1  22059596-22059640   c
            1757-1783           JACYVU010000008.1  22055233-22055259   c
            1784-1822           JACYVU010000008.1  22054551-22054589   c
            1823-1867           JACYVU010000008.1  22053479-22053523   c
            1868-1891           JACYVU010000008.1  22051678-22051701   c
            1892-1930           JACYVU010000008.1  22033904-22033942   c
            1931-1966           JACYVU010000008.1  22031857-22031892   c
            1967-2005           JACYVU010000008.1  22030031-22030069   c
            2006-4325           JACYVU010000008.1  22024798-22027117   c
FEATURES             Location/Qualifiers
     source          1..4325
                     /organism="Rattus norvegicus"
                     /mol_type="mRNA"
                     /strain="BN"
                     /db_xref="taxon:10116"
                     /chromosome="1"
                     /map="1p12-p11"
     gene            1..4325
                     /gene="Trdn"
                     /note="triadin"
                     /db_xref="GeneID:59299"
                     /db_xref="RGD:619856"
     exon            1..103
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2145
                     /gene="Trdn"
                     /function="involved in excitation-contraction coupling of
                     muscle"
                     /note="triadin 49 kDa (TRISK 49); triadin 32 kDa (TRISK
                     32); triadin 95; triadin 1"
                     /codon_start=1
                     /product="triadin"
                     /protein_id="NP_067698.2"
                     /db_xref="GeneID:59299"
                     /db_xref="RGD:619856"
                     /translation="MTEITAEGNASITTTVIDNKNGSVPKSPGKVLKRTVTEDIVTTF
                     SSPAAWLLVIALIITWSAVAIVMFDLVDYKNFSASSIAKIGSDPLKLVNDAVEETTDW
                     IYGFFSLLSDIISSDGDEDDEDADEDIDKGEIEEPPLKRKEIQKEKAEKQEKPEKKIQ
                     TKVSHREKEKGKEKLKGEKPEKKATHKEKLEKKERTETKMAAKEDKKIKTKEKTEEKA
                     KKEMKVGKQEKAKPAAAKAKETPKTTPKAREKDDKETPAVPKHEQKDQYAFCRYMIDM
                     FVHGDLKPGQSPAVPPPSLTASRPALSTPSLEEKEKEEKKKVEKKVTSDTKKKEKGEA
                     KKKSEKETVIDGKGKEPGKPPETKQTTTKLTTQAAATKDEKKEDSKKMKKPPEEKPKG
                     KKQEKKEKHIETAKTPKKEHPAPSEKHRKAKAEQAKEEIAPASTKKALHGKKEEKAKT
                     VEQGKDVKPKLPQPQLKKEEKSEPQPKKEVKLETQLKKEEKSEPQVKKEAKLASSEKG
                     QTRKQNITRPEQVIPHGKPEQKVPKQIKAITAEKTEKAERQEKYHPSIKTEGKPEVTD
                     SGKKKIEKPEKESKVPPKQENLQVRNVTRAEKRGKISKDSKDAPAPKKDKDSKDVLHS
                     KKDKEVTNNVSSPKKQKSPISFFQCVYLDGYNGYGFQFPVTPVQHPGENPGKSNSPGQ
                     KQQEQ"
     exon            104..313
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            314..475
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            476..508
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            509..568
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            569..631
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            632..691
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            692..874
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            875..934
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1006
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1069
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1129
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1183
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1213
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1243
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1261
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1294
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1295..1321
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1348
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1396
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1397..1441
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..1468
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1498
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1528
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1558
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1588
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1615
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1663
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1664..1711
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1712..1756
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1783
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1822
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1823..1867
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1891
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1892..1930
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..1966
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            1967..2005
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
     exon            2006..4325
                     /gene="Trdn"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 accagtgttc tctaatccta cctgattctg caaagtgcca cttgactgga acttttcacc
       61 tgattgattt ctgcacccac catgactgag atcacagctg aaggaaatgc atctataacc
      121 acaactgtga tagacaacaa aaatggatct gttcccaagt cccctggaaa ggtgctgaag
      181 aggactgtca ccgaagacat cgtgacaaca ttcagctccc ctgcagcctg gcttctggtc
      241 atcgccctga ttatcacctg gtcagctgtt gctattgtga tgtttgattt agtggactac
      301 aaaaactttt cagcaagctc catcgccaag attggctctg atcctctaaa actagtgaac
      361 gatgctgtgg aggaaacaac agactggatc tatggcttct tctctttgct atctgatatc
      421 atctcatctg atggtgatga agatgatgag gatgcagatg aggacattga caaaggagaa
      481 atagaagaac ctcccttaaa aagaaaagaa atacaaaaag agaaggctga aaagcaggag
      541 aaacctgaga agaaaataca aactaaagtt tcgcacagag aaaaggagaa aggaaaagaa
      601 aaattaaaag gagaaaaacc tgagaagaaa gcaactcaca aggagaaact tgagaaaaaa
      661 gaaagaacag agacaaagat ggcagcaaaa gaggacaaga aaattaagac taaggaaaag
      721 accgaagaaa aggctaagaa ggaaatgaaa gttgggaaac aggagaaagc gaaaccagca
      781 gctgcaaaag ccaaagaaac tccgaaaaca acaccgaaag ccagagagaa ggatgacaaa
      841 gaaacgccag ctgtgcccaa gcatgagcag aaagatcagt atgcgttctg tcgatatatg
      901 attgacatgt ttgtccatgg ggatttaaaa ccaggacaaa gcccagctgt gccaccacca
      961 tcattgacag cttccagacc tgctttgtca acaccatcac tggaagaaaa agaaaaagaa
     1021 gaaaagaaga aagtggagaa gaaagttact tctgatacaa aaaagaaaga aaaaggagaa
     1081 gccaaaaaga aaagcgagaa agaaactgtc attgatggga aaggaaaaga gccaggaaaa
     1141 cctcctgaaa caaaacaaac aaccaccaaa ctcacaacac aagctgcagc taccaaagat
     1201 gagaagaaag aagattccaa gaaaatgaaa aaacctccag aagagaaacc caagggaaaa
     1261 aaacaggaaa agaaagaaaa gcacatagaa acagcaaaga caccaaaaaa ggaacatcca
     1321 gctccaagtg aaaaacacag aaaagcaaaa gctgagcaag ccaaagaaga gattgctcct
     1381 gcctcaacaa aaaaggccct gcatggaaag aaagaagaga aagccaagac agtggagcaa
     1441 ggcaaagatg taaagcctaa actaccacag ccacaactaa aaaaggaaga gaagtccgag
     1501 ccacaaccaa aaaaagaagt gaagttggag acacaactaa aaaaagaaga gaagtcagag
     1561 cctcaagtta agaaggaagc aaaactagca tcatctgaaa aaggccaaac acgcaaacag
     1621 aacatcacca gaccagagca agttattcct catggtaaac cagaacaaaa agttcccaaa
     1681 cagataaaag ctattacagc agaaaagaca gaaaaagctg aacgccaaga aaaataccat
     1741 ccatctataa aaacagaggg aaaaccagaa gtcacagact cagggaagaa gaaaattgaa
     1801 aaacctgaaa aggaaagtaa agttccacca aaacaagaaa atcttcaggt gcgcaatgtg
     1861 actagagcgg aaaaacgtgg aaaaatatca aaagattcca aagatgcacc agctccaaag
     1921 aaagataaag actccaaaga tgtcctgcat tcaaagaaag ataaagaagt aactaataat
     1981 gtgtcttcac caaagaagca aaaaagtccc atcagtttct tccaatgtgt ctacttggat
     2041 gggtacaatg gctatggatt tcagtttcct gtcactcctg tccaacaccc tggagagaac
     2101 cctggcaaat caaactctcc aggacagaag cagcaagaac aatagacacc catacatgac
     2161 cctgacaact gcttttacat catgaaagtg gaatcttctc ttttgttcac agtggcacgg
     2221 gcagtcaaaa ctaaccagtg ctgagatttc attgtaaaca ttttgcctgg cataaagaaa
     2281 tagcatggac aaaagggttg actaataagc aaatgtgttg agggtctaat acttgagaat
     2341 ctttatttgt gtctgttgct ataggagggg tacttacatt cagctctttc tagtcgttat
     2401 aaggtagtaa tctcattaaa gtttactttt aaatgtaatt ggcacaatta caaaatgaga
     2461 tttatgactt caggtagata atttttaatt tggttatata gactgtgttc taattttaaa
     2521 tagtacagga gcatatataa aagttattct tctgcatcct gtgggtagac tcagtttacc
     2581 caaaaaccta tgtgcgttat tacattcatt tctgtttcca gttctattgt gtcaagactc
     2641 tacataggtg tgtcttacac cagagtgctc taaatccctt gtcatatcta acagatggga
     2701 catgacaaag aataagtact tgttggatct tatctctgag gttgtcttga gctatgctta
     2761 agacattctc tcttatggac atatacttgc agttaagcag gtctggtaaa ccacttgctt
     2821 aatatgcaag ttaatgagat atgaaatttt cacatttctc cagattgtgc cccagtaaat
     2881 ccatcacctg ggtgaaggtt tagatcaaac attaactatg gttgacaaat acaaacatag
     2941 ttttatttct caatacattc tttctgtgag agtaaatttt ttttcaaatg gaaacaatac
     3001 aaattccata aatgtttaag cgagatattt tgggcctagg catgtttatg agatgccttt
     3061 cttttggctg attgaacatt aacaccagtt aaatgaatgg cagtttctaa tatacgtgtc
     3121 caggcatcac tgaaaataac atcttcttgg taatacaaac actcgatttt aatgaacttt
     3181 tcttatcaac tctagaaaac atgactgtac tttttcttca agtttccagt tgtagctgaa
     3241 cttgtgacaa attaacaagt tcaactcatg gaaataactt gagttaccat ttctggcatt
     3301 atcagaagct cagccaatgc tgagctactg actttgtgag caagctgtgt ggttggtctt
     3361 aaagtactac agccaaacac agttcttgag gtccaagaca aaggttcatt ttatcaatat
     3421 tcaggtaaga tgtagatcag atacatcatt agtattaatg atggaatgtt ggtgactctt
     3481 gtaagaaagt cagcttcaac cagatgctga cagactggat tcacactaca gaaaccaaca
     3541 ctacaatgaa ctagtttaat ggagccattt ggaggggaag gagtacataa ttgaccagag
     3601 caaatgatac catctttcaa aacacttcat tcagcaattc aaactcacaa ggagaacagt
     3661 ggataaagcg ctctacttag ttggagtttc acccatgcaa gttcctgagt atggaacaga
     3721 gaacaaatgt gacagttgtt ttaaaagaca tgctacagaa tgggttatcc actaagttat
     3781 tacctttcaa tgactatata ctaagctctt agtctttcta ttctgtgtca gataatacag
     3841 caaaaggttt tacttcatgc tacactggca cagtaaatga cattcaaaaa tgcattatat
     3901 atatatatat atatatatat atatatatat atatatatat atatatatat atatattggg
     3961 tctgtatctc caggttacca ggaaccatca aaacaaacag ctcagagttg ttttggagac
     4021 agataaagtg tcttaatatg gatttgtttg aaaacacttt ctgaaattat ggttttggag
     4081 attacattaa tcttatctcc accaatttcg aaatatccat ctattttctt tatgaaacaa
     4141 attgacaaaa tataagagat gttactataa atttagatgt tagagaaaac aattatggta
     4201 taattaatat taacaataat tattacattt tgtctaaaat ttcaatgttg agtataattt
     4261 gaaaatatta tccaaactgg catctgtttg tatctttaca ttaataaaat acttctgacc
     4321 cctga
//
